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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.j.r unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

16层多探头CT评估冠状动脉狭窄程度的准确性

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 5-5页

作者： garcia m.j. Lessick j. Hoffmann m.H.K. 任付先 Cleveland Clinic Foundation 9500 Euclid Ave Cleveland OH 44195 United StatesDr

背景:多探头CT(mDCT)已被推荐作为评估冠状动脉解剖结构的无创性方法。目的:在多中心研究中确定采用16层CT基于独特的定量分析方法检测阻塞性冠状动脉疾病的诊断准确度。设计、机构和患者:自11个参与地点前瞻性纳入2004年6月至2005年3... 详细信息

背景:多探头CT(mDCT)已被推荐作为评估冠状动脉解剖结构的无创性方法。目的:在多中心研究中确定采用16层CT基于独特的定量分析方法检测阻塞性冠状动脉疾病的诊断准确度。设计、机构和患者:自11个参与地点前瞻性纳入2004年6月至2005年3月间临床转诊拟行非急诊冠状动脉造影的238例患者。

关键词：冠状动脉解剖 CT 诊断准确度无创性方法阴性预测值血管造影管腔直径冠状动脉造影阳性预测值

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.j.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo muñoz Rogelio garcia Cisneros maria jose garcia Larrosa maria del mar Callejon Gil Ignacio garcia Delgado maria Belen jimenez martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic minimum Data Set(BmDS)to compare hospitalization variables among the HCU,the Internal medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BmDS to compare hospitalization variables among the HCU,the Internal medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

Review:Resuspension of wall deposits in spray dryers

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第11期8卷 1762-1774页

作者： HANUS m.j. LANGRISH T.A.G. School of Chemical and Biomolecular Engineering University of Sydney Sydney NSW 2006 Australia

Wall deposition occurs in spray dryers when dried or partially dried particles contact and adhere to the walls during operation, thus reducing the yield of product collected. Wall deposits also present a product contamination risk and a fire or explosion risk when spray drying products that oxidize exothermically, such as milk powder. Re-entrainment is the resuspension of spray dryer wall deposits into the main gas stream for collection as product. Literature suggests that the process for re-entrainment of particles from spray dryer wall deposits is strongly dependent on particle size and gas velocity.

关键词： Wall deposition Spray dryers Dried particles Re-entrainment Adhesive forces

STABILITY AND RESONANCES OF mULTISTEP COSINE mETHODS

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journal of Computational mathematics 2012年第5期30卷 517-532页

作者： B. Cano m.j. moreta Departamento de matemdtica Aplicada IMUVA. Facultad de Ciencias. Paseo Belen 7 CP 47011 Valladolid Spain Departamento de Fundamentos del Andlisis Econdmico I. Universidad Complutense de madrid. Campus de Somosaguas Pozuelo de Alarcdn 28223 Madrid Spain

In a previous paper, some particular multistep cosine methods were constructed which proved to be very efficient because of being able to integrate in a stable and explicit way linearly stiff problems of second-order in time. In the present paper, the conditions which guarantee stability for general methods of this type are given, as well as a thorough study of resonances and filtering for symmetric ones （which, in another paper, have been proved to behave very advantageously with respect to conservation of invariants in Hamiltonian wave equations）. What is given here is a systematic way to analyse and treat any of the methods of this type in the mentioned aspects.

关键词： Exponential integrators multistep cosine methods Second-order partial dif-ferential equations Stability Resonances

HAGEN POISEUILLE FLOW OF A GRANULAR mATERIAL IN A CYLINDER

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journal of Hydrodynamics 2001年第2期13卷 91-95页

作者： Liu, m.j. Tao, m.D. Dept. of mech. and Eng. Sci. Fudan Univ. Shanghai 200433 China

The equations of motion for rapid flow of a granular material were derived and their solutions representing flow driven by a body force along an infinitely-long cylinder were obtained by the numerical method.

关键词： Boundary conditions Cylinders (shapes) Equations of motion Flow of solids Numerical methods

Effect of reverse flotation on magnetic separation concentrates

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International journal of minerals,metallurgy and materials 2012年第8期19卷 669-674页

作者： S.O. Bada A.S. Afolabi m.j. makhula School of Chemical & metallurgical Engineering University of the Witwatersrand P/Bag X3 Wits 2050 Johannesburg South Africa Department of mineral Processing Division Mintek Johannesburg South Africa Department of Civil and Chemical Engineering College of Science Engineering and Technology University of South Africa P/Bag X6 Florida 1710 Johannesburg South Africa

Reverse flotation studies on magnetite samples have revealed that the use of starch as a depressant of Fe-oxides has a hydrophilic effect on the surface of Fe-bearing silicates and significantly decreases Fe in the silica-rich stream when used in combination with an amine （Lilaflot D817m）. In this study, the effect of reverse flotation on the optimization of products obtained fi＇om magnetic separation was inves- tigated. Two different magnetic samples, zones 1 and 2, were milled to 〈75 btm and then subjected to low intensity magnetic separation （LImS）. The LImS test conducted on the 〈75 ~m shown an upgrade of 46.40wt% Fe, 28.40wt% SiO2 and 2.61wt% mnO for zone 1 and 47.60wt% Fe, 29.17wt% SiO2 and 0.50wt% mnO for zone 2. Further milling of the ore to 〈25 ~tm resulted in a higher magnetic-rich product after magnetic separation. Reverse flotation tests were conducted on the agitated magnetic concentrate feed, and the result shows a significant upgrade of Fe compared to that obtained from the non-agitated feed. Iron concentrations greater than 69%, and SiO2 concentrations less than 2% with overall magnetite recoveries greater than 67% and 71% were obtained for zones 1 and 2, respectively.

关键词： magnetite flotation magnetic separation starch amines