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Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock:An Indian perspective

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World Journal of Critical Care Medicine 2024年第1期13卷 65-75页

作者： Yatin Mehta Abdul Samad Ansari Amit Kumar Mandal Dipanjan Chatterjee gauri shankar sharma Prachee Sathe Purvesh V Umraniya Rajib Paul Sachin Gupta Vinod Singh Yogendra Pal Singh Institute of Critical Care and Anesthesiology Medanta The MedicityGurgaon 122001HaryanaIndia Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Pulmonology Sleep and Critical CareFortis HospitalMohaliPunjabMohali 160062PunjabIndia Department of Cardio-Puimonary Critical Care Medica Superspecialty HospitalKolkata 700099India Department of Critical Care Medicine Fortis HospitalNew Delhi 110070India Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Bhailal Amin General HospitalVadodara 390003GujaratIndia Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Anaesthesiology Narayana Superspeciality HospitalGurugram 122002India Department of Critical Care Medicine Institute of Critical Care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Department of Critical Care Medicine Max Super Speciality HospitalDelhi 110092India

BACKGROUND Septic shock is a severe form of sepsis characterised by deterioration in circulatory and cellular-metabolic *** standard therapy,the outcomes are *** adjuvant therapy,such as CytoSorb®extracorporeal haemoadsorption device,has been investigated and shown promising ***,there is a lack of some guidance to make clinical decisions on the use of CytoSorb®haemoadsorption as an adjuvant therapy in septic shock in Indian ***,this expert consensus was *** To formulate/establish specific consensus statements on the use of CytoSorb®haemoadsorption treatment based on the best available evidence and contextualised to the Indian *** We performed a comprehensive literature on CytoSorb®haemoadsorption in sepsis,septic shock in PubMed selecting papers published between January 2011 and March 20232021 in English *** statements for a consensus document were developed based on the summarised literature analysis and identification of knowledge *** a modified Delphi approach combining evidence appraisal and expert opinion,the following topics related to CytoSorb®in septic shock were addressed:need for adjuvant therapy,initiation timeline,need for Interleukin-6 levels,duration of therapy,change of adsorbers,safety,prerequisite condition,efficacy endpoints and management *** expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** Eleven expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** 11 experts in the consensus group(100%)participated in the first,second and third round of *** three iterative voting rounds and adapting two statements,consensus was achieved on nine statements out of nine *** consensus expert panel also recognised the necessity to form an associatio

关键词： Consensus CytoSorb Cytokine Hemoadsorption Refractory Sepsis Septic shock

Codimension-2 bifurcation in a discrete predator-prey system with constant yield predator harvesting

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生物数学学报:英文版 2023年第5期16卷 165-191页

作者： Anuraj Singh Vijay shankar sharma ABV-Indian Institute of Information Technology and Management Gwalior Madhya PradeshIndia

This work investigates the bifurcation analysis in a discrete-time Leslie-Gower predatorprey model with constant yield predator *** stability analysis for the fixed points of the discretized model is shown *** this study,the model undergoes codimension-1 bifurcation such as fold bifurcation(limit point),flip bifurcation(perioddoubling)and Neimark-Sacker bifurcation at a positive fixed ***,the model exhibits codimension-2 bifurcations,including Bogdanov-Takens bifurcation and generalized fip bifurcation at the fixed *** each bifurcation,by using the critical normal form coefficient method,various critical states are *** validate our analytical findings,the bifurcation curves of fixed points are drawn by using *** system exhibits interesting rich dynamics including limit cycles and ***,it has been shown that the predator harvesting may control the chaos in the system.

关键词： Flip bifurcation Neimark-Sacker bifurcation generalized fip bifurcation Bogdanov-Takens bifurcation harvesting

Trusted Cluster-Based Communication for Wireless Sensor Network Using Meta-Heuristic Algorithms

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Computer Systems Science & Engineering 2023年第5期45卷 1935-1951页

作者： Pankaj Kumar sharma Uma shankar Modani Department of Computer Engineeing Mahila Engineering CollegeAjmerIndia Department of E&C Engineering Engineering CollegeAjmerIndia

The mobile transient and sensor network’s routing algorithm detects available multi-hop paths between source and destination ***,some methods are not as reliable or trustworthy as ***,finding a reliable method is an important factor in improving communication *** further enhancement of protected communication,we suggest a trust cluster based secure routing(TCSR)framework for wireless sensor network(WSN)using optimization ***,we introduce an efficient cluster formation using a modified tug of war optimization(MTWO)algorithm,which provides loadbalanced clusters for energy-efficient data ***,we illustrate the optimal head selection using multiple design constraints received signal strength,congestion rate,data loss rate,and throughput of the *** parameters are optimized by a butterfly optimal deep neural network(BO-DNN),which provides first-level security towards the selection of the best head ***,we utilize the lightweight signcryption to encrypt the data between two nodes during data transmission,which provides second-level *** model provides an estimation of the trust level of each route to help a source node to select the most secure *** nodes of the network improve reliability and security by maintaining the reliability *** results showed that the proposed scheme achieved 45.6%of delivery ratio.

关键词： Trust model WSN secure routing cluster formation load-balanced clusters

GeDiPNet: Online resource of curated gene-disease associations for polypharmacological targets discovery

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Genes & Diseases 2023年第3期10卷 647-649页

作者： Indra Kundu Mridula sharma Ram shankar Barai Khushal Pokar Susan Idicula-Thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbai 400012India

There are numerous online databases dedicated to genes associated with human *** redundancy and lack of consistency of disease terms in these databases pose a significant impediment in high throughput data *** address this,we developed GeDiPNet by compiling data available on gene-disease associations from six popular open access sources namely DisGeNET,1 ClinGen.

关键词： databases online analysis.

Adaptive Statistical Spatial Downscaling of Precipitation Supported by High-Resolution Atmospheric Simulation Data for Mountainous Areas of Nepal

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气象学报:英文版 2023年第4期37卷 508-520页

作者： Hua YANG Kun YANG Jun QIN Baohong DING Yaozhi JIANG Yingying CHEN Xu ZHOU Yan WANG shankar sharma National Tibetan Plateau Data Center State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101 University of Chinese Academy of Sciences Beijing 100049 Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing 100084 State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101 Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101

In complex terrain regions, it is very challenging to obtain high accuracy and resolution precipitation data that are required in land hydrological studies. In this study, an adaptive precipitation downscaling method is proposed based on the statistical downscaling model MicroMet. A key input parameter in the MicroMet is the precipitation adjustment factor(PAF) that shows the elevation dependence of precipitation. Its value is estimated conventionally based on station observations and suffers sparse stations in high altitudes. This study proposes to estimate the PAF value and its spatial variability with precipitation data from high-resolution atmospheric simulations and tests the idea in Nepal of South Himalayas, where rainfall stations are relatively dense. The result shows that MicroMet performs the best with the PAF value estimated from the simulation data at the scale of approximately 1.5 degrees. Not only the value at this scale is qualitatively consistent with early knowledge obtained from intensive observations, but also the downscaling performance with this value is better than or comparable to that with the PAF estimated from dense station data. Finally, it is shown that the PAF estimation, although critical, cannot replace the importance of increasing input station density for downscaling.

关键词： precipitation statistical downscaling precipitation adjustment factor adaptive estimation high resolution dynamical downscaling

Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 193-199页

作者： Mahuya Sengupta gauri Dutta sharma Biswajit Chakraborty Department of Biotechnology Assam University Department of Life Science Assam University

Objective:To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl_4 intoxicated Swiss albino ***:first group of mice(n=5) received CCl_4 treatment at a dose of 0.5 mL/kg bw(i.p.) for 7 *** group was fed orally the aqueous extract of turmeric at a dose of 50 mg/kg bw for IS *** third group was given both the turmeric extract(for 15 days,orally) and CCl_4(for last 7 days,i.p.).The fourth group was kept as a *** study the liver function,the transaminase enzymes(SGOT and SGPT) and bilirubin level were measured in the serum of respective *** assaying the immunotherapeutic action of Curcuma longa(***),non specific host response parameters like morphological alteration,phagocytosis,nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages were studied from the respective ***:The result of present study suggested that CCl_4 administration increased the level of SCOT and SGPT and bilirubin level in ***,the aqueous extract of turmeric reduced the level of SGOT, SCFT and bilirubin in CCl_4 intoxicated *** from damaging the liver system,CCl_4 also reduced non specific host response parameters like morphological alteration,phagocytosis, nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal *** of aqueous extract of *** offered significant protection from these damaging actions of CCl_4 on the non specific host response in the peritoneal macrophages of CCl_4 intoxicated ***:In conclusion,the present study suggests that *** has immunotherapeutic properties along with its ability to ameliorate hepatotoxicity.

关键词： Immune system Hepatotoxicity Curcuma longa Immunotherapeutic agents Hepatoprotectivity Turmeric rhizome Hepatoxicity Transaminase enzyme Liver function Bilirubin Nitric oxide Morphological alteration

Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction

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World Journal of Cardiology 2023年第1期15卷 23-32页

作者： Rishi Sethi Lalit Mohan Pravesh Vishwakarma Abhishek Singh Swati sharma Monika Bhandari Ayush Shukla Akhil sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun shankar Narain Sudhanshu Kumar Dwivedi Department of Cardiology King George's Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac *** restoration of brisk flow in the coronary vasculature is critical in reducing mortality and *** patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective *** To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after *** This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary *** received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the *** secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 *** The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,*** rate was 54.6%and 55.8%in the routine and delayed groups,*** was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,*** significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reporte

关键词： Coronary artery disease ST-elevation myocardial infarction Primary percutaneous coronary intervention Pharmacoinvasive strategy Thrombolysis Atherosclerosis

Study of coronary sinus anatomy during levophase of coronary angiography

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World Journal of Cardiology 2022年第6期14卷 372-381页

作者： Akshyaya Pradhan Vrishank Bajaj Pravesh Vishwakarma Monika Bhandari Akhil sharma Gaurav Chaudhary Sharad Chandra Rishi Sethi Varun shankar Narain Sudhanshu Dwivedi Department of Cardiology King George Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND Coronary sinus(CS)imaging has recently gained importance due to increasing need for mapping and ablation of electrophysiological arrhythmias and left ventricular(LV)pacing during cardiac resynchronization therapy(CRT).Retrograde venogram is the current standard for imaging CS and its *** To evaluate CS anatomy during levophase of routine coronary angiography to aid LV lead implantation during *** In this prospective observational study,164 patients undergoing routine coronary angiography for various indications(Chronic stable angina-44.5%,acute coronary syndrome-39.5%,Dilated cardiomyopathy-11%,atypical chest pain-5%)were *** phase(levophase)of left coronary injection was recorded in left anterior oblique-cranial and right anterior oblique-cranial *** of coronary veins,width and shape of CS ostium,angulations of proximal CS with body of CS were ***,size,take-off angle and tortuosity of posterolateral vein(PLV),anterior interventricular veins(AIV)and middle cardiac vein(MCV)were also *** During levophase,visibility grade(Muhlenbruch grade)for coronary veins was 3 in 74%and 2 in 26%of *** of CS did not correlate with body mass *** diameter of CS ostium was15 mm in 48%,42%and 10%of patients *** CS was tubular in 136(83%)patients and funnel-shaped in 28(17%)*** take-off angulation between ostium and body of CS was seen in 16(10%)*** or more PLV were present in 8 patients while PLV was absent in 52(32%)*** of take-off of PLV with body of CS was favourable(0°-45°)in 65(40%)*** angle was 45°-90°in 36 patients and difficult take-off angle(>90°)was seen in 8 *** of PLV reached distal third of myocardium in 84 cases and middle third in 11 *** was no tortuosity in 79 cases,a single bend in 29 cases and more than 2 bends in 4 *** nine(24%)patients had other veins supplying poste

关键词： Posterolateral vein Ostium Angiography Sharp take off Favourable angulation

Enhanced CH4 yield by photocatalytic CO2 reduction using TiO2 nanotube arrays grafted with Au, Ru, and ZnPd nanoparticles

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Nano Research 2016年第11期9卷 3478-3493页

作者： Piyush Kar Samira Farsinezhad Najia Mahdi Yun Zhang Uchenna Obuekwe Himani sharma Jing Shen Natalia Semagina Karthik shankar Department of Electrical and Computer Engineering University of Alberta 9107-116 Street Edmonton Alberta T6G 2V4 Canada Department of Chemical & Materials Engineering University of Alberta 9107-116 Street Edmonton Alberta T66 2V4 Canada NRC National Institute for Nanotechnology 11421 Saskatchewan Dr. NW Edmonton Alberta T6G 2M9 Canada

Metal nanoparticle （NP） co-catalysts on metal oxide semiconductor supports are attracting attention as photocatalysts for a variety of chemical reactions. Related efforts seek to make and use Pt-free catalysts. In this regard, we report here enhanced CH4 formation rates of 25 and 60 μmol·g^-1·h^-1 by photocatalytic CO2 reduction using hitherto unused ZnPd NPs as well as Au and Ru NPs. The NPs are formed by colloidal synthesis and grafted onto short n-type anatase TiO2 nanotube arrays （TNAs）, grown anodically on transparent glass substrates. The interfacial electric fields in the NP-grafted TiO2 nanotubes were probed by ultraviolet photoelectron spectroscopy （UPS）. Au NP-grafted TiO2 nanotubes （Au-TNAs） showed no band bending, but a depletion region was detected in Ru NP-grafted TNAs （Ru-TNAs） and an accumulation layer was observed in ZnPd NP-grafted TNAs （ZnPd-TNAs）. Temperature programmed desorption （TPD） experiments showed significantly greater CO2 adsorption on NP-grafted TNAs. TNAs with grafted NPs exhibit broader and more intense UV-visible absorption bands than bare TNAs. We found that CO2 photoreduction by nanoparticle-grafted TNAs was driven not only by ultraviolet photons with energies greater than the TiO2 band gap, but also by blue photons close to and below the anatase band edge. The enhanced rate of CO2 reduction is attributed to superior use of blue photons in the solar spectrum, excellent reactant adsorption, efficient charge transfer to adsorbates, and low recombination losses.

关键词： metal nanoparticles (NPs) TiO2 nanotube arrays(TNAs) colloidal synthesis band bending built-in potential photocatalytic CO2reduction semiconductorheterojunctions