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Rethinking the diagnosis and treatment of renal anastomotic hemangioma after partial nephrectomy

World Journal of Clinical Cases 2025年第5期13卷 58-60页

作者： Yun-Peng Guo gaurab pokhrel Yu-Yang Wang Quan Wen Gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina First Affiliated Hospital of Zhengzhou University Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Urinary Surgery Tongliao City HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

Renal anastomotic hemangioma(AH)is a rare,benign vascular tumor with unique histopathological features,a disease that is clinically rare,and existing clinical cases offer different treatment *** reported in the text,this is a very unusual case of renal AH with AH secondary to residual renal tissue after renal clear cell carcinoma,describing a rare renal AH and a history of renal clear cell carcinoma,including ultrasound,computed tomography and magnetic re-sonance ***,the available imaging data and the literature do not provide an effective basis for the diagnosis of the disease,raising the lack of un-derstanding and misdiagnosis,where the patient eventually underwent neph-rectomy,but the author is not the most appropriate surgical *** po-stoperative pathological results of the patient are benign lesions,and it is unde-niable that nephrectomy is suspected to be *** reading the literature,we provide different insights into the treatment of the patient,and we hope that this paper can provide some help for the future clinical diagnosis and treatment.

关键词： Anastomotic hemangioma Renal Ultrasound Computed tomography Case report

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Levorotatory Chiral Peptide LHBP Ameliorates Renal Ischemia Reperfusion Injury in a Murine Model

Levorotatory Chiral Peptide LHBP Ameliorates Renal Ischemia ...

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2013中国器官移植大会

作者： gaurab pokhrel 复旦大学附属中山医院泌尿外科

Objective To investigate the protective of new type of levorotatory chiral peptide LHBP on renal ischemia reperfusion injury in mouse. Methods To investigate the role of renal protection,60 male BALB/C murine(20-25 g)were randomly divided into two groups, ,Group IR and Group IR+*** model was made by 30 minutes of bilateral renal ischemia with non-traumatic vascular clamps,

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Testosterone undecanoate supplementation together with human chorionic gonadotropin does not impair spermatogenesis in males with isolated hypogonadotropic hypogonadism:a retrospective study

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Asian Journal of Andrology 2019年第4期21卷 413-418页

作者： Yin-Wei Chen Yong-Hua Niu Hao Xu Dao-Qi Wang Hong-Yang Jiang gaurab pokhrel Tao Wang Shao-Gang Wang Ji-Hong Liu Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Gon adotropin therapy is comm only used to in duce virilizati on and spermatoge nesis in male isolated hypog on adotropic hypog on adism (IHH) patients. In clinical practice, 5.6%-15.0% of male IHH patients show poor responses to gonadotropin treatment;therefore, testosterone (T) suppleme ntation can serve as an alter native therapy to no rmalize serum T levels and promote virilization. However, treatment with exogenous T impairs spermatogenesis and suppresses intratesticular T levels. This retrospective study aimed to determine whether oral testosterone undeca noate (TU) suppleme ntation together with human chorionic gonadotropin (hCG) would negatively affect spermatogenesis in IHH patients compared with hCG alone. One hundred and seven IHH patients were included in our study. Fifty-four patients received intramuscular hCG and oral TU, and 53 patients received intramuscular hCG alone. The median follow-up time was 29 (range: 12-72) mon ths in both groups. Compared with the hCG group, the hCG/TU group required a shorter median time to normalize serum T levels (P < 0.001) and achieve Tanner stage (III and V) of pubic hair and genital development (P < 0.05). However, there were no significant differences in the rate of seminal spermatozoa appearance, sperm concentration, or median time to achieve different sperm concentration thresholds between the groups. In addition, there were no significant differences in side effects, such as acne and gynecomastia, observed in both groups. This study indicates that oral TU supplementation together with hCG does not impair spermatogenesis in treated IHH patients compared with hCG alone, and it shortens the time to normalize serum T levels and promote virilization.

关键词： human chorionic gonadotropin isolated hypogonadotropic hypogonadism spermatogenesis testosterone undecanoate virilization

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细胞色素CYP(450)3A4、3A5和2D6基因单核苷酸多态性对肾移植患者他克莫司代谢的影响

细胞色素CYP(450)3A4、3A5和2D6基因单核苷酸多态性对肾移植患者...

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作者： gaurab pokhrel（佳乌拉）复旦大学

学位级别：硕士

目的：检测肾移植患者细胞色素CYP(450)3A4、3A5和2D6基因单核苷酸多态性(single nucleotide polymorphism,SNP),分析3A4、3A5和2D6的SNP与他克莫司代谢的相关性,探讨其作为预测他克莫司个体化治疗方案的可行性。方法：收集2013年8月至1... 详细信息

目的：检测肾移植患者细胞色素CYP(450)3A4、3A5和2D6基因单核苷酸多态性(single nucleotide polymorphism,SNP),分析3A4、3A5和2D6的SNP与他克莫司代谢的相关性,探讨其作为预测他克莫司个体化治疗方案的可行性。方法：收集2013年8月至12月在我院进行随访的138例稳定并服用他克莫司的肾移植患者。记录单位体重用药剂量数据,检测他克莫司血药谷浓度,测序法对CPY(450)3A4、 3A5和2D6进行单核苷酸多态性检测。分析单核苷酸多态性与浓度调整的单位体重用药剂量的相关性。结果：在138例患者中,CYP3A4野生型137例(49例女性和88例男性),突变型仅1例;CYP3A5野生型71例(27例女性和46例男性),突变型中杂合子55例(20例女性和35例男性),纯合子10例(2例女性和8例男性);CYP2D6野生型73例(28例女性和45例男性),突变型中杂合子34例(11例女性和23例男性),纯合子31例(10例女性和21例男性)。3种基因型在男女人群中分布无统计学差异。CYP3A5野生型与突变型杂合子和纯合子相比,野生型患者需要更高剂量的他克莫司(p=0.002,p=0.039),突变杂合子和纯合子之间无统计学差异;CYP2D6野生型和突变杂合子与突变纯合子相比,野生型和突变杂合子患者需要更高剂量的他克莫司(p=0.003,p=0.029),野生型和突变杂合子之间无统计学差异。结论：1.中国人群中,CYP3A4的基因多态性率很低,因此对他克莫司代谢的影响可以基本忽略。2. CYP3A5的基因多态性与他克莫司的代谢密切相关,野生型的患者需要较高剂量的他克莫司。3. CYP2D6的基因多态性与他克莫司的代谢亦相关,野生型患者需要较高剂量,但影响较CYP 3A5低,当CYP 3A5表现杂合子时,CYP2D6可能发挥主导作用。

关键词：肾移植他克莫司细胞色素CPY(450) 治疗药物检测

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Is Retzius-sparing robot-assisted radical prostatectomy associated with better functional and oncological outcomes? Literature review and meta-analysis

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Asian Journal of Urology 2019年第2期6卷 174-182页

作者： Najib Isse Dirie gaurab pokhrel Wei Guan Mukhtar Adan Mumin Jun Yang Jackson Ferdinand Masau Henglong Hu Shaogang Wang Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Urology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Objective:To evaluate the efficiency,safety and clinical outcomes of Retziussparing robot-assisted radical prostatectomy(RS-RARP)in comparison with the standard ***:A systematic search from Web of Science,PubMed,EMBase,Cochrane Library and Google Scholar was performed using the terms“Retzius-sparing”,“Bocciardi approach”and“robot-assisted radical prostatectomy”.Video articles and abstract papers for academic conferences were ***-analysis of interested outcomes such as positive surgical margins(PSMs)and continence recovery was undertaken.A comprehensive literature review of all studies regarding Retzius-sparing(RS)approach was conducted and ***:From 2010 to 2017,11 original articles about RS-RARP approach were *** that,only four studies comparing the RS-RARP approach to the conventional RARP were comparable for *** overall continence recovery within 1 month after the surgery was noted in the RS group(61%vs.43%;pZ0.004).PSMs of pT2 and pT3 stages were not significantly different between the groups(10.0%vs.7.4%;p Z 0.39 and 13.1%vs.9.5%,p Z 0.56,respectively).Of all the studies,only one reported sexual recovery outcomes after RS treatment in which 40%of the participants achieved sexual intercourse within the first ***:Though more technically demanding than the conventional RARP,the RS technique is a safe and feasible *** meta-analysis and literature review indicates that RS technique,as opposed to the conventional approach,is associated with a faster continence recovery while PSMs were comparable between the two *** limitations of observational studies and the small data in our meta-analysis may prevent an ultimate *** well-designed RCTs are needed to validate and confirm our findings.

关键词： Retzius-sparing Radical prostatectomy Robotics Functional recovery Positive surgical margins

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输尿管硬镜辅助的可视化输尿管通道鞘放置方法的初步应用

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临床泌尿外科杂志 2018年第7期33卷 528-531页

作者：刘卓江弘炀刘夏铭 gaurab pokhrel 李聪王涛余虓王少刚刘继红华中科技大学同济医学院附属同济医院泌尿外科武汉430030

目的:为提高输尿管通道鞘(ureteral access sheath,UAS)放置过程的安全性和准确性,本研究尝试利用输尿管硬镜辅助实现置鞘过程的可视化,并与国内常用的徒手置鞘法进行对比,比较手术操作的安全性和有效性。方法:将94例符合纳入标准的肾... 详细信息

目的:为提高输尿管通道鞘(ureteral access sheath,UAS)放置过程的安全性和准确性,本研究尝试利用输尿管硬镜辅助实现置鞘过程的可视化,并与国内常用的徒手置鞘法进行对比,比较手术操作的安全性和有效性。方法:将94例符合纳入标准的肾结石或输尿管上段结石患者,随机分为A、B两组。A组患者采用输尿管硬镜辅助的可视化置鞘法:将14/12Fr 35cm UAS套在9.5Fr 43cm输尿管硬镜上,在直视下进镜并将UAS放置到输尿管合适位置,退出硬镜再进行软镜碎石术。B组患者采用无X线监视的徒手置鞘法。UAS置入后两组采用相同的技术进行碎石。记录术中UAS放置情况和时间、输尿管损伤情况,随访4~12周,了解清石率及术后并发症情况。结果:与B组比较,A组UAS放置所需时间更短[(35.69±6.54)s vs.(55.71±10.58)s,P0.05]。A组在术中发生输尿管1级损伤1例;B组在术中发生输尿管1级损伤4例,2级损伤1例;3级损伤1例,输尿管损伤发生率A组显著低于B组(2.08%vs.13.04%,P0.05]。两组一期结石清除率差异无统计学意义(91.67%vs.89.13%,P>0.05)。结论:输尿管硬镜辅助的可视化置鞘法安全可行,可控性好,与徒手置鞘法相比能提高操作的安全性和准确性。局限性在于对于术前未预先留置双J管的患者,输尿管硬镜辅助的可视化置鞘法置鞘成功率有所降低。

关键词：泌尿系结石输尿管软镜钬激光碎石可视化技术

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