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Utility of serological markers in inflammatory bowel diseases: Gadget or magic?

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World Journal of Gastroenterology 2007年第14期13卷 2028-2036页

作者： Maria Papp gary L Norman Istvan Altorjay Peter Laszlo Lakatos Department of Gastroenterology University of Debrecen DebrecenHungary INOVA Diagnostics Inc. San Diego United States Department of Medicine Semmelweis University BudapestHungary

The panel of serologic markers for inflammatory bowel diseases （IBD） is rapidly expanding. Although antiSaccharornyces cerev/siae antibodies （ASCA） and atypical perinuclear antineutrophil cytoplasmic antibodies （P-ANCA） remain the most widely investigated, an increasing amount of experimental data is available on newly discovered antibodies directed against various microbial antigens. The role of the assessment of various antibodies in the current IBD diagnostic algorithm is often questionable due to their limited sensitivity. In contrast, the association of serologic markers with disease behavior and phenotype is becoming increasingly well-established. An increasing number of observations confirms that patients with Crohn＇s disease expressing multiple serologic markers at high titers are more likely to have complicated small bowel disease （e.g. stricture and/or perforation） and are at higher risk for surgery than those without, or with low titers of antibodies. Creating homogenous disease sub-groups based on serologic response may help develop more standardized therapeutic approaches and may help in a better understanding of the pathomechanism of IBD. Further prospective clinical studies are needed to establish the clinical role of serologic tests in IBD.

关键词： Serologic markers Inflammatory boweldisease Ulcerative colitis Crohn's disease Indeterminatecolitis Antineutrophil cytoplasmic antibodies Anti-Saccharomyces cerevisiae mannan antibodies Outermembrane porin

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改进数字式卡规适应实际应用需要

今日电子 2000年第9期 6-7页

作者： gary e.Jensen ,王正华

计量工具制造商Mitutoyo(位于美国伊利诺伊州的Aurora),计划在今年年底前推出世界上第一款防冷却液的数字式卡规。放电加工(eDM,electrical Discharge Machining)时,被加工件需要浸入冷却液中;为了适应放电加工应用的需要而开发的具有... 详细信息

计量工具制造商Mitutoyo(位于美国伊利诺伊州的Aurora),计划在今年年底前推出世界上第一款防冷却液的数字式卡规。放电加工(eDM,electrical Discharge Machining)时,被加工件需要浸入冷却液中;为了适应放电加工应用的需要而开发的具有防水性能的卡规,在放电加工过程

关键词：卡规冷却液蓄冷材料放电加工电火花加工

Teaching reproductive endocrinology in Iran: Pilot assessment of hospital-based clinical modules for medical students at Tehran University of Medical Sciences

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Health 2013年第2期5卷 175-178页

作者： Batool H. Rashidi Maryam Nemati Mahya Ghazizadeh Shala A. Salem gary S. Collins e. Scott Sills Centre for Statistics in Medicine Wolfson College Annexe University of Oxford Oxford UK Office for Reproductive Research Pacific Reproductive Center/PRC-Orange County Irvine USA Vali-e-Asr Reproductive Health Research Center Tehran University of Medical Sciences Tehran Iran

This pilot study evaluated effectiveness and acceptance of a new hospital-based reproductive endocrinology curriculum among Iranian medical students. A voluntary, anonymous questionnaire was used to compare two teaching methods as applied to junior medical students at Tehran University of Medical Sciences. Students were randomly assigned to one of two clinical teaching settings;no student experienced both modules. Coursework for the pilot (experimental) group (n = 19) utilized a teaching approach comprising lectures, genetics laboratory, pelvic ultrasound, small group sessions, and opportunities to observe advanced reproductive technologies such as in vitro fertilization, ICSI, and embryo transfer. A control group (n = 34) received reproductive endocrinology instruction by the ‘traditional curriculum’, consisting mainly of lectures. Students were sampled at baseline and again atthe conclusion of their reproductive endocrinology session. Pre- and post-test data were analyzed for both groups;post-test differences between groups were also compared. No significant differences in mean age or gender mix were identified between the two study groups. Overall, the ques- tionnaire did not identify any significant intergroup differences for any parameter investigated. Although student acceptance rate appeared similar for both educational modules, the ratio of students having a “favorable regard” for reproductive medicine declined only among students randomized to the control group (41.2% vs. 32.3%). This report offers the first data on teaching reproductive endocrinology to medical students in Iran. Both traditional and innovative approaches to teaching reproductive endocrinology were well-accepted by students, although negative post-test responses were more common among students in the control group. While periodic quality assessments for existing clinical teaching methods are necessary, introduction of alternative teaching approaches is also important. Additional studies are

关键词： Medical Students Clinical education Reproductive endocrinology Iran

Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 213-222页

作者： Kunwar Shailubhai Vaseem Palejwala Krishna Priya Arjunan Sayali Saykhedkar Bradley Nefsky John A Foss Stephen Comiskey gary S Jacob Scott e Plevy R and D Center Synergy Pharmaceuticals Inc. Baruch Blumberg Institute PA Biotechnology Center Synergy Pharmaceuticals Inc. Departments of Medicine Microbiology and Immunology University of North Carolina School of Medicine

AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine ***: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cellbased assay. For animal studies all test agents were formulated in phosphate buffered saline. Sulfasalazine or 5-amino salicylic acid(5-ASA) served as positive controls. effect of oral treatment with test agents on amelioration of acute colitis induced either by dextran sulfate sodium(DSS) in drinking water or by rectal instillation of trinitrobenzene sulfonic(TNBS) acid, was examined in BALB/c and/or BDF1 mice. Additionally, the effect of orally administered plecanatide on the spontaneous colitis in T-cell receptor alpha knockout(TCRα-/-) mice was also examined. Amelioration of colitis was assessed by monitoring severity of colitis, disease activity index and by histopathology. Frozen colon tissues were used to measure myeloperoxidase ***: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C(GC-C). As expected from the agonists of GC-C, both plecanatide and dolcanatide exhibited potent cG MP-stimulatory activity in T84 cells. Once-daily treatment by oral gavage with either of these analogs(0.05-0.5 mg/kg) ameliorated colitis in both DSS and TNBS-induced models of acute colitis, as assessed by body weight, reduction in colitis severity(P ease activity index(P elioration of colitis by either of the drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. Plecanatide also effectively ameliorated colitis in TCRα-/- mice, a model of spontaneous colitis. As dolcanatide exhibited higher resistance to proteolysis in simulated gastric and intestinal juices, it was selected for further studies. CONCLUSION: This is the first-ever s

关键词： Guanylate cyclase-C Inflammatory bowel disease Uro

Systems Analysis and Design 5th ed.

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乙酰左旋肉碱防治奥沙利铂引起的外周神经病变性疼痛的研究

丛书名：经典原版书库

2004年

作者： Shelly gary B.

本书全面讨论了系统开发生命周期的方方面面,从商业案例分析、需求建模、企业建模、开发策略、数据设计、用户界面设计、系统架构、系统实施和支持到最新的发展趋势,完美地结合了理论和实践工具.

ISBN: (数字)7111129148, 7900142703

ISBN: (纸本)7111129148

关键词： System analysis.

来源：畅想之星图书光盘版（南... 评论

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中国临床药理学与治疗学 2011年第12期16卷 1379-1382页

作者：刘国凯 gary Bennett 北京中医药大学东直门医院麻醉科北京100700 加拿大麦吉尔(McGill)大学麻醉科及疼痛中心

目的:观察乙酰左旋肉碱(ALCAR)对奥沙利铂引起的外周神经病变性疼痛的防治效果。方法:选取SD雄性大鼠20只(150～200g),随机分为两组,ALCAR组与安慰剂组,每组各10只;用5%葡萄糖将奥沙利铂溶液稀释到2mg/mL,连续5d(d 0～d 4)腹腔注射2mg/k... 详细信息

目的:观察乙酰左旋肉碱(ALCAR)对奥沙利铂引起的外周神经病变性疼痛的防治效果。方法:选取SD雄性大鼠20只(150～200g),随机分为两组,ALCAR组与安慰剂组,每组各10只;用5%葡萄糖将奥沙利铂溶液稀释到2mg/mL,连续5d(d 0～d 4)腹腔注射2mg/kg。ALCAR(100mg/kg,p.o.)或对照液从0天开始注射(第1天注射奥沙利铂开始),并继续21d(即最后一次奥沙利铂注射后再持续15d)。并于d 0、d 8、d 15、d 22、d 29、d 35及d 41测定机械异常痛敏[4g von Frey hairs(VFH)]和机械痛敏(15g VFH)。结果:与对照组比较,ALCAR组大鼠在d 8、d 15、d 22、d 29、d 35及d 41机械异常痛敏(4g VFH)和机械痛敏明显改善(P<0.01)。结论:ALCAR可防治奥沙利铂引起的大鼠外周神经病变性疼痛。

关键词：乙酰左旋肉碱奥沙利铂疼痛

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达尔文雀血液和肠内的寄生现象(英文)

动物学报 2005年第3期51卷 507-512页

作者： Rachael Y. DUDANIeC gary HALLAS Sonia KLeINDORFeR Flinders University School of Biological Sciences Bedford Park Adelaide 5042 AustraliaFlinders University School of Biological Sciences Bedford Park Adelaide 5042 AustraliaFlinders University School of Biological Sciences Bedford Park Adelaide 5042 Australia

达尔文雀是种群进化生态学研究的一个模式类群。然而,关于这些鸟类的寄生虫和疾病方面,我们所知甚少。本文对小地雀( Geospiza fuliginosa)的血液和消化道、中地雀( G. fortis)的消化道寄生虫进行了调查。根据对来自3个岛屿127成体血液... 详细信息

达尔文雀是种群进化生态学研究的一个模式类群。然而,关于这些鸟类的寄生虫和疾病方面,我们所知甚少。本文对小地雀( Geospiza fuliginosa)的血液和消化道、中地雀( G. fortis)的消化道寄生虫进行了调查。根据对来自3个岛屿127成体血液样本、22个雏鸟血液和消化道样本的检测,我们没有从小地雀的血液里和中地雀的消化道里发现寄生虫。仅仅从1只来自Floreana岛的小地雀雏鸟的消化道里,发现一种寄生虫(Isosporaspp.) [动物学报51 (3) : 507 -512 , 2005]。

关键词：达尔文寄生现象消化道寄生虫生态学研究血液样本肠 spp 雏鸟进化种群鸟类成体动物

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抗微生物药物间的相互作用

世界医学杂志 2001年第4期5卷 47-50页

作者： gary e Stein 盛瑞媛

Trizivir (Abacavir/Lamivudine/Zidovudine) plus Lopinavir/Ritonavir Induction Therapy Followed by Trizivir-Alone Maintenance for HIV-1-Infected Patients: A 96-Week Pilot Treatment Simplification Study

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World Journal of AIDS 2012年第3期2卷 245-251页

作者： Joseph C. Gathe Dean T. Martin M. Keith Rawlings Benjamin Daquioag John e. Fuchs Vanessa C. Williams Katrina L. Oie gary e. Pakes Cigna Healthcare Corp. Phoenix USA Glaxo-SmithKline Research Triangle Park Durham USA Peabody Clinic Dallas USA Therapeutic Concepts P.A. Houston USA

Objective: The purpose of this study was to investigate whether switching HIV-infected patients stabilized on Trizivir (abacavir 300 mg/lamivudine 150 mg/zidovudine 300 mg) plus lopinavir/ritonavir 400 mg/100mg twice daily to Trizivir alone affects clinical efficacy and tolerability. Methods: This phase 4, open-label, pilot study was conducted over 96 weeks in 23 antiretroviral-na?ve, HIV-infected patients. Initially, these patients received induction therapy with Trizivir plus lopinavir/ritonavir 400 mg/100mg twice daily. Patients who achieved a viral load 3. Nineteen patients completed induction;of the four who did not, three were lost to follow-up and one withdrew due to gastrointestinal adverse events. In 14 induction completers who had viral load measurements taken at week 48, intent-to-treat: observed analysis showed a week 48 viral load 3 higher than the baseline count. Twelve patients completed the subsequent 48-week Trizivir-alone maintenance phase, of whom 11 (92%) achieved viral loads of both 3 above baseline. Trizivir-only maintenance was associated with fewer adverse events than the Trizivir-lopinavir/ritonavir induction phase and with improvement in total cholesterol, LDL-cholesterol, and triglycerides. Conclusions: Trizivir-alone maintenance after Trizivir-lopinavir/ritonavir induction maintained virologic and CD4+ cell response, and was associated with an improved adverse event and lipid profile.

关键词： Abacavir/Lamivudine/Zidovudine HIV-1 Infection Induction-Maintenance Strategy Kaletra Lopinavir/Ritonavir Trizivir