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World Journal of Gastroenterology 2017年第29期23卷 5412-5421页

作者： Tamas Tornai eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp Institute of Internal Medicine Department of Gastroenterology University of Debrecen Faculty of Medicine Department of Laboratory Medicine University of Debrecen Faculty of Medicine Debrecen Inova Diagnostics Inc.San Diego 1^st Department of Pediatrics Semmelweis University 1^st Department of Medicine University of Pecs Gastroenterology Department of Medicine Borsod-Abauj Zemplen County Hospital 1^st Department of Medicine Semmelweis University

To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis (PSC) patients. MeTHODSSera of 67 PSC patients [median age (range): 32 (5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin (AAA IgA/IgG) and gliadin (AGA IgA/IgG)] and for serum level of intestinal fatty acid-binding protein (I-FABP) by eLISA. Markers of lipopolysaccharide (LPS) exposure [LPS binding protein (LBP)] and various anti-microbial antibodies [anti-OMP Plus IgA and endotoxin core IgA antibody (endoCAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99 (14-106) mo]. One hundred and fifty-three healthy subjects (HCONT) and 172 ulcerative colitis (UC) patients were the controls. ReSULTSA total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA IgA, AAA IgG, AGA IgA and AGA IgG, respectively. Frequencies of AAA IgA and AAA IgG (P ere significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA IgA-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15 (1.27-20.86), P = 0.022 or for the Mayo risk score (HR = 4.24 (0.99-18.21), P = 0.052]. AAA IgA-positivity was significantly associated with higher frequency of anti-microbial antibodies (P endoCab IgA and P = 0.012 for anti-OMP Plus IgA) and higher level of the enterocyte damage marker (median I-FABPAAA IgA posvsneg: 365 vs 166 pg/mL, P = 0.011), but not with serum LBP level. CONCLUSIONPresence of IgA type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various micr

关键词： Primary sclerosing cholangitis Gut barrier dysfunction Intestinal fatty acid-binding protein Anti-F-actin antibody Anti-gliadin antibody

effectiveness, safety, and drug sustainability of biologics in elderly patients with inflammatory bowel disease: A retrospective study

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World Journal of Gastroenterology 2022年第33期28卷 4823-4833页

作者： Gustavo Drugg Hahn Jean-Frederic LeBlanc Petra Anna Golovics Panu Wetwittayakhlang Abdulrahman Qatomah Anna Wang Levon Boodaghians Jeremy Liu Chen Kiow Maryam Al Ali gary Wild Waqqas Afif Alain Bitton Peter Laszlo Lakatos Talat Bessissow Division of Gastroenterology IBD CenterMcGill University Health CenterMontreal H3G 1A4QuebecCanada School of Medicine Graduate Course Sciences in Gastroenterology and HepatologyUniversidade Federal do Rio Grande do SulPorto Alegre 90000-000Brazil Division of Gastroenterology McGill University Health CentreMontreal H3G 1A4QuebecCanada Department of Gastroenterology Hungarian Defense ForcesMedical CentreBudapest 1134Hungary Unit of Gastroenterology and Hepatology Division of Internal MedicineFaculty of MedicinePrince of Songkla UniversitySongkhla 90110Thailand Department of Gastroenterology Centre Hospitalier de l’Universitede MontrealMontreal H2X 3E4QuebecCanada

BACKGROUND Biologic therapy resulted in a significant positive impact on the management of inflammatory bowel disease(IBD) however data on the efficacy and side effects of these therapies in the elderly is *** To evaluate retrospectively the drug sustainability, effectiveness, and safety of the biologic therapies in the elderly IBD *** Consecutive elderly(≥ 60 years old) IBD patients, treated with biologics [infliximab(IFX), adalimumab(ADAL), vedolizumab(VDZ), ustekinumab(UST)] followed at the McGill University Inflammatory Bowel Diseases Center were included between January 2000 and *** was measured by clinical scores at 3, 6-9 and 12-18 mo after initiation of the biologic therapy. Patients completing induction therapy were included. Adverse events(Aes) or serious Ae were collected during and within three months of stopping of the biologic *** We identified a total of 147 elderly patients with IBD treated with biologicals during the study period, including 109 with Crohn’s disease and 38 with ulcerative colitis. Patients received the following biologicals: IFX(28.5%), ADAL(38.7%), VDZ(15.6%), UST(17%). The mean duration of biologic treatment was 157.5(SD = 148) wk. Parallel steroid therapy was given in 34% at baseline,19% at 3 mo, 16.3% at 6-9 mo and 6.5% at 12-18 mo. The remission rates at 3, 6-9 and 12-18 mo were not significantly different among biological therapies. Kaplan-Meyer analysis did not show statistical difference for drug sustainability(P = 0.195), time to adverse event(P = 0.158) or infection rates(P = 0.973) between the four biologics studied. The most common Aes that led to drug discontinuation were loss of response, infusion/injection reaction and *** Current biologics were not different regarding drug sustainability, effectiveness, and safety in the elderly IBD population. Therefore, we are not able to suggest a preferred sequencing order among biologicals.

关键词： Inflammatory bowel disease Biologics elderly efficacy Safety Adverse events

Mild and Low-Cost Synthetic Process for Monodispersive Platinum Nanoparitcles on Carbon Aerogel

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Mild and Low-Cost Synthetic Process for Monodispersive Plati...

High-quality-factor tantalum oxide nanomechanical resonators by laser oxidation of TaSe2

2014中国功能材料科技与产业高层论坛

作者： Feng Li Gaoyang Zhao Ying Yang gary Pattrick Richard Moutloali School of Material Science and engineering Xi'an University of Technology College of Aerospace engineering Nanjing University of Aeronautics and Astronautics

A mild synthetic process using formic acid as the reduction agent was applied to prepare 40 wt%Pt/carbon aerogel（CA）*** as-prepared sample was characterized by transmission electron microscopy（TeM）and electrochemical *** results exhibit Pt nanoparticles with narrow particle size distribution are dispersed throughout carbon aerogel ***,the Pt/CA catalyst has smaller Pt nanoparticle mean size than johnson Matthey HiSpecTM 4000（JM4000）.The electrochemical measurement results indicate that the Pt/CA catalyst with Pt loading of 40 wt%possesses similarelectrochemical surface area（eSA）value and oxygen reduction reaction（ORR）activity as JM4000.

关键词： Carbon aerogel PeM fuel cells Catalyst Platinum nanoparticles

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Nano Research 2015年第9期8卷 2842-2849页

作者： Santiago J. CartamiI-Bueno Peter G. Steeneken Frans D. Tichelaar efren Navarro-Moratalla Warner J. Venstra Ronald van Leeuwen eugenio Coronado Herre S.J. van der Zant gary A. Steele Andres Castellanos-Gomez Kavli Institute of Nanoscience Delft University of Technology Lorentzweg 1 2628 CJ Delft The Netherlands Kavli Institute of Nanoscience Delft University of Technology National Centre for HREM Lorentzweg 1 2628 CJ Delft The Netherlands Instituto Ciencia Molecular (ICMol) Univ. Valencia C/Catedrdtico Jos@ Beltrdn 2 E-46980 Paterna Spain

Controlling the strain in two-dimensional （2D） materials is an interesting avenue to tailor the mechanical properties of nanoelectromechanical systems. Here, we demonstrate a technique to fabricate ultrathin tantalum oxide nanomechanical resonators with large stress by the laser oxidation of nano-drumhead resonators composed of tantalum diselenide （TaSe2）, a layered 2D material belonging to the metal dichalcogenides. Before the study of their mechanical properties with a laser interferometer, we verified the oxidation and crystallinity of the freely suspended tantalum oxide using high-resolution electron microscopy. We demonstrate that the stress of tantalum oxide resonators increases by 140 MPa （with respect to pristine TaSe2 resonators）, which causes an enhancement in the quality factor （14 times larger） and resonance frequency （9 times larger） of these resonators.

关键词： TaSe2,tantalum oxide,mechanical resonators,laser oxidation,optical interferometer,high quality factor

Practical Text Mining and Statistical Analysis for Non-structured Text Data Applications 1

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偏头痛的预防性治疗（β-受体阻滞剂）、行为治疗及二者联合使用对发作性偏头痛急性期优化治疗的疗效影响：一项随机对照试验

2012年

作者： gary Miner Dursun Delen John elder Andrew Fast Thomas Hill Robert A. Nisbet

ISBN: (数字)9780123870117

ISBN: (纸本)9780123869791

Practical Text Mining and Statistical Analysis for Non-structured Text Data Applications brings together all the information, tools and methods a professional will need to efficiently use text mining applications and statistical analysis. Winner of a 2012 PROSe Award in Computing and Information Sciences from the Association of American Publishers, this book presents a comprehensive how-to reference that shows the user how to conduct text mining and statistically analyze results. In addition to providing an in-depth examination of core text mining and link detection tools, methods and operations, the book examines advanced preprocessing techniques, knowledge representation considerations, and visualization approaches. Finally, the book explores current real-world, mission-critical applications of text mining and link detection using real world example tutorials in such varied fields as corporate, finance, business intelligence, genomics research, and counterterrorism activities. The world contains an unimaginably vast amount of digital information which is getting ever vaster ever more rapidly. This makes it possible to do many things that previously could not be done: spot business trends, prevent diseases, combat crime and so on. Managed well, the textual data can be used to unlock new sources of economic value, provide fresh insights into science and hold governments to account. As the Internet expands and our natural capacity to process the unstructured text that it contains diminishes, the value of text mining for information retrieval and search will increase dramatically.

关键词： Data mining

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英国医学杂志中文版 2011年第1期14卷 44-45页

作者： Kenneth A Holroyd gary e eordingley Ohio University 李力波(译) 管宇宙(校) 不详北京协和医院神经内科

目的观察偏头痛的预防性治疗（β-受体阻滞剂）、短期行为治疗及二者联合使用能否增强发作性偏头痛急性期优化治疗的疗效。设计观察期为16个月的随机安慰剂对照实验，试验起止日期为2001年7月至2005年11月地点美国俄亥俄州2个门诊中心。

关键词： β-受体阻滞剂随机对照试验预防性治疗优化治疗联合使用行为治疗偏头痛急性期

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增大肺泡表面张力对于各段肺血管阻力的影响

青海医学院学报 1992年第1期13卷 66-66,37页

作者： gary F.NIeMAN TAWFIC S.HAKIM CARL e.BReDeNBeRG 汤燕平

本文的目的是找出肺泡表面张力(ST)上升后发生肺血管阻力(PVR)改变的血管段。在狗的左下肺叶离体标本上,用雾化的磺酰丁二酸二辛钠(OT)吸入或用5％Tween20盐溶液灌洗肺除去存在于肺泡气——液界面处的表面活性物质(Sf)后,ST升高。

关键词：肺泡表面张力肺血管阻力

30万千瓦基本负荷热电联供厂中燃气轮机的实时性能分析和现状监测

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燃气轮机技术 1991年第1期4卷 64-74页

作者： gary L.HAUB WILLIAM e.HAUHe.Jr. CHARLeS O.MYeRS 夏轶人南京燃气轮机研究所

文章叙述在基本负荷为30万千瓦热电联供设备中使用的性能监测和分析系统,该设备同时提供1.903百万磅/小时(0.863百万公斤/小时)的湿蒸汽,用热力的方法强化原油回收工序.它将叙述性能监测系统(自1985年后使用的)发展现状、整个系统所用... 详细信息

文章叙述在基本负荷为30万千瓦热电联供设备中使用的性能监测和分析系统,该设备同时提供1.903百万磅/小时(0.863百万公斤/小时)的湿蒸汽,用热力的方法强化原油回收工序.它将叙述性能监测系统(自1985年后使用的)发展现状、整个系统所用的硬件、性能分析的理论.发展的软件以及传述的能力(reportingcapabilities).分析了几个实例,其结果已说明使用性能监测系统的合理性.

关键词：余热发电燃气轮机实时性能

法证科学中的情境偏差和交叉污染——对侦查、辩诉交易、审判和上诉的腐蚀性影响

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证据科学 2019年第5期27卷 588-607页

作者：王进喜(译) 朱海(译) [澳]gary e dmond [澳]Jason M.Tangen [澳]Rachel A.Searston [澳]Itiel e.Dror 澳大利亚研究理事会新南威尔士大学法学院英国Northumbria大学法学院英国伦敦学院大学法证科学中心中国政法大学中国政法大学司法文明协同创新中心中国政法大学证据科学研究院澳大利亚昆士兰大学心理学院

大多数法证科学证据是在这样的条件下形成的,即未保护分析人员免受案件情境信息对他们决策的影响。本文探讨了这些基本未被认识到的威胁是如何给刑事司法系统带来真正的问题的;从对痕迹的收集和解释到在审判和上诉时对证据进行展示和评... 详细信息

大多数法证科学证据是在这样的条件下形成的,即未保护分析人员免受案件情境信息对他们决策的影响。本文探讨了这些基本未被认识到的威胁是如何给刑事司法系统带来真正的问题的;从对痕迹的收集和解释到在审判和上诉时对证据进行展示和评价。本文解释了分析人员是如何经常接触到与他们的鉴定工作无关的信息(例如关于侦查或主要嫌疑人的信息),并且这些信息没有被记录在他们的报告中,但是这些信息已被证明会影响分析人员对法证科学证据的解释。此外,法证分析人员不仅不必要地接触到这些“与鉴定领域无关”的信息,而且他们受到认知污染的解释和意见往往会被不必要地透露给其他证人-无论是非专业人士还是专业人士。信息的这种来回传播会产生一种“偏差雪球效应”,会导致证据(越来越多地)受到交叉污染,因为在审判和上诉过程中提出的彼此独立的证据要彼此印证。文中指出,律师和法院还没有认识到情境偏差和认知过程是如何扭曲和破坏专家证据的证据价值的。本文建议,法院在采纳和评价归罪性的专家证据时,应该注意到情境偏差和交叉污染的可能性。

关键词：专家证据情境效应确认偏差认知科学人为因素期望效应印证暗示启动效应证明