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Isoform-and cell-state-specific APOE homeostasis and function

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Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： Karina Lindner Anne-Claude gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein E homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol

Influence of preterm birth on the association between gestational diabetes mellitus and childhood developmental vulnerability:a causal mediation analysis

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World Journal of Pediatrics 2024年第1期20卷 54-63页

作者： Bereket Duko Amanuel Tesfay Gebremedhin Gizachew Assefa Tessema gavin Pereira Australian Centre for Precision Health UniSA Clinical and Health SciencesUniversity of South AustraliaNorth TerraceAdelaideSA5000Australia Curtin School of Population Health Faculty of Health SciencesCurtin UniversityKent StreetBentleyWA 6102Australia enAble Institute Curtin UniversityKent StreetBentleyWA6102Australia Centre for Fertility and Health(CeFH) Norwegian Institute of Public HealthOsloNorway

Background Epidemiological studies examining the direct and indirect effects of gestational diabetes mellitus(GDM)on offspring early childhood developmental vulnerability are ***,the aims of this study were to estimate the direct and indirect effects of GDM(through preterm birth)on early childhood developmental *** We conducted a retrospective population-based cohort study on the association between gestational diabetes mellitus and early childhood developmental vulnerability in children born in Western Australia(WA)using maternal,infant and birth records from the Midwives Notification,Hospitalizations,Developmental Anomalies,and the Australian Early Development Census(AEDC)*** used two aggregated outcome measures:developmentally vulnerable on at least one AEDC domain(DV1)and developmentally vulnerable on at least two AEDC domains(DV2).Causal mediation analysis was applied to estimate the natural direct(NDE),indirect(NIE),and total(TE)effects as relative risks(RR).Results In the whole cohort(n=64,356),approximately 22%were classified as DV1 and 11%as DV2 on AEDC *** of the natural direct effect suggested that children exposed to GDM were more likely to be classified as DV1(RR=1.20,95%CI:1.10-1.31)and DV2(RR=1.34,95%CI:1.19-1.50)after adjusting for potential *** 6%and 4%of the effect of GDM on early childhood developmental vulnerability was mediated by preterm birth for DV1 and DV2,*** Children exposed to gestational diabetes mellitus were more likely to be developmentally vulnerable in one or more AEDC *** biological mechanism for these associations is not well explained by mediation through preterm birth.

关键词： Child development Causal mediation analysis Gestational diabetes mellitus Offspring

Management of early oesophageal cancer:An overview

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1255-1258页

作者： gavin G Calpin Matthew G Davey Noel E Donlon Department of Surgery Royal College of Surgeons in IrelandDublin D2Ireland Department of Upper Gastrointestinal Surgery Beaumont HospitalDublin D09V2N0Ireland

The incidence of esophageal cancer,namely the adenocarcinoma subtype,continues to increase exponentially on an annual *** indolent nature of the disease renders a significant proportion inoperable at first presentation,however,with the increased utilisation of endoscopy,many early lesions are now being identified which are suitable for endotherapeutic *** article details the options available for dealing with early esophageal cancer by endoscopic mean obviating the need for surgery thereby avoiding the potential morbidity and mortality of such intervention.

关键词： Esophageal cancer Endotherapy Endoscopic submucosal resection Endoscopic mucosal resection Endoscopy

Modeling urban redevelopment:A novel approach using time-series remote sensing data and machine learning

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Geography and Sustainability 2024年第2期5卷 211-219页

作者： Li Lin Liping Di Chen Zhang Liying Guo Haoteng Zhao Didarul Islam Hui Li Ziao Liu gavin Middleton Center for Spatial Information Science and Systems George Mason UniversityFairfaxVA22030USA Department of Geography and Geoinformation Science George Mason UniversityFairfaxVA22030USA

Accurate mapping and timely monitoring of urban redevelopment are pivotal for urban studies and decisionmakers to foster sustainable urban *** mapping methods heavily depend on field surveys and subjective questionnaires,yielding less objective,reliable,and timely *** advancements in Geographic Information Systems(GIS)and remote-sensing technologies have improved the identification and mapping of urban redevelopment through quantitative analysis using satellite-based ***,challenges persist,particularly concerning accuracy and significant temporal *** study introduces a novel approach to modeling urban redevelopment,leveraging machine learning algorithms and remote-sensing *** methodology can facilitate the accurate and timely identification of urban redevelopment *** study’s machine learning model can analyze time-series remote-sensing data to identify spatio-temporal and spectral patterns related to urban *** model is thoroughly evaluated,and the results indicate that it can accurately capture the time-series patterns of urban *** research’s findings are useful for evaluating urban demographic and economic changes,informing policymaking and urban planning,and contributing to sustainable urban *** model can also serve as a foundation for future research on early-stage urban redevelopment detection and evaluation of the causes and impacts of urban redevelopment.

关键词： Urban redevelopment Urban sustainability Remote sensing Time-series analysis Machine learning

Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

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World Journal of Transplantation 2024年第3期14卷 95-101页

作者： Carlos Verdiales Luke Baxter Hyun Ja Lim gavin Beck Michael A Moser Department of Surgery University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada College of Medicine University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada Canada and Northern Ontario School of Medicine Thunder BayOntario P7B 5E1Canada Department of Community Health and Epidemiology University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada

BACKGROUND Hypothermic machine perfusion(HMP)has demonstrated benefits in terms of early kidney transplant function compared to static cold *** longer preservation times have shown detrimental effects,a previous paired study indicated that longer pump times(the second kidney in a pair)might lead to improved *** To revisit the prior paired study's somewhat unexpected results by reviewing our program's *** A total of 61 pairs of transplant recipients who received kidneys from the same donor(2012-2021)were *** were divided into two groups depending on whether they were transplanted first(K1)or second(K2).Therefore,the patients in each pair had identical donor characteristics,except for time on the *** analyses included Kaplan-Meyer analysis and paired tests,including McNemar's test,student's paired t-test,or Wilcoxon's test,as *** The two groups of recipients had similar demographics(age,body mass index,diabetes,time on dialysis,sensit-ization and retransplants).Cold ischemic times for K1 and K2 were 8.9(95%CI:7.9,9.8)and 14.7 hours(13.7,15.8)(P<0.0001),***,K2 had a higher rate of freedom from biopsy-proven acute rejection at 1 year(P=0.015).Delayed graft function was less common in K2,12/61(20%)than in K1,20/61(33%)(P=0.046).Finally,K2 showed a higher graft survival than K1(P=0.023).CONCLUSION Our results agree with a previous study that suggested possible advantages to longer pump *** studies should encourage further research into HMP's potential anti-inflammatory effect.

关键词： Hypothermic machine perfusion Paired kidney study Early acute rejection

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沉静优雅灰阶美学的儿童肖像

人像摄影 2024年第2期 64-69页

作者： gavin(摄影/文) 不详

商业应用人像摄影,旨在捕捉被拍摄者的面部表情、身体语言和个性,表达独特的魅力和故事。好的人像作品理应具备:引人瞩目的精彩外观,以及能够触动情感共鸣的氛围。一般来说,其关键元素应该包括——。

关键词：情感共鸣面部表情人像摄影拍摄者商业应用身体语言关键元素

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自制最好的石英钟

科技纵览 2024年第2期 18-20页

作者： gavin Watkins 不详

高级计时技术进入家庭。我一直对精准计时技术很感兴趣。现今,我们主要依赖互联网或者来自GPS卫星、广播电台的无线电波提供的计时。但我想要一个不依赖外界也可良好运行的计时时钟,而且一定要比一般的数字时钟或微控制器中使用的石英... 详细信息

高级计时技术进入家庭。我一直对精准计时技术很感兴趣。现今,我们主要依赖互联网或者来自GPS卫星、广播电台的无线电波提供的计时。但我想要一个不依赖外界也可良好运行的计时时钟,而且一定要比一般的数字时钟或微控制器中使用的石英晶体振荡器所提供的时间更准确,这些设备每天的时间偏差约1.7秒,一年的偏差超过10分钟。

关键词：石英晶体振荡器无线电波时间偏差数字时钟微控制器广播电台互联网 GPS卫星

Higgs boson searches at the Tevatron

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Frontiers of physics 2013年第3期8卷 270-284页

作者： gavin J. Davies Imperial College London London SW7 2AZ United Kingdom

This article reviews the Higgs searches at the Tevatron, as presented over the summer of 2012; both standard model （SM） and beyond the standard model （BSM） results are discussed as detailed （arXiv： 1207.0449; Phys. Rev. Lett., 2012, 109： 071804; Phys. Rev. D, 2012, 85： 032005）. We discuss the combination of searches by the CDF and DO Collaborations for the standard model Higgs boson in the mass range 100-200 GeV/c2 produced in the the gg →H, WH, ZH, tfH, and vector boson fusion production modes, and decaying in the H → bb, H → W＋W-, H → ZZ, H →π＋π-, and H →γγ modes. The data, collected at the Fermilab Tevatron collider in p/5 collisions at √s = 1.96 TeV, correspond to integrated luminosities of up to 10 fb^-1. In the absence of signal, we expect to exclude the regions 100 〈 mH 〈 120 GeV/c2 and 139 〈 mH 〈 184 GeV/c2. We exclude, at the 95% C.L., two regions： 100 〈 mH 〈 103 GeV/c2, and 147 〈 mH 〈 180 GeV/c2. We observe a significant excess of events in the mass range between 115 and 140 GeV/c2. The local significance corresponds to 3.0 standard deviations at mH = 120 GeV/ce; the global significance （incorporating the lookelsewhere effect） for such an excess anywhere in the full mass range investigated is approximately 2.5 standard deviations. Furthermore, we separately combine searches for H→ bb-, H → W＋W- and H →γγ. We find that the excess is concentrated in the H →bb channel, appearing in the searches over a broad range of raN; the maximum local significance of 3.3 standard deviations corresponds to a global significance of approximately 3.1 standard deviations. The observed signal strengths in all channels are consistent with the expectation for a standard model Higgs boson at mH = 125 GeV/c2. The production of neutral Higgs bosons in association with b-quarks can be significantly enhanced in various beyond the standard model scenarios, including Supersymmetry. The recent combination of such searches from the two collaborations is discussed.

关键词： Higgs Tevatron

Decentralized Control of Multiagent Navigation Systems

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 922-925页

作者： Boyang Zhang Henri P.gavin IEEE Department of Civil and Environmental Engineering Duke UniversityDurhamNC 27708 USA

Dear editor,In this letter,we introduce a decentralized,nonlinear,discontinuous,and computationally simple control law for large scale multiagent navigation *** control is based on extending Gauss’s principle of least constraint with a dynamic incorporation of inequality constraints,actuator saturation,and actuator *** no individual path planner,each agent executes its motion and generates its control actions by reacting solely to the evolution of its constrained dynamics,which is equivalent to solving a linear matrix equation with a dimension up to around 20 without iteration at each time *** experiments are conducted on hundreds of two-dimensional(2-D)double integrators subjected to path and collision constraints,demonstrating the promise of the proposed method.

关键词： dynamics method constraints