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Deep sclerectomy-trabeculectomy with mitomycin C in treating glaucoma:postoperative long-term results

International Journal of Ophthalmology(English edition) 2022年第12期15卷 1951-1959页

作者： Chung Shen Chean Li Jiang gayathri kanchana niroshani pati arambage Punithawathy Ranjit Ophthalmology Department Royal Stoke University HospitalNewcastle RoadStoke-on-Trent ST46QGUnited Kingdom

AIM:To determine the long-term postoperative outcomes of deep sclerectomy-trabeculectomy(DST)with mitomycin C(MMC)in the treatment of ***:patients who underwent DST with MMC between 2010 and 2017 were included in this retrospective observational *** success was defined as postoperative intraocular pressure(IOP)≤21 mm Hg or 30%reduction of IOP from baseline without any topical IOP-lowering agent,and qualified success defined as IOP≤21 mm Hg or 30%reduction of IOP from baseline with/without single topical *** evaluated the surgical success rates and complication rates of this procedure,as well as described the IOP profiles,best corrected visual acuity(BCVA)profiles and mean deviations(MD)of Humphrey visual field(HVF)24-2 performance at each follow-up time *** linear regression models were constructed to determine estimated predictive values of demographic data,use of topical IOPlowering agents,baseline and postoperative IOP and optical profiles(e.g.,BCVA and MD).RESULTS:Totally 98 eyes(mean postoperative followup 67.5mo)showed mean IOP reduction at every followup *** median BCVA and MD of visual fields were maintained throughout the follow-up intervals when comparing to *** number of IOP-lowering medications decreased from 2.8±0.8 to 0.3±0.7(P=0.068).Totally 84(85.7%)eyes achieved complete success at final *** hyphaema and transient choroidal effusion developed in 15 eyes(15.3%)and 11 eyes(11.2%)*** complications included shallow anterior chamber in 5 eyes(5.1%),bleb leak in 4 eyes(4.1%),bleb revision in 7 eyes(7.1%),bleb needling in 9 eyes(9.2%)and repeat trabeculectomy in 1 eye(1.0%).There was no endophthalmitis,blebitis or macular *** was no significant correlation between postoperative IOP control and postoperative ***:DST with MMC demonstrates effective and sustained long-term outcomes in the treatment of glaucoma with no major complication.

关键词： glaucoma surgical outcome deep sclerectomy trabeculectomy mitomycin C

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