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Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury

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Regenerative Biomaterials 2019年第2期6卷 75-87页

作者： Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis gary anthony brook Department of Neurosurgery RWTH Aachen University HospitalAachenGermany Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Police Headquarters Berlin Medical CommissionBerlinGermany Institute of Neuroscience Universite Catholique de LouvainBrusselsBelgium Donnelly Centre for Cellular&Biomolecular Research University of TorontoTorontoCanada Department of Hand- Plastic and Reconstructive SurgeryBurn Centre Trauma CentreBG Trauma Centre LudwigshafenUniversity of HeidelbergLudwigshafenGermany Department of Plastic Reconstructive and Hand SurgeryBurn CentreRWTH Aachen University HospitalAachenGermany Department of Plastic AestheticHand and Burn SurgeryHelios University Hospital WuppertalUniversity Witten/HerdeckeWuppertalGermany

Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable *** is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic ***,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue ***,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal *** demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host *** reactive astroglial or regenerating axonal profiles could be seen traversing this *** encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the *** of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine.

关键词： spinal cord injury CNS-scarring type-I collagen scaffold astrogliosis fibrosis encapsulation

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Substrate topography as a powerful tool to modify glial cell biology and interactions

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Neural Regeneration Research 2025年第5期20卷 1390-1391页

作者： Pascal Achenbach Haktan Altinova gary A.brook Institute of Neuropathology RWTH Aachen University Hospital Department of Neurosurgery RWTH Aachen University Hospital Aachen Germany Berlin State Office for Health and Social Affairs(LAGeSo) BerlinGermany

Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal *** normal conditions,maintenance of this complex system is structurally and functionally supported by astrocytes (ACs)and other glial cells,the processes of which form a framework surrounding neuronal cell bodies,dendrites,axons,and synapses.

关键词： injuries topography system

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The Dallas Donation after Circulatory Death Transplantation Summit:expanding donation after circulatory death procedures through process improvement,broader utilization,and innovation

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 824-836,I0009页

作者： Michele Finotti Anji Wall anthony D’Alessandro gary Schwartz Chris Sonnenday David Goldberg Ashish Shah Peter Friend Jeff P.Orlowski Greg McKenna Steve Newton Brad Adams William C.Chapman Amit Mathur Marwan Abouljoud Tim Pruett Amelia Hessheimer James F.Trotter Sumeet K.Asrani Giuliano Testa Simmons Transplant Institute Baylor University Medical CenterDallasTXUSA Hepatobiliary and General Surgery Unit Regional Hospital TrevisoDISCOGUniversity of PaduaPaduaItaly Division of Transplantation Department of SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA Department of Thoracic Surgery and Lung Transplantation Baylor University Medical CenterCenter for Advanced Heart and Lung DiseaseDallasTXUSA Department of Surgery University of MichiganAnn ArborMIUSA Division of Digestive Health and Liver Diseases Department of MedicineUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Cardio-Thoracic Surgery Vanderbilt University Medical CenterNashvilleTNUSA Nuffield Department of Surgical Sciences University of OxfordOxfordUK LifeShare Transplant Donor Services of Oklahoma Oklahoma CityOKUSA Administration Baylor University Medical CenterDallasTXUSA Southwest Transplant Alliance DallasTXUSA Department of Surgery/Transplantation Washington UniversitySt.LouisMOUSA Division of Transplant Surgery Department of SurgeryMayo Clinic ArizonaAlix School of MedicinePhoenixAZUSA Divisions of Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMIUSA Department of Surgery University of MinnesotaMinneapolisMNUSA General and Digestive Surgery Hospital Universitario La PazIdiPAZMadridSpain

Despite a significant increase in utilization over the past decade,the number of donation after circulatory death(DCD)organs that are procured and transplanted in the United States(US)remains well below its *** is still room for expansion,as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in *** convened a multidisciplinary transplantation summit to examine various aspects of DCD,with faculty members from around the world with clinical and academic interest in DCD donation and transplantation,including abdominal and cardiothoracic surgeons,organ procurement organization directors,hepatologists,and *** conference focused on identifying barriers to DCD organ utilization and strategies to overcome these *** divide the barriers to DCD utilization into three mains categories:(Ⅰ)policy and process variation;(II)logistical and transportation challenges;and(Ⅲ)higher risk perceptions related to DCD *** each barrier,we proposed a variety of solutions,providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of *** is a specific focus on ex situ machine perfusion,normothermic regional perfusion,and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

关键词： Donation after circulatory death donation(DCD donation) marginal graft donor pool machine perfusion(MP)

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Information Security in the Cloud: Emerging Trends and Challenges

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International Journal of Communications, Network and System Sciences 2024年第5期17卷 69-80页

作者： Keerthana Chitreddy Andrew Mikhl anthony Chinna Manikanta Bandaru Olatunde Abiona Department of Computer Information Systems Indiana University Northwest Gary IN USA

This article explores the evolution of cloud computing, its advantages over traditional on-premises infrastructure, and its impact on information security. The study presents a comprehensive literature review covering various cloud infrastructure offerings and security models. Additionally, it deeply analyzes real-life case studies illustrating successful cloud migrations and highlights common information security threats in current cloud computing. The article concludes by offering recommendations to businesses to protect themselves from cloud data breaches and providing insights into selecting a suitable cloud services provider from an information security perspective.

关键词： Cloud Computing Information Security Cloud Infrastructure Offerings Cloud Migration Security Measures Data Breaches Cloud Service Providers Cybersecurity Cloud Security Case Studies Cloud Threat Landscape Data Encryption Compliance Cloud Security Tools

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Neutron transmission imaging with a portable D-T neutron generator

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Radiation Detection Technology and Methods 2022年第2期6卷 234-243页

作者： Phillip Kerr Nerine Cherepy Jennifer Church gary Guethlein Jim Hall Colby McNamee Sean o'Neal Kyle Champley Andy Townsend Mayuki Sasagawa anthony Hardy Saphon Hok Lawrence Livermore National Laboratory LivermoreCA 94550USA

Purpose A portable fast-neutron imaging system is being developed to provide complementary information to field X-ray *** include inspection of vehicles and infrastructure for corrosion,measurement of material levels in containers,and inspection of munitions and suspicious *** fast-neuron imaging generally provides lower imaging resolution compared to X-rays,fast-neutron interaction cross-sections have a weak dependence on material *** enables imaging of low-Z materials inside high-Z ***,we discuss the limitations and current improvements in fast-neuron *** Limitations in portable fast-neutron imaging systems include low D-T neutron generator output,low light pro-duction in ZnS(Cu)imaging scintillators,low resolution due to scintillator thickness and D-T spot size,and digital-panel darknoise that varies in time and position and that can be 100×larger than the neutron *** have made improvements in these areas through development of a segmented high light yield scintillator,panel noise mitigation techniques,and testing of new high-output,small spot size D-T neutron *** The segmented high light yield fast-neutron scintillator demonstrated 5×increase in light compared to ZnS(Cu).An additional 2×improvement in signal-to-noise was demonstrated with panel-noise mitigation *** MCNP calculations also show good agreement with neutron imaging results Conclusions We have demonstrated improvements in fast-neutron imaging through development of a segmented high light yield neutron scintillator,mitigation of digital panel noise,and preliminary testing with new high-output,small spot size D-T neutron *** have also demonstrated good results modeling fast-neutron images and scatter effects using MCNP.

关键词： Fast-neutron radiography Portable neutron imaging Neutron scintillators Monte Carlo simulation

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CMOS RFIC ARCHITECTURES FOR IEEE 802.15.4 NETWORKS

CMOS RFIC ARCHITECTURES FOR IEEE 802.15.4 NETWORKS

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2005中国通信集成电路技术与应用研讨会

作者： John Notor anthony Caviglia gary Levy Cadence Design Systems Inc．6210 Old Dobbin Lane Suite 100 ColumbiaMaryland 21045USA

While the wireless industry has been focusing on increasing high data throughput, the emerging IEEE 802.15.4 (ZigBee) protocol targets a set of applications that require simple wireless connectivity, relaxed throughput, very low power consumption, and lower module cost. This article will summarize the 2.4 GHz radio physical layer (PHY) technical specifications, examine alternative modem implementations, and compare possible architectures for the receiver and the transmitter in terms of performance, estimated chip area, and production cost.

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可控震源底板动态的试验分析

可控震源底板动态的试验分析

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美国勘探地球物理学家学会第61届年会

作者： Robert A. brook gary A. Crews 汪庭璋 ARCO Oil and Gas Co. ARCO Oil and Gas Co.

由于相位和力控的原因,当今工业所用的大多数可控震源采用地面力的加权求和近似。现已证明,底板装置的非刚性运动是导致这种近似误差的主要原因。因此,机械工程师面临着制造出一个非常轻的但又具有刚性的底板的这种矛盾的设计目标。本...

由于相位和力控的原因,当今工业所用的大多数可控震源采用地面力的加权求和近似。现已证明,底板装置的非刚性运动是导致这种近似误差的主要原因。因此,机械工程师面临着制造出一个非常轻的但又具有刚性的底板的这种矛盾的设计目标。本文介绍测定了两个底板装置的动态的试验。第1台是一个行将替换的老设备,第2台是一个新的,由于增加了刚性,所设计的装置稍微重一些。此结果说明了因底板弯曲采用加权求和测量所引起的误差级。此项试验能够鉴别常规作业中不易觉察的老式底板结构问题。此结果是加权求和测量的相位与受力两种情况的有效误差。在振动器的反馈信号中,这种潜在的误差在我们的采集工作中产生了重要的质量控制问题。此外,这个误差极大地歪曲了震源信号的总效应,或者造成近场测量结果的复杂性。

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Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates

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International Journal of Oral Science 2014年第2期6卷 77-86页

作者： Han Zhou Michael D Weir Joseph M Antonucci gary E Schumacher Xue-Dong Zhou Hockin H K Xu Department of Endodontics Prosthodontics and Operative Dentistry University of Maryland Dental School Baltimore USA State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Biomaterials Group Biosystems and Biomaterials Division National Institute of Standards and TechnologyGaithersburg USA Dr. anthony Volpe Research Center American Dental Association Foundation Gaithersburg USA Center for Stem Cell Biology & Regenerative Medicine University of Maryland School of Medicine Baltimore USA Department of Mechanical Engineering University of Maryland Baltimore County USA

Antibacterial adhesives are promising to inhibit biofilms and secondary caries. The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives, and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time. Six quaternary ammonium methacrylates with chain lengths of 3, 6, 9, 12, 16 and 18 were synthesized and incorporated into Scotchbond Multi-Purpose. Streptococcus mutans bacteria were cultured on resin to form biofilms. Confocal laser scanning microscopy was used to measure biofilm thickness, live/dead volumes and live-bacteria percentage vs. distance from resin surface. Biofilm thickness was the greatest for Scotchbond control; it decreased with increasing chain length, reaching a minimum at chain length 16. Live-biofilm volume had a similar trend. Dead-biofilm volume increased with increasing chain length. The adhesive with chain length 9 had 37% live bacteria near resin surface, but close to 100% live bacteria in the biofilm top section. For chain length 16, there were nearly 0% live bacteria throughout the three-dimensional biofilm. In conclusion, strong antibacterial activity was achieved by adding quaternary ammonium into adhesive, with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16. Antibacterial adhesives typically only inhibited bacteria close to its surface; however, adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm. Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries.

关键词： alkyl chain length antibacterial bondingagent dental caries quaternaryammonium methacrylate Streptococcusmutans three-dimensional biofilm

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Spatially-Explicit, Exposure-Based Assessment of Surface Water Vulnerability from Land Use Threats for Time-Efficient and Cost-Effective Watershed Development Planning

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Journal of Geoscience and Environment Protection 2018年第6期6卷 35-55页

作者： Robert L. France gary Pardy Faculty of Agriculture Dalhousie University Truro Canada Integral Geomatics Sydney Canada

The utility of a spatially-explicit, exposure-based model was examined for its suitability as a tool for rapidly assessing surface water vulnerability in watershed planning. This simple GIS-model uses three types of easily obtainable spatial information: (1) sources of land use-induced change;(2) intensity of watershed drainage;and (3) sensitivity of drainage basins to change. This model was applied to the Thomas brook watershed in Nova Scotia, Canada, which has been the site of previous studies, conducted over multiple years, using detailed, effects-based, hydrologic models. Doing so allowed us the opportunity to compare the two approaches. Results showed a good concordance in the derived mapped outputs between the two models. Given the rapid ease and inexpensive cost of using the GIS, exposure-based model, we believe it to offer great promise in terms of prioritizing locations for further study or for intervention of best management practices, as well as for planning where to best direct future water-sensitive development through build-out analyses.

关键词： Watershed GIS Analysis Surface Water Vulnerability

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LiDAR Helps Differentiate Stand Health and Productivity Levels within a Northern Hardwood Forest

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Open Journal of Forestry 2020年第1期10卷 66-80页

作者： Christopher F. Hansen Paul G. Schaberg Allan M. Strong Shelly A. Rayback gary J. Hawley Rubenstein School of Environment and Natural Resources The University of Vermont Burlington VT USA USDA Forest Service Northern Research Station Burlington VT USA Geography Department The University of Vermont Burlington VT USA

Light detection and ranging (LiDAR) data can provide detailed information about three-dimensional forest structure. However, links between forest structure and tree function have not been fully evaluated using LiDAR. We assessed the relationship of LiDAR-derived structural categories to tree health and productivity on 36 hardwood plots at the Hubbard brook Experimental Forest, New Hampshire, USA. We established nine plot replicates for each of four LiDAR-based vegetation categories: 1) high crown and high understory closure;2) high crown and low understory closure;3) low crown and high understory closure;and 4) low crown and low understory closure. Ground-based measures of canopy structure, site, stand and individual tree measures were collected on plots during summer 2012. Significant differences among LiDAR categories were found for several response variables. Lower basal area increment for sugar maple (Acer saccharum), decreased foliar nutrition for yellow birch (Betula alleghaniensis), and lower overall crown health were all associated with high understory closure provided that overstory closure was also high. These results suggest that LiDAR measures can be used to assess competitive interactions between overstory and understory vegetation, and that LiDAR shows promise for identifying stands with reduced health and productivity due to factors such as competition or overstocking.

关键词： Basal Area Increment Crown Health Foliar Nutrition Tree Function Tree Mortality

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