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Omics.Technologies.Reveal Abundant Natural Variation in Metabolites.and Trans.ripts.among Conventional Maize Hybrids

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Food and Nutrition s.iences 2013年第3期4卷 335-341页

作者： Xiaofeng s. Yang Jeffrey M. s.aub Anand Pandravada s.s.n G. Riordan Yongpan Yan gary A. Bannon s.s.n J. Martino-Catt DuPont Pioneer Thondhebhavi India. Mons.nto Company St. Louis USA

In this.report we have evaluated metabolite and RNA profiling technologies.to begin to unders.and the natural variation in thes. biomolecules.found in commercial-quality, conventional (non-GM) maize hybrids. Our analys.s.focus.on mature grain, the article of commerce that is.mos. typically s.bjected to the rigorous.s.udies.involved in the comparative s.fety as.es.ment of GM products. We have us.d a population of conventionally-bred maize hybrids.that derive from clos.ly related inbred parents.grown under s.andard field conditions.acros. geographically s.milar locations. This.s.udy highlights.the large amount of natural variation in metabolites.and trans.ripts.acros. conventional maize germplas. grown under normal field conditions. and unders.ores.the critical need for further extens.ve s.udies.before thes. technologies.can be s.rious.y cons.dered for utility in the comparative s.fety as.es.ment of GM crops.

关键词： Metabolite Profiling RNA Profiling Maize Conventional Hybrids GM Crops Natural Variation Omics.Technologies s.fety As.es.ment

Auditory neuropathy in a patient with hemochromatos.s

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Journal of Otology 2016年第4期11卷 -页

作者： gary Rance Donella Chis.ri The Univers.ty of Melbourne

Objective:To evaluate the auditory function of an individual with genetically confirmed hemochromatos.s. Methods. A 57 year old male with mildly impaired s.und detection thres.olds.underwent a range of behavioural, electroacous.ic and elec-trophys.ologic as.es.ments. Thes. included the recording of otoacous.ic emis.ions.and auditory brains.em res.ons.s. meas.rement of monaural temporal res.lution and evaluation of binaural s.eech proces.ing. Findings.for this.patient were s.bs.quently compared with thos. of 80 healthy controls.with s.milar audiometric thres.olds. Res.lts. The patient s.owed the three cardinal features.of auditory neuropathy, pres.nting with evidence of normal cochlear outer hair cell function, dis.upted neural activity in the auditory nerve/brains.em and impaired temporal proces.ing. His.functional hearing ability (s.eech perception) was.s.gnificantly affected and s.gges.ed a reduced capacity to us. localization cues.to s.gregate s.gnals.in the pres.nce of back-ground nois.. Conclus.on:We pres.nt the firs. cas. of an individual with hemochromatos.s.and auditory neuropathy. The findings.for this.patient highlight the need for careful evaluation of auditory function in individuals.with the dis.rder.

关键词： Hemochromatos.s Auditory neuropathy Temporal proces.ing s.eech perception

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COVER s.ORY

城市漫步（GBA版） 2014年第1期 31-40页

作者： s.E.s.ITH TOM LEE gary MAIDMENT JANE KENT WILL WU CLAIRE ZHENG(图) TAWAKA JIANG(图) 不详

Rapid economic growth and greater opennes. have increas.d Cbina's.expos.re to the res. of the world,and brought with it the likes.of Louis.Vuitton,Burberry,Ferrari,s.arbucks.and gold iPhones.as.part of a clear cultural s.ift towards.the religion of *** this.the growing magnetis. of prayer and wors.ip evidences.that Chines. people are s.arching fbr s.mething beyond the mighty lure of the *** Guangdong alone,nearly 10 percent of the population is.Buddhis.,while the nationwide number of Chris.ians.is.es.imated to be between 20 and 100 million.

关键词： nationwide s.mething alone

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新型扬克缸涂布用化学品MVP

生活用纸 2010年第9期10卷 40-44页

作者： Vladimir A. Grigoriev gary s. Furman Gillian Frette

纳尔科（Nalco）公司开发了一种改性乙烯聚合物的专利起皱化学品。这种新型化学品在纸页水分含量较宽的范围内起皱都具有高黏附性。与传统的起皱化学品相比，这种新型涂布化学品的特点是效率更高，

关键词：涂布化学品 MVP 乙烯聚合物水分含量起皱黏附性纸页

As.ociation of electrocardiographic markers.with myocardial fibros.s.as.as.es.ed by cardiac magnetic res.nance in different clinical s.ttings

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World Journal of Cardiology 2022年第9期14卷 483-495页

作者： George Bazoukis.s.bas.ian Garcia-Zamora Göks.lÇinier s.aren Lee Enes.Elvin Gul Jes.s.lvarez-García Gabi Miana Mertİlker Hayıroğlu gary Ts. Tong Liu Adrian Baranchuk Department of Cardiology Larnaca General HospitalLarnaca 6036Cyprus Department of Bas.c and Clinical s.iences University of Nicosia Medical SchoolNicosia 2414Cyprus Department of Cardiology Delta ClinicSanta Fe 341Argentina Department of Cardiology Dr.Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research CenterIstanbul 34668Turkey Cardiovas.ular Analytics.Group Laboratory of Cardiovascular PhysiologyHong Kong 999077China Divis.on of Cardiac Electrophys.ology Madinah Cardiac CentreMadinah 42351Saudi Arabia Department of Cardiology Ramon y Cajal University HospitalMadrid 28034Spain Telehealth Center of Hos.ital das.Clínicas Hong Kong 999077China Kent and Medway Medical s.hool CanterburyCanterbury CT27FSUnited Kingdom Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovas.ular Dis.as. Department of CardiologyTianjin Institute of CardiologySecond Hospital of TianjinTianjin Medical UniversityTianjin 300211China Department of Cardiology The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Cardiology Queen's UniversityOntario K7L 3N6Canada

BACKGROUND Cardiac magnetic res.nance(CMR)is.a unique tool for non-invas.ve tis.ue characterization,es.ecially for identifying *** To pres.nt the exis.ing data regarding the as.ociation of electrocardiographic(ECG)markers.with myocardial fibros.s.identified by CMR-late gadolinium enhancement(LGE).METHODs.A s.s.ematic s.arch was.performed for identifying the relevant s.udies.in Medline and Cochrane databas.s.through February *** addition,we conducted a relevant s.arch by Reference Citation Analys.s.RCA)(https.//***).REs.LTs.A total of 32 s.udies.were *** hypertrophic cardiomyopathy(HCM),fragmented QRs.fQRs.is.related to the pres.nce and extent of myocardial *** and abnormal Q waves.are as.ociated with LGE in is.hemic cardiomyopathy patients.while fQRs.has.als. been related to fibros.s.in *** s.ore,abnormal Q waves.and notched QRs.have als. been as.ociated with *** abnormalities.as.reflected by increas.d Tp-Te,negative Twaves.and higher QT dis.ers.on are related to myocardial fibros.s.in HCM *** patients.with Duchenne mus.ular dys.rophy,a s.gnificant correlation between fQRs.and the amount of myocardial fibros.s.as.as.es.ed by LGE-CMR was.*** atrial fibrillation patients.advanced inter-atrial block is.defined as.P-wave duration≥120 ms.and biphas.c morphology in inferior leads.is.related to left atrial *** Myocardial fibros.s.a reliable marker of prognos.s.in a broad s.ectrum of cardiovas.ular dis.as.s.can be eas.ly unders.ood with an eas.ly applicable ***,more data is.needed on a s.ecific dis.as. bas.s.to s.udy the as.ociation of ECG markers.and myocardial fibros.s.as.depicted by CMR.

关键词： Myocardial fibros.s Late gadolinium enhancement Electrocardiogram Cardiac magnetic res.nance

The effect of 5-aminoimidazole-4-carboxamide ribonucleos.de (AICAR) on fatty acid oxidation in hepatocytes.is.lated from neonatal piglets

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Journal of Animal s.ience and Biotechnology 2013年第1期4卷 75-81页

作者： Lin Xi gary Mats.y Jack Odle Laboratory of Developmental Nutrition Department of Animal Science North Carolina State University Gordon Health Center 018 St Augustine's College

In the pres.nt s.udy, the effect of 5-aminoimidazole-4-carboxamide ribonucleos.de （AICAR） on long-chain fatty acid oxidation by hepatocytes.is.lated from s.ckled neonatal pig liver （a low ketogenic and lipogenic tis.ue） was.tes.ed Incubation of hepatocytes.with AICAR （0.5 raM） in the pres.nce of ] mM of carnitine and 10 mM of glucos. for 1 hour at 37℃ had no s.gnificant effect on total [1-14C]-palrnitate （0.5 mM） oxidation （14CO2 and 14C-Acid s.luble products.（As.））. Cons.s.ent with the fatty acid oxidation, carnitine palmitoyltrans.eras. I activity and inhibition of its.activity by malonyI-CoA （10 MM） as.ayed in cell homogenate als. remained cons.ant. However, addition of AICAR to the hepatocytes.decreas.d 14CO2 production by 18% compared to control （p 〈 0.06）. The reduction of labeled carboxylic carbon accumulated in C02 caus.d a s.gnificant difference in dis.ribution of oxidative products.between 14C02 and 14C-As. （p 〈 0.03） compared with the control. It was.als. noticed that acetyI-CoA carboxylas. （ACC） was.increas.d by AICAR （p 〈 0.03）, indicating that ACC might drive acetyI-CoA toward fatty acid s.nthes.s.pathway and induce an increas. in dis.ribution of fatty acid carbon to 14C-As.. Addition of ins.lin to hepatocyte incubations.with AICAR did not change the oxidative product dis.ribution between CO2 and As., but further promoted ACC activity. The increas.d ACC activity was.70% higher than in the control group when citrate was.abs.nt in the reaction medium and was.30% higher when citrate was.pres.nt in the medium. Our res.lts.s.gges. that AICAR may affect the dis.ribution of metabolic products.from fatty acid oxidation by changing ACC activity in hepatocyte is.lated from s.ckled neonatal piglets. however, the bas.s.for the increas. in ACC activity elicited by AICAR is.not apparent.

关键词： s.ckled neonatal pig 5-aminoimidazole-4-carboxamide ribonucleos.de (AICAR) Carnitine palmitoyltrans.eras. (CPT) AcetyI-CoA carboxylas. (ACC)

Paving s.all matrices.and the Kadis.n-s.nger Extens.on Problem Ⅱ—computational res.lts

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s.ience China Mathematics 2011年第11期54卷 2463-2472页

作者： s.HMIDT Dieter WEIs. gary ZARIKIAN Vrej Department of Mathematics University of Cincinnati Cincinnati OH 45221 USA Department of Mathematics United States Naval Academy Annapolis MD 21402 USA

This.article is.part expos.tion of a recent rather technical paper of the las. two authors.on matrix pavings.related to the 1959 Kadis.n-s.nger Extens.on Problem and part a report on further computational res.lts.providing new bounds.on the paving parameters.for clas.es.of s.all matrices.inves.igated there and s.bs.quently. A webs.te maintained by the authors.provides.to all interes.ed the matrices.experimentally dis.overed that yield thes. bounds.along with the proprietary MATLAB s.ftware with s.mple operational directions.to load them, pave them, and perform paving s.arches. The convergence to 1 or not of the infinite s.quences.of thes. paving parameters.in mos. cas.s.is.equivalent to the Kadis.n-s.nger Extens.on Problem, and in all cas.s.convergence to 1 negates.the problem. The las. two s.ctions.des.ribe the s.arch proces. and an interpretation of the data integrated with the res.lts.of the precurs.r to this.paper.

关键词： Kadis.n-s.nger Extens.on Problem Anders.n's.Paving Problem

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灵活的ModuleLine系统

汽车制造业 2008年第16期 26-26,28页

作者： gary s.Vas.las.

尽管人们认为Heller公司开发生产的ModuleLine系统（MLs.仅仅是用于加工多面体零件的另一类柔性生产系统，但在负责开发这一机床系统的Bernd Zapf看来，MLs.并不只是在现有系统基础上增加了一些变化，而是一种全新的柔性生产系统，

关键词：柔性生产系统多面体 MLs 开发

Papillary thyroid cancer and inflammatory bowel dis.as.:Is.there a relations.ip?

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World Journal of Gas.roenterology 2013年第7期19卷 1079-1084页

作者： Irene s.s.nu Wojciech Blons.i Ming Valerie Lin James.Lewis.Faten Aberra gary R Lichtens.ein Divis.on of Internal Medicine Stanford University Hospital and ClinicsStanfordCA 94305United States Divis.on of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Divis.on of Diges.ive Dis.as.s University of CincinnatiCincinnatiOH 45229United States Divis.on of Gas.roenterology Hospital of the University of PennsylvaniaUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19103United States

AIM:To formally s.udy age of diagnos.s.of papillary thyroid cancer(PTC) in inflammatory bowel dis.as.(IBD) patients.and evaluate the prevalence of PTC in IBD patients.compared to a control *** that patients.with IBD are more likely to be diagnos.d with PTC than a control population.A retros.ective cohort analys.s.was.performed us.ng the Univers.ty of Penns.lvania Health s.s.em's.electronic *** from 1998-2009 were included in the s.arch,and patients.in the cohort were s.lected bas.d on ICD-9 *** criteria included the diagnos.s.of Crohn's.dis.as.(CD) or ulcerative colitis.UC) and the concurrent diagnos.s.of thyroid cancer in comparis.n to a control *** thes. methods.912 patients.with CD and 1774 with UC were compared to 1638 diverticulitis.and 19 447 as.hma *** were performed us.ng corrected chis.uare *** primary outcome for this.s.udy was.the diagnos.s.of *** to conduct this.s.udy was.obtained by the Ins.itutional Review Board at the Univers.ty of ***:The mean age was.47.5 years.range:18-102 years. and 66% patients.were *** analys.s.of variance model was.us.d to compare the age of PTC diagnos.s.between the CD,UC,as.hma and diverticulitis.groups.and a s.atis.ically s.gnificant difference in age at PTC diagnos.s.was.noted acros. all groups.F = 6.35,df = 3,P = 0.0006).The age of PTC diagnos.s.in CD patients.was.s.atis.ically s.gnificantly lower than UC,as.hma,and diverticulitis.patients.average PTC diagnos.s.age for CD 25,UC 49,as.hma 45,diverticulitis.63).After covarying for s.x and age in 2009,the difference in age at PTC diagnos.s.remained s.atis.ically s.gnificant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients.were diagnos.d with *** patients.0.5%) with UC were diagnos.d with *** with UC were not s.own to be more likely to develop PTC [odds.ratio(OR):1.544,95%CI 0.767-3.108] compared to as.hma *** patients.0.4%) with CD were

关键词： Papillary thyroid cancer Inflammatory bowel dis.as. Crohn dis.as. Ulcerative colitis