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Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries

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Acta Pharmacologica Sinica 2007年第9期28卷 1422-1428页

作者： gary D STONER Robeena m AZIZ Division of Hematology and Oncology and Comprehensive Cancer Center Division of Environmental Health Sciences College of Public HealthThe Ohio State UniversityColumbusOH 43210USAUS Food and Drug AdministrationCenter for Drug Evaluation and ResearchSilver SpringMD 20903USA

Aim:This study was conducted to determine if short-term treatment of N-nitrosomethylbenzylamine (NmBA)-induced tumors in the rat esophagus withdietary freeze-dried black raspberries (FBR) would result in tumor regression andenhanced survival of the ***:Four-week-old male Fisher-344 ratswere administered an AIN-76A control diet and injected subcutaneously with 0.5mg/kg NmBA once per week for 15 *** 19 weeks,when rats had an averageof 5-6 tumors (papillomas) per esophagus,they were given a control diet contain-ing either 5%,10%,or 20% *** 7 weeks of berry treatment,all survivingrats were killed and tumor incidence,number and volume were ***:Esophageal tumor incidences,numbers and volumes in NmBA-treated rats werenot influenced by any of the berry *** were progressive increasesin the survival of NmBA-treated rats fed 5%-20% FBR diets;however,theseincreases were not ***:FBR at 5%,10%,and 20% of the diethad no effect on the development of NmBA-induced tumors in the rat esophagusor on animal survival when administered for 7 weeks beginning at the papillomastage of tumor ***,FBR appear to have no therapeutic value inthe treatment of esophageal *** contrast,dietary FBR are highly effectivein preventing the development of NmBA-induced esophageal tumors in rats whenadministered before and during NmBA treatment or shortly after NmBA treat-ment when the esophagi contain preneoplastic (dysplastic) lesions of varyingdegrees of severity.

关键词： chemoprevention therapy esophagus squamous cell carcinoma rodent black raspberries

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan gary John V.mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept mari S.Poblete Charmaine Grace m.Cabebe Adriel Vincent R.Te melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria m.Castro mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo michael maniwan Andrei P.martin Calvin Y.martinez John Alfred H.Lim Rena Ivy Bascuna Rachel m.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz m.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIm:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pm the Visayas(Pma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

The BRICS and Beyond： Insights into Human Development/Security from ＂Global Governance＂？

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Fudan Journal of the Humanities and Social Sciences 2014年第3期7卷 381-394页

作者： Timothy m. shaw mcCormack Graduate School University of Massachusetts Boston 100 Morrissey BoulevardBoston MA 02125-3393 USA

The decade of the BRICS is leading to the reanalysis of global relations, encouraged by the simultaneous rise of emerging markets and decline of the eurozone PIIGS. But is the trajectory towards global reorder and/or disorder？ Development like capitalisms and regionalisms is increasingly diverse： heterogeneous transnational networks best approached through a global studies frame？ Together these factors impact the balance between developmental and fragile states in African as elsewhere. And there are debates about what is emerging： companies？ econo- mies？ states？ and/or societies？ meanwhile, the ＂global＂ increasingly includes informal and illegal economies, especially TOC, including transnational Chinese mafias. Transnational governance continues to widen its scope to include airline and container alliances as well as a trio of commissions on drugs.

关键词： BRICS Development Global governance Regionalisms. Transnational

低升糖指数饮食对肥胖症、冠心病、糖尿病相关性研究进展(英文)

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社区医学杂志 2010年第17期8卷 34-36页

作者：陈海燕 Janet m.shaw 美国盐湖城犹他大学健康学院运动生理系

随着肥胖症、冠心病、糖尿病患者数量的飙升,社会负担的增加,欧美国家不得不对自己的饮食习惯进行调整。继而提出的升糖指数(Glycemic Index),25年来被无数营养学家和食品公司所强调和追捧。本综述通过对葡萄糖在体内的代谢机制以及能... 详细信息

随着肥胖症、冠心病、糖尿病患者数量的飙升,社会负担的增加,欧美国家不得不对自己的饮食习惯进行调整。继而提出的升糖指数(Glycemic Index),25年来被无数营养学家和食品公司所强调和追捧。本综述通过对葡萄糖在体内的代谢机制以及能量转化的分析,引用大量低升糖指数饮食对肥胖、冠心病、糖尿病患者长期影响的科学研究论文,证明低升糖指数饮食对肥胖症、冠心病、糖尿病控制的相关性不显著。

关键词：升糖指数/血糖生成指数营养代谢常量营养葡萄糖胰岛素

Communication,Computation,and Governance:A multiscalar Vantage on the Prehispanic mesoamerican World

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Journal of Social Computing 2022年第1期3卷 91-118页

作者： gary m.Feinman David m.Carballo the Negaunee Integrative Research Center Field Museum of Natural HistoryChicagoIL 60605USA Anthropology Archaeologyand Latin American StudiesBoston UniversityBostonMA 02215USA

Writing has often been put forth as one indicator of *** correspondence dovetails with the even broader cross-species expectation that the degrees of social complexity and levels of computational communication should closely *** in a general sense across human cooperative arrangements,a basic relationship between these variables undoubtedly exists,more detailed and fine-grained analyses indicate important axes of ***,our focus is on prehispanic mesoamerica and the means of computation and communication employed over more than three millennia(ca.1500 BCE-1520 CE).We take a multiscalar and diachronic analytical frame,in which we look at 30 central places,six macroregions,and mesoamerica as *** unraveling elements of“social complexity”,and decoupling computation from communication,we illustrate that institutional differences in governance had a marked effect on the specific modes and technologies through which prehispanic mesoamerican peoples communicated across time and *** and spatial scale,though relevant,do not alone determine time/space diversity in media of computational *** article is part of the theme issue“Evolution of Collective Computational Abilities of(Pre)Historic Societies”.

关键词： mesoamerica archaeology communication computation writing polity scale calendrics maya Aztec

Evolving technologies for growing,imaging and analyzing 3D root system architecture of crop plants

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Journal of Integrative Plant Biology 2016年第3期58卷 230-241页

作者： miguel A.Pieros Brandon G.Larson Jon E.Shaff David J.Schneider Alexandre Xavier Falcao Lixing Yuan Randy T.Clark Eric J.Craft Tyler W.Davis Pierre-Luc Pradier Nathanael m.shaw Ithipong Assaranurak Susan R.mc Couch Craig Sturrock malcolm Bennett Leon V.Kochian USDA-ARS Robert Holley Center for Agriculture and Health538 Tower RoadIthacaNY 14580USA Department of Information Systems Institute of ComputingUniversity of CampinasAv.Albert Einstein1251CEP 13083-852CampinasSPBrazil Department of Plant Nutrition China Agricultural UniversityBeijing 100193China Department of Plant Breeding and Genetics Cornell UniversityIthacaNY 14853USA Centre for Plant Integrative Biology School of BiosciencesUniversity of NottinghamSutton BoningtonLE12 5RDUK College of Science King Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

A plant＇s ability to maintain or improve its yield under limiting conditions,such as nutrient de ficiency or drought,can be strongly in fluenced by root system architecture（RSA）,the three-dimensional distribution of the different root types in the soil. The ability to image,track and quantify these root system attributes in a dynamic fashion is a useful tool in assessing desirable genetic and physiological root traits. Recent advances in imaging technology and phenotyping software have resulted in substantive progress in describing and quantifying RSA. We have designed a hydroponic growth system which retains the three-dimensional RSA of the plant root system,while allowing for aeration,solution replenishment and the imposition of nutrient treatments,as well as high-quality imaging of the root system. The simplicity and flexibility of the system allows for modi fications tailored to the RSA of different crop species and improved throughput. This paper details the recent improvements and innovations in our root growth and imaging system which allows for greater image sensitivity（detection of fine roots and other root details）,higher ef ficiency,and a broad array of growing conditions for plants that more closely mimic those found under field conditions.

关键词： Abiotic stress digital root phenotyping mineral nutrition root system architecture

Vascular disease in the older adult

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Journal of Geriatric Cardiology 2016年第9期13卷 727-732页

作者： Andrew P miller Christopher m Huff gary S Roubin Cardio Vascular Associates Birmingham Alabama USA

1 Introduction Among older adults, incidence and prevalence of aortic disease, peripheral arterial disease （PAD）, and venous thromboembolism （VTE） increase as age-related alterations in vascular structure and function are compounded by longer exposure to cardiovascular disease （CVD） risk factors. This review highlights the unique presentations and treatment strategies for aortic dissection, abdominal aortic aneurysm （AAA）, PAD, and VTE in older adults.

关键词： Aortic diseases Cardiovascular disease Peripheral arterial disease The elderly

Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson Brandon J.Vilarello Tiana m.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

mitochondria as a therapeutic:a potential new frontier in driving the shift from tissue repair to regeneration

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Regenerative Biomaterials 2023年第1期10卷 1332-1355页

作者： Evan N.main Thaiz m.Cruz gary L.Bowlin Department of Biomedical Engineering University of Memphis330 Engineering Technology BuildingMemphisTN 38152USA

Fibrosis,or scar tissue development,is associated with numerous pathologies and is often considered a worst-case scenario in terms of wound healing or the implantation of a *** that remains is a disorganized,densely packed and poorly vascularized bundle of connective tissue,which was once functional *** creates a significant obstacle to the restoration of tissue function or integration with any ***,it is of paramount importance in tissue engineering and regenerative medicine to emphasize regeneration,the successful recovery of native tissue function,as opposed to repair,the replacement of the native tissue(often with scar tissue).A technique dubbed‘mitochondrial transplantation’is a burgeoning field of research that shows promise in in vitro,in vivo and various clinical applications in preventing cell death,reducing inflammation,restoring cell metabolism and proper oxidative balance,among other reported ***,there is currently a lack of research regarding the potential for mitochondrial therapies within tissue engineering and regenerative ***,this review explores these promising findings and outlines the potential for mitochondrial transplantation-based therapies as a new frontier of scientific research with respect to driving regeneration in wound healing and host-biomaterial interactions,the current successes of mitochondrial transplantation that warrant this potential and the critical questions and remaining obstacles that remain in the field.

关键词： mitochondrial transplantation host-biomaterial integration biomaterials wound healing fibrosis