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Extracellular Disintegration of Viral proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

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CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua Huang Fangxu pu Entao Li Guiyou Wang Wei Wang Yun Ding gary Wong Sandra Chiu Jiaming Lan Aiguo Hu Shanghai Key Laboratory of Advanced polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key Laboratory of Molecular Virology&Immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical Laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses ***,state-of-the-art treatments still lag behind the continual emergence of new *** to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural ***,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)*** core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the *** EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

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可生物降解塑料取代传统塑料--对碳排放的影响

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Engineering 2024年第1期32卷 152-162页

作者： Guanyi Chen Jianyuan Li Yunan Sun Zhi Wang gary ALeeke Christian Moretti Zhanjun Cheng Yuan Wang Ning Li Lan Mu Jinyu Li Junyu Tao Beibei Yan Li'an Hou Interdisciplinary Innovation Lab for Environment and Energy School of Mechanical Engineering&School of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China School of Ecology and Environment Tibet UniversityLhasa 850012China Tianjin Key Laboratory of Biomass Wastes UtilizationTianjin Engineering Research Center for Organic Wastes Safe Disposal and Energy UtilizationTianjin 300072China School of Chemical Engineering University of BirminghamBirmingham B152TTUK Department of Environmental Systems Science ETH ZürichZürich CH-8092Switzerland

In recent years,a great deal of attention has been focused on the environmental impact of plastics,includ-ing the carbon emissions related to plastics,which has promoted the application of biodegradable *** worldwide have shown high interest in replacing traditional plastics with biodegradable ***,no systematic comparison has been conducted on the carbon emissions of biodegrad-able versus traditional plastic *** study evaluates the carbon emissions of traditional and biodegradable plastic products(Bpps)over four stages and briefly discusses environmental and economic *** scenarios-namely,the traditional method,chemical recycling,industrial composting,and anaerobic digestion-are considered for the disposal of waste Bpps(WBpps).The analysis takes China as a case *** results show that the carbon emissions of 1000traditional plastic products(plastic bags,lunch boxes,cups,etc.)were52.09-150.36 carbon emissions equivalent of per kilogram(kg CO_(2)eq),with the stage of plastic production contributing 50.71%-50.77%.In comparison,1000 similar Bpps topped out at 21.06-56.86 kg CO_(2)eq,approximately 13.53%-62.19%lower than traditional plastic *** difference was mainly at the stages of plastic production and waste disposal,and the Bpps showed significant carbon reduction potential at the raw material acquisition *** disposal plays an important role in environmental impact,and composting and anaerobic digestion are considered to be preferable disposal methods for ***,the high cost of biodegradable plastics is a challenge for their widespread *** study has important reference significance for the sustainable development of the biodegradableplastics industry.

关键词： Carbon emissions Biodegradable plastics Different disposal scenarios Daily life consumption Environmental and economic discussion

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The presence of functional blood vessels in the ischemic core provides a therapeutic target for stroke recovery

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Neural Regeneration Research 2023年第12期18卷 2653-2654页

作者： gary p.Morris Brad A.Sutherland Tasmanian School of Medicine College of Health and MedicineUniversity of TasmaniaHobartTasmaniaAustralia

Ischemic stro ke occurs when a blood vessel in the brain is *** the immediate *** flow becomes deficient in regions supplied by the blocked *** leads to the development of a core region,where blood flow is reduced to pidly,and a penumbral region,where blood flow is reduced to a level that is not capable of supporting neuronal function,but is sufficient to maintain cell viability(Morris et al.,2023).

关键词： al. therapeutic maintain

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What the Tea Industry Reveals About China’s Next Chapter

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北京周报(英文版) 2024年第25期 24页

作者： gary Sigley

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates

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pediatric Investigation 2024年第2期8卷 135-138页

作者： Samantha Gilg Sebastian Acosta Rohit S.Loomba Claire Rizk gary E.Stapleton David Faraoni Fabio Savorgnan Department of pediatrics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of pediatrics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of pediatrics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA Department of Anesthesiology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The standard of care in the management of d-transposition of the great arteries(TGA)includes the arterial switch operation(ASO).1,2 Although some institutions have begun to publish the results of performing the ASO within the first few hours of life,most centers continue to"electively"delay ASO for several days to allow for a reduction in pulmonary vascular resistance and the stabilization of renal and liver function.1,2 The early initiation of prostaglandin E1(pGE)infusion to maintain ductal patency is a nearly universal component of therapy in order to maintain adequate arterial oxygen saturation and systemic oxygen delivery during the pre-operative period via intercirculatory mixing at the atrial septal and patent ductus arteriosus levels1,3.

关键词： balloon maintain stabilization

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Cardiovascular care for older adults： hypertension and stroke in the older adult

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Journal of Geriatric Cardiology 2016年第5期13卷 373-379页

作者： Andrew p Miller Ann M Navar gary S Roubin Suzanne Oparil CardioVascular Associates Birmingham Alabama USA Duke Clinical Research Institute Durham North Carolina USA Vascular Biology & Hypertension program Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham Alabama USA

1 Introduction Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiovascular risk factors. This chapter is aimed at connecting age-related alterations in vascular function and structure to the resultant target organ damage, and to raise awareness of unique presentations and treatment strategies for hypertension and stroke in older adults.

关键词： Aging Cerebrovascular disease Clinical trials Hypertension Stroke

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不锈钢薄管折弯成型与回弹有限元模拟分析

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机械制造与自动化 2024年第3期53卷 155-157,180页

作者：褚艺光周圣何统统王丙旭 gary Barber 杭州佐帕斯工业有限公司浙江杭州310018 浙江理工大学机械与自动控制学院浙江杭州310018 奥克兰大学汽车摩擦学中心美国罗彻斯特48309

基于Simufact Forming软件建立不锈钢薄管折弯成型的有限元仿真模型,模拟薄管折弯成型过程并分析接触面摩擦因数和折弯速度对薄管折弯后回弹程度的影响。结果表明:随着薄管折弯角度的不断增大,折弯区域的等效应力逐渐增大,局部高应力区... 详细信息

基于Simufact Forming软件建立不锈钢薄管折弯成型的有限元仿真模型,模拟薄管折弯成型过程并分析接触面摩擦因数和折弯速度对薄管折弯后回弹程度的影响。结果表明:随着薄管折弯角度的不断增大,折弯区域的等效应力逐渐增大,局部高应力区域增大,外侧壁厚逐渐减小,内侧壁厚逐渐增大;薄管折弯后回弹量随摩擦因数的增大或折弯速度的减小呈现先增大后减小的趋势;当摩擦因数为0.2或折弯速度为2 s内190°时,薄管的回弹量最大。该结果能够为薄管折弯成型模拟仿真和回弹量预测提供一定的参考。

关键词：不锈钢薄管折弯成型回弹有限元模型模拟分析

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A Bayesian Mixture Model Approach to Disparity Testing

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Applied Mathematics（应用数学） 2024年第3期 214页

作者： gary C.McDonald

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The relationship between sleep disorders and testosterone in men

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Asian Journal of Andrology 2014年第2期16卷 262-265,I0009,I0010页

作者： gary Wittert Discipline of Medicine and Freemasons Foundation Centre for Men's Health University of Adelaide Adelaide South Australia Australia.

plasma testosterone levels display circadian variation, peaking during sleep, and reaching a nadir in the late afternoon, with a superimposed ultradian rhythm with pulses every 90 min reflecting the underlying rhythm of pulsatile luteinizing hormone （LH） secretion. The increase in testosterone is sleep, rather than circadian rhythm, dependent and requires at least 3h of sleep with a normal architecture. Various disorders of sleep including abnormalities of sleep quality, duration, circadian rhythm disruption, and sleep-disordered breathing may result in a reduction in testosterone levels. The evidence, to support a direct effect of sleep restriction or circadian rhythm disruption on testosterone independent of an effect on sex hormone binding globulin （SHBG）, or the presence of comorbid conditions, is equivocal and on balance seems tenuous. Obstructive sleep apnea （OSA） appears to have no direct effect on testosterone, after adjusting for age and obesity. However, a possible indirect causal process may exist mediated by the effect of OSA on obesity. Treatment of moderate to severe OSA with continuous positive airway pressure （CpAp） does not reliably increase testosterone levels in most studies. In contrast, a reduction in weight does so predictably and linearly in proportion to the amount of weight lost. Apart from a very transient deleterious effect, testosterone treatment does not adversely affect OSA. The data on the effect of sleep quality on testosterone may depend on whether testosterone is given as replacement, in supratherapeutic doses, or in the context abuse. Experimental data suggest that testosterone may modulate individual vulnerability to subjective symptoms of sleep restriction. Low testosterone may affect overall sleep quality which is improved by replacement doses. Large doses of exogenous testosterone and anabolic/androgenic steroid abuse are associated with abnormalities of sleep duration and architecture.

关键词： obesity obstructive sleep apnea shift work sleep restriction testosterone

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