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Comparing accuracy of cochlear measurements on magnetic resonance imaging and computed tomography:A step towards radiation-free cochlear implantation

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Journal of Otology 2023年第4期18卷 208-213页

作者： Anurita Swarup Vinusree Karakkandy Preetam Chappity Suprava Naik Sanjay Kumar Behera Pradipta Kumar Parida Mohnish Grover gaurav Gupta Prajna Paramita Giri Saurav Sarkar Pradeep Pradhan Dillip Kumar Samal Aswathi Kallyadan Veetil Asutosh Adhikari Saurav Nayak Department of ENT and HNS All India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia Department of Radiodiagnosis All India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia Department of Community and Family Medicine All India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia Department of Biochemistry All India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia Department of ENT Sawai Man Singh Medical CollegeJaipurRajasthanIndia Department of ENT Sardar Patel Medical CollegeBikanerRajasthanIndia

Objective:Computed Tomography(CT)and Magnetic Resonance Imaging(MRI)are commonly employed in pre-operative evaluation for cochlear implant ***,with a decrease in the age of implantation,even minor radiation exposure can cause detrimental effects on children over their *** current study compares different cochlear measurements from CT and MRI scans and evaluates the feasibility of using only an MRI scan for radiological evaluation before cochlear ***:A longitudinal observational study was conducted on 94 ears/47 children,employing CT and MRI *** CT and MRI scan measurements include,A value,B value,Cochlear duct length(CDL),twoturn cochlear length,alpha and beta angles to look for cochlear *** nerve diameter was measured using *** values were ***:The mean difference between measurements from CT and MRI scans for A value,B value,CDL,and two-turn cochlear length values was 0.567±0.413 mm,0.406±0.368 mm,2.365±1.675 mm,and 2.063±1.477 mm respectively without any significant *** alpha and beta angle measures were comparable,with no statistically significant ***:The study suggests that MRI scans can be the only radiological investigation needed with no radiation risk and reduces the cost of cochlear implant program in the paediatric *** is no significant difference between the measurements obtained from CT and MRI ***,observed discrepancies in cochlear measurements across different populations require regionally or race-specific standardized values to ensure accurate diagnosis and precision in cochlear implant *** aspect must be addressed to ensure positive outcomes for patients.

关键词： Cochlear implant Hearing loss Cochlea anatomy Radiology

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Small interfering RNA for cancer treatment:overcoming hurdles in delivery

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2075-2109页

作者： Nitin Bharat Charbe Nikhil D.Amnerkar B.Ramesh Murtaza M.Tambuwala Hamid A.Bakshi Alaa A.A.Aljabali Saurabh C.Khadse Rajendran Satheeshkumar Saurabh Satija Meenu Metha Dinesh Kumar Chellappan Garima Shrivastava gaurav Gupta Poonam Negi Kamal Dua Flavia C.Zacconin Departamento de Quimica Orgánica Facultad de Química y de FarmaciaPontificia Universidad Católica de ChileSantiago 7820436Chile Sri Adichunchunagiri College of Pharmacy Sri Adichunchunagiri UniversityBG NagarKarnataka 571418India Adv V.R.Manohar Institute of Diploma in Pharmacy NagpurMaharashtra 441110India School of Pharmacy and Pharmaceutical Science Ulster UniversityColeraineNorthern Ireland BT521SAUK Faculty of Pharmacy Department of Pharmaceutics and Pharmaceutical TechnologyYarmouk UniversityIrbid 21163Jordan Department of Pharmaceutical Chemistry R.C.Patel Institute of Pharmaceutical Education and ResearchDist.DhuleMaharashtra 425405India Discipline of Pharmacy Graduate School of HealthUniversity of Technology SydneyNSW 2007Australia School of Pharmaceutical Sciences Lovely Professional UniversityPhagwara 144411 PunjabIndia Department of Life Sciences School of PharmacyInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Biochemical Engineering and Biotechnology Indian Institute of TechnologyDelhiNew Delhi 110016India School of Pharmacy Suresh Gyan Vihar UniversityJagatpuraJaipur 302017India School of Pharmaceutical Sciences Shoolini University of Biotechnology and Management SciencesSolan 173229India Priority Research Centre for Healthy Lungs Hunter Medical Research Institute(HMRI)and School of Biomedical Sciences and PharmacyUniversity of NewcastleNSW 2308Australia Institute for Biological and Medical Engineering Schools of EngineeringMedicine and Biological SciencesPontificia Universidad Católica de ChileSantiago 4860Chile

In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy ***,nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer *** review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer *** also provides the necessary information about siRNA development and its mechanism of ***,this review gives us a clear picture of lipid and polymer-based drug delivery systems,which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

关键词： Small interfering RNA(siRNA) Nanomedicine Liposomes Micelles Cancer Polymer

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On-table reconstruction and fixation of Mason type III radial head fractures

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Chinese Journal of Traumatology 2015年第5期18卷 288-292页

作者： G.N. Kiran Kumar gaurav Sharma Kamran Farooque Vijay Sharma Vaibhav Jain Ravijot Singh Vivek Morey Department of Orthopaedics All India Institute of Medical Sciences New Delhi 110029~ India

Purpose： To evaluate the functional and radiological outcome of comminuted radial head fractures, which were not amenable for classical open reduction with internal fixation, treated by on-table reconstruction and fixation using low profile plates. Methods： We reviewed 6 patients of Mason type Ill radial head fractures treated by on-table recon- struction technique between 2011 and 2013. There were 5 men and 1 woman with a mean age of 35 years （range 25-46 years）. All surgeries were carried out at our tertiary care level 1 trauma centre within a mean of 3 days （range 1-8 days） from date of injury using on-table reconstruction technique. The functional outcome was measured using elbow functional rating index described by Broberg and Morrey and the patient-based Disabilities of the Arm, Shoulder and Hand （DASH） outcome measure. Results： The mean follow-up period was 25 months, The average elbow flexion was 135~ （range 125~ -140~） and the average flexion contracture was 5~ （range 0-10~）. The average supination and pronation was 75~ （range ？0o-80~） and 70~ （range 65^-82~） respectively. According to Broberg and Morrey scoring system, the average score was 90 points （range 75-100）. The mean DASH score was 2.49 points, Conclusion： On-table reconstruction and fixation of comminuted radial head fractures using low profile plates is a reasonable option. The reconstructed radial head acts as spacer and provides reasonably good results and no surgical intervention is required for asymptomatic nonunion of these fractures regardless of the radiological findings.

关键词： On-table reconstruction technique Radial head fractures Bone plates

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多变量统计与数据挖掘、完井优化和地质研究相结合对多产层页岩区带进行资产评估

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石油地质科技动态 2018年第2期 38-50页

作者： Abhishek gaurav 周显菊江文全

本研究目的是综合多来源数据，包括公共来源的地质、完井、生产和租赁数据，建立评估资产真实经济潜力的有效方法。我们在对待并购或转让资产进行评估时采用了三段方法论，其中心思想是将完井优化视为一个不断变化的过程。这意味着，之... 详细信息

本研究目的是综合多来源数据，包括公共来源的地质、完井、生产和租赁数据，建立评估资产真实经济潜力的有效方法。我们在对待并购或转让资产进行评估时采用了三段方法论，其中心思想是将完井优化视为一个不断变化的过程。这意味着，之前被忽视的对象可能会因得益于完并技术的进步而更具经济价值。将数据挖掘和现有地质信息相结合，有助于识别影响井生产动态的关键参数。完井参数优化后，就能够确定待收购资产的真实潜力了。将地质因素、完井参数、归一化的产量标准曲线、钻井和完井成本及租赁费用等考虑在内时，我们就可以在一个统一的基础上对比不同的资产。采用这个方法，有可能会在之前被忽视的地区发现资产收购机会。一些应该纳入考虑的地质因素包括深度（真垂深）、地层压力、现有PVT／GOR研究成果以及有关断层／裂缝的先验知识。影响产量的完井参数比较多，但可以合理地假设最为重要的参数包括水平井段长度、压裂段间距、流体类型、支撑剂用量、泵入速度和单段射孔簇数等。支撑剂用量和泵入速度为互相依赖的关系。对于在产水平井数量较多的地区，完井、地质和生产数据通常可从公共来源（如得州铁路委员会）获取。多井的数据集成后可纳入巨大的数据集，换言之，大数据。将上述因素都考虑在研究范围之内后，就可以通过生产动态与参数的对比快速进行模式识别。对应特定研究区最优参数的标准曲线就可用于经济预测。本文综合了投资决策的各种因素。数据可视化技术的进步和公共资源大数据的可利用性可进一步助力本方法的应用。勘探开发公司、投行和私募组织都可应用本文所述的方法做出明智的投资决策。，

关键词：资产评估地质信息参数优化数据挖掘多变量统计完井多产层可视化技术

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Performance evaluation of NeuMoDx 96 system for hepatitis B and C viral load

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World Journal of Virology 2023年第4期12卷 233-241页

作者： Gagan Chooramani Jasmine Samal Nitiksha Rani gaurav Singh Reshu Agarwal Meenu Bajpai Manoj Kumar Manya Prasad Ekta Gupta Department of Clinical Virology Institute of Liver&Biliary SciencesNew Delhi 110070India Department Transfusion Medicine Institute of Liver&Biliary SciencesNew Delhi 110070India Department of Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Epidemiology and Clinical Research Institute of Liver and Biliary SciencesNew Delhi 110070India

BACKGROUND Hepatitis B virus(HBV)and hepatitis C virus(HCV)viral load(VL)estimation is essential for the management of both HBV and HCV *** to a longer turnaround time for VL estimation,many patients drop out from the cascade of *** achieve the global goals of reducing morbidity and mortality due to HBV/HCV and moving towards their elimination by 2030,molecular diagnostic platforms with faster and random(*** sample)access are *** To evaluate the performance of the recently launched NeuMoDx 96 random access system with the conventional COBAS^(■)AmpliPrep/COBAS TaqMan system for HBV and HCV VL *** Archived once-thawed plasma samples were retrieved and tested on both *** between the assays was determined by linear regression and Bland-Altman *** study included samples from 186 patients,99 for HBV of which 49 were true infected HBV cases(hepatitis B surface antigen,antihepatitis B core antibody,and HBV DNA-positive)and 87 for HCV assay in which 39 were true positives for HCV infection(anti-HCV and HCV RNA-positive).RESULTS The median VL detected by NeuMoDx for HBV was 2.9(interquartile range[IQR]:2.0-4.3)log_(10)IU/mL and by COBAS it was 3.70(IQR:2.28-4.56)log_(10)IU/mL,with excellent correlation(R2=0.98).In HCV,the median VL detected by NeuMoDx was 4.9(IQR:4.2-5.4)log_(10)IU/mL and by COBAS it was 5.10(IQR:4.07-5.80)log_(10)IU/mL with good correlation(R2=0.96).CONCLUSION The overall concordance between both the systems was 100%for both HBV and HCV VL ***,no genotype-specific bias for HBV/HCV VL quantification was seen in both the *** findings reveal that NeuMoDx HBV and HCV quantitative assays have shown overall good clinical performance and provide faster results with 100%sensitivity and specificity compared to the COBAS AmpliPrep/COBAS TaqMan system.

关键词： Hepatitis B Hepatitis C NeuMoDx Random access Viral load COBAS AmpliPrep

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3D手势识别背后的技术

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电子产品世界 2012年第9期19卷 27-29,32页

作者： Dong-Ik Ko gaurav Agarwal 德州仪器

探讨了3D手势识别需要的技术。

关键词：手势识别 3D视觉 DSP

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A Hybrid CNN-Brown-Bear Optimization Framework for Enhanced Detection of URL Phishing Attacks

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Computers, Materials & Continua 2024年第12期81卷 4853-4874页

作者： Brij B.Gupta Akshat gaurav Razaz Waheeb Attar Varsha Arya Shavi Bansal Ahmed Alhomoud Kwok Tai Chui Department of Computer Science and Information Engineering Asia UniversityTaichung413TaiwanChina Computer Engineering Ronin InstituteMontclairNJ 07043USA Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Business Administration Asia UniversityTaichung413TaiwanChina Department of Research and Innovation Insights2TechinfoJaipur302001India Department of Computer Science College of ScienceNorthern Border UniversityArar91431Saudi Arabia Department of Electronic Engineering and Computer Science Hong Kong Metropolitan University(HKMU)Hong KongChina

Phishing attacks are more than two-decade-old attacks that attackers use to steal passwords related to financial *** the first reported incident in 1995,its impact keeps on ***,during COVID-19,due to the increase in digitization,there is an exponential increase in the number of victims of phishing *** deep learning and machine learning techniques are available to detect phishing ***,most of the techniques did not use efficient optimization *** this context,our proposed model used random forest-based techniques to select the best features,and then the Brown-Bear optimization algorithm(BBOA)was used to fine-tune the hyper-parameters of the convolutional neural network(CNN)*** test our model,we used a dataset from Kaggle comprising 11,000+*** addition to that,the dataset also consists of the 30 features that are extracted from the website uniform resource locator(URL).The target variable has two classes:“Safe”and“Phishing.”Due to the use of BBOA,our proposed model detects malicious URLs with an accuracy of 93%and a precision of 92%.In addition,comparing our model with standard techniques,such as GRU(Gated Recurrent Unit),LSTM(Long Short-Term Memory),RNN(Recurrent Neural Network),ANN(Artificial Neural Network),SVM(Support Vector Machine),and LR(Logistic Regression),presents the effectiveness of our proposed ***,the comparison with past literature showcases the contribution and novelty of our proposed model.

关键词： Phishing attack CNN brown-bear optimization

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Cuckoo Search-Optimized Deep CNN for Enhanced Cyber Security in IoT Networks

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Computers, Materials & Continua 2024年第12期81卷 4109-4124页

作者： Brij B.Gupta Akshat gaurav Varsha Arya Razaz Waheeb Attar Shavi Bansal Ahmed Alhomoud Kwok Tai Chui Department of Computer Science and Information Engineering Asia UniversityTaichung413TaiwanChina Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057MaharashtraIndia Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Business Administration Asia UniversityTaichung413TaiwanChina Department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Research and Innovation Insights2TechinfoJaipur302001India Department of Computer Science Faculty of ScienceNorthern Border UniversityArar91431Saudi Arabia Department of Electronic Engineering and Computer Science Hong Kong Metropolitan University(HKMU)Hong Kong518031China

Phishing attacks seriously threaten information privacy and security within the Internet of Things(IoT)*** phishing attack detection solutions have been developed for IoT;however,many of these are either not optimally efficient or lack the lightweight characteristics needed for practical *** paper proposes and optimizes a lightweight deep-learning model for phishing attack *** model employs a two-fold optimization approach:first,it utilizes the analysis of the variance(ANOVA)F-test to select the optimal features for phishing detection,and second,it applies the Cuckoo Search algorithm to tune the hyperparameters(learning rate and dropout rate)of the deep learning ***,our model is trained in only five epochs,making it more lightweight than other deep learning(DL)and machine learning(ML)*** proposed model achieved a phishing detection accuracy of 91%,with a precision of 92%for the’normal’class and 91%for the‘attack’***,the model’s recall and F1-score are 91%for both *** also compared our approach with traditional DL/ML models and past literature,demonstrating that our model is more *** study enhances the security of sensitive information and IoT devices by offering a novel and effective approach to phishing detection.

关键词： Deep learning phishing Cuckoo Search cable news network(CNN) IoT ANOVA F-test

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综合运用地质、机器学习、模式识别和多元统计法计算二叠盆地页岩水平井EUR

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石油地质科技动态 2018年第2期 20-37页

作者： Abhishek gaurav 宋建平江文全

本次研究的目的是以研究区附近在产的页岩水平井的各种参数作为输入，综合运用地质、机器学习、模式识别和统计分析等手段，准确地计算页岩水平井的估计最终开采量（EUIk）。本次研究利用局部的地质信息，通过机器学习来识别能够改善生... 详细信息

本次研究的目的是以研究区附近在产的页岩水平井的各种参数作为输入，综合运用地质、机器学习、模式识别和统计分析等手段，准确地计算页岩水平井的估计最终开采量（EUIk）。本次研究利用局部的地质信息，通过机器学习来识别能够改善生产动态的关键井参数。然后开展模式识别，同时要确保每种类型井中的井数具有统计意义。这也是一种质量控制手段，以免仅仅基于机器学习的结果做出结论。利用现有文献中有关井产量与各种井参数之间的相关性对结论进行验证。选取拥有最佳（可控）参数的井，建立研究区目的层段的标准曲线。上述方法使标准曲线／EUR计算过程实现科学化、系统化和无缝化。机器学习有助于识别与较好井生产动态具有相关性的关键井参数。视觉模式识别增强了对最后一步识别出的相关性的信心。不同的参数对不同区域／目的层的产量有不同的影响，这也证实了在对任何一个页岩区块进行评价时，都需要开展深入的研究，这样才能得出合理的结论。选取研究区内完井质量最佳的井，建立了沃尔夫坎普（Wolfcamp）组各产层段的标准曲线，．利用文中所讲的方法识别出了最佳的完井参数。这样做有助于识别研究区水平井开发的真实经济潜力。本文描述了一种资料密集型的科学新方法，以步进（step—wise）的方式系统地利用井资料建立评价区内井的标准曲线并计算其EUR，进而确定所评价区块的真实经济潜力。除了所讲的大数据挖掘方法之外，本次研究还得出了以下最重要的认识，即要对页岩资产进行最佳的评价，关键在于建立可控的井参数与井产量的关系。一旦建立了这种关系，就能够更加准确地建立标准曲线和计算估计最终开采量（EUR）。

关键词：视觉模式识别水平井开发机器学习计算过程地质信息综合运用 EUR 多元统计法

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Urban Pond Water Contamination in India

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Journal of Environmental Protection 2016年第1期7卷 52-59页

作者： Ankit Yadav Pravin Kumar Sahu Suryakant Chakradhari Keshaw Prakash Rajhans Shobhana Ramteke Nohar Singh Dahariya gaurav Agnihotri Khageshwar Singh Patel School of Studies in Chemistry/Environmental Science Pt. Ravishankar Shukla University Raipur India

The stagnant water reservoirs in urban area of India are severely contaminated with surfactant and microbe due to anthropogenic activities. In this work, water quality of pond water of the most industrialized city: Raipur, CG, India is described. The concentration of surfactant in the term of sodium lauryl sulfate (SLS) in water (n = 16) is ranged from 7.0 - 27 mg/L with mean value of 17 ± 3 mg/L. All ponds are found to be contaminated with microbes i.e. bacteria, algae and fungi at elevated levels. The physico-chemical characteristics of the pond water are discussed.

关键词： Surfactant Water Quality Microbe Pond

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