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Age of onset of diabetes and all-cause mor.ality

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Wor.d Jour.al of Diabetes 2020年第4期11卷 95-99页

作者： gary Yee Ang Health Ser.ices and Outcomes r.sear.h National Healthcare GroupSingapore 138543Singapore

Diabetes mellitus continues to pr.sent a lar.e social,financial and health system bur.en acr.ss the *** r.lationship between age of onset of the differ.nt types of diabetes and all-cause mor.ality is *** this r.view paper.the r.lationship between age of onset of the differ.nt types of diabetes and all-cause mor.ality will be r.viewed and an update of the cur.ent evidence will be *** is str.ng evidence of the r.lationship between age of onset of type 2 diabetes mellitus(T2 DM) and all-cause mor.ality,good evidence of the r.lationship between age of onset of T1 DM and all-cause mor.ality and no evidence of the r.lationship between age of onset of gestational diabetes or.pr.diabetes and all-cause *** r.sear.h is needed to look at whether.aggr.ssive management of ear.ier.onset of T2 DM can help to r.duce pr.matur. mor.ality.

关键词： Diabetes mellitus Age of onset Mor.ality Type 1 diabetes Type 2 diabetes Gestational diabetes Pr.diabetes

A model of r.gional economic development with incr.asing r.tur.s

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Jour.al of Zhejiang Univer.ity-Science A(Applied Physics & Engineer.ng) 2007年第1期8卷 164-170页

作者： QIAN Edwar. Y. YAO Yao-jun CHEN gary Center.for.r.sear.h of Pr.vate Economy Zhejiang University Hangzhou 310027 China College of Finance Zhejiang Gongshang University Hangzhou 310018 China Depar.ment of Management Setenee University of Waterloo Waterloo ON N2L 3G1 Canada

This paper.develops mathematically and empir.cally tr.ctable r.gional and inter.egional model of economic devel-opment with incr.asing r.tur.s to scale (Ir.) under.the neoclassical assumptions. A one-sector. two-r.gion model in which one r.gion exhibits Ir. is pr.sented and the whole nation pr.sents constant r.tur.s to scale. The development of the local Ir. economy is shown to be constr.ined to a “moving equilibr.um” path. The pr.liminar. empir.cal r.sults ar. sufficiently suppor.ive of the ar.ument to encour.ge fur.her.r.sear.h along the lines of the model. In par.icular. the neoclassical model does not pr.dict negative coefficients on the r.al r.ntal value of capital in r.gr.ssions explaining population or.employment r.lative to that in the nation.

关键词： Economic development Incr.asing r.tur.s Moving equilibr.um

Per.ectlyMatched Layer.withMixed Spectr.l Elements for.the Pr.pagation of Linear.zedWater.aves

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Communications in Computational Physics 2012年第2期11卷 285-302页

作者： gary Cohen Sebastien Imper.ale INr.A Domaine de VoluceauRocquencourt-BP 10578153 Le Chesnay CedexFrance

After.setting a mixed for.ulation for.the pr.pagation of linear.zed water.waves pr.blem,we define its spectr.l element ***,in or.er.to take into account unbounded domains,we constr.ct absor.ing per.ectly matched layer.for.the *** appr.ximate these per.ectly matched layer.by mixed spectr.l elements and show their.stability using the“fr.zen coefficient”***,numer.cal r.sults will pr.ve the efficiency of the per.ectly matched layer.compar.d to classical absor.ing boundar. conditions.

关键词： Linear.zed water.waves per.ectly matched layer mixed finite elements

Pur.fication and Char.cter.sation of Xanthine Oxidor.ductases fr.m Local Bovids in Malta

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Advances in Enzyme r.sear.h 2014年第1期2卷 54-63页

作者： Mar.ta Vella Ther.se Hunter.Claude Far.ugia Ar.en r. Pear.on gary Hunter Astbur. Centr. for.Str.ctur.l Molecular.Biology University of Leeds Leeds UK Depar.ment of Chemistr. University of Malta Msida Malta Depar.ment of Physiology and Biochemistr. University of Malta Msida Malta

Xanthine oxidor.ductase (XOr. is a molybdoflavopr.tein mainly involved in pur.ne catabolism. It exists in two for.s, the oxidase (XO) and dehydr.genase (XDH) which ar. inter.conver.ible within mammalian cells. Although var.ous r.sear.her. have r.por.ed the extr.ction of mammalian XOr. no extr.ctions have yet been car.ied out in Malta and subsequently no char.cter.zations ar. available. In this study, XOr.was successfully pur.fied fr.m bovine, capr.ne and ovine milk thr.ugh a multistep pur.fication pr.cess involving both chemical and chr.matogr.phic techniques. The molecular.weights of the native enzyme wer. found to be 295 kDa, 281 kDa and 275 kDa, r.pr.senting the bovine, capr.ne and ovine XOr.r.spectively. Wester. blot showed XOr.to be r.pr.sented on SDS-PAGE by a minimum of thr.e major.bands having molecular.weights of 151 kDa, 131 kDa and 85 kDa. While all samples showed activity on native PAGE, spectr.photometr.c assays r.vealed the bovine XOr.to be the most active. Sur.r.singly, the addition of NAD+ to the assay mixtur. inhibited enzyme activity of the bovine and capr.ne XOr.wher.as the ovine XOr.doubled its activity in r.sponse to NAD+. The latter.also showed a lower.binding affinity to hepar.n. Following incubation with tr.psin, XOr.was ir.ever.ibly conver.ed to its oxidase for. in all samples as r.flected by the obser.ed incr.ase in XO activity.

关键词： Xanthine Xanthine Dehydr.genase Xanthine Oxidase Milk Bovid Malta

The inter.ction between the Wnt/β-catenin signaling cascade and PKG activation in cancer

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The Jour.al of Biomedical r.sear.h 2017年第3期31卷 189-196页

作者： Kevin Lee gary A Piazza Dr.g Discover. r.sear.h Center Mitchell Cancer InstituteUniversity of South AlabamaMobileAL 36604-1405USA

The activation of the Wnt/β-catenin signaling cascade has been well studied and documented in color.ctal cancer.Cr.）.The long-ter. use of non-ster.idal anti-inflammator. dr.gs（NSAIDs） has been shown to r.duce the incidence and r.sk of death fr.m Cr. in numer.us epidemiological *** NSA1 D sulindac has also been r.por.ed to cause r.gr.ssion of pr.cancer.us adenomas in individuals with familial adenomatous polyposis who ar. at high r.sk of developing *** mechanism r.sponsible for.cancer.chemopr.ventive activity of NSAIDs is not well under.tood but may be unr.lated to their.cyclooxygenase inhibitor. *** evidence suggests that sulindac inhibits the gr.wth of colon tumor.cells by suppr.ssing the activity of cer.ain phosphodiester.se isozymes to activate cGMβ-dependent pr.tein kinase,PKG,thr.ugh the elevation of the second messenger.cyclic guanosine monophosphote,*** activation has been shown to inhibit the nuclear.tr.nslocation of β-catenin,r.duce β-catenin mr.A and pr.tein levels,and suppr.ss the tr.nscr.ptional activity of β-*** r.view descr.bes the r.lationship between the Wnt/β-catenin signaling cascade and the activation of PKG thr.ugh PDE inhibition and elevation of intr.cellular.cGMP levels.

关键词： Wnt β-catenin PKG cGMP PDE NSAID colon cancer br.ast cancer

Pr.natal r.sk factor. for.inter.alizing and exter.alizing pr.blems in childhood

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Wor.d Jour.al of Pediatr.cs 2020年第4期16卷 341-355页

作者： Joyce Tien gary D.Lewis Jianghong Liu Depar.ment of Family and Community Health School of NursingUniversity of PennsylvaniaPhiladelphiaPA19104USA Univer.ity of Ar.ansas for.Medical Sciences Little RockARUSA

Backgr.und A gr.wing body of r.sear.h has documented the effects of pr.natal r.sk factor. on a wide spectr.m of adver.e offspr.ng health *** behavior.pr.blems,such as exter.alizing and inter.alizing pr.blems,ar. no *** compr.hensive liter.tur. r.view aims to summar.ze and synthesize cur.ent r.sear.h about commonly exper.enced pr.natal r.sk factor. associated with inter.alizing and exter.alizing pr.blems,with a focus on their.impact dur.ng childhood and *** mechanisms as well as implications ar. also *** sour.es The EBSCO,Web of Science,PubMed,Google Scholar.and Scopus databases wer. sear.hed for.studies examining the association between pr.natal r.sk factor. and offspr.ng inter.alizing/exter.alizing pr.blems,using keywor.s“pr.natal”or.per.natal”or.bir.h complications”in combination with“inter.alizing”or.exter.alizing”.r.levant ar.icles,including exper.mental r.sear.h,systematic r.views,meta-analyses,cr.ss-sectional and longitudinal cohor. studies,and theor.tical liter.tur.,wer. r.viewed and synthesized to for. the basis of this integr.tive *** Pr.natal r.sk factor. that have been widely investigated with r.gar.s to offspr.ng inter.alizing and exter.alizing pr.blems encompass health-r.lated r.sk factor.,including mater.al over.eight/obesity,substance use/abuse,envir.nmental toxicant exposur.,mater.al infection/inflammation,as well as psychosocial r.sk factor.,including intimate par.ner.violence,and anxiety/***,both epidemiological and exper.mental studies suppor. the adver.e associations between these pr.natal factor. and incr.ased r.sk of emotional/behavior.l pr.blem development dur.ng childhood and *** mechanisms of action under.ying these associations include hor.onal and immune system *** include pr.natal education,scr.ening,and inter.ention *** Pr.natal r.sk factor. ar. associated with a constellation of offspr.ng inter.alizin

关键词： Exter.alizing Inter.alizing Obstetr.cal Pr.gnancy Pr.natal r.sk factor.

Genetic diver.ity and population str.ctur. of Leptosphaer.a maculans isolates in Wester. Canada

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Jour.al of Genetics and Genomics 2021年第11期48卷 994-1006页

作者： Qilin Chen gary Peng r.ndy Kutcher.Fengqun Yu Saskatoon r.sear.h and Development Centr. Agriculture and Agri-Food CanadaSaskatoonCanada Depar.ment of Plant Sciences Crop Development CentreUniversity of SKSaskatoonSKCanada

Leptosphaer.a maculans is a ser.ous concer. for.canola pr.duction *** effective disease management,knowledge of the pathogen’s genetic var.ability and population str.ctur. is a *** this study,whole-genome sequencing was per.or.ed for.162 of 1590 *** isolates collected in the year. 2007e2008 and 2012e2014 in Wester. *** var.ants in genome-wide and specific r.gions including avir.lence(Avr.genes wer. char.cter.zed.A total of 31,870 high-quality polymor.hic DNA var.ants wer. used to study *** genetic diver.ity and population *** analysis showed that 150 isolates wer. cluster.d into 2 main gr.ups and 4 subgr.ups by DNA var.ants located in either.Avr.or.small secr.ted pr.tein-encoding genes and into 2 main gr.ups and 6 subgr.ups by genome-wide *** analysis of nucleotide diver.ity and differ.ntiation also confir.ed genetic var.ation within a population and among *** component analysis with genome-wide var.ants showed that the isolates collected in 2012e2014 wer. mor. genetically diver.e than those collected in *** str.ctur. analysis discover.d thr.e distinct *** isolates fr.m Saskatchewan and Alber.a wer. of similar.genetic composition,Manitoba isolates wer. highly ***-wide association study detected DNA var.ants in genes Avr.m4-7,Lema_T86300,and Lema_T86310 associated with the year. of collection.

关键词： Leptosphaer.a maculans DNA var.ants Blackleg Genetic diver.ity Population str.ctur.

r.sponse of gr.ase film at low speeds under.pur. r.lling r.cipr.cating motion

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Fr.ction 2020年第1期8卷 115-135页

作者： Yiming HAN Jing WANG Shanshan WANG Qian ZOU gary BAr.Er School of Mechanical and Automotive Engineer.ng Qingdao University of TechnologyHuangdao CampusQingdao 266520China School of Engineer.ng and Computer.Science Oakland UniversityRochesterMI 48309USA

Using an optical inter.er.metr.c technique,the gr.ase film distr.bution under.a pur. r.lling r.cipr.cating motion is obser.ed on a ball‐disk test r.g,to explor. the tr.nsient r.sponse of gr.ase,which is expected to fill the contact with thickener.fiber.and r.n for.a long time under.steady‐state *** is found that the r.cipr.cating motion r.duces the accumulation of the thickener.fiber.gr.dually with *** maximum film thickness for.s ar.und the str.ke *** 1,000 wor.ing cycles,ver. sever. star.ation occur. so that either.the centr.l or.minimum film thickness becomes near.y constant over.one wor.ing ***,the life of gr.ase lubr.cation under.a tr.nsient condition is far.below that under.steady‐state ***,it is also found that by selecting a smaller.str.ke length,the thickener.fiber.spr.ads out in the contact instead of being r.moved fr.m the contact at the 1,000th wor.ing *** incr.asing the maximum entr.ining speed of the r.cipr.cating motion to a cer.ain value,dur.ng which the thickener.fiber.is not expected to accumulate under.a steady‐state condition,sever. star.ation occur. ver. quickly,causing sur.ace damage.

关键词： gr.ase lubr.cation r.cipr.cation pur. r.lling gr.ase star.ation thickener.fiber

Auditor. neur.pathy in a patient with hemochr.matosis

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Jour.al of Otology 2016年第4期11卷 -页

作者： gary r.nce Donella Chisar. The Univer.ity of Melbour.e

Objective:To evaluate the auditor. function of an individual with genetically confir.ed hemochr.matosis. Methods: A 57 year.old male with mildly impair.d sound detection thr.sholds under.ent a r.nge of behaviour.l, electr.acoustic and elec-tr.physiologic assessments. These included the r.cor.ing of otoacoustic emissions and auditor. br.instem r.sponses, measur.ment of monaur.l tempor.l r.solution and evaluation of binaur.l speech pr.cessing. Findings for.this patient wer. subsequently compar.d with those of 80 healthy contr.ls with similar.audiometr.c thr.sholds. r.sults: The patient showed the thr.e car.inal featur.s of auditor. neur.pathy, pr.senting with evidence of nor.al cochlear.outer.hair.cell function, disr.pted neur.l activity in the auditor. ner.e/br.instem and impair.d tempor.l pr.cessing. His functional hear.ng ability (speech per.eption) was significantly affected and suggested a r.duced capacity to use localization cues to segr.gate signals in the pr.sence of back-gr.und noise. Conclusion:We pr.sent the fir.t case of an individual with hemochr.matosis and auditor. neur.pathy. The findings for.this patient highlight the need for.car.ful evaluation of auditor. function in individuals with the disor.er.

关键词： Hemochr.matosis Auditor. neur.pathy Tempor.l pr.cessing Speech per.eption