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Chinese Medical Journal 2013年第6期126卷 1013-1018页

作者： gary s. mintz Chief Medical Officer Cardiovascular Research Foundation 111 East 59th Street-llth Floor New York NY 10022 USA

It is now more than two decades since Nico Pijls and Bernard DeBruyne introduced fractional flow reserve （FFR） as a way to assess stenosis severity in the catheterization laboratory and since Paul Yock invented grayscale intravascular ultrasound （IVUs） that then spawned many second-generation intravascular imaging techniques such as （1） Virtual histology-IVUs （VH-IVUs） that uses both amplitude and radiofrequency ultrasound information to classify plaque as necrotic core,

关键词： intravascular imaging physiology cath lab environment

sirolimus-eluting stent fractures associated with aneurysm and very late stent thrombosis in the right coronary artery

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上海医学 2007年第Z1期30卷 226-229页

作者： LIU Xuebo gary s.mintz stéphane G.Carlier Martin B.Leon Department of Cardiology Zhongshan HospitalFudan University Columbia University Medical Center and Cardiovassular Research Faundation New York

Although the occurrence of coronary stent fracture is rare, recent reports showed that stent fracture after sirolimus-eluting stent (sEs) implantation may be associated with neointimal hyperplasia and restenosis. We report two cases of stent fracture that occurred late after elective sEs implantation into the right coronary artery (RCA) that were related to the aneurysm, restenosis, thrombosis, and vessel occlusion.

关键词： stent aneurysm eluting restenosis elective implantation distal occlusion longitudinal unstable

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血管内超声部分研究进展

当代医学 2000年第7期6卷 41-41,66页

作者： Ultrasound gary s.mintz 李越王青解放军总医院

1 对冠状动脉粥样硬化及再狭窄的认识 Glagov及其同事在病理方面的研究表明,在动脉粥样硬化早期阶段,冠状动脉的正性重构(一种增加动脉面积的病理变化过程)起到了维持动脉内径的作用。这就解释了为何血管内超声(intravascular ul-trasou... 详细信息

1 对冠状动脉粥样硬化及再狭窄的认识 Glagov及其同事在病理方面的研究表明,在动脉粥样硬化早期阶段,冠状动脉的正性重构(一种增加动脉面积的病理变化过程)起到了维持动脉内径的作用。这就解释了为何血管内超声(intravascular ul-trasound,IVUs)在冠心病病人“动脉造影正常”

关键词：冠状动脉粥样硬化血管内超声冠状动脉再狭窄

^(192)Ir射线治疗老年冠脉支架内再狭窄的机制和1年临床随访:系列血管内超声分析

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海南医学 2003年第12期14卷 2-4页

作者：吴智勇 gary s.mintz 海南省人民医院心血管中心海口570311 Cardiovascular Research Foundation New YorkUSA

目的　探讨1 92 Ir对老年冠心病支架内再狭窄的 1年的临床疗效及机制。方法　 99例老年冠心病支架内再狭窄病人经常规介入治疗后随机分为1 92 Ir治疗组和安慰剂组 ,在放疗后即刻和 6个月行血管内超声检查 ,分别测量支架、管腔及增生内... 详细信息

目的　探讨1 92 Ir对老年冠心病支架内再狭窄的 1年的临床疗效及机制。方法　 99例老年冠心病支架内再狭窄病人经常规介入治疗后随机分为1 92 Ir治疗组和安慰剂组 ,在放疗后即刻和 6个月行血管内超声检查 ,分别测量支架、管腔及增生内膜的内径和面积 ,并临床随访 1年 ,对所得参数进行统计学处理。结果　 99例病人中 ,糖尿病 3 9.4%,有支架内再狭窄史 5 8.6%,弥漫性病变 68%,静脉桥病变 18.5 %;两组治疗前后及两组间支架内径和面积无显著性变化 ,两组间放疗后即刻各参数也无显著性变化。随访中 ,治疗组和安慰剂组的最小腔内径、最小腔内面积和平均腔内面积分别为 :2 .0 3± 0 .47与 1.5 9± 0 .65mm ,P <0 .0 0 1;4.3 0± 2 .0 0与 2 .81± 2 .5 6mm2 ,P =0 .0 0 6;6.47± 2 .5 3与 5 .0 3± 3 .82mm2 ,P =0 .0 94。治疗组与对照组平均新生内膜和新生内膜百分比分别为 2 .2 2± 1.2 6与 3 .3 7± 1.89,P =0 .0 11;3 5± 17%与 5 7± 2 3 %,P <0 .0 0 1。 6个月的再狭窄率 ,治疗组与对照组分别为 :2 4.71%与 78.6%,p <0 .0 1。临床随访 1年 ,治疗组与对照组主要的心脏事件、靶血管及靶病变再介入治疗分别为 73 .0 %与 48.6%,P =0 .0 2 7;2 3 .8%与 5 1.4%,P =0 .0 0 6;11.6%与 40 .97%,P =0 .0 0 7。结论?

关键词： 192^Ir射线老年人冠脉支架内再狭窄作用机制随访血管内超声放射疗法冠心病

In vivo IVUs-based 2D and 3D coronary plaque models had good agreement for plaque progression analysis

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In vivo IVUS-based 2D and 3D coronary plaque models had good...

第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议

作者： Hongjian Wang Liang Wang Jie Zheng Jian Zhu Akiko Maehara Chun Yang Richard Bach David Muccigrosso gary s.mintz Dalin Tang school of Biological science & Medical Engineering Southeast University Mathematical sciences Department Worcester Polytechnic Institute Mallinckrodt Institute of Radiology Washington University Department of Cardiology Zhongda HospitalSoutheast University Columbia University The Cardiovascular Research Foundation Network Technology Research Institute China United Network Communications Co.Ltd. Cardiovascular Division Washington University School of Medicine

Image-based 3D computational models have been used for atherosclerotic plaque progression and vulnerability research and considerable progress has been ***,a major obstacle exists when implementing these research results for patient screening and clinical applications.3D plaque model construction is really time consuming and not practical for implementation at present *** this paper,2D structure-only and 3D fluid-

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First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease： results of the first in man FIREHAWK trial

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Chinese Medical Journal 2012年第6期125卷 970-976页

作者： QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian gary s. mintz Martin B. Leon GAO Run-lin Department of Cardiology Cardiovascular Institute and Fu Wai Hospital Chinese Academy Of Medical Sciences and Peking Union Medical College Beijing 100037 China Catheterization Laboratory Cardiovascular Institute and Fu Wai Hospital Chinese Academy Of Medical Sciences and Peking Union Medical College Beijing 100037 China Yale University school of Medicine New Haven CT USA Cardiovascular Research Foundation New York NY USA Columbia University Medical Center New York NY USA

Background Durable polymers used for first-generation drug-eluting stents （DEs） potentially contribute to persistent inflammation and late DEs thrombosis. We report the first in human experience with the rapamycin-eluting biodegradable polymer coated cobalt-chromium FIREHAWK stent with abluminal groove. Methods A total of 21 patients with stable or unstable angina, or prior myocardial infarction, with single de novo native coronary stenoses 〈30 mm in length in vessel sizes ranging from 2.25 to 4.0 mm were enrolled. The primary endpoint was major adverse cardiac events （MACE） at 30 days defined as the composite of cardiac death, myocardial infarction （Q and non-Q）, or ischemia-driven target lesion revascularization. secondary endpoints include device, lesion, and clinical success rates, 4-month in-stent late lumen loss by quantitative coronary angiography （QCA）, proportion of uncovered or malapposed stent struts by optical coherence tomograpphy （OCT） at 4 months, and MACE at 4, 12, 24 and 36-month follow-up. Results Device success was 95.7%, lesion and clinical success was 100.0%. There were no MACE events at 30 days. One patient died of non-cardiac hemorrhagic stroke 5 days after index procedure. At 4 months, in-stent late loss was （0.13±0.18） mm, and complete strut coverage was 96.2% by OCT with 0.1% strut malapposition. At 4-month follow-up there was no additional MACE events, and a single target vessel （non-target lesion） revascularization. Conclusions The FIREHAWK abluminal groove biodegradable polymer rapamycin-eluting stent demonstrated feasibility, safety and efficacy in this first in human experience. OCT findings indicated excellent stent strut coverage 4 months after implantation. Larger studies are required to confirm whether the early FIREHAWK stent results translate into longer term restenosis and thrombosis benefits.

关键词： rapamycin-eluting stent first-in-man study optical coherence tomography coronary artery disease

Intravascular ultrasound guidance improves the long term prognosis in patients with unprotected left main coronary artery disease undergoing percutaneous coronary interventions:a single center analysis from a 1899 patients cohort

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中国循环杂志 2016年第Z1期31卷 -页

作者： Yida Tang Jian Tian Changdong Guan gary s mintz Wenyao Wang Kuo Zhang Jue Chen Yongjian Wu shubin Qiao Yuejin Yang Bo Xu Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical Colege Beijing China The Cardiovascular Research Foundation NewYork-Presbyterian Hospital/Columbia University MedicalCenter New York USA

Patient-specific FsI models based on IVUs and OCT images with follow-up for more accurate coronary plaque progression predictions

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Patient-specific FSI models based on IVUS and OCT images wit...

第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Xiaoya Guo Dalin Tang David Molony Chun Yang Habib samady Jie Zheng gary s.mintz Akiko Maehara Jian Zhu Genshan Ma Don P.Giddens Department of Mathematics Southeast University Mathematical sciences Department Worcester Polytechnic Institute Department of Medicine Emory University School of Medicine Mallinckrodt Institute of Radiology Washington University The Cardiovascular Research Foundation Columbia University Department of Cardiology Zhongda HospitalSoutheast University The Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology

Objective Medical imaging resolution has been a limitation for image-based coronary plaque models to obtain accurate morphological and stress/strain data for plaque progression investigation. The resolution for intra-vascular ultrasound (IVUs) images is around 100-150 micron which is not enough to identify vulnerable plaques with thin cap thickness s 15-20 um resolution and has become a powerful tool to detect vulnerable plaques with thin fibrous cap. But OCT has limited penetration and

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Multi-risk-factor decision-making strategy for improved coronary plaque burden increase prediction:A patient-specific IVUs follow-up study using 3D FsI models

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Multi-risk-factor decision-making strategy for improved coro...

第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Liang Wang Dalin Tang Akiko Maehara Zheyang Wu Chun Yang Muccigrosso David Jie Zheng Richard Bach Kristen L.Billiar Genshan Ma gary s.mintz southeast University Mathematical sciences Department Worcester Polytechnic Institute Columbia University The Cardiovascular Research Foundation Mallinckrodt Institute of Radiology Washington University Cardiovascular Division Washington University School of Medicine Department of Biomedical Engineering Worcester Polytechnic Institute Department of Cardiology Zhongda HospitalSoutheast University

Objective Plaque progression and vulnerability are influenced by many risk factors. Our goal is to find a simple way to combine multiple risk factors and achieve better plaque development predictions. Methods A sample size of 254 intravascular ultrasound (IVUs) slices with noticeable change of plaque burden was obtained from 9 patients who underwent baseline and follow-up IVUs, and FsI modeling for plaque mechanical condi-

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冠状动脉支架内再狭窄介入术后即刻结果对长期疗效的影响

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冠状动脉支架内再狭窄介入术后即刻结果对长期疗效的影响

第七届全国老年医学学术会议暨海内外华人老年医学学术会议

作者：吴智勇肖芙蓉 gary s.mintz Neil J.Weissman 海南省人民医院心血管中心 Cardiovascular Research Institute WaShington Hospital CenterWashington DCUSA

目的应用系列血管内超声分析冠状动脉支架内再狭窄介入术后即刻结果是否影响其长期疗效。方法对180例冠状动脉支架内再狭窄患者分为Ir放疗组(106例)和安慰剂组(74例),平均随访6个月。

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