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Electrocardiographic measures of repolarization dispersion and their relationships with echocardiographic indices of ventricular remodeling and premature ventricular beats in hypertension

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Journal of Geriatric Cardiology 2017年第12期14卷 717-724页

作者： Ana Ciobanu gary Tse Tong Liu maria V Deaconu Gabriela S Gheorghe Adriana m Iliesiu Ioan T Nanea Department of Internal medicine and Cardiology Theodor Burghele Clinical Hospital Carol Davila University of Medicine and Pharmacy Bucharest Romania Department of medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sci- ences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China

Objective To examine the relationship between Tpeak- Tend interval （Tpe） and Tpe/QT ratio with occurrence of ventricular premature beats （VPBs） and left ventricular remodeling in hypertension. methods A total of 52 patients with mild to moderate essential hypertension were included, undergoing echocardiography and 24-hours Holter monitoring. Ventricular remodeling was assessed by left ventricular mass index （LVmI） using the Devereux formula and diastolic fimction by transmitral E and A wave velocities and E/A ratio. Tpe was measured in the precordial leads. The end of the T wave was set by the method of the tangent to the steepest descending slope of the T wave. Results Tpe and Tpe/QT in leads V2 （r = 0.33, P = 0.01; r = 0.27, P = 0.04 respectively） and V3 （r = 0.40, P = 0.002; r = 0.40, P = 0.003, respectively） correlated significantly with LVmI. A significant inverse relationship was observed between E/A ratio and QT （r = -0.33, P = 0.01）, Tpe in V3 （r = -0.39, P = 0.003） and Tpe/QT in V3 （r = -0.31, P = 0.02）. Tpe in V3, V5, mean Tpe and maximum Tpe with cut-offvalues of 60 ms, 59 ms, 62 ms and 71 ms, respectively, associated with the occurrence of ventricular premature beats. Conclusions The repolarization parameters Tpe interval and Tpe/QT ratio correlate with LVmI and indices of left ventricular diastolic function and show better predictive values than traditional parameters such as QT interval and QT dispersion. Lead V3 is the best lead for measuring Tpe and Tpe/QT. These ECG indices can therefore be used in clinical practice to monitor LV remodeling and predict occurrence of VPBs.

关键词： Hypertension Repolarization Tpeak-Tend Ventricular remodeling

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Crocodile blood supplementation protect svascular function in diabetic mice

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Food Production, Processing and Nutrition 2021年第1期3卷 283-295页

作者： Chui Yiu Bamboo Chook Francis m.Chen gary Tse Fung Ping Leung Wing Tak Wong School of Life Sciences Faculty of ScienceThe Chinese University of Hong KongShatinNTHong Kong SAR State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina

Cardiovascular disease is a major cause of mortality in diabetic patients due to the heightened oxidative stress and pro-inflammatory state in vascular *** approaches targeting cardiovascular health for diabetic patients are urgently *** blood,an emerging dietary supplement,was suggested to have anti-oxidative and anti-inflammatory effects in vitro,which have yet to be proven in animal *** study thereby aimed to evaluate whether crocodile blood can protect vascular function in diabetic mice against oxidation and *** db/db mice and their counterparts db/m+mice were treated daily with crocodile blood soluble fraction(CBSF)or vehicle via oral gavage for 4 weeks before their aortae were harvested for endothelium-dependent relaxation(EDR)quantification using wire myograph,which is a well-established functional study for vascular function *** culture experiments culturing mouse aortae from C57BL/6 J mice with or without IL-1βand CBSF were done to evaluate the direct effect of CBSF on endothelial *** oxygen species(ROS)levels in mouse aortae were assessed by dihydroethidium(DHE)staining with inflammatory markers in endothelial cells quantified by quantitative polymerase chain reaction(qPCR).CBSF significantly improved deteriorated EDR in db/db diabetic mice through both diet supplementation and direct culture,with suppression of ROS level in mouse *** also maintained EDR and reduced ROS levels in mouse aortae against the presence of pro-inflammatory IL-1β.Under the pro-inflammatory state induced by IL-1β,gene expressions of inflammatory cytokines were downregulated,while the protective transcripts UCP2 and SIRT6 were upregulated in endothelial *** study suggests a novel beneficial effect of crocodile blood on vascular function in diabetic mice and that supplementation of diet with crocodile blood may act as a complementary approach to protect against vascular diseases through anti

关键词： Crocodile blood Diabetes mellitus Vascular endothelial function Anti-oxidative Anti-inflammatory

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Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-Seq approach

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Animal models and Experimental medicine 2024年第1期7卷 36-47页

作者： Roa'a H.S.Yosief Iqbal m.Lone Aharon Nachshon Heinz Himmelbauer Irit Gat-Viks Fuad A.Iraqi Department of Clinical microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael School of molecular Cell Biology and Biotechnology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic *** aim of this study was to search for candidate genes associated with host susceptibility to Aspergillus fumigatus(Af)using an RNAseq approach in CC lines and hepatic gene ***:We studied 31 male mice from 25 CC lines at 8 weeks old;the mice were infected with *** tissues were extracted from these mice 5 days post-infection,and next-generation RNA-sequencing(RNAseq)was *** GENE-E analysis platform was used to generate a clustered heat map ***:Significant variation in body weight changes between CC lines was *** gene expression revealed 12 top prioritized candidate genes differ-entially expressed in resistant versus susceptible mice based on body weight ***,three candidate genes are located within genomic intervals of the previ-ously mapped quantitative trait loci(QTL),including Gm16270 and Stox1 on chromo-some 10 and Gm11033 on chromosome ***:Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards *** a next step,eQTL analysis will be performed for our RNA-Seq *** candidate genes from our study will be further assessed with a human cohort with aspergillosis.

关键词： aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-Seq

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Does Acute Improvement in muscle Recovery with Curcumin Supplementation Translate to Long-Term Training?

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Journal of Science in Sport and Exercise 2019年第3期1卷 203-207页

作者： Brian K.mcFarlin Elizabeth A.Tanner melody A.gary Asheal A.Davis Erin m.Bowman Richard S.gary Applied Physiology Laboratory University of North TexasPhysical Education BuildingRoom 2091921 Chestnut StreetDentonTX 76201USA Department of Biological Sciences University of North TexasDentonTXUSA

Dietary polyphenols,such as curcumin,green tea catechins,and pomegranate extract,may have the ability to enhance the effectiveness of long-term training programs by managing training-induced *** recovery may translate to increased capacity to train and perform more *** dietary polyphenol curcumin has been reported to block the action of COX-2 and NF-kB signaling and would allow for increased capacity to train leading to heightened adaptations and the potential for ergogenic *** actions are very similar to the targeted actions of non-steroidal anti-inflammatory drugs(NSAIDs),but without the side-effects of *** review will compare and contrast the known effects of cur-cumin and identify common design elements between existing *** this critical review of the existing literature it is our goal to establish a set of best practices that could be applied to an athletic population that is interested in using oral curcumin supplementation as a recovery agent.

关键词： Exercise-induced muscle injury Inflammatory cytokines Inflammation Soreness Distance running Exercise training

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A new record of Cleantioides emarginata Kwon & Kim, 1992 (Crustacea, Isopoda, Valvifera) from Changjiang River estuary, China

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Chinese Journal of Oceanology and Limnology 2013年第3期31卷 625-631页

作者：刘文亮 gary C. B. POORE The State Key Laboratory of Estuarine and Coastal Research East China Normal University museum Victoria GPO Box 666Melbourne

Abstract At present, descriptions of Cleantioides emarginata Kwon ＆ K/m, 1992 have been limited to the type locality of Pusan, In this study, we discovered this species in the Changjiang （Yangtze） River estuary, China. This represents an extension of the known geographical range of C. emarginata. In addition, we present information of a colour pattern not previously described, along with details on the estuarine habitat of the species.

关键词： Isopoda Valvifera new record estuarine species Chinese waters

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Testicular volume and clinical correlates of hypothalamic–pituitary–testicular function:A cross-sectional study in obese men

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Asian Journal of Andrology 2020年第4期22卷 354-359页

作者： mark Ng Tang Fui Rudolf Hoermann gary Wittert mathis Grossmann Department of medicine Austin Health University of MelbourneMelbourneVictoria 3084Australia Department of Endocrinology Austin HealthMelbourneVictoria 3084Australia School of medicine University of AdelaideAdelaideSouth Australia 5005Australia

The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic–pituitary–testicular(HPT)axis *** was a cross-sectional substudy of a larger randomized controlled trial including obese men,body mass index(BmI)≥30 kg m−2,with a total testosterone levelmol l−*** volume was measured by orchidometer,testosterone by liquid chromatography/tandem mass spectrometry,and body composition by dual-energy X-ray *** completed the Aging males'Symptoms(AmS)score,International Index of Erectile Function-5(IIEF-5),physical function,and handgrip dynamometer ***-nine men participated with a median(interquartile range[IQR])age of 53.1(47.6,59.2)years,BmI of 37.0(34.6,40.5)kg m−2,and a total testosterone of 7.0(6.1,7.9)nmol l−*** testicular volume was 18(IQR:10,20)*** volume was negatively correlated with BmI(τ=−0.1952,P=0.010)and total fat mass(τ=−0.2115,P=0.005)independent of age and *** BmI,testosterone,sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were present in a multivariable model,only BmI(-0.38 ml change in testicular volume per 1 kg m-2BmI;95%CI:−0.74,−0.02;P=0.04)and LH(-0.92 ml change in testicular volume per 1 IU l-1 LH;95%CI:−1.75,−0.095;P=0.03)remained independent significant predictors of testicular *** volume was positively correlated with IIEF-5(τ=0.2092,P=0.021),but not related to handgrip strength,physical function tests,or *** obese men,testicular volume is inversely and independently associated with measures of adiposity,but not with most clinical or biochemical markers of HPT axis *** a clinical perspective,this suggests that obesity might compromise the reliability of reduced testicular volume as a sign of androgen deficiency in men.

关键词： hypothalamic-pituitary-gonadal axis testicular volume testosterone

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Boosting extraction of Pb in contaminated soil via interfacial solar evaporation of multifunctional sponge

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Green Energy & Environment 2023年第5期8卷 1459-1468页

作者： Pan Wu Xuan Wu Yida Wang Jingyuan Zhao Haolan Xu gary Owens Future Industries Institute UniSA STEMUniversity of South AustraliaMawson Lakes CampusSA 5095Australia

Interfacial solar water evaporation is a reliable way to accelerate water evaporation and contaminant *** the recent advance in photothermal technology,a functional sponge was prepared by coating a sodium alginate(SA)impregnated sponge with a surface layer of reduced graphene oxide(rGO)to act as a photothermal conversion medium and then subsequently evaluated for its ability to enhance Pb extraction from contaminated soil driven by interfacial solar *** SA loaded sponge had a Pb adsorption capacity of 107.4 mg g^(-1).Coating the top surface of the SA sponge with rGO increased water evaporation performance to 1.81 kg m^(-2)h^(-1)in soil media under one sun illumination and with a wind velocity of 2 m s^(-1).Over 12 continuous days of indoor evaporation testing,the Pb extraction efficiency was increased by 22.0%under 1 sun illumination relative to that observed without ***,Pb extraction was further improved by 48.9%under outdoor evaporation conditions compared to indoor ***,this initial work shows the significant potential of interfacial solar evaporation technologies for Pb contaminated soil remediation,which should also be applicable to a variety of other environmental contaminants.

关键词： Photothermal materials Interfacial solar evaporation Reduced graphene oxide Pb extraction Soil remediation

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Nitric oxide regulation of plant metabolism

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molecular Plant 2022年第2期15卷 228-242页

作者： Kapuganti Jagadis Gupta Vemula Chandra Kaladhar Teresa B.Fitzpatrick Alisdair R.Fernie Ian max møller gary J.Loake National Institute of Plant Genome Research Aruna Asaf Ali MargNew DelhiDelhi 110067 India Vitamins and Environmental Stress Responses in Plants Department of Botany and Plant BiologyUniversity of GenevaGeneva 1211 Switzerland max-Planck-Institute of molecular Plant Physiology Am Mühlenberg 1Potsdam-Golm 14476 Germany Department of molecular Biology and Genetics Aarhus UniversityForsøgsvej 14200 SlagelseDenmark Institute of molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK

Nitric oxide(NO)has emerged as an important signal molecule in plants,having myriad roles in plant *** addition,NO also orchestrates both biotic and abiotic stress responses,during which intensive cellular metabolic reprogramming *** to these responses is the location of NO biosynthetic and scavenging pathways in diverse cellular compartments,enabling plants to effectively organize signal transduction *** regulates plant metabolism and,in turn,metabolic pathways reciprocally regu-late NO accumulation and ***,these diverse cellular processes are inextricably *** re-view addresses the numerous redox pathways,located in the various subcellular compartments that pro-duce NO,in addition to the mechanisms underpinning NO *** focus on how this molecular dance is integrated into the metabolic state of the *** this context,a reciprocal relationship be-tween NO accumulation and metabolite production is often *** also showcase cellular pathways,including those associated with nitrate reduction,that provide evidence for this integration of NO function and ***,we discuss the potential importance of the biochemical reactions governing NO levels in determining plant responses to a changing environment.

关键词： hypoxi amitochondria metabolism nitric oxide S-nitrosylation pyridoxine reactive nitrogen species reactive oxygen species

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SUBSURFACE TEmPERATURE AND ITS RELATION TO DYNAmIC HEIGHT AT 130°E ACROSS THENORTH EQUATORIAL CURRENT

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Chinese Journal of Oceanology and Limnology 1993年第2期11卷 143-148页

作者：曲堂栋 gary meyers 胡敦欣 Institute of Oceanology Academia Sinica Qingdao 266071 Division of Oceanography CSIRO Hobart Australia

Temperature profiles down to 1500m(CTD) collected by Academia Sinica from 1986 to 1990 are used and discussed in relation to the dynamic heights at130 E across the North Equatorial Current (NEC). An extremely high correlation between subsurface (say at 400 m depth) temperature and dynamic height relative to 1500 db is found, and the corresponding regression relationships suggest a method to estimate gpostrophic circulation from subsurface temperature alone. These suggest that the conclusions from extensive studies on this topic in Australian waters also apply to the NEC region, at least at130 E , thus making the subsurface thermal structure an excellent indicator of the variation of the NEC.

关键词： subsurface temperature dynamic height relation

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A photothermal reservoir for highly efficient solar steam generation without bulk water

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Science Bulletin 2019年第21期64卷 1625-1633页

作者： Xuan Wu Ting Gao Chenhui Han Jingsan Xu gary Owens Haolan Xu Future Industries Institute University of South AustraliaMawson Lakes CampusSA 5095Australia School of Chemistry Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQLD 4001Australia

A solid photothermal reservoir is designed to implement solar-steam generation in the absence of bulk *** photothermal reservoir is composed of a water absorbing core encapsulated by a photothermal reduced graphene oxide based aerogel sheet which absorbs light and converts it into heat thus evaporating the stored *** photothermal reservoir is able to store 6.5 times its own weight in water,which is sufficient for one day solar evaporation,thus no external water supplement is *** solar-steam generation,since no bulk water is involved,the photothermal reservoir minimizes heat conduction loss,and maximizes both of the exposed evaporation surface area and net energy gain from the environment,leading to an energy efficiency beyond the theoretical *** extremely high water evaporation rate of 4.0 kg m-2 h-1(normalized to projection area)is achieved in laboratory studies over a cylinder photothermal reservoir with a diameter of 5.2 cm and a height of 15 cm under 1.0 sun *** evaluation of the photothermal reservoir outdoors as part of a desalination device demonstrates a similar evaporation rate where the salinity of the clean water produced is lower than 24 *** the photothermal reservoir shows great potential for real world applications in portable solarthermal desalination.

关键词： Solar-steam generation Photothermal Aerogel Solar-thermal energy

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