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World Journal of Gastroenterology 2022年第21期28卷 2302-2319页

作者： Noel E Donlon Maria Davern Fiona o'connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R Dunne Stephen Maher Jacintha o'Sullivan John V Reynolds Joanne Lysaght Department of Surgery Trinity Translational Medicine InstituteSt James HospitalDublin D08Ireland

BACKGRoUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials *** locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(oAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative *** To immunophenotype oAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell *** In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials *** surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in oAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative *** aim of this body of work was to immunophenotype oAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell *** study was a hybrid combination of in vitro and ex vivo *** of serum immune proteins was performed by enzyme-linked immunosorbent *** cytometry staining was performed to evaluate IC expression for in vitro oAC cell lines and ex vivo oAC *** viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 *** We identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in *** were two distinct subco

关键词： oesophageal Cancer Radiotherapy Immunotherapy Immunology Surgery oncology

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

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Cancer Drug Resistance 2021年第2期4卷 264-297页

作者： Aleksandra Benko David Medina-Cruz Ada Vernet-Crua Catherine P.o'connell MałgorzataŚwiętek Hamed Barabadi Muthupandian Saravanan Thomas J.Webster AGH University of Science and Technology Faculty of Materials Science and CeramicsKrakow 30059Poland Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Institute of Macromolecular Chemistry Czech Academy of SciencesPrague 16206Czech Republic Department of Pharmaceutical Biotechnology School of PharmacyShahid Beheshti University of Medical SciencesTehran 19919-53381Iran Department of Medical Microbiology and Immunology Division of Biomedical SciencesSchool of MedicineCollege of Health SciencesMekelle UniversityMekelle 231Ethiopia.

Cancer is one of the biggest healthcare concerns in our century,a disease whose treatment has become even more difficult following reports of drug-resistant *** this happens,chemotherapy treatments fail or decrease in efficiency,leading to catastrophic consequences to the *** discovery,along with the fact that drug resistance limits the efficacy of current treatments,has led to a new wave of discovery for new methods of *** use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in *** in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive ***,these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better *** review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers,including polymeric,viral,lipid-based,metal-based,carbon-based,and magnetic nanocarriers,opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

关键词： Drug-resistance cancer nanotechnology nanocarriers drug delivery

CHP发动机用不同压缩比的生物甲烷和引燃燃料的双燃料试验(英文)

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燃烧科学与技术 2019年第2期25卷 139-148页

作者： Brautsch M Lechner R Roll A o’connell N 王楚翘罗福强安贝格-魏登应用技术大学CHP技术中心德国安贝格92224 安贝格-魏登应用技术大学能源工程学院德国安贝格92224 江苏大学汽车与交通工程学院镇江212013 伯明翰大学化工学院

使用生物甲烷作为气体燃料,使用加热油和各种生物燃料作为引燃燃料,测试了来自相同柴油机的两种不同的双燃料配置.结果表明,相比压缩比为19∶1的"柔性双燃料模式",压缩比为16∶1的"引燃模式"有更高的生物甲烷比率,在小载荷下电效率值较... 详细信息

使用生物甲烷作为气体燃料,使用加热油和各种生物燃料作为引燃燃料,测试了来自相同柴油机的两种不同的双燃料配置.结果表明,相比压缩比为19∶1的"柔性双燃料模式",压缩比为16∶1的"引燃模式"有更高的生物甲烷比率,在小载荷下电效率值较低,在中载荷下两者相同,在高负载时电效率值较高.该两种模式均可实现超过42%的电效率及大约1的功率系数,这证明了所研究的CHP发动机台架具有良好的热效率与电效率.

关键词：生物燃料 CHP 双燃料热效率

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Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

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World Journal of otorhinolaryngology-Head and Neck Surgery 2021年第9期7卷 139-145页

作者： Aviv Spillinger Christopher M.Low Byron M.Smith Janalee K.Stokken Erin K.o'Brien garret Choby Deportment of otoloryngolosy-Head and Neck Surgery Mayo ClinicRochesterMN55905USA Biomedical Statistics and Informatics Mayo ClinicRochesterMN55905USA

non-invasive chronic rhinosinusitis(CRS)following liver or kidney transplant and determine factors associated with disease-related complications,selection of endoscopic sinus surgery(ESS),and disease resolution in this *** design:Retrospective chart ***:An academic tertiary care center(Mayo Clinic,Rochester,Minnesota).Subjects and methods:Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were *** and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications,selection of ESS,and disease ***:Fifty-seven patients met inclusion *** patients developed intraorbital or intracranial complications of their *** modeling demonstrated that the presence of polyps(P=0.036)was associated with undergoing ESS within one year of presentation.A higher Lund-Mackay(LM)computed tomography score(P=0.023)and older age(P=0.018)were significantly associated with decreased disease *** other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this ***:The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally *** liver-and kidney-recipients stable on immunosuppressive medication for many years,prognostic factors for CRS may mirror those for immunocompetent patients.

关键词： Rhinosinusitis Chronic rhinosinusitis Non-invasive rhinosinusitis Kidney transplant Liver transplant Immunocompromised Immunosuppressed

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Assessing Colorectal Cancer Screening Behaviors and Knowledge among At-Risk Hispanics in Southern New Mexico

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Journal of Cancer Therapy 2013年第6期4卷 15-25页

作者： Janeth I. Sanchez Rebecca Palacios Beti Thompson Vanessa Martinez Mary A. o’connell Fred Hutchinson Cancer Research Center Seattle Washington USA Plant and Environmental Sciences New Mexico State University Las Cruces New Mexico USA Public Health Sciences New Mexico State University Las Cruces New Mexico USA

Purpose: Colorectal cancer (CRC) mortality rates in New Mexico (NM) continue to be higher than national rates. Hispanic CRC mortality rates in NM surpass those of overall Hispanics in the US. This study was designed to characterize and understand factors contributing to low CRC screening rates in this border region. Methods: A CRC Knowledge Assessment Survey (KAS) was administered in either English or Spanish to 247 individuals attending community events throughout southern NM. A subset of these individuals completed an online CRC risk assessment survey managed by the National Cancer Institute (NCI). Data analysis tested for significant differences in knowledge, physician-patient CRC interactions, CRC risk level perception, and screening rates across diverse ethnic and age groups. Results: Both CRC knowledge and physician-patient CRC interactions were positively associated with participant screening history. Significant age and ethnic differences for CRC knowledge, physician-patient CRC interactions, and screening history in the NM border sample were also seen. Age-eligible Hispanics (50+) as well as those less than 50 years of age had lower CRC knowledge and were less likely to engage in physician-patient CRC interactions than non-Hispanic Whites (NHWs). The age-eligible Hispanics also reported lower CRC screening rates than their NHW counterparts. Conclusions: Low CRC knowledge and limited physician-patient CRC interactions appear to contribute to low screening rates in this NM population. Expanding education and outreach efforts for this border population are essential to promote early CRC detection and thereby decrease overall CRC mortality rates.

关键词： Colorectal Cancer Health Disparity Hispanics Knowledge New Mexico Screening

BUSINESS STATISTICS IN PRACTICE / 4th ed.

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Analgesic Regimen and Readmission Following Tonsillectomy

丛书名： The McGraw-Hill/Irwin series operations and decision sciences

2007年

作者： BRUCE L. BoWERMAN RICHARD T. o'connell WITH MEG

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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International Journal of otolaryngology and Head & Neck Surgery 2013年第4期2卷 121-125页

作者： Lyudmila Kishikova Matthew D. Smith Jason C. Fleming Michael o’connell Brighton and Sussex Medical School Brighton UK ENT Department Brighton and Sussex University Hospitals Trust Brighton UK

objective: To define the analgesic regimen given following tonsillectomy in a large ENT department and correlate this with readmission for secondary complications. Methods: We performed a retrospective case note review of patients undergoing tonsillectomy within a six month period. Demographic information and relevant case information was collected including operative details, discharge medication and readmission details. Results: 125 patients underwent tonsillectomy during the period. 17 different post-operative analgesic regimens were identified with the most common being a paracetamol and ibuprofen combination (26.4%). 13 patients (10.4%) were readmitted following discharge from hospital post-operatively, four (3.2%) for issues related to pain. There was no correlation between analgesic regimens and readmission. Conclusion: No apparent link between readmission and analgesic regimen was identified. The vast variation of analgesic regimens used has prompted development of a formal step-based analgesic protocol.

关键词： Tonsillectomy Analgesia Post-operative Complications

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斯坦福最具人气课程（英文）

大学英语 2015年第7期 33-39页

作者： Ainsley o’connell 扬帆

在美国名校斯坦福大学,最受欢迎的课程居然不是＂计算机科学＂,而是一门更为重要的课程——＂设计你的人生＂!Before Kanyi Maqubela became an investment partner at the Collaborative Fund,an early-stage venture capital firm foc... 详细信息

关键词：课程 capital 人气 Before 斯坦福大学计算机科学 the 名校

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开罐器女王

中学生英语 2022年第11期 22-28页

作者： Linda o'connell 梁小明湖北省武汉电力职业技术学院

20世纪50年代,我还是个孩子,那时母亲们穿着围裙,准备着家常菜。我母亲不是那种典型的母亲,她从不穿围裙。她赢得了"开罐器女王"的称号,因为她不太会做饭。她也不烤饼干或蛋糕,但我们总是从附近的面包店里买。当母亲想用丰盛的晚餐给我...

20世纪50年代,我还是个孩子,那时母亲们穿着围裙,准备着家常菜。我母亲不是那种典型的母亲,她从不穿围裙。她赢得了"开罐器女王"的称号,因为她不太会做饭。她也不烤饼干或蛋糕,但我们总是从附近的面包店里买。当母亲想用丰盛的晚餐给我们留下深刻印象时,她没有做烤肉。她在我们说话之前就直接把烤牛肉片和肉汁从罐头里倒在了一堆土豆泥上。

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