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Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1796-1807页

作者： Ren-Qi Mu Jun-Wei Lv Cai-Yun ma Xiao-Hui ma Dong Xing Hou-Sheng ma Department of Radiology Yantai Mountain HospitalYantai 264001Shandong ProvinceChina Department of Radiology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina Department of Gynaecology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina The First Clinical Medical College Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Rectal carcinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of *** present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum carbohydrate antigen 19-9(CA19-9)and CA125 Levels have been used in clinical practice to evaluate the T stage and differentiation of ***,the accuracy of these evaluation modalities still needs further *** study explores the application and value of these methods in evaluating the T stage and differentiation degree of *** To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathological processes and prognosis of RC *** A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from may 2018 to January *** were categorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation *** addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation *** levels of DCE-MRI parameters and serum CA19-9 and CA125 in different groups of patients were *** addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(ve)in assessing the differentiation and T staging of RC patients was ***,the usefulness of DCE-MRI parameters combined with serum CA19-9 and CA125 Levels in the evaluation of RC differentiation and T staging was *** Ktrans,ve,CA19-9 and CA125 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(Pve(AUCs)of the Ktran and ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0

关键词： Rectal carcinoma Volume transfer constant Rate constant Extravascular extracellular volume fraction Serum carbohydrate antigen 19-9 Serum carbohydrate antigen 125

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Insights into dammarane-type triterpenoid saponin biosynthesis from the telomere-totelomere genome of Gynostemma pentaphyllum

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Plant Communications 2024年第8期5卷 100-103页

作者： Lingling Yun Chuyi Zhang Tongtong Liang Yu Tian Guoxu ma Vincent Courdavault Sijie Sun Baiping ma Ziqin Li Rucan Li Feng Cao Xiaofeng Shen Jianhe Wei Ying Li Baolin Guo Chao Sun Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Biomole cules et Biotechnologies ve ge tales EA2106Universite de Tours37200 ToursFrance Beijing Institute of Radiation Medicine Beijing 100850China Present address:National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Dear Editor,Gynostemma pentaphyllum(Thunb.)makino,a perennial climbing vine in the Cucurbitaceae family,has been widely used in traditional medicine for over 600 years(Blumert and Liu,1999).It serves as a valuable natural source of over 200 dammaranetype saponins with notable bioactive properties,including anti-cancer,cardioprotective,hepatoprotective,neuroprotective,and anti-diabetic activities(Li et al.,2016;Nguyen et al.,2021).

关键词： protective Gynostemma saponins

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Toward a Greener Tomorrow Officials and business leaders call for better global climate governance

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Beijing Review 2024年第35期67卷 32-33页

作者： ma Miaomiao 不详

*** giant Apple *** to invest in China,the company's CEO Tim Cook said during the China Development Forum(CDF)in Beijing on march *** also noted how Chinese suppliers have contributed to the iPhone maker's carbon-neut... 详细信息

关键词： continue neutral Greene

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ECMpy 2.0:A Python package for automated construction and analysis of enzyme-constrained models

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Synthetic and Systems Biotechnology 2024年第3期9卷 494-502页

作者： Zhitao mao Jinhui Niu Jianxiao Zhao Yuanyuan Huang Ke Wu Liyuan Yun Jirun Guan Qianqian Yuan Xiaoping Liao Zhiwen Wang Hongwu ma Biodesign Center Key Laboratory of Engineering Biology for Low-carbon ManufacturingTianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308China National Center of Technology Innovation for Synthetic Biology Tianjin300308China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin300072China College of Biotechnology Tianjin University of Science and TechnologyTianjin300457China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhenChina Tianjin Agricultural College Tianjin300384China Haihe Laboratory of Synthetic Biology Tianjin300308China

Genome-scale metabolic models(GEMs)have been widely employed to predict microorganism ***,GEMs only consider stoichiometric constraints,leading to a linear increase in simulated growth and product yields as substrate uptake rates *** divergence from experimental measurements prompted the creation of enzyme-constrained models(ecModels)for various species,successfully enhancing chemical *** upon studies that allocate macromolecule resources,we developed a Python-based workflow(ECMpy)that constructs an enzyme-constrained *** involves directly imposing an enzyme amount constraint in GEM and accounting for protein subunit composition in ***,this procedure de-mands manual collection of enzyme kinetic parameter information and subunit composition details,making it rather *** this work,we’ve enhanced the ECMpy toolbox to version 2.0,broadening its scope to automatically generate ecGEMs for a wider array of *** 2.0 automates the retrieval of enzyme kinetic parameters and employs machine learning for predicting these parameters,which significantly enhances parameter ***,ECMpy 2.0 introduces common analytical and visualization features for ecModels,rendering computational results more user ***,ECMpy 2.0 seamlessly integrates three published algorithms that exploit ecModels to uncover potential targets for metabolic *** 2.0 is available at https://***/tibbdc/ECMpy or as a pip package(https://***/project/ECMpy/).

关键词： Enzyme-constrained model Python package Automated construction Multiple analysis functions

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Specific metabolic impairments indicate loss of sustained liver improvements in metabolic dysfunction-associated steatotic liver disease treatment

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 632-649,I0025-I0035页

作者： Ling Luo Junzhao Ye Shuyu Zhuo Bo ma Weiyi mai Xiaopei Cao Liuqin Liang Wei Wang Shiting Feng Zhi Dong Bihui Zhong Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Nutrition The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Gastroenterology The East Division of the First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Endocrinology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Rheumatology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Ultrasound The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Radiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Background:High liver fat content(LFC)induces increased risks of both hepatic and extrahepatic progression in metabolic dysfunction-associated steatotic liver disease(maSLD),while maintaining a significant decline in magnetic resonance imaging-based proton density fat fraction(MRI-PDFF)(≥30%decline relative to baseline)without worsening fibrosis results in improved histological severity and ***,the factors associated with the loss of sustained responses to treatment remain unclear,and we aim to identify ***:Consecutive treatment-naïve.maSLD patients between January 2015 and February 2022,with follow-up until April 2023,were included in this prospective cohort *** quantified by MRI-PDFF and liver stiffness measurements(LSM)determined by two-dimensional shear wave elastography(2D-SWE)were evaluated at weeks 0,24 and ***-PDFF response was defined as a≥30%relative decline in PDFF values,and LSM response was defined as a≥1 stage decline from ***:A total of 602 maSLD patients were *** the 303 patients with a 24-week MRI-PDFF response and complete follow-up of 48 weeks,the rate of loss of MRI-PDFF response was 29.4%,and multivariable logistic regression analyses showed that 24-week insulin resistance(IR),still regular exercise and caloric restriction after 24 weeks,and the relative decline in LFC were risk factors for loss of MRI-PDFF *** of LSM response at 48 weeks occurred in 15.9%of patients,and multivariable analysis confirmed 24-week serum total bile acid(TBA)levels and the relative decline in TBA from baseline as independent *** significant association was found at 48 weeks between loss of MRI-PDFF response and loss of LSM ***:maSLD patients with IR and high TBA levels are at higher risks of subsequent diminished sustained improvements of steatosis and fibrosis,respectively.

关键词： Metabolic dysfunction-associated steatotic liver disease(maSLD) loss of response magnetic resonance imaging-based proton density fat fraction response(MRI-PDFF response) liver stiffness measurements response(LSM response)

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Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

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Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury *** cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous *** proteins are thus candidate targets for spinal cord injury *** previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model ***,the specific mechanism and potential targets involved remain to be *** this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive *** found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal *** analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed *** staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord *** expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve ***,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB *** suggests that Sma d 3/Sox9 and maP K/Sox9 pathways may be involved in the effects of photobiomodulatio

关键词： chondroitin sulfate proteoglycans Erk maPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

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Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population:An integrated genomic and transcriptional analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 282-297页

作者： Yifei Wang Yidan ma Lei He Jun Du Xiaoguang Li Peng Jiao Xiaonan Wu Xiaomao Xu Wei Zhou Li Yang Jing Di Changbin Zhu Liming Xu Tianlin Sun Lin Li Dongge Liu Zheng Wang Department of Pathology Department of Minimally Invasive Tumor Therapies Center Department of Thoracic Surgery Department of Oncology Department of Respiratory and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Amoy Diagnostics Co. Ltd.Xiamen 361027China

Objective:The clinical significance of homologous recombination deficiency(HRD)in breast cancer,ovarian cancer,and prostate cancer has been established,but the value of HRD in non-small cell lung cancer(NSCLC)has not been fully *** study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical ***:A total of 355 treatment-naïve NSCLC patients were retrospectively *** status was assessed using the AmoyDx Genomic Scar Score(GSS),with a score of≥50 considered ***,transcriptomic,tumor microenvironmental characteristics and prognosis between HRD-positive and HRDnegative patients were ***:Of the patients,25.1%(89/355)were *** to HRD-negative patients,HRDpositive patients had more somatic pathogenic homologous recombination repair(HRR)mutations,higher tumor mutation burden(TMB)(Pver gene mutations(Pve NSCLC had more amplifications in PI3K pathway and cell cycle genes,MET and MYC in epidermal growth factor receptor(EGFR)/anaplastic lymphoma kinase(ALK)mutant NSCLC,and more PIK3CA and AURKA in EGFR/ALK wild-type ***-positive NSCLC displayed higher tumor proliferation and immunosuppression ***-negative NSCLC showed activated signatures of major histocompatibility complex(MHC)-II,interferon(IFN)-γand effector memory CD8+T ***-positive patients had a worse prognosis and shorter progressionfree survival(PFS)to targeted therapy(first-and third-generation EGFR-TKIs)(P=0.042).Additionally,HRDpositive,EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy ***:Unique genomic and transcriptional characteristics were found in HRD-positive *** prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive *** study highlights potential actionable alterations in HRD

关键词： Non-small cell lung cancer homologous recombination deficiency genetic alterations transcriptional analysis tumor microenvironment prognosis

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IEEE 802.15.4非信标使能模式在车联网中的性能评估

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机械设计与制造 2024年第5期399卷 113-118页

作者：周向马丽武汉交通职业学院湖北武汉430070 湖北工业大学工程技术学院湖北武汉430068

车联网是车与车之间广泛使用的网络技术,是车与车之间经济、高效的通讯渠道。IEEE 802.15.4由一层简单物理层和一层节能型介质访问控制层所组成,是当前所有通讯标准中车联网网络的最佳选择。基于此,这里选择适合车联网的IEEE 802.15.4... 详细信息

车联网是车与车之间广泛使用的网络技术,是车与车之间经济、高效的通讯渠道。IEEE 802.15.4由一层简单物理层和一层节能型介质访问控制层所组成,是当前所有通讯标准中车联网网络的最佳选择。基于此,这里选择适合车联网的IEEE 802.15.4非信标使能模式作为分析模型,将其应用于车联网中,具体包含非饱和通讯量模式和大型网络,并分别研究了IEEE 802.15.4适合车联网的非信标使能模式的性能,这对车辆积极调整广播速度,在车与车之间联网通讯中取得更高的成功具有一定的参考价值。

关键词：分析模型 IEEE 802.15.4 车联网(IoV) 车辆—基础设施(V2I)通讯车辆—车辆(V2V)通讯

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基于语义的多层式图书自动分类实证研究

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图书馆学研究 2024年第8期 62-76页

作者：高斌马菊红顾婷江苏科技大学图书馆

为解决图书馆图书分类中出现的人工分类的一致性与分类效率问题,将多层式图书自动分类系统应用于图书分类工作,同时导入语义概念作为改进分类效果的策略,从而提高分类质量。针对分类过程中出现的数据量或文献特征量可能不足的问题,利用W... 详细信息

为解决图书馆图书分类中出现的人工分类的一致性与分类效率问题,将多层式图书自动分类系统应用于图书分类工作,同时导入语义概念作为改进分类效果的策略,从而提高分类质量。针对分类过程中出现的数据量或文献特征量可能不足的问题,利用Word2vec工具保留目标词与上下文之间的语义关系特征,将带有语义的词汇扩展为特征词汇,借此改善分类效果。将图书馆畅想之星中文电子书中得到的数据,使用4种分类器(朴素贝叶斯、支持向量机、决策树、K近邻算法)实际应用于多层式图书自动分类系统。在语义方面,使用Word2vec训练语料,并建构类似索引典的同义词词典,再扩展特征词汇,最终以正确率评估分类效果。实验结果显示,多层式图书自动分类系统在图书馆分类方面具有很好的效果,其所提出的策略确实能够提升图书分类的准确度。

关键词：分类号多层式图书自动分类 Word2vec

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绿色设计视域下茶渣再生产品设计与应用实践

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包装工程 2024年第2期45卷 331-338,364页

作者：赵晨马云余明亮西安工程大学西安710048

目的探究基于绿色设计理念影响下废弃茶渣在再生和循环利用中的相关产品设计及其具象应用实践的体现。方法以绿色环保型产品设计构思作为出发点,运用绿色设计更新的5R原则作为理论支撑依据并总结归纳出20项用户设计评价指标。通过使用... 详细信息

目的探究基于绿色设计理念影响下废弃茶渣在再生和循环利用中的相关产品设计及其具象应用实践的体现。方法以绿色环保型产品设计构思作为出发点,运用绿色设计更新的5R原则作为理论支撑依据并总结归纳出20项用户设计评价指标。通过使用SPSS将绿色感知价值所对应的废弃茶渣、所用材料的特性,以及用户使用产品的期望型需求等相关的20项因子进行主成分分析,分别得到3项设计要点(绿色价值设计要点、情感价值设计要点、形象价值设计要点)以指导设计及应用实践。结论立足用户日常需求的绿色产品设计,通过3项设计要点的有效数据和具体分析,茶渣再生设计的系列产品主要围绕废弃茶渣和辅助环保型材料进行设计和实践应用。最终通过模糊综合评价方法对用户进行系列产品的反馈验证,从而使产品的较高实现性和可用性能可较好地达到用户满意度。

关键词：绿色设计理念茶渣再生设计 5R原则绿色感知价值因子分析产品应用实践

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