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Prenatal risk factors for internalizing and externalizing problems in childhood

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World Journal of Pediatrics 2020年第4期16卷 341-355页

作者： Joyce Tien gary D.lewis Jianghong Liu Department of Family and Community Health School of NursingUniversity of PennsylvaniaPhiladelphiaPA19104USA University of Arkansas for Medical Sciences Little RockARUSA

Background A growing body of research has documented the effects of prenatal risk factors on a wide spectrum of adverse offspring health *** behavior problems,such as externalizing and internalizing problems,are no *** comprehensive literature review aims to summarize and synthesize current research about commonly experienced prenatal risk factors associated with internalizing and externalizing problems,with a focus on their impact during childhood and *** mechanisms as well as implications are also *** sources The EBSCO,Web of Science,PubMed,Google Scholar,and Scopus databases were searched for studies examining the association between prenatal risk factors and offspring internalizing/externalizing problems,using keywords“prenatal”or“perinatal”or“birth complications”in combination with“internalizing”or“externalizing”.Relevant articles,including experimental research,systematic reviews,meta-analyses,cross-sectional and longitudinal cohort studies,and theoretical literature,were reviewed and synthesized to form the basis of this integrative *** Prenatal risk factors that have been widely investigated with regards to offspring internalizing and externalizing problems encompass health-related risk factors,including maternal overweight/obesity,substance use/abuse,environmental toxicant exposure,maternal infection/inflammation,as well as psychosocial risk factors,including intimate partner violence,and anxiety/***,both epidemiological and experimental studies support the adverse associations between these prenatal factors and increased risk of emotional/behavioral problem development during childhood and *** mechanisms of action underlying these associations include hormonal and immune system *** include prenatal education,screening,and intervention *** Prenatal risk factors are associated with a constellation of offspring internalizin

关键词： Externalizing Internalizing Obstetrical Pregnancy Prenatal risk factors

Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer

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Cancer Communications 2018年第1期38卷 136-144页

作者： Bin S.Teh gary D.lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist HospitalCancer Centerand Research InstituteWeill Cornell Medical College6565 FanninSte#DB1-077HoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical Branch at GalvestonGalvestonTX 77555USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiology and Radiation Oncology Kitasato University School of MedicineSagamihara 252-0374Japan

Background:Technical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal ***,the optimal radiation fractionation regimen for localized prostate cancer is *** and clinical evidence suggest that hypofractionation may improve the therapeutic ratio of *** report our institutional outcomes using moderately hypofractionated,intensity-modulated radio-therapy(IMRT),and an endorectal balloon,with emphasis on long-term biochemical control and treatment-related adverse events in patients with localized prostate ***:Between January 1997 and April 2004,596 patients with cT1-T3 prostate cancer underwent IMRT using a moderate hypofractionation regimen(76.70 Gy at 2.19 Gy/fraction)with an endorectal *** D’Amico clas-sification,226(37.9%),264(44.3%),and 106(17.8%)patients had low-,intermediate-,or high-risk disease,*** majority of intermediate-and high-risk patients received androgen deprivation *** relapse-free survival(bRFS)was evaluated using 2005 Phoenix criteria and estimated using the Kaplan-Meier ***:The median follow-up was 62 *** 5-and 10-year bRFS rates were 92.7%and 87.7%.For low-,intermediate-,and high-risk patients,the 5-year bRFS rates were 96.9%,93.3%,and 82.0%,respectively;the 10-year bRFS rates were 91.4%,89.3%,and 76.2%,***-specific antigen,Gleason score,and T stage were significant predictors of bRFS(all P<0.01).The 5-year rates of severe(≥Grade 3)adverse events were very low:1.2%for gastrointestinal events and 1.1%for genitourinary ***:Long-term outcomes after moderately hypofractionated IMRT are *** hypofrac-tionation represents a safe,efficacious,alternative regimen in the treatment of localized prostate cancer.

关键词： Prostate cancer Intensity-modulated radiotherapy Moderate hypofractionation

Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database

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Cancer Communications 2019年第1期39卷 548-556页

作者： gary D.lewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz Albert Chen Andrew Farach Sandra S.Hatch E.Brian Butler Jenny Chang Bin S.Teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA

Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast *** studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the ***-rank test was performed to evaluate associations of clinical characteristics with overall survival(OS).Cox proportional hazards model was used to determine variables associated with ***:Overall,2660 patients with IMPC met the selection criteria;the 5-year OS rate was 87.5%and 24.9%of patients had nodal involvement at *** with≥4 positive lymph nodes had shorter OS than node-negative patients,whereas patients with 1-3 positive nodes had similar OS to node-negative ***<65 years,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged *** benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included age<65 years,<4 positive lymph nodes,receipt of radiotherapy,and estrogen receptor *** results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy.

关键词： Breast cancer Invasive micropapillary carcinoma Radiotherapy Surgery Survival Hormone receptor

对局限性前列腺癌患者采用直肠内球囊中度低分割调强放射治疗的长期结局

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癌症 2018年第12期37卷 523-532页

作者： Bin S.Teh gary D.lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler Department of Radiation Oncology Houston Methodist Hospital Cancer Center and Research Institute Weill Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston Department of Radiation Oncology Baylor College of Medicine Department of Radiology and Radiation Oncology Kitasato University School of Medicine

背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(inte... 详细信息

背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(intensity?modulated radiotherapy,IMRT)和直肠内球囊对局限性前列腺癌患者的治疗结局,重点关注患者的长期生化控制和治疗相关不良事件。方法从1997年1月到2004年4月,596例c T1–T3前列腺癌患者使用带直肠内球囊的中度低分割方案(76.70 Gy,2.19 Gy/次)进行IMRT。根据D'Amico分类低风险、中风险或高风险患者分别226(37.9%)例、264(44.3%)例和106(17.8%)例。大多数中、高风险患者接受雄激素剥夺治疗。使用2005年Phoenix标准评估无生化复发生存(biochemical relapse?freeSurvival,bRFS),并使用Kaplan?Meier法进行估算。结果中位随访时间为62个月。总的5年bRFS和10年bRFS率分别为92.7%和87.7%。低风险、中风险和高风险患者的5年bRFS率分别为96.9%、93.3%和82.0%,10年bRFS率分别为91.4%、89.3%和76.2%。前列腺特异性抗原、Gleason评分和T分期是bRFS的重要预测因子(均P<0.01)。重度(≥3级)不良事件的5年发生率非常低:胃肠道不良事件和泌尿生殖系统不良事件的发生率分别为1.2%和1.1%。结论中度低分割IMRT后的长期结局令人鼓舞。中度低分割是治疗局限性前列腺癌的安全、有效的替代方案。

关键词：前列腺癌调强放疗中度低分割

Papillary thyroid cancer and inflammatory bowel disease:Is there a relationship?

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World Journal of Gastroenterology 2013年第7期19卷 1079-1084页

作者： Irene S Sonu Wojciech Blonski Ming Valerie Lin James lewis Faten Aberra gary R Lichtenstein Division of Internal Medicine Stanford University Hospital and ClinicsStanfordCA 94305United States Division of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Division of Digestive Diseases University of CincinnatiCincinnatiOH 45229United States Division of Gastroenterology Hospital of the University of PennsylvaniaUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19103United States

AIM:To formally study age of diagnosis of papillary thyroid cancer(PTC) in inflammatory bowel disease(IBD) patients and evaluate the prevalence of PTC in IBD patients compared to a control *** that patients with IBD are more likely to be diagnosed with PTC than a control population.A retrospective cohort analysis was performed using the University of Pennsylvania Health System's electronic *** from 1998-2009 were included in the search,and patients in the cohort were selected based on ICD-9 *** criteria included the diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) and the concurrent diagnosis of thyroid cancer in comparison to a control *** these methods 912 patients with CD and 1774 with UC were compared to 1638 diverticulitis and 19 447 asthma *** were performed using corrected chisquare *** primary outcome for this study was the diagnosis of *** to conduct this study was obtained by the Institutional Review Board at the University of ***:The mean age was 47.5 years(range:18-102 years) and 66% patients were *** analysis of variance model was used to compare the age of PTC diagnosis between the CD,UC,asthma and diverticulitis groups,and a statistically significant difference in age at PTC diagnosis was noted across all groups(F = 6.35,df = 3,P = 0.0006).The age of PTC diagnosis in CD patients was statistically significantly lower than UC,asthma,and diverticulitis patients(average PTC diagnosis age for CD 25,UC 49,asthma 45,diverticulitis 63).After covarying for sex and age in 2009,the difference in age at PTC diagnosis remained statistically significant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients were diagnosed with *** patients(0.5%) with UC were diagnosed with *** with UC were not shown to be more likely to develop PTC [odds ratio(OR):1.544,95%CI 0.767-3.108] compared to asthma *** patients(0.4%) with CD were

关键词： Papillary thyroid cancer Inflammatory bowel disease Crohn disease Ulcerative colitis

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世界500强所欣赏的简历和求职技巧

星际探索卓瑞尔天文台“第一道光”射电天文馆

作者： (美)吉恩·科文(Gene Corwin) (美)佳里·约瑟夫·格拉波(gary Joseph Grappo) (美)阿蒂尔·刘易斯(Adele lewis)

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室内设计与装修 2023年第6期 70-73页

作者： Julian Gitsham gary Collins Adam Atraktzi Oliver Kampshoff Sarah Willats Clive lewis Kaja Swiezewska Trang Dao David Brown(摄影) Hassell 不详

“第一道光”射电天文馆由建筑事务所Hassell设计。该项目建成开放后,世界各地的访客在著名的卓瑞尔天文台的参观体验得到很大提升,他们将射电天文学理论,转化成了迷人的星际探索。作为这块场地上最大的公共建筑,展馆的设计以捕捉太空... 详细信息

“第一道光”射电天文馆由建筑事务所Hassell设计。该项目建成开放后,世界各地的访客在著名的卓瑞尔天文台的参观体验得到很大提升,他们将射电天文学理论,转化成了迷人的星际探索。作为这块场地上最大的公共建筑,展馆的设计以捕捉太空爱好者的好奇心为主旨,引发人们科学探索的欲望,在广袤无垠太空收获天文学的发现。

关键词：建筑事务所射电天文学公共建筑广袤无垠瑞尔天文馆天文台好奇心

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惊涛拍岸

科技新时代（下半月） 2005年第10期 12-12页

作者： gary lewis（拍摄者）

拍摄者自述：“这是去年度假时拍摄的，当时我爬到了一个较高的地方，耐心等候漂亮的浪花出现。”

关键词：拍摄

Taking care of volunteers in a stroke trial: a new assisted-management strategy

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Stroke & Vascular Neurology 2016年第3期1卷 108-114页

作者： Amber C Stuart Jason J Sico Catherine M Viscoli Ashis H Tayal Silvio E Inzucchi gary A Ford Karen L Furie Robert Cote J David Spence David Tanne Walter N Kernan on behalf of the IRIS Trial Investigators Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Service Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Neuroscience Institute Allegheny Health NetworkPittsburghPennsylvaniaUSA lewis Katz School of Medicine at Temple University PhiladelphiaPennsylvaniaUSA Division of Medical Sciences Oxford UniversityOxfordUK The Warren Alpert Medical School of Brown University ProvidenceRhode IslandUSA Department of Neurology Neurosurgery and MedicineMcGill UniversityMontrealQuebecCanada University of Western Ontario LondonOntarioCanada 10Sheba Medical CenterTel Aviv UniversityTel AvivIsrael 不详

Background and purpose:Providing participants with evidence-based care for secondary prevention is an ethical and scientific priority for trials in stroke *** optimal strategy,however,is *** report the performance of a new approach for delivering preventive care to trial ***:Participants were enrolled in the Insulin Resistance Intervention after Stroke trial,which examined the insulin sensitiser,pioglitazone versus placebo for prevention of stroke and myocardial infarction after ischaemic stroke or transient ischaemic *** care was the responsibility of the participants’personal healthcare providers,but investigators monitored care and provided feedback *** studied achievement of 8 prevention goals at baseline and 3 annual visits,with a focus on 3 priority goals:blood pressure<140/90 mm Hg,lowdensity lipoprotein(LDL)cholesterol<2.59 mmol/L and antithrombotic ***:The proportion of participants achieving the priority goals was highest for antithrombotic use(96–99%in each year)and similar for blood pressure(66–72%in each year)and LDL(68–70%in each year).All 3 priority goals were achieved by 47–52%of participants in any given ***,only 22%of participants achieved all 3 goals in each ***:A strategy of monitoring care and providing feedback was associated with high average yearly achievement of 3 priority secondary prevention goals,but the majority of trial participants did not persist in being at goal over *** registration number:NCT00091949.

关键词： prevention annually goals