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Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound

Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 40-51页

作者： Nantaporn Namviriyachote Vimolmas Lipipun Yada Akkhawattanangkul Phingphol charoonrut Garnpimol C.Ritthidej Faculty of Pharmaceutical Sciences Chulalongkorn UniversityBangkok 10330Thailand Faculty of Veterinary Science Mahidol UniversityNakhon Pathom 73170Thailand

Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,respectively.The foam was instantly formed by interaction of polyols and diisocyanate.Hydroxypropyl methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing sheets.Although the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active components.Among natural polyols formulations,foam sheets with alginate showed the highest silver and AS release.Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed.Antimicrobial testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations.In pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions.In conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment.

关键词： Polyurethane foam dressing Natural polyols Silver nanoparticles Asiaticoside Wound healing

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Physico-mechanical characterization of polyurethane foam dressings containing natural polyols

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 114-115页

作者： Nantaporn Namviriyachote Kitipun Manosittisak Garnpimol C.Ritthidej Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkok 10330Thailand Bangkok Botanica co. Ltd.Bangkok 10600Thailand

Advanced wound dressings are replaced traditional dressings in order to provide appropriate environment for healing and also to promote cell migration[1].The key characteristics of wound dressings are non-toxic,highly absorbed,air permeable,biocompatible and have good mechanical properties[2].Due to providing moist environment and also protecting maceration at the wound edge area,foam dressings are used in various clinical applications[3].They are mostly prepared from polyurethane between polyols and isocyanate polymerization.

关键词： Polyurethane foam Natural polyols Starch Physico-mechanical properties

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Effect of cationic microemulsion on hemolysis and immune cell uptake

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 164-165页

作者： Sakalanunt Lamaisakul Angkana Tantituvanont Vimolmas Lipipun Garnpimol C.Ritthidej Department of Pharmaceutics and Industrial Pharmacy Chulalongkorn UniversityBangkok 10330Thailand Department of Biochemistry and Microbiology Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkok 10330Thailand

Squalene-based oil-in-water nanoemulsions, constituents in influenza vaccines, have been approved in Europe as human licensed adjuvants (1)With similar constituents but easier manufacturing procedure and greater physical stability [2],microemulsion was of interest. To improve cellular uptake,positive surface charge of nanosystems has been reported(3)In the present study, cationic microemulsions were prepared, characterized and evaluated in immune cell.

关键词： cationic microemulsion Hemolysis Adjuvant Immune cell uptake

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Nicotine transdermal patch for smoking cessation using combination of hydrophilic and hydrophobic polymers as matrix film formers

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 207-208页

作者： Danaipat Sukphong Thesisanin Rojanaratha Marut Srivarnitpoom chaisan Sriwichupong Garnpimol C.Ritthidej Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical Science Chulalongkorn University

One of the most popular nicotine replacement therapies (NRTs)available in the market nowadays is the nicotine patches, which provide a source of nicotine to reduce the withdrawal symptoms experienced when smoking is stopped. Nicotine transdermal patch to satisfy addicted smoker’s cravings as oninvasive, self medicated therefore patient compliance and less frequent administration than oral was investigated to contain2 layers;backing layer, adhesive with drug layer.

关键词： Nicotine Transdermal patch Eudragit Hydroxypropyl methylcellulose

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Impact of formulation parameters on physical characteristics of spray dried nanoemulsions and their reconstitutions

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 197-198页

作者： Htoo Htet Myat garnpimol c. ritthidej International Program (Pharmaceutical Technology) Department of Pharmaceutics and Industrial PharmacyFaculty of Pharmaceutical Sciences Chulalongkorn University

Nanoemulsion as small droplet dispersion allows them to uniformly deposit on substrates,increases the rate of bioavailability,absorption and has a better uptake.Although it is generally accepted that nanoemulsions are stable for years,Oswald ripening which can damage nanoemulsion has been reported[1].In this study,converting nanoemulsion as liquid formulation into solid powders was attempted by using spray drying method.The obtained powders were then characterized,reconstituted and compared to the initial nanoemulsion.

关键词： Nanoemulsion Maltodextrin Spray drying Particle size

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Development of novel cationic microemulsion as parenteral adjuvant for influenza vaccine

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Asian Journal of Pharmaceutical Sciences 2020年第5期15卷 591-604页

作者： Sakalanunt Lamaisakul Angkana Tantituvanont Vimolmas Lipipun garnpimol ritthidej Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkok 10330Thailand Department of Biochemistry and Microbiology Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkok 10330Thailand

Squalene-based oil-in-water(O/W)emulsions have been used as effective and safe adjuvants in approved influenza vaccines.However,there are concerns regarding the safety and side effects of increasing risk of narcolepsy.In present study,novel O/W microemulsions(MEs)containing wheat germ oil,D-alpha tocopheryl polyethylene glycol 1000 succinate(TPGS)and cremophor EL(creEL)or Solutol HS15 were formulated with/without a cationic surfactant,cetyltrimethylammonium bromide(cTAB)and then sterilized by autoclaving.Their physical properties and biological efficacies were evaluated.The results demonstrated that autoclaving reduced the droplet size to^20 nm with narrow size distributions resulting in monodisperse systems with good stability up to 3 years.Hemolytic activity,viscosity,pH,and osmolality were appropriate for parenteral use.Bovine serum albumin(BSA),a model antigen,after mixing with MEs retained the protein integrity,assessed by SDS-PAGE and cD spectroscopy.Greater percentages of 28 Sc cell viability were observed from creEL-based MEs.Uptake of FITc-BSA-MEs increased with the increasing concentration of cTAB confirmed by cLSM images.Furthermore,cationic creEL-based MEs could induce Th1 cytokine synthesis with an increase in TNF-α and IL-12 levels and a decrease in IL-10 level.In vivo immunization study in mice of adjuvants admixed with influenza virus solution revealed that nonionic and selected cationic creEL-MEs enhanced immune responses as measured by influenza-specific serum antibody titers and hemagglutination inhibition titers.Particularly,cationic creEL-based ME showed better humoral and cellular immunity with higher IgG2 a titer than nonionic creEL-based ME and antigen alone.No differences in immune responses were observed between mice immunized with selected cationic creEL-based ME and marketed adjuvant.In addition,the selected ME induced antigen-sparing while retained immune stimulating effects compared to antigen alone.No inflammatory change in muscle fiber structure was observed.Accordingly,the develop

关键词： cationic microemulsion Adjuvant Influenza virus Vaccine

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controlled release tablets of verapamil hydrochloride

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 219-220页

作者： Treephu Kimlek Tossaporn Prasertporn Jiramet Sawantranon chaisan Sriwichupong garnpimol ritthidej Pharmaceutical Technology Field Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical Sciences Chulalongkorn University

Verapamil is a calcium channel blocker drug which reduces heart rhythm and blood pressure in high blood pressure patient.The steady state of this drug has to be continually controlled to obtain optimal efficacy.In addition,patient compliance needs to be considered.Therefore,controlled release tablet of verapamil hydrochloride was essentially developed using hydrophilic matrix polymer,namely hydroxypropylmethyl cellulose(HPMc)and sodium alginate,and compared to marketed product[1].HPMc,a pH-independent polymer,hydrates to form a gel layer at the surface of the tablet to sustain the drug release.Sodium alginate,a pH-dependent gelling polymer,converts to insoluble alginic acid after exposure to acidic condition in stomach.

关键词： Verapamil controlled release HPMc Sodium alginate

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Formulation development of nifedipine controlled-release coated tablets

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 118-119页

作者： Ananya Ubonratana Sirachaya choosakul Nara Nilnakara chaisan Sriwichupong garnpimol ritthidej Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical Sciences Chulalongkorn University

Due to frequent administration of oral nifedipine tablet, controlled or sustained release of the drug will improve patient compliance, stable blood level and side effect decrement [1,2].Various extended release nifedipine products have been commercially available. In this study, extended release tablets of this drug were formulated using sodium alginate,hydroxypropylmethylcellulose (HPMc) as controlled release matrix materials.

关键词： Nifedipine Extended release tablet Matrix Sodium alginate HPMc

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