检索结果-南通市图书馆

Journal of Genetics and Genomics 2015年第9期42卷 507-510页

作者： Zhou Tan Zhongkai Hu Emily Y.Cai Cantas Alev Ting Yang Zhen Li Joyce Sung Yasser Yehia El-Sayed gary m.shaw David K.Stevenson Atul J.Butte Guojun Sheng Karl G.Sylvester Harvey J.Cohen Xuefeng B.Ling Institute of Developmental and Regenerative Biology Hangzhou Normal University Department of Surgery Stanford University Lab for Early Embryogenesis RIKEN Center for Developmental Biology Department of Obstetrics and Gynecology Stanford University Department of Pediatrics Stanford University Stanford

Over 11% of all pregnancies in the US result in preterm birth, greatly contributing to perinatal morbidity and mortality （Goldenberg and Rouse, 1998）. Preterm birth etiologies remain largely unknown, and effective prevention methods have yet to be developed. The use of biofluid （e.g., serum or urine） for the analysis of the naturally occurring peptidome （mW 〈 4000） as a source of biomarkers has been reported for different diseases （Villanueva et al., 2006; Ling et al., 2010a, 2010b, 2010c, 2011）. mass spectrometry-based profiling of naturally occurring peptides can provide an extensive in- ventory of serum peptides derived from either high-abundant endogenous circulating proteins or cell and tissue proteins （Liotta and Petricoin, 2006）.

关键词： Serological Targeted Analysis of an ITIH4 Peptide Isoform A Preterm Birth Biomarker and Its Associated SNP Implications SNP

Application of a simplified ADm1 for full-scale anaerobic co-digestion of cattle slurry and grass silage:assessment of input variability

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第4期18卷 125-139页

作者： Sofia Tisocco Sören Weinrich gary Lyons michael Wills Xinmin Zhan Paul Crosson Civil Engineering College of Science and EngineeringUniversity of GalwayGalwayH91 TK33Ireland Teagasc Animal and Bioscience Research Department Animal and Grassland Research and Innovation CentreDunsanyC15 PW93Ireland Biochemical Conversion Department Deutsches Biomasseforschungszentrum gemeinnützige GmbHLeipzig 04347Germany Faculty of Energy·Building Services·Environmental Engineering Münster University of Applied SciencesSteinfurt 48565Germany Agri-Food and Biosciences Institute HillsboroughBT266DRUK Ryan Institute University of GalwayGalwayH91 TK33Ireland maREI Research Centre for Energy Climate and MarineRyan InstituteUniversity of GalwayGalwayH91 TK33Ireland

mathematical modeling of anaerobic digestion is a powerful tool to predict gas yields and optimize the *** Anaerobic Digestion model No.1(ADm1)is a widely implemented model for this ***,modeling full-scale biogas plants is challenging due to the extensive substrate and parameter characterization *** study describes the modification of the ADm1 through a simplification of individual process phases,characteristic components and required ***,the ability of the simplified model to simulate the co-digestion of grass silage and cattle slurry was evaluated using data from a full-scale biogas *** impacts of substrate composition(crude carbohydrate,protein and lipid concentration)and variability of carbohydrate degradability on simulation results were assessed to identify the most influential *** indicated that the simplified version was able to depict biogas and biomethane production with average model efficiencies,according to the Nash-Sutcliffe efficiency(NSE)coefficient,of 0.70 and 0.67,respectively,and was comparable to the original ADm1(average model efficiencies of 0.71 and 0.63,respectively).The variability of crude carbohydrate,protein and lipid concentration did not significantly impact biogas and biomethane output for the data sets *** contrast,carbohydrate degradability seemed to explain much more of the variability in the biogas and methane ***,the application of simplified models provides a reliable basis for the process simulation and optimization of full-scale agricultural biogas plants.

关键词： ADm1 Agricultural feedstocks Biogas technology Input variability Parameter estimation

SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom m.Green Stephen A.shaw Lauren J.Bonilla Shannon E.Ronca maria Elena Bottazzi Farrah Kheradmand Jill E.Weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical medicine One Baylor PlazaHoustonTX 77030USA molecular Virology&microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

Female Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Emily m. Dantes Jennifer H. shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Department of Biomedical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese females at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in medically underserved areas where healthcare access is limited. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its impact on infertility. Further, these results advocate for enhanced public health education and policies aimed at improving healthcare accessibility, with the goal of mitigating the adverse effects of obesity on reproductive health.

关键词： Female Infertility medical Deserts Obesity South

Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai Lo Jun Yu gary m.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(mTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

molecular Oxygen Abundance in Galactic massive Star Formation Regions Based on SWAS Observations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第9期24卷 85-100页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang Junzhi Wang gary J.melnick Jin-Zeng Li gary A.Fuller Jinjin Xie National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Tsinghua University Research Center for Astronomical Computing Zhejiang Laboratory Jet Propulsion Laboratory California Institute of Technology Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Xinjiang Astronomical Observatory Chinese Academy of Sciences Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi University Center for Astrophysics Harvard&Smithsonian60 Garden Street Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of Manchester I.Physikalisches Institut University of Cologne

molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite （SWAS） *** obtained an averaged O2spectrum based on this sample using the （SWAS） survey data （O2,487.249 GHz,N=3–1,J=3–2）.No emission or absorption feature is seen around the supposed central velocity with a total integration time of ttotal=8.67×10～3hr and an rms noise per channel of 1.45 m *** a kinetic temperature Tkin=30 K,we derive the 3σupper limit of the O2column density to be 3.3×1015cm-2,close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O2abundance upper limit is6.7×10-8,lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O2abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： galaxies: abundances Galaxy: abundances ISm: lines and bands ISm: molecules

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肥胖妇女有孕育神经管缺陷胎儿的危险

四川解剖学杂志 2002年第1期10卷 61-61页

作者： gary m.shaw Ellen m.Velie. Donna Schaffer 吴波第三军医大学组胚教研室

为了研究肥胖对妇女孕育神经管缺陷(Neural tube defect NTD)胎儿的危险性,我们对加利福亚地区肥胖妇女孕育NTD胎儿的情况进行了一次大样本调查.从调查结果发现,肥胖妇女孕育NTD胎儿的危险性要高于正常体重的妇女.其中,尤以孕育脊柱裂(S... 详细信息

为了研究肥胖对妇女孕育神经管缺陷(Neural tube defect NTD)胎儿的危险性,我们对加利福亚地区肥胖妇女孕育NTD胎儿的情况进行了一次大样本调查.从调查结果发现,肥胖妇女孕育NTD胎儿的危险性要高于正常体重的妇女.其中,尤以孕育脊柱裂(Spina bifida)、颅脊柱裂(Craniorachishisis)和露脑(Iniencephaly)畸形胎儿的危险性更大.即使考虑其他各种可能的影响因素,如叶酸摄取、糖尿病、减肥药使用、年龄、教育、饮酒等也未能改变上述分析结果.

关键词：肥胖女性孕育神经管缺陷胎儿畸形

Numerical Analysis on the Effect of n-Si on Cu(In, Ga)Se₂ Based Thin-Films for High-Performance Solar Cells by 1D-SCAPS

在线全文

学校读者我要写书评

暂无评论

Open Journal of Applied Sciences 2024年第5期14卷 1315-1329页

作者： Rasika N. mohottige micheal Farndale gary S. Coombs Shahnoza Saburhhojayeva Department of Natural Sciences Waldorf University Forest City IA USA

We report the performances of a chalcopyrite Cu(In, Ga)Se2 CIGS-based thin-film solar cell with a newly employed high conductive n-Si layer. The data analysis was performed with the help of the 1D-Solar Cell Capacitance Simulator (1D-SCAPS) software program. The new device structure is based on the CIGS layer as the absorber layer, n-Si as the high conductive layer, i-In2S3, and i-ZnO as the buffer and window layers, respectively. The optimum CIGS bandgap was determined first and used to simulate and analyze the cell performance throughout the experiment. This analysis revealed that the absorber layer’s optimum bandgap value has to be 1.4 eV to achieve maximum efficiency of 22.57%. Subsequently, output solar cell parameters were analyzed as a function of CIGS layer thickness, defect density, and the operating temperature with an optimized n-Si layer. The newly modeled device has a p-CIGS/n-Si/In2S3/Al-ZnO structure. The main objective was to improve the overall cell performance while optimizing the thickness of absorber layers, defect density, bandgap, and operating temperature with the newly employed optimized n-Si layer. The increase of absorber layer thickness from 0.2 - 2 µm showed an upward trend in the cell’s performance, while the increase of defect density and operating temperature showed a downward trend in solar cell performance. This study illustrates that the proposed cell structure shows higher cell performances and can be fabricated on the lab-scale and industrial levels.

关键词： n-Si p-CIGS 1D-SCAPS Thin-Films In2S3

Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson Brandon J.Vilarello Tiana m.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy