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Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies

Microsystems & nanoengineering 2023年第1期9卷 161-176页

作者： Lian C.T.Shoute gaser n.abdelrasoul Yuhao Ma Pedro A.Duarte Cole Edwards Ran Zhuo Jie Zeng Yiwei Feng Carmen L.Charlton Jamil n.Kanji Shawn Babiuk Jie Chen Department of Electrical and Computer Engineering University of AlbertaEdmontonABT6G 2V4Canada Public Health Laboratory Alberta Precision LaboratoriesEdmontonABCanada Department of Laboratory Medicine and Pathology University of AlbertaEdmontonABT6G 2B7Canada Li Ka Shing Institute for Virology University of AlbertaEdmontonABCanada Division of Infectious Diseases Department of MedicineCumming School of MedicineUniversity of CalgaryCalgaryABCanada Department of Pathology&Laboratory Medicine Cumming School of MedicineUniversity of CalgaryCalgaryABCanada national Centre for Foreign Animal Disease Canadian Food Inspection AgencyWinnipegMBCanada Department of Immunology University of ManitobaWinnipegMBCanada Department of Biomedical Engineering University of AlbertaEdmontonABT6G 2R3Canada

The COVID-19 pandemic has posed enormous challenges for existing diagnostic tools to detect and monitor ***,there is a need to develop point-of-care(POC)devices to perform fast,accurate,and accessible diagnostic methods to detect infections and monitor immune *** most amenable to miniaturization and suitable for POC applications are biosensors based on electrochemical *** have developed an impedimetric immunosensor based on an interdigitated microelectrode array(IMA)to detect and monitor SARS-CoV-2 antibodies in human *** chemistry was applied to functionalize and covalently immobilize the spike protein(S-protein)of SARS-CoV-2 on the surface of the IMA to serve as the recognition layer and specifically bind anti-spike *** bound to the S-proteins in the recognition layer result in an increase in capacitance and a consequent change in the impedance of the *** impedimetric immunosensor is label-free and uses non-Faradaic impedance with low nonperturbing AC voltage for *** sensitivity of a capacitive immunosensor can be enhanced by simply tuning the ionic strength of the sample *** device exhibits an LOD of 0.4 BAU/ml,as determined from the standard curve using WHO IS for anti-SARS-CoV-2 immunoglobulins;this LOD is similar to the corresponding LODs reported for all validated and established commercial assays,which range from 0.41 to 4.81 BAU/*** proof-of-concept biosensor has been demonstrated to detect anti-spike antibodies in sera from patients infected with COVID-19 within 1 h.

关键词： antibodies impedance free

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