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Metal-Organic Frameworks Housing Active Molecules as bioinspired Catalysts

CCS Chemistry 2024年第6期6卷 1380-1402页

作者： Yin Zhang Peter e.VanNatta Junyu Ren Shengqian Ma Department of Chemistry University of North TexasDentonTexas 76201 Department of Chemical and biomolecular engineering National University of SingaporeSingapore 117585

Optimization of activity,selectivity,and stability of catalysts for practical application is a long-soughtafter *** progress in the advancement of rational catalyst design routinely takes queues from ***,enzymes are renowned for their high efficiency and selectivity in diverse and significant reactions under mild *** the well-known merits of enzymes,they often remain unsuitable for industrial catalysis due to issues,including limited environment(solvent/temperature/pH)compatibility,considerable structural uncertainty,and highly specific reaction *** the context of bioinspired catalysis design,the development of synthetic heterogeneous catalyst analogs,which may not only mimic enzymes to reproduce or even surpass their performance but also bypass their intrinsic limitations,is thus,desirable and has been extensively studied in the context of porous *** metal-organic framework(MOF)is a superior candidate for porous materials towards this goal,thanks to facile and modular preparation,explicit crystalline composition/structure,tunable pore size/environment,and excellent *** introduction of active molecular species such as bioactive molecules(e.g.,proteins,enzymes,peptides,amino acids,porphyrins)and chemically active molecules(e.g.,frustrated Lewis pairs)into metal-organic frameworks(MOFs)via pore encapsulation,chemical postmodification,or bottom-up construction has been shown to facilitate the cooperative enhancement of catalysis through the enforcement of proximity,enhancement of control/activity,and even inducement of unexpected *** this minireview,we sought to summarize the last 5 years of fruitful progress,exploiting MOFs housing active molecules for substantial catalysis applications,including asymmetric reactions,CO_(2)conversion(reduction,cycloaddition),biocatalytic H_(2)O_(2)/dye degradation,and so on,and discuss challenges and opportunities in the prospective exploration of these system

关键词： metal-organic framework bioinspired catalyst active molecular species

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Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta Pharmaceutica Sinica b 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian breidenbach Tobias Claff Alexandra Hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike bartz Norbert Sträter Christa e.Müller Michael Gütschow Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(M^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active M^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of M^(pro),including a prototypical,internally quenched Dabcyl-eDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the M^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 Main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

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Taxonomy,phylogeny,molecular dating and ancestral state reconstruction of Xylariomycetidae(Sordariomycetes)

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Fungal Diversity 2022年第1期112卷 1-88页

作者： Milan C.Samarakoon Kevin D.Hyde Sajeewa S.N.Maharachchikumbura Marc Stadler e.b.gareth jones Itthayakorn Promputtha Nakarin Suwannarach erio Camporesi Timur S.bulgakov Jian-Kui Liu School of Life Science and Technology Center for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Research Center in bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Institute of Microbiology Technische Universität BraunschweigSpielmannstraße 738106 BrunswickGermany Department of botany and Microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand A.M.b.Gruppo Micologico Forlivese"Antonio Cicognani"Via Roma 18ForliItaly Department of Plant Protection Federal Research Centre the Subtropical Scientific Centre of the Russian Academy of SciencesYana Fabritsiusa Street 2/28SochiKrasnodar RegionRussia 354002

Xylariomycetidae(Ascomycota)is a highly diversified group with variable stromatic *** research focused on inconspicuous stromatic xylarialean taxa from China,Italy,Russia,Thailand and the United *** morpho-logical descriptions,illustrations and combined ITS-LSU-rpb2-tub2-tef1 phylogenies revealed 39 taxa from our collections belonging to Amphisphaeriales and Xylariales.A new family(Appendicosporaceae),five new genera(Magnostiolata,Mela-nostictus,Neoamphisphaeria,Nigropunctata and Paravamsapriya),27 new species(Acrocordiella photiniicola,Allocryp-tovalsa sichuanensis,Amphisphaeria parvispora,Anthostomella lamiacearum,Apiospora guiyangensis,***,biscogniauxia magna,eutypa camelliae,Helicogermslita clypeata,Hypocopra zeae,Magnostiolata mucida,Melanostictus longiostiolatus,***,Nemania longipedicellata,***,***,***,Neoamphispha-eria hyalinospora,Neoanthostomella bambusicola,Nigropunctata bambusicola,***,***,Occul-titheca rosae,Paravamsapriya ostiolata,Peroneutypa leucaenae,Seiridium italicum and Vamsapriya mucosa)and seven new host/geographical records are introduced and *** time estimates indicate that Delonicicolales diverged from Amphisphaeriales+Xylariales at 161(123-197)*** and Xylariales diverged 154(117-190)MYA with a crown age of 127(92-165)MYA and 147(111-184)MYA,***(Amphisphaeriales)has a stem age of 89(65-117)*** character state reconstruction indicates that astromatic,clypeate ascomata with aseptate,hyaline ascospores that lack germ slits may probably be ancestral Xylariomycetidae having plant-fungal endo-phytic *** Amphisphaeriales remained mostly astromatic with common septate,hyaline *** variations may have developed mostly during the Cretaceous *** ascospores are common in Xylariales,but they first appeared in Amphisphaeriaceae,Melogrammataceae and Sp

关键词： 33 new taxa Amphisphaeriales Appendicosporaceae evolution Stromata Xylariales

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Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey

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International Journal of Oral Science 2013年第3期5卷 121-129页

作者： Kyle.b.jones Ophir D Klein Program in Craniofacial and Mesenchymal biology University of California Division of Medical Genetics Department of PediatricsUniversity of California Center for Craniofacial Anomalies Department of Orofacial Sciences University of California

The identification and characterization of stem cells is a major focus of developmental biology and regenerative *** advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over *** combined with advanced mathematical and statistical methods,stem cell division dynamics can be studied in new and exciting *** advances in a number of tissues,relatively little attention has been paid to stem cells in the oral *** review will focus on current knowledge about adult oral epithelial stem cells,paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease.

关键词： cancer stem cell invariant asymmetry neutral drift oral epithelial stem cell population asymmetry

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The glassy solid as a statistical ensemble of crystalline microstates

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npj Computational Materials 2020年第1期6卷 1199-1204页

作者： eric b.jones Vladan Stevanović Colorado School of Mines GoldenCO 80401USA National Renewable energy Laboratory GoldenCO 80401USA

We present an alternative and,for the purpose of non-crystalline materials design,a more suitable description of covalent and ionic glassy solids as statistical ensembles of crystalline local minima on the potential energy *** by the concept of partially broken ergodicity,we analytically formulate the set of approximations under which the structural features of ergodic systems such as the radial distribution function(RDF)and powder X-ray diffraction(XRD)intensity can be rigorously expressed as statistical ensemble averages over different local *** is carried out by evaluating these ensemble averages for elemental Si and SiO_(2) over the local minima obtained through the first-principles random structure sampling that we performed using relatively small simulation cells,thereby restricting the sampling to a set of predominantly crystalline *** comparison with XRD and RDF from experiments(amorphous silicon)and molecular dynamics simulations(glassy SiO_(2))shows excellent agreement,thus supporting the ensemble picture of glasses and opening the door to fully predictive description without the need for experimental inputs.

关键词： ensemble crystalline glasses

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Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2024年第4期25卷 324-340页

作者： Natalia V.DeMeNTIeVA Yuri S.SHCHeRbAKOV Olga I.STANISHeVSKAYA Anatoly b.VAKHRAMeeV Tatiana A.LARKINA Artem P.DYSIN Olga A.NIKOLAeVA Anna e.RYAbOVA Anastasiia I.AZOVTSeVA Olga V.MITROFANOVA Grigoriy K.PeGLIVANYAN Natalia R.ReINbACH Darren K.GRIFFIN Michael N.ROMANOV Russian Research Institute of Farm Animal Genetics and breeding-branch of the L.K.ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of biosciences University of KentCanterburyCT27NJUK L.K.ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURe-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history

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Ca-based materials derived from calcined cigarette butts for CO_(2)capture and thermochemical energy storage

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Journal of environmental Sciences 2024年第6期140卷 230-241页

作者： Nabil Amghar Virginia Moreno Pedro e.Sánchez-Jiménez Antonio Perejón Luis A.Pérez-Maqueda Instituto de Ciencia de Materiales de Sevilla C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain Instituto de Tecnología de Materiales(ITM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain Departamento de Química Inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

Cigarette butts(Cbs)are one of the most common types of litter in the *** to the toxic substances they contain,the waste generated poses a harmful risk to the environment,and therefore there is an urgent need for alternative solutions to landfill ***,this work presents a possible revalorization of this waste material,which implies interesting environmental *** were used as sacrificial templates for the preparation of CaO-based materials by impregnation with calcium and magnesium nitrates followed by flaming *** materials presented enhanced porosity for their use in the Calcium Looping process applied either to thermochemical energy storage or CO_(2)capture *** influence of the concentration of Ca and Mg in the impregnating solutions on the multicycle reactivity of the samples was *** improved multicycle performance was obtained in terms of conversion for both applications.

关键词： Cigarette butts Calcium-Looping CO_(2)Capture Thermochemical energy storage

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An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome

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Chinese Journal of Natural Medicines 2024年第3期22卷 249-264页

作者： ZHOU Jiangtao WANG Jun WANG Jiajing LI Deyun HOU Jing LI Jiankuan bAI Yun’e GAO Jianping School of Pharmaceutical Science Shanxi Medical UniversityJinzhong 030600China

Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and *** efficacy of CP-A in treating ulcerative colitis(UC)is,however,not *** study employed an in vitro lipopolysaccharide(LPS)-induced colonic epithelial cell model(NCM460)and an in vivo dextran sulfate sodium(DSS)-induced colitis mouse model to explore CP-A’s protective effects against experimental colitis and its underlying *** monitored the clinical symptoms in mice using various parameters:body weight,disease activity index(DAI),colon length,spleen weight,and histopathological ***,molecular markers were assessed through enzyme-linked immunosorbent assay(eLISA),quantitative real-time polymerase chain reaction(qRT-PCR),immunofluorescence(IF),immunohistochemistry(IHC),and Western blotting *** showed that CP-A significantly reduced reactive oxygen species(ROS),tumor necrosis factor-alpha(TNF-α),and interleukins(IL-6,IL-1β,IL-18)in LPS-induced cells while increasing IL-4 and IL-10 levels and enhancing the expression of Claudin-1,ZO-1,and occludin proteins in NCM460 ***,in vivo findings revealed that CPA administration markedly improved DAI,reduced colon shortening,and decreased the production of myeloperoxidase(MPO),malondialdehyde(MDA),ROS,IL-1β,IL-18,and NOD-like receptor protein 3(NLRP3)inflammasome-associated genes/proteins in UC ***-A treatment also elevated glutathione(GSH)and superoxide dismutase(SOD)levels,stimulated autophagy(LC3b,P62,beclin-1,and ATG5),and reinforced Claudin-1 and ZO-1 expression,thereby aiding in intestinal epithelial barrier repair in colitis ***,the inhibition of autophagy via chloroquine(CQ)diminished CP-A’s protective impact against colitis in *** findings elucidate that CP-A’s therapeutic effect on experimental colitis possibly involves mitigating intestinal inflammation through autophagymediated N

关键词： Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome Autophagy

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Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： bryce David beutler Alastair e Moody Jerry Mathew Thomas benjamin Phillip Sugar Mark b Ulanja Daniel Antwi-Amoabeng Lucas Anthony Tsikitas Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-D-aspartate receptor-associated encephalitis(NMDARe)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMDARe has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-D-aspartate receptor-associated encephalitis Autoimmune encephalitis encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

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Ancylostoma ceylanicum and other zoonotic canine hookworms:neglected public and animal health risks in the Asia-Pacific region

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Animal Diseases 2024年第1期4卷 59-74页

作者： Jan Clyden b.Tenorio lan Kim b.Tabios Tawin Inpankaew Adrian P.Ybanez Saruda Tiwananthagorn Sirikachorn Tangkawattana Sutas Suttiprapa Tropical Medicine Graduate Program Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Tropical Medicine Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand WHO Collaborating Center for Research and Control of Opisthorchiasis(Southeast Asian Liver Fluke Disease) Tropical Disease Research CenterKhon Kaen UniversityKhon Kaen 40002Thailand Department of Veterinary Paraclinical Sciences College of Veterinary MedicineUniversity of Southern MindanaoKabacan9407 CotabatoPhilippines Institute of biology College of ScienceUniversity of the Philippines DilimanManila 1101Philippines Department of Parasitology Faculty of Veterinary MedicineKasetsart UniversityBangkok 10900Thailand College of Veterinary Medicine at barili Campus and Center for Vector-borne and Protozoan Diseases at Main Campus Cebu Technological UniversityCebu City 6000Philippines Department of Veterinary biosciences and Public Health Faculty of Veterinary MedicineChiang Mai UniversityChiang Mai 50100Thailand Research Center for Veterinary biosciences and Veterinary Public Health Chiang Mai UniversityChiang Mai 50100Thailand Faculty of Veterinary Medicine Khon Kaen University.Khon Kaen 40002Thailand

Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 milion cases globally and approximately four million disability-adjusted life years lost *** than one-fth of these cases are attrib-uted to Ancylostoma ceylanicum,an emerging zoonotic health issue in the Asia-Pacific *** review presents key research gaps regarding the epidemiology,diagnosis,control,prevention and elimination of *** and other canine zoonotic hookworms as neglected health *** is the second most prevalent human hook-worm in the region;it is the most common hookworm among dogs and cats-reservoirs of zoonotic *** population genetic and phylogenetic analyses revealed that *** has three possible transmis-sion dynamics:zoonotic,animal-only,and human-only *** actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques(e.g.,Kato-Katz thick smear and floatation techniques)that have reduced diagnostic performance and do not allow accurate species identifica-tion in helminth *** emergence of benzimidazole resistance in soil-transmitted helminths(STHs),includ-ing hookworms,is a concern due to the protracted implementation of mass drug administration(MDA).Resistance is conferred by single nucleotide polymorphisms(SNPs)that occur in theβ-tubulin isotype 1 *** mutations have been reported in drug-resistant *** but have not been found in *** in the *** remains understudied in the Asia-Pacific *** zoonotic nature of the parasite warrants investigation of its occur-rence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic *** detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly *** the high level of hookworm endemicity in the region

关键词： Soil-transmitted helminths Neglected tropical diseases Mass drug administration Deworming Veterinary public health

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