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Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates

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International Journal of Oral Science 2014年第2期6卷 77-86页

作者： Han Zhou michael D Weir Joseph m Antonucci gary E Schumacher Xue-Dong Zhou Hockin H K Xu Department of Endodontics Prosthodontics and Operative Dentistry University of Maryland Dental School Baltimore USA State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Biomaterials Group Biosystems and Biomaterials Division National Institute of Standards and TechnologyGaithersburg USA Dr. Anthony Volpe Research Center American Dental Association Foundation Gaithersburg USA Center for Stem Cell Biology & Regenerative medicine University of Maryland School of Medicine Baltimore USA Department of mechanical Engineering University of Maryland Baltimore County USA

Antibacterial adhesives are promising to inhibit biofilms and secondary caries. The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives, and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time. Six quaternary ammonium methacrylates with chain lengths of 3, 6, 9, 12, 16 and 18 were synthesized and incorporated into Scotchbond multi-Purpose. Streptococcus mutans bacteria were cultured on resin to form biofilms. Confocal laser scanning microscopy was used to measure biofilm thickness, live/dead volumes and live-bacteria percentage vs. distance from resin surface. Biofilm thickness was the greatest for Scotchbond control; it decreased with increasing chain length, reaching a minimum at chain length 16. Live-biofilm volume had a similar trend. Dead-biofilm volume increased with increasing chain length. The adhesive with chain length 9 had 37% live bacteria near resin surface, but close to 100% live bacteria in the biofilm top section. For chain length 16, there were nearly 0% live bacteria throughout the three-dimensional biofilm. In conclusion, strong antibacterial activity was achieved by adding quaternary ammonium into adhesive, with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16. Antibacterial adhesives typically only inhibited bacteria close to its surface; however, adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm. Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries.

关键词： alkyl chain length antibacterial bondingagent dental caries quaternaryammonium methacrylate Streptococcusmutans three-dimensional biofilm

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Electrocardiographic measures of repolarization dispersion and their relationships with echocardiographic indices of ventricular remodeling and premature ventricular beats in hypertension

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Journal of Geriatric Cardiology 2017年第12期14卷 717-724页

作者： Ana Ciobanu gary Tse Tong Liu maria V Deaconu Gabriela S Gheorghe Adriana m Iliesiu Ioan T Nanea Department of Internal medicine and Cardiology Theodor Burghele Clinical Hospital Carol Davila University of Medicine and Pharmacy Bucharest Romania Department of medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sci- ences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China

ObjectiveTo 检验在 T 山峰- T 结束间隔( Tpe )和有室的早熟的敲击( VPB )并且在 *** 的左室的改变的出现的 Tpe/QT 比率 52 总计病人与对中等必要高血压温和被包括，经历监视的 echocardiography 和24小时的 Holter 。室的改变被 tr... 详细信息

ObjectiveTo 检验在 T 山峰- T 结束间隔( Tpe )和有室的早熟的敲击( VPB )并且在 *** 的左室的改变的出现的 Tpe/QT 比率 52 总计病人与对中等必要高血压温和被包括，经历监视的 echocardiography 和24小时的 Holter 。室的改变被 transmitral E 和 A 波浪速度和 E/A 比率被左室的集体索引(LVmI ) 用 Devereux 公式和心脏舒张的功能估计。Tpe 处于心前区的领先被测量。T 波浪的结束被正切的方法在领先 V 2 设为 T *** 和 Tpe/QT 的最陡峭的下降斜坡(r = 0.33， P = 0.01；r = 0.27， P = 0.04 分别地) 并且 V 3(r = 0.40， P = 0.002；r = 0.40， P = 0.003，分别地) 与 LVmI 显著地相关。一种重要反的关系在 E/A 比率和 QT 之间被观察(r = 0.33， P = 0.01 ) ，在 V 3 的 Tpe (r = 0.39， P = 0.003 ) 并且在 V 3 的 Tpe/QT (r = 0.31， P = 0.02 ) 。在 V 3, V 5,平均数 Tpe 的 Tpe 和有 60 ms ， 59 ms ， 62 ms 和 71 ms 的截止价值的最大的 Tpe ，分别地与左室的心脏舒张的功能和表演的 LVmI 和索引与室的早熟的 *** 极化参数 Tpe 间隔和 Tpe/QT 比率相互关联的出现联系了更好预兆的值比象 QT 那样的传统的参数间隔和 QT 分散。铅 V 3 是为测量 Tpe 和 Tpe/QT 的最好的铅。这些 ECG 索引能因此在临床的实践被使用监视改变的 LV 并且预言 VPB 的出现。

关键词：极化参数高血压索引早熟分散 Holter Tpe 参数显示

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Crocodile blood supplementation protect svascular function in diabetic mice

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Food Production, Processing and Nutrition 2021年第1期3卷 283-295页

作者： Chui Yiu Bamboo Chook Francis m.Chen gary Tse Fung Ping Leung Wing Tak Wong School of Life Sciences Faculty of ScienceThe Chinese University of Hong KongShatinNTHong Kong SAR State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina

Cardiovascular disease is a major cause of mortality in diabetic patients due to the heightened oxidative stress and pro-inflammatory state in vascular *** approaches targeting cardiovascular health for diabetic patients are urgently *** blood,an emerging dietary supplement,was suggested to have anti-oxidative and anti-inflammatory effects in vitro,which have yet to be proven in animal *** study thereby aimed to evaluate whether crocodile blood can protect vascular function in diabetic mice against oxidation and *** db/db mice and their counterparts db/m+mice were treated daily with crocodile blood soluble fraction(CBSF)or vehicle via oral gavage for 4 weeks before their aortae were harvested for endothelium-dependent relaxation(EDR)quantification using wire myograph,which is a well-established functional study for vascular function *** culture experiments culturing mouse aortae from C57BL/6 J mice with or without IL-1βand CBSF were done to evaluate the direct effect of CBSF on endothelial *** oxygen species(ROS)levels in mouse aortae were assessed by dihydroethidium(DHE)staining with inflammatory markers in endothelial cells quantified by quantitative polymerase chain reaction(qPCR).CBSF significantly improved deteriorated EDR in db/db diabetic mice through both diet supplementation and direct culture,with suppression of ROS level in mouse *** also maintained EDR and reduced ROS levels in mouse aortae against the presence of pro-inflammatory IL-1β.Under the pro-inflammatory state induced by IL-1β,gene expressions of inflammatory cytokines were downregulated,while the protective transcripts UCP2 and SIRT6 were upregulated in endothelial *** study suggests a novel beneficial effect of crocodile blood on vascular function in diabetic mice and that supplementation of diet with crocodile blood may act as a complementary approach to protect against vascular diseases through anti

关键词： Crocodile blood Diabetes mellitus Vascular endothelial function Anti-oxidative Anti-inflammatory

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Organizational behaviour : 6th ed.

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2005年

作者： gary Johns Alan m. Saks.

来源：畅想之星图书光盘版（南... 评论

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Does Acute Improvement in muscle Recovery with Curcumin Supplementation Translate to Long-Term Training?

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Journal of Science in Sport and Exercise 2019年第3期1卷 203-207页

作者： Brian K.mcFarlin Elizabeth A.Tanner melody A.gary Asheal A.Davis Erin m.Bowman Richard S.gary Applied Physiology Laboratory University of North TexasPhysical Education BuildingRoom 2091921 Chestnut StreetDentonTX 76201USA Department of Biological Sciences University of North TexasDentonTXUSA

Dietary polyphenols,such as curcumin,green tea catechins,and pomegranate extract,may have the ability to enhance the effectiveness of long-term training programs by managing training-induced *** recovery may translate to increased capacity to train and perform more *** dietary polyphenol curcumin has been reported to block the action of COX-2 and NF-kB signaling and would allow for increased capacity to train leading to heightened adaptations and the potential for ergogenic *** actions are very similar to the targeted actions of non-steroidal anti-inflammatory drugs(NSAIDs),but without the side-effects of *** review will compare and contrast the known effects of cur-cumin and identify common design elements between existing *** this critical review of the existing literature it is our goal to establish a set of best practices that could be applied to an athletic population that is interested in using oral curcumin supplementation as a recovery agent.

关键词： Exercise-induced muscle injury Inflammatory cytokines Inflammation Soreness Distance running Exercise training

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A new record of Cleantioides emarginata Kwon & Kim, 1992 (Crustacea, Isopoda, Valvifera) from Changjiang River estuary, China

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Chinese Journal of Oceanology and Limnology 2013年第3期31卷 625-631页

作者：刘文亮 gary C. B. POORE The State Key Laboratory of Estuarine and Coastal Research East China Normal University museum Victoria GPO Box 666Melbourne

At present, descriptions of Cleantioides emarginata Kwon & Kim, 1992 have been limited to the type locality of Pusan, Korea. In this study, we discovered this species in the Changjiang (Yangtze) River estuary, China. This represents an extension of the known geographical range of C. emarginata. In addition, we present information of a colour pattern not previously described, along with details on the estuarine habitat of the species.

关键词：地理范围彩色图案栖息地

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Testicular volume and clinical correlates of hypothalamic–pituitary–testicular function:A cross-sectional study in obese men

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Asian Journal of Andrology 2020年第4期22卷 354-359页

作者： mark Ng Tang Fui Rudolf Hoermann gary Wittert mathis Grossmann Department of medicine Austin Health University of MelbourneMelbourneVictoria 3084Australia Department of Endocrinology Austin HealthMelbourneVictoria 3084Australia School of medicine University of AdelaideAdelaideSouth Australia 5005Australia

The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic–pituitary–testicular(HPT)axis *** was a cross-sectional substudy of a larger randomized controlled trial including obese men,body mass index(BmI)≥30 kg m−2,with a total testosterone levelmol l−*** volume was measured by orchidometer,testosterone by liquid chromatography/tandem mass spectrometry,and body composition by dual-energy X-ray *** completed the Aging males'Symptoms(AmS)score,International Index of Erectile Function-5(IIEF-5),physical function,and handgrip dynamometer ***-nine men participated with a median(interquartile range[IQR])age of 53.1(47.6,59.2)years,BmI of 37.0(34.6,40.5)kg m−2,and a total testosterone of 7.0(6.1,7.9)nmol l−*** testicular volume was 18(IQR:10,20)*** volume was negatively correlated with BmI(τ=−0.1952,P=0.010)and total fat mass(τ=−0.2115,P=0.005)independent of age and *** BmI,testosterone,sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were present in a multivariable model,only BmI(-0.38 ml change in testicular volume per 1 kg m-2BmI;95%CI:−0.74,−0.02;P=0.04)and LH(-0.92 ml change in testicular volume per 1 IU l-1 LH;95%CI:−1.75,−0.095;P=0.03)remained independent significant predictors of testicular *** volume was positively correlated with IIEF-5(τ=0.2092,P=0.021),but not related to handgrip strength,physical function tests,or *** obese men,testicular volume is inversely and independently associated with measures of adiposity,but not with most clinical or biochemical markers of HPT axis *** a clinical perspective,this suggests that obesity might compromise the reliability of reduced testicular volume as a sign of androgen deficiency in men.

关键词： hypothalamic-pituitary-gonadal axis testicular volume testosterone

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SUBSURFACE TEmPERATURE AND ITS RELATION TO DYNAmIC HEIGHT AT 130°E ACROSS THENORTH EQUATORIAL CURRENT

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Chinese Journal of Oceanology and Limnology 1993年第2期11卷 143-148页

作者：曲堂栋 gary meyers 胡敦欣 Institute of Oceanology Academia Sinica Qingdao 266071 Division of Oceanography CSIRO Hobart Australia

Temperature profiles down to 1500m(CTD) collected by Academia Sinica from 1986 to 1990 are used and discussed in relation to the dynamic heights at130 E across the North Equatorial Current (NEC). An extremely high correlation between subsurface (say at 400 m depth) temperature and dynamic height relative to 1500 db is found, and the corresponding regression relationships suggest a method to estimate gpostrophic circulation from subsurface temperature alone. These suggest that the conclusions from extensive studies on this topic in Australian waters also apply to the NEC region, at least at130 E , thus making the subsurface thermal structure an excellent indicator of the variation of the NEC.

关键词： subsurface temperature dynamic height relation

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A photothermal reservoir for highly efficient solar steam generation without bulk water

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Science Bulletin 2019年第21期64卷 1625-1633页

作者： Xuan Wu Ting Gao Chenhui Han Jingsan Xu gary Owens Haolan Xu Future Industries Institute University of South AustraliaMawson Lakes CampusSA 5095Australia School of Chemistry Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQLD 4001Australia

A solid photothermal reservoir is designed to implement solar-steam generation in the absence of bulk *** photothermal reservoir is composed of a water absorbing core encapsulated by a photothermal reduced graphene oxide based aerogel sheet which absorbs light and converts it into heat thus evaporating the stored *** photothermal reservoir is able to store 6.5 times its own weight in water,which is sufficient for one day solar evaporation,thus no external water supplement is *** solar-steam generation,since no bulk water is involved,the photothermal reservoir minimizes heat conduction loss,and maximizes both of the exposed evaporation surface area and net energy gain from the environment,leading to an energy efficiency beyond the theoretical *** extremely high water evaporation rate of 4.0 kg m-2 h-1(normalized to projection area)is achieved in laboratory studies over a cylinder photothermal reservoir with a diameter of 5.2 cm and a height of 15 cm under 1.0 sun *** evaluation of the photothermal reservoir outdoors as part of a desalination device demonstrates a similar evaporation rate where the salinity of the clean water produced is lower than 24 *** the photothermal reservoir shows great potential for real world applications in portable solarthermal desalination.

关键词： Solar-steam generation Photothermal Aerogel Solar-thermal energy

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P波随时间衰减:以两条加利福尼亚地震破裂带为例(英文)

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地球物理学报 2005年第4期48卷 851-860页

作者： gary A Henderson Seismological Laboratory Department of Physics University of Toronto Canada

地震预测是地震学研究一个基本目标,而理解地震周期是地震预测的重要环节.遗憾的是,由于地震断层带不但结构复杂,大地震前后短时间内的震源过程更是随时间迅速变化,这些复杂因素使得常规研究方法不再适用.一类特殊的微震成群地发生在主... 详细信息

地震预测是地震学研究一个基本目标,而理解地震周期是地震预测的重要环节.遗憾的是,由于地震断层带不但结构复杂,大地震前后短时间内的震源过程更是随时间迅速变化,这些复杂因素使得常规研究方法不再适用.一类特殊的微震成群地发生在主震断层几乎同一地点上,震源系数几乎相同,近年来地震学界通称其为震群(earthquakemultiplet).本文论证如何将这类特殊的微震作为一组人工震源来阐述美国西部两次大地震(LomaPrieta和morganHill)的震后弛豫过程.在加利福尼亚LomaPrieta(1989年9月18日,m7.0)及morganHill(1984年4月24日,m6.2)附近的主震破裂带中就发生了此类震群.其中有两组各包含11个重复地震的震群,分别位于这两个破裂带中,其波形资料质量高,波形及震级变化极小,因而可与实验室条件下的人工震源相比.这些震群地震资料可直接用于计算P波沿波程衰减(即t)的时间性变化,其方法的简单性及结果的精确性都与实验室水平相当.我们的结果显示,每个震群周围分别存在一个异常体,在其各自主震之后的10个月中,该异常体中的P波衰减迅速上升并降落.衰减峰值发生在LomaPrieta地震后2～3周,其震群深度为10.2km.此峰值在morganHill地震后5～6个月发生,其震群中心深度为2.6km.这两个事例中,t波动峰值都超过此前获得的加利福尼亚大致同一地区t绝对值的100%[1].此结果显示了因同震裂隙张开和震后弛豫过程(如流体移动、裂隙复原及岩石压缩),以及孔隙度和流体饱和度在主震源体部分区域发生的变化.衰减达峰值的时间之显著差异则提示我们,裂隙闭合及伴随的流体移动是负载敏感的,深度越大达峰值越快,反之亦然.如将此方法应用于主震前多重地震的资料,将有望更好地理解最终导致主震断层带大破裂的震前微破裂的物理过程.

关键词：加利福尼亚地震破裂带 P波 morgan 地震预测人工震源弛豫过程流体移动 1989年 1984年实验室条件实验室水平流体饱和度重要环节地震周期震源过程研究方法美国西部资料质量地震资料中心深度负载敏感方法应用

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