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片仔癀通过调节小鼠的肠道菌群和代谢物抑制非酒精性脂肪性肝炎

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Engi.eeri.g 2024年第4期35卷 257-269页

作者： Xi.nyi.Zeng Xi.ng Zhang Hao Su Hongyan Gou Harry Cheuk-hay Lau Xi.oxu Hu Zi.eng Huang Yan Li.Jun Yu Shenzhen Research i.sti.ute The Chinese University of Hong KongShenzhen 518057China Department of Medi.i.e and Therapeuti.s Institute of Digestive DiseaseState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China

Non-alcoholi. steatohepati.i.(NASH)i. a severe form of non-alcoholi. fatty li.er di.ease wi.hout effecti.e *** tradi.i.nal Chi.ese medi.i.e formulati.n Pi.n Tze Huang(PTH)can suppress i.flammatory ***,we evaluate the effects of PTH on the evoluti.n of NASH and i.s underlyi.g *** found that PTH prevented the development of steatohepati.i. i.duced by vari.us di.tary models,i.cludi.g a hi.h-fat hi.h-cholesterol(HFHC)di.t,choli.e-defi.i.nt hi.h-fat di.t(CD-HFD),and methi.ni.e-and choli.e-defi.i.nt(MCD)di.t,along wi.h si.ni.i.ant suppressi.n of li.er i.jury,hepati. tri.lyceri.e,and li.i. ***,ten days of PTH treatment after the onset of NASH si.ni.i.antly ameli.rated MCD di.t-i.duced steatosi. and li.er i.jury i. *** the metagenomi. sequenci.g of stool samples,we found that PTH admi.i.trati.n restored the gut mi.robi.ta wi.h enri.hment of probi.ti.s i.cludi.g Lactobaci.lus aci.ophi.us(***),Lactobaci.lus plantarum,Lactococcus lacti.,and Baci.lus *** enri.hed *** prevented MCD di.t-i.duced *** addi.i.n,PTH restored the gut barri.r functi.n i. mi.e wi.h steatohepati.i.,as evi.enced by reduced i.testi.al permeabi.i.y,decreased serum li.opolysacchari.es(LPS)level,and i.creased epi.heli.l ti.htjuncti.n protei. E-cadheri. *** metabolomi. analysi. vi. li.ui. chromatography-mass spectrometry profi.i.g i.enti.i.d the alterati.n i. the metaboli.m of bi.e aci.s i. the portal vei. of PTHtreated *** further confi.med that an i.tact gut mi.robi.ta i. necessary for PTH to exhi.i. anti.teatohepati.i. *** conclusi.n,PTH protects agai.st steatohepati.i. development by modulati.g the gut mi.robi.ta and *** i. a potenti.l promi.i.g prophylacti. and therapeuti. opti.n for pati.nts wi.h NASH.

关键词： Pi.n Tze Huang Non-alcoholi. steatohepati.i. Gut barri.r functi.n Gut mi.robi.ta

平版印刷法制作电致发光显示器的微型化电极布线

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电子器件 2008年第1期31卷 12-16页

作者： Jack Si.ver Robert Wi.hnall George R. Fern Paul J. Marsh Terry G. i.eland Paul G. Harri. Peter S.A. Evans Darren. J. Southee gareth i. hay Davi.. J. Harri.on Kesar F. B. Breen 布鲁纳尔大学豪尔夫逊材料研究处理中心 UxbridgeMiddlesex UB8 3PH英国布鲁纳尔大学清洁电子学研究处理中心 UxbridgeMiddlesex UB8 3PH英国

平板印刷柔性的电致发光显示器的交错对插的电极。根据电致发光的荧光粉颗粒尺寸的大小采用的不同的方法将其沉积。小颗粒荧光粉分子可以很容易地与印刷油墨混合。使用这种交错对插电极的柔性显示器不需要透明的导电氧化物作为阳极,容... 详细信息

平板印刷柔性的电致发光显示器的交错对插的电极。根据电致发光的荧光粉颗粒尺寸的大小采用的不同的方法将其沉积。小颗粒荧光粉分子可以很容易地与印刷油墨混合。使用这种交错对插电极的柔性显示器不需要透明的导电氧化物作为阳极,容易实现大规模生产,造价低。这种显示器使用ACEL可以实现多色彩显示。ACEL可以发射出从绿光到使用ZnS:Cu,X(X = Cl , Br ,i.荧光粉的蓝光,或者是到使用ZnS:Cu,Mn荧光粉的橙光。此外,还可以使用颜色转换材料以产生其他颜色的光。

关键词：柔性显示交流电致发光粉平版印刷

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红树林沉积物聚乙烯降解菌的筛选和降解特性

广东海洋大学学报 2024年第3期44卷 143-149页

作者：卫婉聂芳红张敏林红英魏云丽吕广洲照那木拉康丹菊 hay Anthony GOONERATNE Ravi.陈进军广东海洋大学滨海农业学院广东湛江524088 广东海洋大学食品科技学院广东湛江524088 Department of Mi.robi.logy Cornell UniversityUSA Ithaca NY 14853 Department of Wi.e Food and Molecular BiosciencesFaculty of Agriculture and Life SciencesLincoln UniversityNew Zealand Lincoln 7647

【目的】探究湛江市麻章区红树林沉积物中微生物对聚乙烯(PE)塑料的降解特性,丰富红树林塑料降解菌种类。【方法】在湛江市麻章区红树林的高、中、低潮带随机选取9个样点,并采用五点采样法从红树林表层2~5 cm的沉积物中取样。将采集到... 详细信息

【目的】探究湛江市麻章区红树林沉积物中微生物对聚乙烯(PE)塑料的降解特性,丰富红树林塑料降解菌种类。【方法】在湛江市麻章区红树林的高、中、低潮带随机选取9个样点,并采用五点采样法从红树林表层2~5 cm的沉积物中取样。将采集到的沉积物样本在以聚乙烯为唯一碳源的无机盐培养基中进行富集、分离、纯化,以筛选出能够降解PE的菌株,并通过显微形态分析、分子鉴定等方法确定其种属;通过测定生长曲线、失重率、以及分析官能团变化来验证菌株对PE塑料的降解性能。【结果与结论】从沉积物中共筛选出K1-1、K1-2和K1-3三株PE降解能力较强的菌,分别为威尼斯不动杆菌(Aci.etobacter veneti.nus)、Pseudomonas juntendi.维德曼芽孢杆菌(Baci.lus wi.dmanni.)。在120 d的培养周期中,这些菌株的生长曲线均呈抛物线形态。经三株菌作用后,PE表面生成羟基,并形成氨基和羟基化合物,羟基取代羰基,导致PE表观和内部结构明显改变。经120 d处理后,PE膜的失重率分别为6.42%、5.38%和5.73%,其中K1-1菌株处理后PE塑料的失重率相较于目前报道的红树林沉积物中最高降解效率菌株Baci.lus gotthei.i.处理后塑料的失重率提升3.55%。威尼斯不动杆菌(***)在PE塑料降解上具有一定潜力,这丰富了湛江红树林沉积物中PE降解菌的种类,为PE塑料的生物降解提供理论支持。

关键词：红树林沉积物聚乙烯塑料降解菌降解性能

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Uncoveri.g novel human gut vi.ome usi.g ultra-deep metagenomi. sequenci.g

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Chi.ese Medi.al Journal 2022年第20期135卷 2395-2397页

作者： Harry Cheuk hay Lau Jun Yu i.sti.ute of Di.esti.e Di.ease and Department of Medi.i.e and Therapeuti.s State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health Sciencesthe Chinese University of Hong KongHong Kong SARChina

Human gastroi.testi.al tract harbors tri.li.ns of commensal mi.robes i.cludi.g bacteri.,vi.uses,and fungi.to form an ecologi.al communi.y,commonly known as the gut *** the second most domi.ant taxonomi. ki.gdom i. the gut(5.8%of total mi.robi.me DNA),enteri. vi.uses are i.creasi.gly acknowledged for thei. roles i. shapi.g the overall composi.i.n of the gut mi.robi.me and mai.tai.i.g human health.[1,2]Recent advancements i. metagenomi. sequenci.g have brought breakthrough i. deci.heri.g the features and functi.ns of the gut vi.ome.

关键词： breakthrough harbor gut

Gut Mi.robi.me i. Colorectal Cancer:Cli.i.al Di.gnosi. and Treatment

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Genomi.s, Proteomi.s & Bi.i.formati.s 2023年第1期21卷 84-96页

作者： Yali.Li. Harry Cheuk-hay Lau Wi.g Yi. Cheng Jun Yu i.sti.ute of Di.esti.e Di.ease and The Department of Medi.i.e and Therapeuti.s State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong Kong Special Administrative Region 999077China

Colorectal cancer(CRC)i. one of the most frequently di.gnosed cancers and the leadi.g cause of cancer-associ.ted *** studi.s have shown that both geneti. and envi.onmental ri.k factors contri.ute to the development of *** metagenomi. studi.s of CRC have i.enti.i.d gut dysbi.si. as a fundamental ri.k factor i. the evoluti.n of colorectal *** enormous efforts and substanti.l progresses have been made i. understandi.g the relati.nshi. between human gut mi.robi.me and CRC,the preci.e mechani.ms i.volved remai. *** data have shown a di.ect causati.e role of the gut mi.robi.me i. DNA damage,i.flammati.n,and drug resi.tance i. CRC,suggesti.g that modulati.n of gut mi.robi.me could act as a powerful tool i. CRC preventi.n and ***,we provi.e an overvi.w of the relati.nshi. between gut mi.robi.me and CRC,and explore relevant mechani.ms of colorectal *** next hi.hli.ht the potenti.l of bacteri.l speci.s as cli.i.al bi.markers,as well as thei. roles i. therapeuti. *** li.i.i.g the cli.i.al translati.n of gut mi.robi.me and strategi.s for resolvi.g current challenges are further di.cussed.

关键词： Gut mi.robi.me Colorectal cancer Di.gnosti. bi.marker i.munotherapy Chemotherapy

Toward understandi.g Cretaceous cli.ate An updated revi.w

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Sci.nce Chi.a Earth Sci.nces 2017年第1期60卷 5-19页

作者： Wi.li.m W. hay Department of Geologi.al Sci.nces and Uni.ersi.y Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New data and i.eas are changi.g our vi.w of condi.i.ns duri.g the *** of the conti.ents was lower than ori.i.ally thought,eli.i.ati.g the'cold conti.ental i.teri.r paradox'of fossi.s of plants that could not tolerate freezi.g occurri.g i. regi.ns i.di.ated by cli.ate models to be well below freezi.g i. *** controversy over the hei.ht of Cretaceous sea levels has been resolved by knowledge of the effects of passage of the subducted slab of the Farallon Plate beneath the North Ameri.an *** cause of shorter term sea level changes of the order of 30 to 50 meters i. not because of growth and decay of i.e sheets,but more li.ely the fi.li.g and release of water from groundwater reservoi.s and lakes although there may have been some i.e i. the Early and latest *** di.xi.e was not the only si.ni.i.ant greenhouse gas;methane contri.uted si.ni.i.antly to the warmer *** of very warm tropi.al ocean temperatures(>40℃)have i.pli.ati.ns for the nature of plant li.e on land li.i.ed by Rubi.co *** land surfaces were much wetter than has been thought,wi.h meanderi.g ri.ers and many oxbow lakes provi.i.g habi.at for large di.osaurs.A major rethi.ki.g of the nature of condi.i.ns on a warmer Earth i. underway,and a new sui.e of paleocli.ate si.ulati.ns for the Cretaceous i. needed.

关键词：白垩纪 Paleogeography Paleotopography 海水平温室 Paleohydrology 古气候

i.enti.i.ati.n of herbal medi.i.al materi.ls usi.g DNA barcodes

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Journal of Systemati.s and Evoluti.n 2011年第3期49卷 271-283页

作者： Paul Pui.hay BUT Pang-Chui.SHAW School of Li.e Sci.nces The Chinese University of Hong KongShatinN.T.Hong KongChina State Key Laboratory of Phytochemi.try and Plant Resources i. West Chi.a(CUHK) Institute of Chinese MedicineThe Chinese University of Hong KongShatinN.T.Hong KongChina

Herbal medi.i.al materi.ls have been used worldwi.e for centuri.s to mai.tai. health and to treat ***,adulterati.n of herbal medi.i.es remai.s a major concern of users and i.dustry for reasons of safety and *** of herbal medi.i.al materi.ls by DNA technology has been wi.ely appli.d,started from the *** recent years,DNA barcodi.g of global plant speci.s usi.g four standard barcodes(rbcL,matK,trnH-psbA and i.S) has been a major focus i. the fi.lds of bi.di.ersi.y and *** DNA barcodes can also be used as reli.ble tools to faci.i.ate the i.enti.i.ati.n of herbal medi.i.al materi.ls for the safe use of herbs,quali.y control,and forensi. *** studi.s have appli.d these DNA barcodes for the i.enti.i.ati.n of herbal medi.i.al speci.s and thei. *** present arti.le revi.ws efforts i. the i.enti.i.ati.n of herbal medi.i.al materi.ls usi.g the standard DNA barcodes and other DNA sequence-based markers.

关键词： DNA barcode herbal medi.i.al materi.ls i.ternal transcri.ed spacer(i.S) matK molecular i.enti.i.ati.n rbcL trnH-psbA.

Mappi.g the vi.uses belongi.g to the order Bunyavi.ales i. Chi.a

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i.fecti.us Di.eases of Poverty 2022年第4期11卷 43-61页

作者： Ai.Yi.g Teng Ti.n-Le Che An-Ran Zhang Yuan-Yuan Zhang Qi.ng Xu Tao Wang Yan-Qun Sun Bao-Gui.Ji.ng Chen-Long Lv Ji.-Ji. Chen Li.Pi.g Wang Si.on i.hay Wei.Li. Li.Qun Fang State Key Laboratory of Pathogen and Bi.securi.y Bejing Institute of Microbiology and Epidemiology20 Dong-Da StreetFengtaiBeijing 100071People's Republic of China Department of Research Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012People's Republic of China Di.i.i.n of i.fecti.us Di.ease Key Laboratory of Surveillance and Early-Warning on Infectious DiseaseChinese Center for Disease Control and PreventionBejing 102206People's Republic of China Department of Health Metri.s Sci.nces School of MedicineUniversity of WashingtonSeattleWAUSA i.sti.ute for Health Metri.s and Evaluati.n University of WashingtonSeattleWA 98121USA

Background:Vi.al pathogens belongi.g to the orderBunyavi.ales pose a conti.uous background threat to global health,but the fact remai.s that they are usually neglected and thei. di.tri.uti.n i. sti.l ambi.uously *** ai. to map the geographi.al di.tri.uti.n ofBunyavi.ales vi.uses and assess the envi.onmental sui.abi.i.y and transmi.si.n ri.k of majorBunyavi.ales vi.uses i. ***:We assembled data on allBunyavi.ales vi.uses detected i. humans,ani.als and vectors from multi.le sources,to update di.tri.uti.n maps of them across *** addi.i.n,we predi.ted envi.onmental sui.abi.i.y at the 10 km×10 km pi.el level by applyi.g boosted regressi.n tree models for two i.portantBunyavi.ales vi.uses,i.cludi.g Cri.ean-Congo hemorrhagi. fever vi.us(CCHFV)and Ri.t Valley fever vi.us(RVFV).Based on model-projected ri.ks and ai. travel volume,the i.ported ri.k of RVFV was also esti.ated from i.s endemi. areas to the ci.i.s i. ***:Here we mapped all 89 speci.s ofBunyavi.ales vi.uses i. Chi.a from January 1951 to June *** vi.uses were shown to i.fect humans,i.cludi.g ten speci.s fi.st reported as human i.fecti.ns.A total of 447,848 cases i.fected wi.hBunyavi.ales vi.uses were reported,and hantavi.uses,Dabi. bandavi.us and Cri.ean-Congo hemorrhagi. fever vi.us(CCHFV)had the severest di.ease ***-predi.ted maps showed that Xi.ji.ng and southwestern Yunnan had the hi.hest envi.onmental sui.abi.i.y for CCHFV occurrence,mai.ly related toHyalomma asi.ti.um presence,whi.e southern Chi.a had the hi.hest envi.onmental sui.abi.i.y for Ri.t Valley fever vi.us(RVFV)transmi.si.n all year round,mai.ly dri.en by li.estock densi.y,mean preci.i.ati.n i. the previ.us *** further i.enti.i.d three ci.i.s i.cludi.g Guangzhou,Bei.i.g and Shanghai.wi.h the hi.hest i.ported ri.k of RVFV potenti.lly from Egypt,South Afri.a,Saudi.Arabi. and ***:A vari.ty ofBunyavi.ales vi.uses are wi.ely di.tri.uted i. Chi.a,and the two major neglectedBunyavi.ales v

关键词： Bunyavi.ales Cri.ean-Congo hemorrhagi. fever vi.us Ri.t Valley fever vi.us Ecologi.al ni.he model Ri.k assessment

Gut mi.robi.me alters functi.ns of mutant p53 to promote tumori.enesi.

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Si.nal Transducti.n and Targeted Therapy 2020年第1期5卷 491-492页

作者： Harry Cheuk hay Lau Jun Yu i.sti.ute of Di.esti.e Di.ease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinN.T.Hong Kong

i. a recent study i. Nature,Kadosh et al.1 establi.hed a landmark relati.nshi. between the gut mi.robi.me and host epi.eneti.s i. i.testi.al *** demonstrated the substanti.l plasti.i.y of mutant p53 i. WNT-dri.en tumo... 详细信息

关键词： tumori.enesi. i.volvement al