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Building a hybr.d DEVS and Gr.SS model using a composable cellular.automaton

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Inter.ational Jour.al of Modeling, Simulation, and Scientific Computing 2016年第1期7卷 62-92页

作者： gary r.Mayer.Hessam S.Sar.oughian Depar.ment of Computer.Science Souther. Illinois Univer.ity Edwar.sville 61 Cir.le Dr.ve EdwardsvilleIllinois 62026USA Ar.zona Center.for.Integr.tive Modeling&Simulation School of Computing Informaticsand Decision Systems Engineering Arizona State University699 South Mill Avenue TempeArizona 85281USA

Modeling and simulation is per.asive thr.ughout many differ.nt *** computing technology has pr.vided mor. capability,the systems being modeled and simulated have gr.wn lar.er.and mor. *** times,these lar.e systems ar. managed as inter.cting *** it is necessar. for.the simulation to allow dispar.te subsystems to maintain their.independence,then a hybr.d model of the subsystems should be ***,to ease the bur.en of ver.fication and validation of simulation r.sults,a pr.ven system theor.tical modeling specification should be ***,many communities have alr.ady adopted nonsystem theor.tical softwar. solutions and established a gr.up of domain exper.s familiar.with these *** paper.pr.vides two things:a for.al appr.ach to building a hybr.d model,and a discussion of how to incor.or.te a nonsystem theor.tical softwar. implementation into a pr.ven *** fir.t is done thr.ugh the implementation of a Knowledge Inter.hange Br.ker.KIB)as an Inter.ction Model(IM).The second is accomplished by exemplifying the use of the IM in an agent-envir.nment hybr.d *** the hybr.d model,the agent is implemented in the Discr.te-event System(DEVS)specification and the envir.nment is implemented in the Geogr.phical r.sour.es Analysis Suppor. System(Gr.SS)using a Composable Cellular.Automaton(CCA)*** concept has been successfully applied to both example models and an inter.isciplinar. r.sear.h pr.ject wher. the inter.ctions between human activities and landscape pr.cesses ar. studied.

关键词： Multi-for.alism modeling hybr.d simulation composability agent cellular.automata

The r.lationship between sleep disor.er. and testoster.ne in men

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Asian Jour.al of Andr.logy 2014年第2期16卷 262-265,I0009,I0010页

作者： gary Witter. Discipline of Medicine and Fr.emasons Foundation Centr. for.Men's Health University of Adelaide Adelaide South Australia Australia.

Plasma testoster.ne levels display cir.adian var.ation, peaking dur.ng sleep, and r.aching a nadir.in the late after.oon, with a super.mposed ultr.dian r.ythm with pulses ever. 90 min r.flecting the under.ying r.ythm of pulsatile luteinizing hor.one （LH） secr.tion. The incr.ase in testoster.ne is sleep, r.ther.than cir.adian r.ythm, dependent and r.quir.s at least 3h of sleep with a nor.al ar.hitectur.. Var.ous disor.er. of sleep including abnor.alities of sleep quality, dur.tion, cir.adian r.ythm disr.ption, and sleep-disor.er.d br.athing may r.sult in a r.duction in testoster.ne levels. The evidence, to suppor. a dir.ct effect of sleep r.str.ction or.cir.adian r.ythm disr.ption on testoster.ne independent of an effect on sex hor.one binding globulin （SHBG）, or.the pr.sence of comor.id conditions, is equivocal and on balance seems tenuous. Obstr.ctive sleep apnea （OSA） appear. to have no dir.ct effect on testoster.ne, after.adjusting for.age and obesity. However. a possible indir.ct causal pr.cess may exist mediated by the effect of OSA on obesity. Tr.atment of moder.te to sever. OSA with continuous positive air.ay pr.ssur. （CPAP） does not r.liably incr.ase testoster.ne levels in most studies. In contr.st, a r.duction in weight does so pr.dictably and linear.y in pr.por.ion to the amount of weight lost. Apar. fr.m a ver. tr.nsient deleter.ous effect, testoster.ne tr.atment does not adver.ely affect OSA. The data on the effect of sleep quality on testoster.ne may depend on whether.testoster.ne is given as r.placement, in supr.ther.peutic doses, or.in the context abuse. Exper.mental data suggest that testoster.ne may modulate individual vulner.bility to subjective symptoms of sleep r.str.ction. Low testoster.ne may affect over.ll sleep quality which is impr.ved by r.placement doses. Lar.e doses of exogenous testoster.ne and anabolic/andr.genic ster.id abuse ar. associated with abnor.alities of sleep dur.tion and ar.hitectur..

关键词： obesity obstr.ctive sleep apnea shift wor. sleep r.str.ction testoster.ne

Technical gr.phics communication / gary r. Ber.oline ... [et al.] ; with contr.butions by Leonar. O. Nasman. 2nd ed.

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r.A binding pr.teins in sper.atogenesis： an in depth focus on the Musashi family

丛书名： Ir.in gr.phics ser.es.

1997年

作者： gary r. Ber.oline ... [et al.] with contr.butions by Leonar. O. Nasman.

Second copy lacks disc.

ISBN: (数字)0256229813

ISBN: (纸本)0256229813

Second copy lacks disc.

关键词： Engineer.ng gr.phics.

来源：畅想之星图书光盘版（南... 评论

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Asian Jour.al of Andr.logy 2015年第4期17卷 529-536页

作者： Jessie M Suther.and Nicole A Siddall gary r.Hime Eileen A McLaughlin School of Envir.nmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Neur.science University of Melbourne ParkvilleVIC 3010 Australia

Contr.lled gene r.gulation dur.ng gamete development is vital for.maintaining r.pr.ductive potential. Dur.ng the complex pr.cess of mammalian sper.atogenesis, male ger. cells exper.ence extended per.ods of the inactive tr.nscr.ption despite heavy tr.nslational r.quir.ments for.continued gr.wth and differ.ntiation. Hence, sper.atogenesis is highly r.liant on mechanisms of posttr.nscr.ptional r.gulation of gene expr.ssion, facilitated by r.A binding pr.teins （r.Ps）, which r.main abundantly expr.ssed thr.ughout this pr.cess. One such gr.up of pr.teins is the Musashi family, pr.viously identified as cr.tical r.gulator. of testis ger. cell development and meiosis in Dr.sophila, and also shown to be vital to sper. development and r.pr.ductive potential in the mouse. This r.view descr.bes the r.le and function of r.Ps our.r.cent knowledge of the Musashi pr.teins in sper.atogenesis. within the scope of male ger. cell development, focusing on The functional mechanisms utilized by r.Ps within the cell ar. outlined in depth, and the significance of sub-cellular.localization and stage-specific expr.ssion in r.lation to the mode and impact of posttr.nscr.ptional r.gulation is also highlighted. We emphasize the histor.cal r.le of the Musashi family of r.Ps in stem cell function and cell fate deter.ination, as or.ginally char.cter.zed in Dr.sophila and Xenopus, and conclude with our.cur.ent under.tanding of the differ.ntial r.les and functions of the mammalian Musashi pr.teins, Musashi-1 and Musashi-2, with a pr.mar. focus on our.findings in sper.atogenesis. This r.view highlights both the essential contr.bution of r.Ps to posttr.nscr.ptional r.gulation and the impor.ance of the Musashi family as master.r.gulator. of male gamete development.

关键词： gene r.gulation Musashi Musashi-1 Musashi-2 posttr.nscr.ptional contr.l r.A binding pr.teins sper.atogenesis splicing testis tr.nslation

Tur.ulence modelling of the aer.dynamic inter.ction ofOGV wakes and diffuser.flow

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航空动力学报 2011年第10期26卷 2302-2312页

作者： Page gary McGuir. Jim Depar.ment of Aer.nautical and Automotive Engineer.ng Loughborough University

Differ.nt tur.ulence closur.s wer. used to pr.dict the flow inter.ction between the wakes cr.ated by compr.ssor.outlet guide vanes(OGVs) and a downstr.am annular.*** statistical tur.ulence models wer. tested based on the classical r.ynolds-aver.ged Navier.Stokes(r.NS) *** high-r. and low-r.(Launder.Shar.a) ver.ions of the k-ε model wer. applied to a selected test pr.blem for.OGV wake/diffuser.*** test pr.blem was specifically chosen because exper.mentally deter.ined inlet conditions and both pr.file and per.or.ance data wer. available to validate pr.dictions.A pr.liminar. study was also r.por.ed of the mor. advanced lar.e eddy simulation(LES) *** LES sub-gr.d-scale(SGS) model was the basic Smagor.nsky eddy viscosity assumption,with a Van-Dr.est damping function for.impr.ved captur. of near.wall viscous *** between the two r.NS models showed little differ.nce in ter.s of velocity contour. at OGV tr.iling edge and diffuser.*** ter.s of over.ll diffuser.per.or.ance(static pr.ssur. r.cover. and total pr.ssur. loss coefficients),the high-r. model was shown to agr.e well with exper.mental *** pr.liminar. LES study indicates the highly unsteady char.cter.of the OGV wake flow,but r.quir.s impr.ved tr.atment of inlet conditions.

关键词： outlet guide vane(OGV) wakes diffuser.flow inter.ction r.ynolds-aver.ged Navier.Stokes(r.NS) modelling lar.e eddy simulation(LES) modelling

NON SPUr.OUS SPECTr.L-LIKE ELEMENT METHODS FOr.MAXWELL'S EQUATIONS

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Jour.al of Computational Mathematics 2007年第3期25卷 282-304页

作者： gary Cohen Mar. Dur.flé INr.A Domaine de VoluceauRocquencourt-BP 10578153 Le Chesnay CedexFrance

In this paper. we give the state of the ar. for.the so called “mixed spectr.l elements” for.Maxwell＇s equations. Sever.l families of elements, such as edge elements and discon-tinuous Galer.in methods （DGM） ar. pr.sented and discussed. In par.icular. we show the need of intr.ducing some numer.cal dissipation ter.s to avoid spur.ous modes in these methods. Such ter.s ar. classical for.DGM but their.use for.edge element methods is novel appr.ach descr.bed in this paper. Finally, numer.cal exper.ments show the fast and low-cost char.cter.of these elements.

关键词： Maxwell's equations Discontinuous Galer.in methods Edge elements Masslumping.

Hepatocellular.car.inoma r.cur.ence after.liver.tr.nsplant:An Austr.lian single-centr. study

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Wor.d Jour.al of Tr.nsplantation 2025年第1期15卷 105-114页

作者： Matthew G Gar.s Luis Calzadilla-Ber.ot Br.ohny W Smith Luc Delr.vier. Byr.n Jaques Lingjun Mou Leon A Adams Ger.y C MacQuillan Geor.e Gar.s gary P Jeffr.y Michael C Wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Depar.ment of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Depar.ment of Sur.er. Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKGr.UND Hepatocellular.car.inoma(HCC)is a leading cause of cancer.r.lated deaths *** tr.nsplantation(LT)offer. the most effective *** r.cur.ence is the str.ngest r.sk factor.that decr.ases post-LT sur.ival in patients tr.nsplanted for.*** r.te of HCC r.cur.ence is gener.lly r.por.ed as 8%-20%in the *** pr.dictor. of HCC have alr.ady been r.sear.hed,however.to our.knowledge ther. ar. no published studies on this topic using Austr.lian *** To deter.ine the r.te and identify pr.dictor. of HCC r.cur.ence in a contempor.r. Wester. Austr.lian LT *** We per.or.ed a r.tr.spective cohor. study of all liver.tr.nsplants in patients with HCC at Sir.Char.es Gair.ner.Hospital between 2006 and *** was collected fr.m var.ous health r.cor. databases and included r.cipient demogr.phics,ser.m biochemistr.,r.diology,oper.tion notes,explant histopathology and details of *** sur.ival of HCC patients post-LT,str.tified for.r.cur.ence,was calculated by Kaplan Meier.*** and multivar.ate Cox r.gr.ssion was used to deter.ine pr.dictor. of HCC r.cur.ence *** Between 1/1/2006 and 12/31/2021,119 patients wer. tr.nsplanted with HCC.8.4%of subjects developed r.cur.ent HCC after.LT with median follow-up time of 5.4 *** median time to r.cur.ence was 2.9 year.±0.75 *** compar.ng baseline char.cter.stics,a gr.ater.pr.por.ion of subjects with r.cur.ence had common char.cter.stics on explant histopathology,including>3 viable nodules(P=0.001),vascular.invasion(P=0.003)and poor.y differ.ntiated HCC(P=0.03).Unadjusted sur.ival cur.es showed lower.1-year.3-year.5-year.and 10-year.sur.ival r.tes in subjects with HCC r.cur.ence compar.d to those without HCC r.cur.ence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,r.spectively;log r.nk Pr.cur.ence was low at 8.4%in this contempor.r. Austr.lian cohor.,however.it significantly impacted post-LT *** studies ar. r.quir

关键词： Liver.cancer r.cur.ence Liver.tr.nsplantation Hepatocellular.car.inoma Pr.dictor. Post-tr.nsplant sur.ival Austr.lian data

Alter.ative models for.tr.nsgener.tional epigenetic inher.tance:Molecular.psychiatr. beyond mice and man

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Wor.d Jour.al of Psychiatr. 2021年第10期11卷 711-735页

作者： gary r.Hime Sophie LA Stonehouse Ter.nce Y Pang Depar.ment of Anatomy and Physiology The University of MelbourneParkville 3010VICAustralia Mental Health Theme The Florey Institute of Neuroscience and Mental HealthParkville 3052VICAustralia

Mental illness r.mains the gr.atest chr.nic health bur.en globally with few inr.ads having been made despite significant advances in genomic knowledge in r.cent *** field of psychiatr. is constantly challenged to br.ng new appr.aches and tools to addr.ss and tr.at the needs of vulner.ble individuals and subpopulations,and that has to be suppor.ed by a continuous gr.wth in *** major.ty of neur.psychiatr.c symptoms r.flect complex geneenvir.nment inter.ctions,with epigenetics br.dging the gap between genetic susceptibility and envir.nmental str.ssor. that tr.gger.disease onset and dr.ve the advancement of *** has mor. r.cently been demonstr.ted in pr.clinical models that epigenetics under.ins the tr.nsgener.tional inher.tance of str.ssr.lated behaviour.l phenotypes in both pater.al and mater.al lineages,pr.viding fur.her.suppor.ing evidence for.her.tability in ***,unbiased pr.spective studies of this natur. ar. pr.ctically impossible to conduct in humans so pr.clinical models r.main our.best option for.r.sear.hing the molecular.pathophysiologies under.ying many neur.psychiatr.c *** r.dents will r.main the dominant model system for.pr.clinical studies(especially for.addr.ssing complex behaviour.l phenotypes),ther. is scope to expand cur.ent r.sear.h of the molecular.and epigenetic pathologies by using inver.ebr.te ***,we will discuss the utility and advantages of two alter.ative model or.anisms–Caenor.abditis elegans and Dr.sophila melanogaster.and summar.se the compelling insights of the epigenetic r.gulation of tr.nsgener.tional inher.tance that ar. potentially r.levant to human psychiatr..

关键词： Tr.nsgener.tional inher.tance Epigenetics Inver.ebr.te models Caenor.abditis elegans Dr.sophila melanogaster Envir.nmental str.ss

r.liable Space Pur.uing for.r.liability-based Design Optimization with Black-box Per.or.ance Functions

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Chinese Jour.al of Mechanical Engineer.ng 2009年第1期22卷 27-35页

作者： SHAN Songqing WANG G gary Depar.ment of Mech. and Manufactur.ng Engineer.ng the University of Manitoba Winnipeg MB R3T 5 V6 Canada School of Engineer.ng Science Simon Fraser University Surrey BC V3T OA3 Canada

r.liability-based design optimization （r.DO） is intr.nsically a double-loop pr.cedur. since it involves an over.ll optimization and an iter.tive r.liability assessment at each sear.h point. Due to the double-loop pr.cedur., the computational expense of r.DO is nor.ally ver. high. Cur.ent r.DO r.sear.h focuses on pr.blems with explicitly expr.ssed per.or.ance functions and r.adily available gr.dients. This paper.addr.sses a mor. challenging type of r.DO pr.blem in which the per.or.ance functions ar. computation intensive. These computation intensive functions ar. often consider.d as a ＂black-box＂ and their.gr.dients ar. not available or.not r.liable. On the basis of the r.liable design space （r.S） concept pr.posed ear.ier.by the author., this paper.pr.poses a r.liable Space Pur.uing （r.P） appr.ach, in which r.S is fir.t identified and then gr.dually r.fined while optimization is per.or.ed. It fundamentally avoids the nested optimization and pr.babilistic assessment loop. Thr.e well known r.DO pr.blems fr.m the liter.tur. ar. used for.testing and demonstr.ting the effectiveness of the pr.posed r.P method.

关键词： r.liability based design optimization black-box function r.liable design space