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Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism

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Food Science and Human Wellness 2023年第6期12卷 2087-2094页

作者： William t.moore Jing Luo Dongmin Liu Department of Human Nutrition Foods and ExerciseCollege of Agricultural and Life SciencesVirginia TechBlacksburg 24060USA Department of Biology and Chemistry Liberty UniversityLynchburg 24515USA Department of Human Nutrition Foods and ExerciseVirginia Tech1981 Kraft DriveCorporate Research CenterBlacksburg 24061USA

Insulin resistance is a hallmark of type-2 diabetes(t2D)*** skeletal muscle(SkM)is the major tissue for insulin-mediated glucose disposal,insulin resistance in SkM is considered a major risk factor for developing ***,the identifi cation of compounds that enhance the ability of SkM to take up glucose is a promising strategy for preventing *** previous work showed that kaempferol,a fl avonol present in many foods,improves insulin sensitivity in obese mice,however,the mechanism underlying this beneficial action remains ***,we show that kaempferol directly stimulates glucose uptake and prevents lipotoxicity-impaired glucose uptake in primary human *** stimulates Akt phosphorylation in a time-dependent manner in human SkM *** effect of kaempferol on glucose uptake was blunted by inhibition of glucose transporter 4,phosphoinositide 3-kinase(PI3K),or *** addition,kaempferol induced AMPK phosphorylation,and inhibition of AMPK prevented kaempferol-stimulated Akt *** vivo,kaempferol administration induced rapid glucose disposal accompanied with increased Akt and AMPK phosphorylation in SkM tissue of the *** together,these fi ndings suggest that kaempferol stimulates glucose uptake in SkM via an AMPK/Akt dependent mechanism,and it may be a viable therapeutic agent for insulin resistance.

关键词： Kaempferol Skeletal muscle AMPK Akt Insulin resistance

Mitigation of atrazine,S-metolachlor,and diazinon using common emergent aquatic vegetation

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Journal of Environmental Sciences 2017年第6期29卷 114-121页

作者： Matthew t.moore Martin A.Locke Robert Krǒger Water Quality and Ecology Research Unit USDA Agricultural Research ServiceNational Sedimentation LaboratoryOxfordMS 38655USA

By the year 2050, the population of the United States is expected to reach over 418 million, while the global population will reach 9.6 billion. to provide safe food and fiber, agriculture must balance pesticide usage against impacts on natural resources. Challenges arise when storms cause runoff to be transported to aquatic receiving systems. Vegetated systems such as drainage ditches and constructed wetlands have been proposed as management practices to alleviate pesticide runoff. twelve experimental mesocosms （1.3 ±0.71 ± 0.61 m） were filled with sediment and planted with a monoculture of one of three wetland plant species （typha latifolia, Leersia oryzoides, and Sparganium arnericanurn）. three mesocosms remained unvegetated to serve as controls. All mesocosms were amended with 9.2 ± 0.8 μg/L, 12 ± 0.4 μg/L, and 3.1 ± 0.2 μg/L of atrazine, metolachlor, and diazinon, respectively, over a 4 hr hydraulic retention time to simulate storm runoff. Following the 4 hr amendment, non-amended water was flushed through mesocosms for an additional 4 hr. Outflow water samples were taken hourly from pre-amendment through 8 hr, and again at 12, 24, 48, 72, and 168 hr post-amendment. L. oryzoides and t. latifolia had mean atrazine, metolachlor, and diazinon retentions from B1%-55% for the first 4 hr of the experiment. Aside from S. arnericanum and atrazine （25% retention）, unvegetated controls had the lowest pesticide retention （17%-28%） of all compared mesocosms. While native aquatic vegetation shows promise for mitigation of pesticide runoff, further studies increasing the hydraulic retention time for improved efficiency should be examined.

关键词： Phytoremediation Pesticide Mesocosm Wetland

Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

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Research in Astronomy and Astrophysics 2024年第9期24卷 83-98页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei tsai Donghui Quan Xia Zhang Junzhi Wang gary J.Melnick Jin-Zeng Li gary A.Fuller Jinjin Xie National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China tsinghua University Beijing 100084China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Center for Astrophysics Harvard&Smithsonian60 Garden StreetMS 66CambridgeMA 02138USA Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of ManchesterOxford RoadManchesterM139PLUK I.Physikalisches Institut University of CologneZülpicher Str.7750937 KölnGermany

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite(SWAS)*** obtained an averaged O_(2)spectrum based on this sample using the(SWAS)survey data(O_(2),487.249 GHz,N=3-1,J=3-2).No emission or absorption feature is seen around the supposed central velocity with a total integration time of t_(total)=8.67×10^(3)hr and an rms noise per channel of 1.45 m *** a kinetic temperature t_(kin)=30 K,we derive the 3σupper limit of the O_(2)column density to be 3.3×10^(15)cm^(-2),close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O_(2)abundance upper limit is6.7×10^(-8),lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O_(2)abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： ISM:molecules galaxies:abundances ISM:lines and bands Galaxy:abundances

Long-term Integration Ability of the Submillimeter Wave Astronomy Satellite(SWAS)Spectral Line Receivers

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Research in Astronomy and Astrophysics 2024年第6期24卷 315-322页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei tsai Rudolf Schieder gary J.Melnick National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China KOSMA I.Physik.InstitutUniversität zu KölnZülpicher Str.7750937 KölnGermany Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetMS 66CambridgeMA 02138USA

the Submillimeter Wave Astronomy Satellite(SWAS)was the first space telescope capable of high spectral resolution observations of terahertz spectral *** have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit *** CI,O_(2),H_(2)O,and^(13)CO spectra taken toward all observed Galactic sources were *** present results are based on spectra with a total integration time of up to 2.72×10~4hr(■10~8s).the noise in the spectra is generally consistent with that expected from the radiometer equation,without any sign of approaching a noise *** noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

关键词： telescopes space vehicles:instruments instrumentation:miscellaneous ISM:lines and bands

Luteolin， a common flavone in vegetables， acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress

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Food Science and Human Wellness 2024年

作者： Alex Xiong Gao tracy Chenxi Xia Maggie Suisui Guo gary Kawing Yuen Kevin Qiyun Wu tina tingxia Dong Karl Wah-Keung tsim Shenzhen Key Laboratory of Edible and Medicinal Bioresources， HKUSt Shenzhen Research Institute Division of Life Science and Center for Chinese Medicine， the Hong Kong University of Science and technology

this study aims to uncover the hormetic process of luteolin， a common dietary flavone， in neuronal cells through its role in inducing mitochondrial stress. In rat pheochromocytoma PC12 cells， luteolin at low concentrations caused a mild and reversible loss of mitochondrial membrane potential (MMP)， while high concentrations of luteolin triggered intense and sustained depolarization of MMP. the MMP disturbance was shown to have a close association with the trophic and/or toxic effects triggered by luteolin; because the common mitochondrial uncouplers shared similar bi-phase dose-response on cell viability， as that of luteolin. Along with the induced MMP pertubation， luteolin triggered the development of autophagy and mitophagy， as determined by mCherry-GFP-LC3B tandem protein， and by the co-localization of mitochondrial/lysosomal staining. Subsequent application of autophagy inhibitors in the cultures blocked the luteolin-induced neurotrophic activities and sensitized the cells to be less resistant to luteolin-mediated cytotoxicity. Other flavonoids also displayed similar properties in the cultures， indicating that these compounds act as hormetic pharmacological inducers that stimulate cells to become more resilient and adapt to threats. this study provides a unifying mechanistic explanation for the neuro-beneficial effects of luteolin and other flavonoids.

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采用可编程串行接口设计背板

电子产品世界 2001年第9期8卷 61-63页

作者： Michael t.moore Cypress半导体公司

在网络路由器或交换机以及企业存储设备等系统中的高速背板中,通信系统正在使速度限制超越传统的1Gbps大关.PCI或VME之类的共享总线拓朴结构曾用于背板应用,然而,它们在可伸缩性、带宽和距离方面受到限制,即使最新的PCI-X也只能在刚过1G... 详细信息

在网络路由器或交换机以及企业存储设备等系统中的高速背板中,通信系统正在使速度限制超越传统的1Gbps大关.PCI或VME之类的共享总线拓朴结构曾用于背板应用,然而,它们在可伸缩性、带宽和距离方面受到限制,即使最新的PCI-X也只能在刚过1Gbyte/s的速率下使用.共享总线拓朴主要的限制因素在于高的I/O和有限的距离.由于任何一条引线或连线的损坏都将造成整个接口故障,所以可靠性也是共享总线的一个问题.共享总线的最大有效距离是18英寸.

关键词：串行接口背板通信网网络设备

Influence of the Atlantic Multidecadal Oscillation on the Winter Climate of East China

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Advances in Atmospheric Sciences 2007年第1期24卷 126-135页

作者：李双林 gary t.BAtES Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 NOAA ESRL-CIRES Climate Diagnostics CenterUniversity of ColoradoBoulderColorado NOAA ESRL-CIRES Climate Diagnostics Center University of ColoradoBoulderColorado

the Atlantic Multidecadal Oscillation （AMO）, the multidecadal variation of North Atlantic sea surface temperature （SSt）, exhibits an oscillation with a period of 65-80 years and an amplitude of 0.4℃. Observational composite analyses reveal that the warm phase AMO is linked to warmer winters in East China, with enhanced precipitation in the north of this region and reduced precipitation in the south, on multidecadal time scales. the pattern is reversed during the cold phase AMO. Whether the AMO acts as a forcing of the multidecadal winter climate of East China is explored by investigating the atmospheric response to warm AMO SSt anomalies in a large ensemble of atmospheric general circulation model （AGCM） experiments. the results from three AGCMs are consistent and suggest that the AMO warmth favors warmer winters in East China. this influence is realized through inducing negative surface air pressure anomalies in the hemispheric-wide domain extending from the midlatitude North Atlantic to midlatitude Eurasia. these negative surface anomalies favor the weakening of the Mongolian Cold High, and thus induce a weaker East Asian Winter Monsoon.

关键词： Atlantic Multidccadal Oscillation winter climate East China

Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.tervo Patricia t.Jacobson Brandon J.Vilarello tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.gary David A.Gudis Paule V.Joseph D.P.Devanand terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(tDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

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应用于存储及网络中的新一代存储器方案

电子测试（新电子） 2004年第5期 67-69页

作者： Michael t.moore Manoj Roge Cypress公司

近年来,由于因特网业务的平均带宽每6个月到9个月就增加一倍,因此对用于业务传输的网络容量(带宽)以及由该业务所生成的数据存储容量的要求也不断提高。诸如电子商务、数据挖掘、数据库、客户关系管理等应用产生了数量可观的数据进行处... 详细信息

近年来,由于因特网业务的平均带宽每6个月到9个月就增加一倍,因此对用于业务传输的网络容量(带宽)以及由该业务所生成的数据存储容量的要求也不断提高。诸如电子商务、数据挖掘、数据库、客户关系管理等应用产生了数量可观的数据进行处理,并且要求具有容错性能以及每周7天、每天24小时的全球范围内的快速数据存取。这就引发了对高容量、快速且可随时进行存取的存储器的需求。

关键词：存储器 SAN 存储区域网络 NAS 网络附属存储