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Stricturing Crohn's disease-like colitis in a patient treated with belatacept

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World Journal of Gastroenterology 2017年第48期23卷 8660-8665页

作者： Anne Bozon Guillaume Jeantet Benjamin Rivière Natalie Funakoshi gaspard Dufour Roman Combes Jean-Christophe Valats Sylvie Delmas Jean Emmanuel Serre Michael Bismuth Jeanne Ramos Moglie Le Quintrec Pierre Blanc Guillaume Pineton de Chambrun Gastroenterology Department Saint-Eloi HospitalMontpellier University Hospital Nephrology Department Lapeyronie HospitalMontpellier University Hospital Pathology Department Guy de Chauliac HospitalMontpellier University Hospital

Cytotoxic T-lymphocyte-associated antigen 4(CTLA-4) modifying agents have been involved in the development of intestinal inflammation,especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept,a recombinant CTLA-4-Ig fusion protein.

关键词： Crohn’s disease Colitis Belatacept HHV-6 Inflammatory bowel disease

Determinants of Neurocognitive Impairment in HIV in a Cohort of Patients on Antiretroviral Therapy Followed in Bangui (Central African Republic)

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Neuroscience & Medicine 2016年第1期7卷 1-9页

作者： Mbelesso Pascal Tekpa gaspard Ndouongou-Kouna Philomène Yangatimbi Emmanuel Amakade-Woyengba Phrygie Avilah Honisse Hortense Neurology Department H&#244pital de l’Amitié de Bangui Bangui Central African Republic Department of Infectious and Tropical Diseases H&#244pital de l’Amitié de Bangui Bangui Central African Republic Université des Sciences de la Santé Libreville Gabon Faculté des Sciences de la Santé Université de Bangui Bangui Central African Republic Hôpital de Jour Centre National Hospitalier Universitaire de Bangui Bangui Central African Republic

Infection with HIV is one of the deadliest epidemics of our time and its type is widespread in the Central African Republic. It is frequently accompanied by neurological complications. Objective: To contribute to a better understanding of neurocognitive disorders in patients living with HIV (PLHIV) in Bangui, and to identify associated factors using the International HIV Dementia Scale (IHDS) as a screening tool. We conducted a descriptive and analytical cross-sectional study from 1 December 2014 to 30 January 2015, in a cohort of patients seen on one of the supported sites in Bangui. A total of 400 patients were received in follow-up visit during the study period of which 244 met the inclusion criteria. The prevalence of neurocognitive disorders was 25%, 95% CI [19.70 - 30.92]. The mean age of subjects was 42.77 ± 9.58 with extremes ranging from 24 - 64 years. The sex ratio (F/M) was 4.5 in. The average score for different tests was 10.93 ± 1.13 with extremes of 7 and 12. The disorder was more about the gestural sequence. Determinants of neurocognitive disorders in the cohort were older age and lower educational level (p < 0.05). It is useful to conduct further studies to confirm these results by combining a battery of neuropsychological tests to recommend this test for all the support sites of PLHIV in the country.

关键词： HIV Neurocognitive Disorders Determinants Central African Republic

基于多时相MODIS的NDVI分层数据在卢旺达玉米历法评估中的应用（英文）

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Journal of Resources and Ecology 2018年第3期9卷 273-280页

作者： MUGABOWINDEKWE Maurice MUYIZERE Aline 李发东乔云峰 RWANYIZIRI gaspard 卢旺达大学科学与技术学院地理信息系统与遥感中心(CGIS) 卢旺达基加利3900 Bright Green Nature公司环境管理部卢旺达基加利2916 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101 中国科学院大学资源与环境学院北京100190 卢旺达大学科学与技术学院地理与城市规划系卢旺达基加利3900

作物历作为一种可以提供特定地区作物生长周期相关信息的重要工具,对有效的农业管理十分重要。由于农业生态系统的特点不同,不同地区的作物历也各不相同。本研究基于多时相MODIS的NDVI分层数据,评估在卢旺达不同地区实践玉米作物日历的... 详细信息

作物历作为一种可以提供特定地区作物生长周期相关信息的重要工具,对有效的农业管理十分重要。由于农业生态系统的特点不同,不同地区的作物历也各不相同。本研究基于多时相MODIS的NDVI分层数据,评估在卢旺达不同地区实践玉米作物日历的差异。有针对性地选取了4个以农业为主的NDVI层并随机采访433名当地农民。这些信息有助于了解当地玉米种植情况和收获日期,以便生成玉米生长历的各个NDVI层。对玉米生长历执行k-均值非监督分类,将其分类生成4组不考虑NDVI层的玉米生长日历。ANOVA结果显示,在p=0.05时,无论NDVI层数如何,由NDVI层生成的玉米作物历与实际不考虑NDVI层的作物历之间均存在显著差异。在p=0.05时,卡方检验和t检验的结果显示,不仅玉米生长日历与作物生长季数之间有显著的相关关系,而且玉米生长日历与NDVI层数之间同样存在显著相关。最终来看,认为存在一个适用于卢旺达全国各地的通用玉米生长日历的现有认知与本研究的结果相左。然而,本研究结果与卢旺达农业生态系统从东到西主要在海拔和降雨模式变化方面存在差异的事实一致。

关键词： NDVI数据分层作物历玉米生长季卢旺达

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对新一代口服避孕药的评价

国外医学(计划生育分册) 1986年第1期 27-28页

作者： gaspard U 吴一鹗

一、最近的流行病学资料:近十年来,流行病学的调查使人们注意到口服雌孕激素避孕药对生育年龄妇女(15～49岁)能引起心血管病变。因此口服避孕药(OC)的推广普遍减慢,尤其是在美国。最近,在更广泛和更长期的流行病学研究基础上,对避孕药... 详细信息

一、最近的流行病学资料:近十年来,流行病学的调查使人们注意到口服雌孕激素避孕药对生育年龄妇女(15～49岁)能引起心血管病变。因此口服避孕药(OC)的推广普遍减慢,尤其是在美国。最近,在更广泛和更长期的流行病学研究基础上,对避孕药的不利作用有了更明确的认识。由血管因素引起的死亡率和发病率,不论是静脉方面(血栓静脉炎、肺血栓栓塞)或动脉方面(心肌梗死、脑血管意外、高血压),在服药组都高于对照组。但须指出:

关键词：口服避孕药新一代糖代谢脂代谢发病率死亡率女用避孕药人口自然变动炔雌醇甲炔诺酮

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亚马逊的避税方法惹麻烦了

商业周刊（中文版） 2016年第18期 31-32页

作者： gaspard Seba David Kocieniewski 陈柳

亚马逊电商资产的价值取决于提问的主体是谁上报的数字“对于任何有数学常识的人来说都很荒谬”

关键词：亚马逊避税方法资产

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法国内幕交易团伙覆灭记

商业周刊（中文版） 2018年第21期 24-26页

作者： gaspard Sebag 许子轩(译)

这是一个忙碌的周四，法国兴业银行（Societt Generale SA）董事总经理斯特凡纳·菲玛（Stephane Fima）焦躁不安。在与同事的电话会议结束后，菲玛给他的朋友托马斯·塞利格曼（Thomas Seligman）打了电话。菲玛支支吾吾地说，他很担... 详细信息

这是一个忙碌的周四，法国兴业银行（Societt Generale SA）董事总经理斯特凡纳·菲玛（Stephane Fima）焦躁不安。在与同事的电话会议结束后，菲玛给他的朋友托马斯·塞利格曼（Thomas Seligman）打了电话。菲玛支支吾吾地说，他很担心，希望能“保持安全”，然后就开始向塞利格曼说出一系列看似随机的数字。

关键词：法国兴业银行内幕交易覆灭团伙电话会议总经理托马斯董事

Reaction injection molding of hydrophilicin-hydrophobic femtolitre-well arrays

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Microsystems & Nanoengineering 2019年第1期5卷 429-435页

作者： Reza Zandi Shafagh Deborah Decrop Karen Ven Arno Vanderbeke Robert Hanusa Jolien Breukers gaspard Pardon Tommy Haraldsson Jeroen Lammertyn Wouter van der Wijngaart Department of Micro-and Nanosystems KTH Royal Institute of TechnologyStockholmSweden Department of Biosystems KU LeuvenWillem de Croylaan 423001 LeuvenBelgium

Patterning of micro-and nanoscale topologies and surface properties of polymer devices is of particular importance for a broad range of life science applications,including cell-adhesion assays and highly sensitive *** manufacturing of such devices necessitates cumbersome multiple-step fabrication procedures and results in surface properties which degrade over *** critically hinders their wide-spread ***,we simultaneously mold and surface energy pattern microstructures in off-stoichiometric thiol-ene by area-selective monomer selfassembly in a rapid micro-reaction injection molding *** replicated arrays of 1,843,650 hydrophilic-inhydrophobic femtolitre-wells with long-term stable surface properties and magnetically trapped beads with 75%and 87.2%efficiency in single-and multiple-seeding events,*** results form the basis for ultrasensitive digital biosensors,specifically,and for the fabrication of medical devices and life science research tools,generally.

关键词： arrays hinder beads

Developing a Forest Management Plan (DFMP) for Gatsibo District in the Eastern Province of Rwanda

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Open Journal of Forestry 2018年第2期8卷 247-265页

作者： Felix Rurangwa Mwangi James Kinyanjui Frederick Bazimaziki Jacques Peeters Anicet Munyehirwe Francis Musoke gaspard Nelson Habiyaremye Dismas Bakundukize Prime Ngabonziza Jost Uwase Rwanda Water and Forestry Authority (RWFA) Kigali Rwanda Department of Natural Resources Karatina University Karatina Kenya Belgian Technical Cooperation Kigali Rwanda Inclusive Business and Consultancy (IB & C Ltd.) Kigali Rwanda The International Union for Conservation of Nature (Forest Landscape Restoration Kigali Office) Kigali Rwanda Rwanda Land Management and Use Authority Kigali Rwanda

In support of conservation of its fragile land resource, the government of Rwanda has proposed the management of all forests in the country under a specific management plan. This assignment sought to develop a management plan for the public productive forests of Gatsibo District in Eastern province of Rwanda. Data was collected from 1468 plots, proportionally allocated by size to the 375 forest stands. Information about the forest (qualitative data) was recorded and then forest measurements (inventory) done in a concentric cycle of 9.77 m and 3.99 m radius and all data recorded in a digital format using the survey CTO platform. The data was summarized and analyzed in a harmonized forest management tool for Rwanda comprising of six interlinked excel files based on Rwanda’s silvicultural regimes and treatments. This analysis resulted to planning for silvicultural activities in each forest up to the year 2070. Results show that the public plantation forests of Gatsibo are poorly stocked mainly due to poor management and the best stocked forest had a basal area of only 13.3 m2/ha. This implied low forest volumes for each of the wood requirements;timber wood, service wood and energy wood. Eucalyptus forests are the most common but are poorly stocked compared to the Pinus patula forests which are even aged by plantation. A projection of stocks shows that the forests can be sustained with an average wood volume of 73 m3/ha, to provide harvests yearly and reduce the wood supply and demand gap in the district. A viability analysis indicates that some forests are viable for leasing with good profits in the short term (10 years) and full term planning (40 years). However, some forests may not be commercially viable due to their current stocks and agro bioclimatic conditions, and these would be rehabilitated for ecosystem services. This plan supports the restoration of the forests of Gatsibo district through provision of specific guidelines for the management of the forests.

关键词： Forest Management Planning

Assessment of the Impact of Environment Protection in Rwanda:A Case Study of Rugezi Marshland

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NASS Journal of Agricultural Sciences 2022年第1期4卷 49-55页

作者： Ntabakirabose gaspard Harold Ogwal Jean Baptiste Habinshuti Musoni Protais Jeanne Pauline Munganyinka David Mwehia Mburu Maniriho Festus Ministry of Agriculture and Animal Resources KigaliRwanda Department of Biological and Environmental Sciences School of Natural and Applied SciencesKampala International UniversityKampalaUganda Department of Materials Science and Engineering African University of Science and TechnologyAbujaNigeria Musanze District Ministry of Local GovernmentKigaliRwanda Department of Land Resources Planning and Management College of Agriculture&Natural ResourcesJomo Kenyatta University of Agriculture and Technology(JKUAT) NairobiKenya 6.College of AgricultureAnimal Sciences and Veterinary Medicine(UR-CAVM)University of RwandaKigaliRwanda

Environmental protection is one of the most important measures to achieve the long run and sustainability of living organisms in the *** study was conducted in Burera and Gicumbi districts with the main aim of assessing the impact of environment protection in Rwanda.A case study of Rugezi *** were collected using a structured questionnaire and analyzed using SPSS statistical software version 20 and STATA statistical software vision ***-farm income,occupation,educational level,age,and farm size,showed a positive relationship with Rugezi marchland *** such as value of product distance to Rugezi marchland,gender,and family size had a negative influence on Rugezi marchland *** study also indicated that factors such as water management,increase of grass species,increase of wild animals and birds,modern house construction,zero grazing keeping revealing a positive relationship with Rugezi marchland *** most serious problems encountered are the lack of occupation and low level of education.

关键词： Assessment Impact Environment protection Rugezi Marshland