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Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut

Molecular Plant 2017年第2期10卷 309-322页

作者： Josh Clevenger Ye Chu Carolina Chavarro gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. Varshney Peggy Ozias-Akins Department of Horticulture and Institute of Plant Breeding Genetics & Genomics The University of Georgia 2356 Rainwater Road Tifton GA 31793 USA Center for Applied Genetic Technologies and Institute of Plant Breeding Genetics & Genomics The University of Georgia Athens GA 30602 USA International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Hyderabad 502324 India University of Brasilia Institute of Biological Sciences Campus Darcy Ribeiro 70910-900 Brasilia DF Brazil Embrapa Genetic Resources and Biotechnology 70770-917 Brasflia DF Brazil eUSDA-ARS PGRCU Griffin GA 30223 USA Agricultural Research Organization Plant Sciences Institute 7528809 Rishon LeZion Israel Department of Plant and Soil Science Texas Tech University Lubbock TX 79409-2122 USA Department of Crop and Soil Sciences North Carolina State University Box 7629 Raleigh NC 28695-7629 USA USDA-ARS Tifton GA 31793. USA

Peanut （Arachis hypogaea; 2n = 4x = 40） is a nutritious food and a good source of vitamins, minerals, and healthy fats. Expansion of genetic and genomic resources for genetic enhancement of cultivated peanut has gained momentum from the sequenced genomes of the diploid ancestors of cultivated peanut. To facil- itate high-throughput genotyping of Arachis species, 20 genotypes were re-sequenced and genome-wide single nucleotide poiymorphisms （SNPs） were selected to develop a large-scale SNP genotyping array. For flexibility in genotyping applications, SNPs polymorphic between tetraploid and diploid species were included for use in cultivated and interspecific populations. A set of 384 accessions was used to test the array resulting in 54 564 markers that produced high-quality polymorphic clusters between diploid species, 47 116 polymorphic markers between cultivated and interspecific hybrids, and 15 897 polymorphic markers within A. hypogaea germplasm. An additional 1193 markers were identified that illuminated genomic re- gions exhibiting tetrasomic recombination. Furthermore, a set of elite cultivars that make up the pedigree of US runner germplasm were genotyped and used to identify genomic regions that have undergone pos- itive selection. These observations provide key insights on the inclusion of new genetic diversity in culti- vated peanut and will inform the development of high-resolution mapping populations. Due to its efficiency, scope, and flexibility, the newly developed SNP array will be very useful for further genetic and breeding applications in Arachis.

关键词： single nucleotide polymorphism groundnut Arachis hypogaea

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Diagnostic assays developed for the control of foot-andmouth disease in India

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World Journal of Virology 2015年第3期4卷 295-302页

作者： gaurav Kumar Sharma Sonalika Mahajan Rakesh Matura Saravanan Subramaniam Rajeev Ranjan Jitendra Biswal Manoranjan Rout Jajati Keshari Mohapatra Bana Bihari Dash Aniket Sanyal Bramhadev Pattnaik Project Directorate on Foot and Mouth Disease Indian Council of Agricultural Research

Foot-and-mouth disease(FMD) is a highly contagious and economically devastating disease of livestock, primarily affecting cattle, buffalo and pigs. FMD virus serotypes O, A and Asia1 are prevalent in India and systematic efforts are on to control and eventually eradicate the disease from the country. FMD epidemiology is complex due to factors like co-circulation, extinction, emergence and re-emergence of genotypes/lineages within the three serotypes, animal movement, diverse farm practices and large number of susceptible livestock in the country. Systematic vaccination, prompt diagnosis, strict biosecurity measures, and regular monitoring of vaccinal immunity and surveillance of virus circulation are indispensible features for the effective implementation of the control measures. Availability of suitable companion diagnostic tests is very important in this endeavour. In this review, the diagnostic assays developed and validated in India and their contribution in FMD control programme is presented.

关键词： Foot-and-mouth disease Diagnosis Serosurveillance Sero-monitoring Multiplex polymerase chain reaction Real-time polymerase chain reaction Lineage differentiating polymerase chain reaction

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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Mass Disaster: Will Dental Records be Effectively Useful in Developing Nations?

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Journal of Forensic Science and Medicine 2015年第1期1卷 72-72页

作者： gaurav Sharma Archna Nagpal Department of Oral Medicine and Radiology S.R.Dental CollegeFaridabadHaryana Department of Oral Medicine and Radiology PDM Dental College and Research InstituteBahadurgarhHaryanaIndia

Sir,Dentistry is growing at a rapid rate and now there is certainly an increased awareness of oral health care among the general population of developing *** are numerous studies conducted on the important role of forensic odontology in developing ***,I have always been intrigued about whether in case of a mass disaster,the records of the patients would actually be available to the concerned forensic odontologist or the forensics *** is a lack of any common record of the patients in resource‑constrained *** data is obtained by general dental practitioners but most of the time,the data is not recorded in either soft copy(through digital imaging)or conventional intraoral periapical film and is generally *** obvious reason for this is the lack of any archiving *** is no compulsion to keep the records of the patients and thus,valuable data is *** would like to recommend a system for archiving records that can be cited in a ***,there are certain practical difficulties involved such as the lack of any dental insurance scheme in emerging nations due to which the general dental practitioners may lack the motivation to archive records and place these records on a ***,the practitioners would feel uncomfortable placing their patients’records on a common website.

关键词： motivation disaster records

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基于拓扑优化的扭力梁式轿车后桥结构轻量化设计

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汽车工程学报 2019年第2期9卷 143-148页

作者：汪彬陈光权施卓奇董卫平 gaurav Kesireddy 张洪延浙江师范大学浙江金华321004 托莱多大学美国托莱多oh43606

在某轿车原扭力梁后桥的基础上,建立了扭力梁式后桥的结构力学模型,具体分析了原车后桥的模态及在静止、制动或启动及侧翻工况下的强度。在此基础上进行原车后桥的拓扑结构轻量化设计,通过在原后桥的基础上获得后桥空间设计域及非设计域... 详细信息

在某轿车原扭力梁后桥的基础上,建立了扭力梁式后桥的结构力学模型,具体分析了原车后桥的模态及在静止、制动或启动及侧翻工况下的强度。在此基础上进行原车后桥的拓扑结构轻量化设计,通过在原后桥的基础上获得后桥空间设计域及非设计域,定义设计目标、设计函数、加载条件及响应,迭代计算获得了最佳的结构拓扑方案。根据结构拓扑优化的最终结果,通过CAD重构获得了拓扑结构轻量化的后桥设计。模态及强度计算结果显示,优化后的后桥前三阶模态频率较原后桥有大幅减小,不同工况下后桥的应力分布更趋合理,在设计域内及安装位置不变的条件下,新后桥的质量由原后桥的19.06 kg减少到17.67 kg,减重7.29%。

关键词：后桥轻量化结构优化拓扑优化

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原发免疫性血小板减少症(下篇)

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血栓与止血学 2016年第2期22卷 195-199页

作者：郭珊珊于天启陈志雄 gaurav Kistanguri Keith R.McCrae 广州中医药大学第三附属医院广州510240 广州中医药大学广州510405 不详

7治疗和预后7.1儿童患者约80%ITP患儿可自愈,往往都在6个月内,偶尔超过1年或更久[29,30]。新诊断ITP患儿严重出血发生率约1/200,颅内出血发生率低于1/500,多发生于确诊首个月内。确需治疗者,应用短疗程肾上腺皮质激素、静脉注射免疫球... 详细信息

7治疗和预后7.1儿童患者约80%ITP患儿可自愈,往往都在6个月内,偶尔超过1年或更久[29,30]。新诊断ITP患儿严重出血发生率约1/200,颅内出血发生率低于1/500,多发生于确诊首个月内。确需治疗者,应用短疗程肾上腺皮质激素、静脉注射免疫球蛋白、抗D（Rh阳性者）往往很快起效。有数种治疗方法应用于另外20%发展成持续性ITP的患儿。

关键词：免疫血小板减少症

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Proportion of thyroid cancer and other cancers in the democratic republic of Congo

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World Journal of Experimental Medicine 2023年第3期13卷 17-27页

作者： John Bukasa-Kakamba Ayrton I Bangolo Pascal Bayauli Branly Mbunga Francis Iyese Aliocha Nkodila Ali Atoot gaurav Anand Stacy H Lee Maimona Chaudhary Pamela Q Fernandes Hari PSS Mannam Adithya Polavarapu Merajunissa Merajunnissa Abdullah Azhar Mohan N Alichetty gauravdeep Singh Georgemar V Arana Jr Imranjot Sekhon Manbir Singh JoséD Rodriguez-Castro Adam Atoot Simcha Weissman Jean Rene M’buyamba Endocrine and Metabolic Disorders Department University of KinshasaKinshasa KinshasaCongo Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States School of Public Health University of KinshasaKinshasa KinshasaCongo Family Medicine Protestant University of CongoKinshasa KinshasaCongo Department of Medicine Hackensack University-Palisades Medical CenterNorth BergenNJ 07047United States

BACKGROUND Cancer diagnosis is increasing around the world and in the Democratic Republic of the Congo(DRC).The proportion of thyroid cancer has increased over the past three *** are very few studies on cancer epidemiology,and in particular on thyroid cancer in the *** To establish the most recent proportion of thyroid cancer in the DRC compared to other *** This is a retrospective and descriptive study of 6106 consecutive cancer cases listed in the pathological registers of 4 Laboratories in the city of *** study included all cancer cases recorded in the registers between 2005 and *** From a sample of 6106 patients,including all cancer types,68.3%cases were female and 31.7%were *** and cervical cancer were the most common types of cancer in women and,prostate and skin cancer were the most common types in *** cancer was sixth in proportion in women and eleventh in men compared to all *** carcinoma was the most common of thyroid *** cancers such as anaplastic and medullary thyroid carcinomas had a proportion of 7%and 2%,*** Newer diagnostic tools led to a surge in cancer diagnoses in the *** cancer has more than doubled its proportion over the last several decades in the country.

关键词： Thyroid cancer Papillary carcinoma Cancer Democratic Republic of the Congo Africa Proportion

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Rosai-Dorfman病特异性表达OCT2:显示独特的单核-巨噬细胞表型

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临床与实验病理学杂志 2022年 942页

作者： Ravindran A gaurav G Go R S 王婷余英豪福建省泉州市中医院病理科中国人民解放军联勤保障部队第九〇〇医院病理科

Rosai-Dorfman病是一类累及淋巴结且具有显著异质性和临床特征的自限性组织细胞疾病,确诊该病前需排除其他组织肿瘤,尤其需与Erdheim-Chester病和朗格汉斯细胞组织细胞增生症鉴别。作者收集33例Rosai-Dorfman病,对其组织学和免疫表型特...

Rosai-Dorfman病是一类累及淋巴结且具有显著异质性和临床特征的自限性组织细胞疾病,确诊该病前需排除其他组织肿瘤,尤其需与Erdheim-Chester病和朗格汉斯细胞组织细胞增生症鉴别。作者收集33例Rosai-Dorfman病,对其组织学和免疫表型特征进分析。患者年龄21～79岁,中位年龄54岁,女性占多数(73%,n=24)。根据WHO(2016)组织细胞肿瘤修订新分类,24例皮肤外病变被归为“R”组,其余9例病变局限于皮肤或皮下组织则归入“C”组。

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Rosai-Dorfman病特异性表达OCT2:显示独特的单核-巨噬细胞表型

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临床与实验病理学杂志 2022年第8期38卷 942-942页

作者：王婷(摘译) 余英豪(审校) Ravindran A gaurav G Go R S 福建省泉州市中医院病理科泉州362000 中国人民解放军联勤保障部队第九○○医院病理科福州350025 不详

Rosai-Dorfman病是一类累及淋巴结且具有显著异质性和临床特征的自限性组织细胞疾病,确诊该病前需排除其他组织肿瘤,尤其需与Erdheim-Chester病和朗格汉斯细胞组织细胞增生症鉴别。作者收集33例Rosai-Dorfman病,对其组织学和免疫表型特... 详细信息

Rosai-Dorfman病是一类累及淋巴结且具有显著异质性和临床特征的自限性组织细胞疾病,确诊该病前需排除其他组织肿瘤,尤其需与Erdheim-Chester病和朗格汉斯细胞组织细胞增生症鉴别。作者收集33例Rosai-Dorfman病,对其组织学和免疫表型特征进分析。患者年龄21~79岁,中位年龄54岁,女性占多数(73%,n=24)。根据WHO(2016)组织细胞肿瘤修订新分类,24例皮肤外病变被归为“R”组.

关键词：朗格汉斯细胞组织细胞增生症组织细胞肿瘤自限性患者年龄特异性表达临床特征淋巴结组织学

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原发免疫性血小板减少症(上篇)

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血栓与止血学 2016年第1期22卷 113-117页

作者：郭珊珊于天启陈志雄 gaurav Kistanguri Keith R.McCrae 广州中医药大学第三附属医院广州510240 广州中医药大学广州510405 不详

1定义及历史沿革原发免疫性血小板减少症是一种常见血液系统疾病，可发生于不同年龄、不同性别、不同种族。原先被称为“特发性血小板减少性紫癜（idiopathic thrombocytopenic purpura，ITP），近年，国际ITP工作组建议将其定名为原发... 详细信息

1定义及历史沿革原发免疫性血小板减少症是一种常见血液系统疾病，可发生于不同年龄、不同性别、不同种族。原先被称为“特发性血小板减少性紫癜（idiopathic thrombocytopenic purpura，ITP），近年，国际ITP工作组建议将其定名为原发免疫性血小板减少症（immunethrombocyto penia），保留原缩写ITP。

关键词：免疫血小板减少症

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