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Prognostic value of cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis:A systematic review and meta-analysis

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Cancer Innovation 2024年第3期3卷 22-32页

作者： Wenhua Song Nan Zhang Tonglian Lv Yang zhao Guangping Li gary Tse Tong Liu Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Radiology Second Hospital of Tianjin Medical UniversityTianjinChina School of Nursing and Health Studies Hong Kong Metropolitan UniversityHong KongChina Cardiac Electrophysiology Unit Cardiovascular Analytics GroupPowerHealth LimitedHong KongChina

Background:The role of surgery in metastatic breast cancer(MBC)is currently *** novel statistical and deep learning(DL)methods promise to infer the suitability of surgery at the individual ***:The objective of this study was to identify the most applicable DL model for determining patients with MBC who could benefit from surgery and the type of surgery ***:We introduced the deep survival regression with mixture effects(DSME),a semi-parametric DL model integrating three causal inference *** models were trained to make individualized treatment *** who received treatments in line with the DL models'recommendations were compared with those who underwent treatments divergent from the *** probability weighting(IPW)was used to minimize *** effects of various features on surgery selection were visualized and quantified using multivariate linear regression and causal ***:In total,5269 female patients with MBC were *** was an independent protective factor,outperforming other models in recommend-ing surgery(IPW-adjusted hazard ratio[HR]=0.39,95%confidence interval[CI]:0.19–0.78)and type of surgery(IPW-adjusted HR=0.66,95%CI:0.48–0.93).DSME was superior to other models and traditional guidelines,suggesting a higher proportion of patients benefiting from surgery,especially breast-conserving *** debiased effect of patient characteristics,including age,tumor size,metastatic sites,lymph node status,and breast cancer subtypes,on surgery decision was also ***:Our findings suggested that DSME could effectively identify patients with MBC likely to benefit from surgery and the specific type of surgery *** method can facilitate the development of efficient,reliable treatment recommendation systems and provide quantifiable evidence for decision-making.

关键词： breast surgery causal inference deep learning metastatic breast cancer

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ALBlendTM-雅保化工的新型复配添加剂造粒和改善聚合物品质的技术

ALBlendTM-雅保化工的新型复配添加剂造粒和改善聚合物品质的技术

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2005塑料助剂生产与应用技术信息交流会

作者： gary zhao 朱峰 Albemarle

雅保公司(ALBEMARLE CORPORATION)是一家从事精细及特殊化工产品生产及销售的美国公司。网址***。雅保公司在全球范围内约有3700名员工,近 20亿美元的年销售额,是一家在美国纽约证券交易所上市的上市公司。雅保公司的业务主要包括聚合... 详细信息

雅保公司(ALBEMARLE CORPORATION)是一家从事精细及特殊化工产品生产及销售的美国公司。网址***。雅保公司在全球范围内约有3700名员工,近 20亿美元的年销售额,是一家在美国纽约证券交易所上市的上市公司。雅保公司的业务主要包括聚合物化学品,精细化工产品和催化剂三大部分。就其关键的核心业务而言,雅保公司在同类产品供应商中名列前茅。雅保公司是目前世界上最大的烷基铝供应商, 同时也是溴化物产品、阻燃剂和炼油催化剂的最

关键词：阻燃剂聚合物添加剂复配技术

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Cardiovascular disease burden in patients with urological cancers:The new discipline of uro-cardio-oncology

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Cancer Innovation 2024年第2期3卷 28-44页

作者： Yi Zheng Ying Liu Ziliang Chen Yunpeng Zhang Zuo Qi Ning Wu Zhiqiang zhao gary Tse Yong Wang Hailong Hu Yuanjie Niu Tong Liu Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina School of Nursing and Health Studies Hong Kong Metropolitan UniversityHong KongChina

Cancer remains a major cause of mortality worldwide,and urological cancers are the most common cancers among *** therapeutic agents have been used to treat urological cancer,leading to improved survival for ***,this has been accompanied by an increase in the frequency of survivors with cardiovascular complications caused by anticancer medica***,we propose the novel discipline of uro-cardio-oncology,an evolving subspecialty focused on the complex interactions between cardiovascular disease and urological *** this comprehensive review,we discuss the various cardiovascular toxicities induced by different classes of antineoplastic agents used to treat urological cancers,including androgen deprivation therapy,vascular endothelial growth factor receptor tyrosine kinase inhibitors,immune checkpoint inhibitors,and *** addition,we discuss possible mechanisms underlying the cardiovascular toxicity associated with anticancer therapy and outline strategies for the surveillance,diagnosis,and effective management of cardiovascular compli***,we provide an analysis of future perspectives in this emerging specialty,identifying areas in need of further research.

关键词： anticancer therapy cardiovascular toxicity mechanism multidisciplinary management urological cancer

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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi zhao Jian-Bo Shao Daniel Kwok-keung Ng gary Wing-kin Wong Zheng-Yan zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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Oxidative desulfurization of fuels using ionic liquids： A review

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Frontiers of Chemical Science and Engineering 2015年第3期9卷 262-279页

作者： Hua zhao gary A. Baker Department of Chemistry and Forensic Science Savannah State University Savannah GA 31404 USA Department of Chemistry University of Missouri-Columbia Columbia MO 65211 USA

Extractive oxidation, wherein aromatic sulfur- containing compounds are extracted and subsequently oxidized to their corresponding sulfones, has proven to be one of the most effective desulfurization methods for producing ultra-low sulfur content fuels. As non-volatile and highly designable solvents, ionic liquids （ILs） have attracted considerable attention for the oxidative desulfur- ization of fuels. In this review, we systematically discuss the utility of ILs in catalytic and extractive oxidation, including their role as extractant, catalyst, or both. We also discuss the challenges facing the use of ILs in this regard, including their relatively high cost and excessive viscosity, as well as their efficiency and stability as catalyst.

关键词： oxidative desulfurization ionic liquids extraction fuels petroleum polyoxometalates

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An ACE/CRIS-observation-based Galactic Cosmic Rays heavy nuclei spectra model Ⅱ

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Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 100-111页

作者： Shuai Fu LingLing zhao gary PZank Miao Wang Yong Jiang Institute of Space Weather Nanjing University of Information Science and TechnologyNanjing 210044China Center for Space Plasma and Aeronomic Research(CSPAR) University of Alabama in HuntsvilleHuntsville AL 35805USA Department of Space Science University of Alabama in HuntsvilleHuntsville AL 35899USA

An observation-based Galactic Cosmic Ray(GCR)spectral model for heavy nuclei is *** and Qin[*** Phys.118,1837(2013)]proposed an empirical elemental GCR spectra model for nuclear charge 5≤z≤28 over the energy range^30 to 500 Me V/nuc,which is proved to be successful in predicting yearly averaged GCR heavy nuclei *** on the latest highly statistically precise measurements from ACE/CRIS,a further elemental GCR model with monthly averaged spectra is *** model can reproduce the past and predict the future GCR intensity monthly by correlating model parameters with the continuous sunspot number(SSN)*** effects of solar activity on GCR modulation are considered separately for odd and even solar *** with other comprehensive GCR models,our modeling results are satisfyingly consistent with the GCR spectral measurements from ACE/SIS and IMP-8,and have comparable prediction accuracy as the Badhwar&O’Neill 2014 model.A detailed error analysis is also ***,the GCR carbon and iron nuclei fluxes for the subsequent two solar cycles(SC 25 and 26)are predicted and they show a potential trend in reduced flux amplitude,which is suspected to be relevant to possible weak solar cycles.

关键词： Galactic Cosmic Rays spectral model solar modulation heavy nuclei

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Boosting extraction of Pb in contaminated soil via interfacial solar evaporation of multifunctional sponge

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Green Energy & Environment 2023年第5期8卷 1459-1468页

作者： Pan Wu Xuan Wu Yida Wang Jingyuan zhao Haolan Xu gary Owens Future Industries Institute UniSA STEMUniversity of South AustraliaMawson Lakes CampusSA 5095Australia

Interfacial solar water evaporation is a reliable way to accelerate water evaporation and contaminant *** the recent advance in photothermal technology,a functional sponge was prepared by coating a sodium alginate(SA)impregnated sponge with a surface layer of reduced graphene oxide(rGO)to act as a photothermal conversion medium and then subsequently evaluated for its ability to enhance Pb extraction from contaminated soil driven by interfacial solar *** SA loaded sponge had a Pb adsorption capacity of 107.4 mg g^(-1).Coating the top surface of the SA sponge with rGO increased water evaporation performance to 1.81 kg m^(-2)h^(-1)in soil media under one sun illumination and with a wind velocity of 2 m s^(-1).Over 12 continuous days of indoor evaporation testing,the Pb extraction efficiency was increased by 22.0%under 1 sun illumination relative to that observed without ***,Pb extraction was further improved by 48.9%under outdoor evaporation conditions compared to indoor ***,this initial work shows the significant potential of interfacial solar evaporation technologies for Pb contaminated soil remediation,which should also be applicable to a variety of other environmental contaminants.

关键词： Photothermal materials Interfacial solar evaporation Reduced graphene oxide Pb extraction Soil remediation

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Angle-Based Beamforming in mmWave Massive MIMO Systems with Low Feedback Overhead Using Multi-Pattern Codebooks

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China Communications 2019年第9期16卷 18-30页

作者： Yuyan zhao Yanan Liu gary Boudreau Akram Bin Sediq Xianbin Wang Department of Electrical and Computer Engineering Western UniversityLondonON N6A 5B9Canada Ericsson Canada OttawaON K2K 2V6Canada

The integration of millimeter-wave(mmWave)communications and massive multiple input multiple output(MIMO)techniques is a promising solution to dramatically increase the 5G network *** using large antenna arrays,beamforming can be adopted to improve the 5G capacity by employing spatial domain *** a frequency division duplexing(FDD)based 5G mmWave MIMO system,beamforming operation requires timely downlink channel state information(CSI)***,the rapid channel variations caused by short wavelength of mmWave band,and the high-level feedback information required due to the large number of antennas in massive MIMO system lead to the significantly increased beamforming *** this paper,by exploiting the higher angular stability of such channels,we propose an angle-based beamforming scheme to reduce the feedback frequency and the number of feedback *** facilitate this approach users are initially selected to reduce the intra-zone interference before ***,location related feedback,which is not affected by the number of antennas,is adopted to reduce *** simulation results show that two proposed user selection algorithms can adapt to scenarios with diverse requirements,while the feedback overhead of proposed angle-based beamforming algorithm is sharply reduce compared with that of CSIbased beamforming algorithm.

关键词： angle-based beamforming codebook feedback reduction user selection

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Enhanced Offset Averaging Technique for Flash ADC Design

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Tsinghua Science and Technology 2011年第3期16卷 285-289页

作者： Siqiang FAN He TANG Hui zhao Xin WANG Albert WANG Bin zhao gary G ZHANG Freescale Semiconductor Inc Irvine CA 92618 USA Department of Electrical Engineering University of California Riverside CA 92521USA Skyworks Solutions Inc.Irvine CA 92617 USA

This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters （ADC）. The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology.

关键词： analog-to-digital converter flash analog-to-digital converters (ADC) integrated circuit (IC) offset averaging resistor averaging capacitor averaging

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Effects of fruit thinning on ascorbate–glutathione cycle metabolism in black currants(Ribes nigrum L.)

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Journal of Forestry Research 2017年第5期28卷 903-908页

作者： Dong Qin Lijuan zhao Yu gary Gao Fangxiao Li Shulei Li Junwei Huo Shuang Lou Peng Liu College of Horticulture Northeast Agricultural University/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region)Ministry of Agriculture OSU South Centers The Ohio State University Wangcun Center Primary School of Zhoucun District

To elucidate mechanisms regulating ascorbic acid (AsA) biosynthesis and accumulation in the fruit and leaves of black currants, AsA and the activities of key enzymes in the ascorbate-glutathione (AsA-GSH) cycle were measured from fruit set to fruit ripening during fruit thinning treatments of three common commercial black currant cultivars that differed in their AsA levels: 'Risager' (low), 'Brodtrop' (medium) and 'Adelinia' (high). Treatments were 50% fruit reduction (50% of total fruit set) by hand, control was no thinning. Fruit thinning treatment significantly increased AsA content in fruit of all three cultivars from weeks 2 to 8, significantly decreased AsA content in leaves from weeks 3 to 8. Dehydroascorbate reductase and monodehydroascorbate reductase activities in fruit and leaves had a similar pattern, increasing during week 2, rose until they peaked in week 4. Ascorbate peroxidase activity in fruit in the thinning treatment was slightly lower than in the control. Fruit thinning was shown to be a good model to test AsA biosynthesis regulation and accumulation in black currants. The results from our study provided strong evidence that AsA-GSH cycle involved in AsA synthesis and accumulation in fruit.

关键词： Synthesis and accumulation Enzymatic activity Black currants

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