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COVID-19 and oral cancer:Critical viewpoint

World Journal of Clinical Oncology 2022年第8期13卷 725-728页

作者： Dharmarajan Gopalakrishnan sachin C sarode gargi s sarode Namrata sengupta Department of Periodontology Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Department of Oral Pathology and Microbiology Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia

The outbreak of severe acute respiratory syndrome coronavirus 2(sARs-CoV-2) has marked the beginning of a new pandemic named coronavirus disease 2019(COVID-19). The World Health Organization has announced it as a health emergency that is of international concern. The disease has been reported to cause respiratory illness, pneumonia and even hinder the immunity of an individual. Individuals with disturbed immune responses have been found to be quite susceptible to this viral infection. Oral cancer patients are also at high risk in this pandemic situation and might encounter severe detrimental outcomes. Angiotensin receptors, documented in studies as the path of entry of this virus, are highly expressed in the epithelial cells of oral mucosa, making the group of individuals with oral cancers even more vulnerable. Extracellular matrix metalloproteinase inducer is another potential target for sARs-CoV-2. An exhaustion of angiotensin converting enzyme 2 cell receptors leads to protumoral effects, whereas a downregulation of extracellular matrix metalloproteinase inducer leads to antitumoral effects. Thus, it causes a variation of the biological behavior of the tumor. This article focusses on the molecular mechanisms, effects and pathophysiology of COVID-19 in oral squamous cell carcinoma patients. The different molecular changes in oral squamous cell carcinoma in the background of COVID-19 will modify various environmental factors for this pathology and have an effect on the carcinogenesis process. Understanding the behavior of the tumor will help plan advanced treatment strategies for oral squamous cell carcinoma patients in the background of COVID-19.

关键词： COVID-19 sARs-CoV-2 Oral cancer Head and neck carcinomas Oral squamous cell carcinoma

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Electrochemical performance of a symmetric supercapacitor device designed using laser-induced multilayered graphene

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新型炭材料(中英文) 2024年

作者： gargi Dhiman Kavita Kumari Bon-Heun Koo Faheem Ahmed Nagih M.shaalan saurabh Dalela Parvez A.Alvi Ranjeet Kumar Brajpuriya shalendra Kumar Department of Physics School of Advanced EngineeringUPES Industrial Technology Research Institute Changwon National University Changwon Department of Applied sciences and Humanities Faculty of Engineering and Technology Jamia Millia Islamia Department of Physics College of Science King Faisal University Physics Department Faculty of Science Assiut University Department of Pure & Applied Physics University of Kota Department of Physical science

This study demonstrates a facile and economical approach for fabricating laser-induced graphene（LIG）, which results in improved electrochemical performance. Polyimide polymer was used as a starting material for LIG synthesis and irradiated under ambient conditions using a CO2laser. The prepared LIG samples were characterized by Raman spectroscopy and FTIR, which validated the formation of multilayered graphene containing sp2 hybridized C=C bonds. The FE-sEM revealed three-dimensional sheetlike structures, while HR-TEM images displayed lattice planes with an interplanar spacing of approximately 0.33 nm, corresponding to the（002） plane of graphene. The electrochemical performance of the as-prepared LIG samples demonstrated a remarkable areal specific capacitance（CA） of 51 mF cm-2(170 F g-1) at 1 mA cm-2(3.3 A g-1) in a three-electrode configuration with 1M KOH as the aqueous electrolyte. The LIG electrodes produced an energy density of ～3.5 μWh cm-2and a power density of ～350 μW cm-2,demonstrating significant energy storage capabilities. Additionally, the electrodes exhibited excellent cyclic stability, retaining 87%of their specific capacitance after 3 000 cycles at 1 mA/cm2. The symmetric supercapacitor fabricated with LIG electrodes and the tested 1M KOH electrolyte showed a specific capacitance of 23 mF cm-2and maintained excellent retention after 10,000 cycles,showing LIG's potential for supercapacitor applications.

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Diagnosis and Detection of Alzheimer’s Disease Using Learning Algorithm

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Big Data Mining and Analytics 2023年第4期6卷 504-512页

作者： gargi Pant shukla santosh Kumar saroj Kumar Pandey Rohit Agarwal Neeraj Varshney Ankit Kumar the Department of Management Doon Business SchoolDehradun 248001India. Jaipuria Institute of Management Jaipur 302033India Department of Computer Engineering and Apllications GLA UniversityMathura 281406India.

In Computer-Aided Detection(CAD)brain disease classification is a vital ***’s Disease(AD)and brain tumors are the primary reasons of *** studies of these diseases are carried out by Magnetic Resonance Imaging(MRI),Positron Emission Tomography(PET),and Computed Tomography(CT)scans which require expertise to understand the *** disease is the most prevalent in the elderly and can be fatal in its later *** result can be determined by calculating the mini-mental state exam score,following which the MRI scan of the brain is *** from that,various classification algorithms,such as machine learning and deep learning,are useful for diagnosing MRI ***,they do have some limitations in terms of *** paper proposes some insightful pre-processing methods that significantly improve the classification performance of these MRI ***,it reduced the time it took to train the model of various pre-existing learning algorithms.A dataset was obtained from Alzheimer’s Disease Neurological Initiative(ADNI)and converted from a 4D format to a 2D *** clipping,grayscale image conversion,and histogram equalization techniques were used to pre-process the *** pre-processing,we proposed three learning algorithms for AD classification,that is random forest,XGBoost,and Convolution Neural Networks(CNN).Results are computed on dataset and show that it outperformed with exiting work in terms of accuracy is 97.57%and sensitivity is 97.60%.

关键词： alzheimer’s disease deep learning random forest XGBoost

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Quality of life and oral potentially malignant disorders: Critical appraisal and prospects

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World Journal of Clinical Oncology 2018年第4期9卷 56-59页

作者： shailesh M Gondivkar Rahul R Bhowate Amol R Gadbail sachin C sarode shankargouda Patil Department of Oral Medicine and Radiology Government Dental College and Hospital Department of Oral Medicine and Radiology Sharad Pawar Dental College and Hospital Department of Dentistry Indira Gandhi Government Medical College and Hospital Department of Oral Pathology and Microbiology Dr. D.Y. Patil Dental College and Hospital Department of Maxillofacial surgery and Diagnostic sciences Division of Oral Pathology College of Dentistry Jazan University

Quality of life(QoL) is a vital and often required health outcome measure that is relevant to patient care. A healthy oral cavity enables person to perform daily activities without any limitations. However, any disturbance may result in impaired QoL. The oral health-remains an essential element of people's health and well-being. In recent years, the tradition of clinical practice and research has been changed by incorporating QoL assessment, as it helps in assessment of patients' needs and monitoring treatment responses. Oral potentially malignant disorders(OPMDs) are a group of chronic disorders including oral leukoplakia(OL), oral lichen planus and oral submucous fibrosis(OsF). It is evident that patients with OPMDs experience significant health-related symptoms, functional limitations and psycho-social impairment, compromising their Qo L. Moreover, the worsening of Qo L has been associated with advanced stages of OPMDs. Despite of increasing number of OPMD cases in recent decades, limited literature is available regarding QoL in this population. Although, there is higher prevalence of habit-related OPMDs, particularly OsF and OL in southern Asian countries, only a few studies have been performed in these populations. Moreover, these studies administered generic Qo L instruments, which offer less sensitivity to clinical changes. However, condition-specific instruments are more sensitive and allows better measurement of QoL. As the impacts of different conditions on OHRQoL may vary, the development and validation of a QoL instrument specific to each clinical entity of OPMDs is currently needed.

关键词： Quality of life Oral potentially malignant disorders Oral submucous fibrosis Oral lichen planus Oral leukoplakia

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Proteomic profiling of various human dental stem cells-a systematic review

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World Journal of stem Cells 2020年第10期12卷 1214-1236页

作者： Jagadish Hosmani Khalil Assiri Hussain Mohammed Almubarak Master Luqman Mannakandath Ahmed Al-Hakami shankargouda Patil Deepa Babji sachin sarode Anantharam Devaraj Harish C Chandramoorthy Diagnostic Dental sciences College of DentistryKing Khalid UniversityAbha 61471AsirSaudi Arabia Diagnostic Dental sciences King Khalid UniversityAbha 61471AsirSaudi Arabia Center for stem Cell Research and Department of Microbiology and Clinical Parasitology King Khalid UniversityAbha 61421AsirSaudi Arabia Maxillofacial surgery and Diagnostic sciences Division of oral PathologyJazan 45142JazanSaudi Arabia Department of Oral Pathology and Microbiology Maratha Mandal's NG Halgekar Institute of Dental Sciences and Research CentreBelgaun 590010KarnatakaIndia Department of Oral Pathology Y Patil Dental College and HospitalPune 411018MaharashtraIndia

BACKGROUND The proteomic signature or profile best describes the functional component of a cell during its routine metabolic and survival *** complexity in differentiation and maturation is observed in stem/progenitor *** role of functional proteins at the cellular level has long been attributed to anatomical niches,and stem cells do not deflect from this *** dental stem cells(hDsCs),on the whole,are a combination of mesenchymal and epithelial coordinates observed throughout craniofacial bones to *** To specify the proteomic profile and compare each type of hDsC with other mesenchymal stem cells(MsCs)of various ***,we analyzed the characteristics of the microenvironment and preconditioning changes associated with the proteomic profile of hDsCs and their influence on committed lineage *** Literature searches were performed in PubMed,EMBAsE,scopus,and Web of science databases,from January 1990 to December *** extra inquiry of the grey literature was completed on Google scholar,ProQuest,and *** MesH terms(PubMed)and keywords related to dental stem cells were used independently and in *** The initial search resulted in 134 *** the 134 full-texts assessed,96 articles were excluded and 38 articles that met the eligibility criteria were *** overall assessment of hDsCs and other MsCs suggests that differences in the proteomic profile can be due to stem cellular complexity acquired from varied tissue sources during embryonic ***,our comparison of the proteomic profile suffered inconsistencies due to the heterogeneity of various *** believe that the existence of a heterogeneous population of stem cells at a given niche determines the modalities of regeneration or tissue *** prominences to the differences present between various hDsCs have been reasoned *** systematic review on proteomic studies of various hDs

关键词： Apical papilla stem cells Dental follicle stem cells Dental pulp stem cells Periodontal ligament stem cells Proteomics

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HIV Diagnosis in Resource Constrained setting: How Good Is the Current Algorithm?

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World Journal of AIDs 2014年第1期4卷 45-51页

作者： Nayana Ingole Purva sarkate supriya Paranjpe Rahul sarode sameer shinde Preeti Mehta Department of Microbiology Seth G S Medical College and KEM Hospital Parel Mumbai India

Background: The conventional HIV testing algorithm in most of the developed countries consists of two tests: an HIV enzyme immunoassay capable of identifying HIV-1 and HIV-2 antibodies and a confirmatory HIV-1 Western blot or immunofluorescence assay. However, the current algorithm for HIV diagnosis in India uses three sequential antibody assays. There has always been doubt regarding the benefits of this algorithm. Objective: To determine the utility of the current diagnostic algorithm and to find out the proportion of indeterminate or discrepant results. Methods: Retrospective analysis of HIV antibody testing data was carried out over a period of five years after institutional ethics committee approval. The specimens positive with the screening test and negative with both the supplemental tests were labeled as discrepant. specimens positive with any of the two tests (screening and one of the supplemental tests) and negative with the remaining supplemental test were labeled as indeterminate. These indeterminate specimens were confirmed by immunoblotting. Results: A total of 141,296 samples were tested. Of these, 71 (0.05%) samples were indeterminate and 292 (0.21%) were discrepant. Western blot was done on 60 indeterminate samples of which 10 (16.67%) were positive for HIV 1 antibodies, 14 (23.33%) were negative for HIV antibodies and 36 (60%) had indeterminate result. Conclusion: In view of the low numbers of indeterminate and discrepant results, the current algorithm appears to be appropriate in our resource constrained setting. However, the algorithm for HIV testing should also include DNA PCR testing facility to resolve western blot indeterminate results.

关键词： HIV Indeterminate Discrepant Rapid Tests Western Blot Algorithm

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容易误诊?后循环缺血性卒中

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英国医学杂志中文版 2019年第5期22卷 298-302页

作者： gargi Banerjee sheldon P stone David J Werring 黄欣莹(译) 毛晨晖(校) stroke Research Centre Department of Brain Repair and RehabilitationUCL Institute of Neurology and the National Hospital for Neurology and NeurosurgeryLondon WC1B5EHUK Department of Medicine Royal Free CampusUniversity College London Medical Schooland University College HospitalLondonUK 北京协和医院神经科

63岁男性,既往有高血压,焦虑,伴有视觉先兆的偏头痛病史。因头痛5天急诊就诊(见“患者视角”)。头痛初性质同既往偏头痛,但程度逐渐加重,伴随间断复视、行走不稳、构音及吞咽困难。患者于急诊诊断偏头痛,予输液和对症止痛治疗。第二天,... 详细信息

63岁男性,既往有高血压,焦虑,伴有视觉先兆的偏头痛病史。因头痛5天急诊就诊(见“患者视角”)。头痛初性质同既往偏头痛,但程度逐渐加重,伴随间断复视、行走不稳、构音及吞咽困难。患者于急诊诊断偏头痛,予输液和对症止痛治疗。第二天,症状加重,体格检查提示垂直性复视,凝视可诱发眼震,右侧过指试验阳性,共济失调步态。

关键词：缺血性卒中后循环误诊急诊诊断偏头痛行走不稳吞咽困难止痛治疗

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古杜的幸运日

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英语画刊（初三版） 2009年第11期 1-3页

作者： gargi Pant

一天，加亚特在家门口捡到一个粉红色的信封，上面没有署名。加亚特很喜欢信封上的图案，于是把它放进了口袋里……

关键词：中学英语阅读教学阅读材料

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古杜的幸运日

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中学生英语 2021年第27期 22-27页

作者： gargi Pant 杨舟

阳光透过加亚特里的窗户照进来,撩开了她的眼皮。她打了个哈欠,伸了个懒腰,然后从床上爬起来——这是她以前做过无数次的事情。对加亚特里来说,今天和其他任何一天没什么两样。加亚特里·维尔玛是一个聪明的12岁女孩,她的眼睛闪闪发光,...

阳光透过加亚特里的窗户照进来,撩开了她的眼皮。她打了个哈欠,伸了个懒腰,然后从床上爬起来——这是她以前做过无数次的事情。对加亚特里来说,今天和其他任何一天没什么两样。加亚特里·维尔玛是一个聪明的12岁女孩,她的眼睛闪闪发光,笑容带着酒窝。她是当地一所学校八年级的学生,一直在向上帝祈祷能有一辆新的自行车。

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New Half tone Operators for High Data Compression in VideoConferencing

New Half tone Operators for High Data Compression in VideoCo...

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2012 International Conference on software and Computer Applications(ICsCA 2012)

作者： H.B.Kekre Tanuja K.sarode sanjay R.sange Pallavi Halarnkar senior Professor Department of Computer science MPSTMENMIMS University Professor Department of Computer science TSECBandraMumbai University Mumbai

Optimization of bandwidth is major challenge in networking field for transmission of data in application like video *** compress such a huge video data,combination of lossy half tone and lossless Run-Length-Encoding（RLE） technique is proposed so as to obtain low-bit rate video data *** tone is the binary image,in which long strings of 1’s and 0’s are present,on it RLE is *** experimental result shows the higher compression ratio（CR）,minimum Root Mean square Error（RMsE） and high Peak signal-to-Noise Ratio（PsNR） with acceptable image *** of the paper is that,this technique can be used for video *** video conferencing person’s face is the object and usually background is constant where RLE effectively gives higher CR for long string of *** sample images of different people captured by Nikon camera are used for *** images are bitmap（.BMP） 256 X 256 in *** same technique can be used for storage of movies,CCTV footage etc.

关键词： half toning Run-Length-Encoding Low-Bit rate video data compression

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