检索结果-南通市图书馆

long-term Integration Ability of the Submillimeter Wave Astronomy Satellite(SWAS)Spectral line Receivers

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第6期24卷 315-322页

作者： Bing-Ru Wang Di li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Rudolf Schieder gary J.Melnick National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China KOSMA I.Physik.InstitutUniversität zu KölnZülpicher Str.7750937 KölnGermany Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetMS 66CambridgeMA 02138USA

The Submillimeter Wave Astronomy Satellite(SWAS)was the first space telescope capable of high spectral resolution observations of terahertz spectral *** have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit *** CI,O_(2),H_(2)O,and^(13)CO spectra taken toward all observed Galactic sources were *** present results are based on spectra with a total integration time of up to 2.72×10~4hr(■10~8s).The noise in the spectra is generally consistent with that expected from the radiometer equation,without any sign of approaching a noise *** noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

关键词： telescopes space vehicles:instruments instrumentation:miscellaneous ISM:lines and bands

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew F.gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen li Yan Wu Zhuoyu li Xiaohua Huang Fangxu Pu Entao li Guiyou Wang Wei Wang Yun Ding gary Wong Sandra Chiu Jiaming lan Aiguo Hu Shanghai Key laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key laboratory of Molecular Virology&Immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses ***,state-of-the-art treatments still lag behind the continual emergence of new *** to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural ***,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)*** core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the *** EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

Chromosomal disorders and male infertility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第1期14卷 32-39,175页

作者： gary l Harton Helen G Tempest Reprogenetics Livingston NJ 07039 USA Department of Human and Molecular Genetics Herbert Wertheim College of Medicine Florida International University Miami FL 33132 USA

Infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family. Despite this, the molecular and genetic factors underlying the cause of infertility remain largely undiscovered. Nevertheless, more and more genetic factors associated with infertility are being identified. This review will focus on our current understanding of the chromosomal basis of male infertility specifically： chromosomal aneuploidy, structural and numerical karyotype abnormalities and Y chromosomal microdeletions. Chromosomal aneuploidy is the leading cause of pregnancy loss and developmental disabilities in humans. Aneuploidy is predominantly maternal in origin, but concerns have been raised regarding the safety of intracytoplasmic sperm injection as infertile men have significantly higher levels of sperm aneuploidy compared to their fertile counterparts. Males with numerical or structural karyotype abnormalities are also at an increased risk of producing aneuploid sperm. Our current understanding of how sperm aneuploidy translates to embryo aneuploidy will be reviewed, as well as the application of preimplantation genetic diagnosis （PGD） in such cases. Clinical recommendations where possible will be made, as well as discussion of the use of emerging array technology in PGD and its potential applications in male infertility.

关键词： chromosomal aneuploidy chromosomal translocation intracytoplasmic sperm injection in vitro fertilization male infertility non-disjunction preimplantation genetic diagnosis Y-chromosome microdeletion

Dickson Polynomials Over Finite Fields

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数学进展 1991年第1期 24-32页

作者： gary l.Mullen The Pennsylvania State University U.S.A

In this paper we will study Dickson polynomials of the first and second kinds over finite fields. For these polynomials we will discuss some known properties, point out some similarities and differences between the tw... 详细信息

关键词： Dickson Polynomials Over Finite Fields DPSK

Development of a new humane toxin for predator control in New Zealand

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2010年第1期5卷 31-36页

作者： Charles T.EASON Elaine C.MURPHY Steve hix Duncan B.MACMORRAN Faculty of Agriculture and life Sciences Department of EcologyLincoln UniversityLincoln Connovation limited AucklandNew Zealand Department of Conservation ChristchurchNew Zealand

The endemic fauna of New Zealand evolved in the absence of mammalian predators and their introduction has been responsible for many extinctions and *** species including possums(Trichosurus vulpecula Kerr),ship rats(Rattus rattus l.)and stoats(Mustela erminea l.)are targeted to protect native *** methodologies currently rely largely on labor-intensive trapping or the use of increasingly unpopular poisons,or poisons that are linked with low welfare ***,the development of safer humane predator toxins and delivery systems is highly ***-aminopropiophenone(PAPP)is being developed as a toxin for feral cats(Felis catus l.)and *** appear to be much more susceptible to PAPP than birds,so it potentially has high target specificity,at least in New *** trials with 20 feral cats and 15 stoats have been undertaken using meat baits containing a proprietary formulation of PAPP.A PAPP dose of 20-34 mg kg^(-1)was lethal for feral cats and 37-95 mg kg^(-1)was lethal for *** assessments suggest that PAPP,for the control of feral cats and stoats,is a humane and effective *** causes methaemoglobinaemia,resulting in central nervous system anoxia,lethargy and death.

关键词： cyanide feral cat(Felis catus) para-aminopropiophenone pest control stoat(Mustela erminea) welfare

Regeneration patterns of key pine species in a mixed-pine forest indicate a positive effect of variable retention harvesting and an increase in recruitment with time

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2020年第4期7卷 659-671页

作者： Priscilla A.Nyamai P.Charles Goebel R.Gregory Corace III David M.hix Natural Resources Management Program Grand Valley State University1 Campus DrAllendaleMI 49401USA. Department of Forest Rangelandand Fire SciencesUniversity of Idaho875 Perimeter Drive MS 1133MoscowID 83844USA. Alpena-Montmorency Conservation District 1900 M-32 WAlpenaMI 49707USA. School of Environment and Natural Resources The Ohio State University2021 Coffey RoadColumbusOH 43210USA.

Background:Many fire-dependent forests have experienced significant declines in species,structural,and functional *** changes are attributed in part to traditional management approaches that were dominated by even-aged regeneration methods such as *** retention harvesting(VRH)is an ecologically based forestry practice that involves retention of some mature overstory trees and other biological structures in the postharvest stand to emulate the effects of natural disturbance *** this study,we examined the effect of a VRH treatment on recruitment of historically dominant pine species and understory vegetation twoand six years after its implementation in a naturally regenerated mixed pine forest in the Upper Peninsula of Michigan,***:We found greater regeneration of red pine(Pinus resinosa l.)and eastern white pine(Pinus strobus l.)in VRH stands compared to the unharvested *** red pine recruitment was very low during the first 2 years,both species increased significantly from year two to year *** responses for the two species did not differ significantly between the aggregated and dispersed retention *** also found high recruitment of deciduous tree species,consisting primarily of sprouts,and red pine exhibited a negative correlation with these ***,time,and the interaction of treatment and time were significant factors in red pine *** had a strong effect on the understory vegetation,with significant decreases in shrubs and ferns over ***:The results suggest that VRH enhanced recruitment of red pine and eastern white pine and that this recruitment increased with *** identify competition from sprouts and unfavorable seedbed conditions as the main factors that limited recruitment of red pine during the first 2 *** reduce competing vegetation and improve seedbed conditions,we suggest following the VRH with a prescribed fire,mechanically removing s

关键词： Variable retention harvesting Aggregated retention Dispersed retention Mixed-pine forest Pinus resinosa Pinus strobus

Current understanding of the molecular mechanisms in Parkinson's disease:Targets for potential treatments

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2017年第1期6卷 256-290页

作者： Panchanan Maiti Jayeeta Manna gary l.Dunbar Field Neurosciences Institute laboratory for Restorative Neurology Mt.PleasantMI 48859USA Program in Neuroscience Mt.PleasantMI 48859USA Department of Psychology Central Michigan UniversityMt.PleasantMI 48859USA Field Neurosciences Institute St.Mary’s of MichiganSaginawMI 48604USA Department of Biology Saginaw Valley State UniversitySaginawMI 48604USA Department of Physiology University of Tennessee Health Science CenterMemphisTN 38105USA

Gradual degeneration and loss of dopaminergic neurons in the substantia nigra,pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson’s disease(PD).In addition,half of the PD patients also exhibit frontostriatal-mediated executive dysfunction,including deficits in attention,short-term working memory,speed of mental processing,and *** most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of ***,these therapies neither restore the lost or degenerated dopaminergic neurons,nor prevent or delay the disease progression,the need for more effective therapeutics is *** this review,we provide a comprehensive overview of the current understanding of the molecular signaling pathways involved in PD,particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this *** involvement of molecular chaperones,autophagy-lysosomal pathways,and proteasome systems in PD are also *** addition,emerging therapies,including pharmacological manipulations,surgical procedures,stem cell transplantation,gene therapy,as well as complementary,supportive and rehabilitation therapies to prevent or delay the progression of this complex disease are reviewed.

关键词： Parkinson’s disease Neurodegeneration Protein misfolding Molecular chaperones Cell therapy

Mitochondria as a therapeutic:a potential new frontier in driving the shift from tissue repair to regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2023年第1期10卷 1332-1355页

作者： Evan N.Main Thaiz M.Cruz gary l.Bowlin Department of Biomedical Engineering University of Memphis330 Engineering Technology BuildingMemphisTN 38152USA

Fibrosis,or scar tissue development,is associated with numerous pathologies and is often considered a worst-case scenario in terms of wound healing or the implantation of a *** that remains is a disorganized,densely packed and poorly vascularized bundle of connective tissue,which was once functional *** creates a significant obstacle to the restoration of tissue function or integration with any ***,it is of paramount importance in tissue engineering and regenerative medicine to emphasize regeneration,the successful recovery of native tissue function,as opposed to repair,the replacement of the native tissue(often with scar tissue).A technique dubbed‘mitochondrial transplantation’is a burgeoning field of research that shows promise in in vitro,in vivo and various clinical applications in preventing cell death,reducing inflammation,restoring cell metabolism and proper oxidative balance,among other reported ***,there is currently a lack of research regarding the potential for mitochondrial therapies within tissue engineering and regenerative ***,this review explores these promising findings and outlines the potential for mitochondrial transplantation-based therapies as a new frontier of scientific research with respect to driving regeneration in wound healing and host-biomaterial interactions,the current successes of mitochondrial transplantation that warrant this potential and the critical questions and remaining obstacles that remain in the field.

关键词： mitochondrial transplantation host-biomaterial integration biomaterials wound healing fibrosis