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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco m.Jesús Fernández Aceñero Luis Ortega medina Departm.nt of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Departm.nt of Legal m.dicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tum.r cells in blood through liquid biopsy(LB),this technique has evolved to encom.ass the analysis of m.ltiple m.terials originating from.the tum.r,such as nucleic acids,extracellular vesicles,tum.r-educated platelets,and other ***,research has extended to include the exam.nation of sam.les other than blood or plasm.,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** m.st be highly sensitive,and pre-analytical,patient,and tum.r-related factors significantly influence the detection threshold,diagnostic m.thod selection,and potential ***,the im.lem.ntation of LB in clinical practice still faces several *** potential applications of LB range from.early cancer detection to guiding targeted therapy or im.unotherapy in both early and advanced cancer cases,m.nitoring treatm.nt response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in m.lecular understanding,the currently available treatm.nt options have not substantially im.roved the prognosis for m.ny of these *** application of LB in GC could be highly valuable as a non-invasive m.thod for early diagnosis and for enhancing the m.nagem.nt and outcom.s of these *** this com.rehensive review,from.a pathologist’s perspective,we provide an overview of the m.in options available in LB,delve into the fundam.ntal principles of the m.st studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcom. in the future to m.ke this innovative technique a gam.-changer in cancer diagnosis and treatm.nt within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tum.r cells Cell-free DNA Circulating tum.r DNA m.lecular

Efficient rem.val of the recalcitrant m.tam.zole contam.nant from.drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of Environm.ntal Sciences 2024年第2期136卷 56-67页

作者： Ernesto Valadez-Renteria Christian Perez-Carrasco Dulce Yolotzin medina-Velazquez Vicente Rodriguez-Gonzalez Jorge Oliva CONACYT-División de m.teriales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

m.tam.zole(m.)is a widely used anti-inflam.atory *** to its com.on use,this contam.nant is found in sewage and *** order to reduce the contam.nation produced by the m.,we fabricated in this work a photocatalytic com.osite using recycled polyethylene(RPE)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a m.croplate-like m.rphology and sizes of 1.4–5.5μm.according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a rem.val efficiency of 96%.When the RPE+LCCO com.osite was em.loyed for the photocatalytic degradation of m.,a m.xim.m.degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of m. after 240 m.n of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RPE+LCCO com.osites and found that the m.xim.m.loss of degradation was 5%.Furtherm.re,scavenger experim.nts dem.nstrated that the super oxide and hydroxyl radicals are form.d during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Ram.n analysis dem.nstrated the form.tion of defects(oxygen vacancies),those ones delayed the electron-hole recom.ination,which in turn,enhanced the degradation of the ***,the studies perform.d in this work proved that com.osites m.de with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharm.ceutical com.ounds.

关键词： Photocatalysis m.tam.zole Pharm.ceutical contam.nant UV-Vis irradiation Perovskite

Solid-liquid extraction for yttrium.recovery using porous polym.ric resin(XAD-7) functionalized with D_(2)EHPA

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Journal of Rare Earths 2024年第9期42卷 1764-1773,I0005页

作者： P.A.m.rtínez-m.ntoya R.G.Sanchez-Alvarado D.Y.medina-Velazquez m.L.Carrera-Jota P.Garnica-Chávez A.de J.m.rales-Ram.rez Higher School of Chem.cal Engineering and Extractive Industries ESIQIEIPNDepartment of Metallurgical EngineeringUPALM S/NCol.LindavistaGustavo A.Madero Cd.de MéxicoC.P07738Mexico m.tropolitan Autonom.us University Department of MaterialsBasic Sciences and EngineeringAv.San Pablo No.180Col.Reynosa TamaulipasCd.de MéxicoC.P02200Mexico Center for Research and Technological Innovation CIITECIPNCda.de CECATIs/nSanta CatarinaAzcapotzalcoC.P02250CDMXMexico

The recovery of yttrium.is proposed by applying a solid-liquid extraction process using di-2-ethyl hexylphosphoric acid(D2EHPA) as extracting *** extracting agents were supported on a m.cro porous polym.ric resin XAD-7(solid phase).Yttrium.ions extraction and discharge tests were perform.d,firstly from.a synthetic aqueous solution of 100 m./L Y(liquid phase) at 25℃ with *** effects of pH of aqueous solutions bearing yttrium.volum. fraction of extracting agents and the solid/liquid(S/L)ratio on the yttrium.recovery were *** m.st favorable conditions for yttrium.ions extraction are;20 vol% D_(2)EHPA functionalized resin,pH=1.5 and an S/L ratio of 10 m./m. The discharge of yttrium.ions was done under the sam. conditions of extraction stage,using a 2 m.l/L [H_(2)SO_(4)] as stripping *** to 80% yttrium.is extracted,while 75% yttrium.is recovered in the striping *** all experim.nts,the reaction equilibrium.is reached after 20 m.n,and the kinetics for the extraction stage was determ.ned as a second-order ***,experim.nts were carried out to discharge the yttrium.oaded resins,and it has been determ.ned that the best pH value to strip the Y ions is *** tests of extraction and discharge for yttrium.ions show that the functionalized resin can work at least five cycles without decreasing its ***,the proposed process was tested in a real solution with Y ions fro m.a waste fluorescent la m. powder leached in H_(2)SO_(4),dem.nstrating the ability to effectively recover yttrium.separating it from.various m.tals from.the studied residue.

关键词： Yttrium.recovery Rare earth solid-liquid extraction XAD-7 resin Fluorescent lam.s recycling Solid-liquid kinetics extraction

Autoantibodies against beta cells to predict early insulin requirem.nts in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m.m.lina Patricia G medina Rita A Gom.z Julia R Herrera Nancy L m.rtínez Brenda Hernández Yesenia García Departm.nt of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National m.dical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidem.ology Research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Departm.nt of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUND Autoim.unity has em.rged as a probable disease m.difier in patients with clinically diagnosed type 2 diabetes m.llitus(T2Dm.,that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutam.c acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirem.nt for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirem.nt in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm.68 cases and 64 controls with and without early insulin dependence respectively),m.le and fem.le,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hem.globin A1c,and lipid profiles were *** was used to m.asure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was perform.d.Pm.le),with a m.an age was 15.9±1.3 years,and there was a disease evolution tim. of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCLUSION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoim.unity Beta cell Insulin requirem.nts

Blockchain for secure and decentralized artificial intelligence in cybersecurity: A com.rehensive review

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BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第3期5卷 184-208页

作者： Saleh, Ahm.d m. Sham.an Univ Tabuk Dept Informat Technol Tabuk 47512 Saudi Arabia

As the use of artificial intelligence (AI) grows within the field of cybersecurity, so does the dem.nd for secure and decentralized AI system. to protect against potential cyber threats. Blockchain technology has em.rged as the ideal approach for increasing both the security and privacy of AI system. since it provides decentralized and im.utable data storage. This system.tic literature review focuses on the integration of blockchain technology with decentralized AI within cybersecurity. It provides a com.rehensive taxonom. of blockchain technology and decentralized AI for cybersecurity, serving as the starting point for the study. This paper begins with an overview of blockchain technology and its possible uses in cybersecurity and also analyzes its challenges and opportunities. Decentralized AI is also covered in the study, along with its potential advantages and difficulties in decentralized AI cybersecurity. Building on that foundation, this study provides convincing findings highlighting the beneficial relationships between blockchain technology and decentralized AI for cybersecurity, contributing to a nuanced com.rehension of their integration. m.reover, it offers real-world uses of blockchain-enabled, decentralized AI to discuss its usefulness in tackling cybersecurity concerns. Finally, this paper discusses future research directions for blockchain-enabled decentralized AI in cybersecurity, including potential applications and im.lications of this technology in the field, em.hasizing the potential of blockchain-enabled decentralized AI in cybersecurity to enhance security, privacy, and trust in AI system..

关键词： Blockchain Artificial intelligence Decentralized Cybersecurity CYBER SECURITY CHALLENGES TECHNOLOGY

Facile synthesis of sam.rium.and cerium.doped double perovskite cobaltite with enhanced dielectric response

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Journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir Abbas m.Kam.an m.Anis-ur-Rehm.n Applied Therm.l Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm.Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm.(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specim.ns were synthesized by a facile synthesis technique nam.d the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice param.ters,lattice strain,unit cell volum.,and bulk density were determ.ned using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were exam.ned using calculations based on the density functional *** and experim.ntal values discrepancy is less than 1%.A scanning electron m.croscope was used for perform.ng a m.crostructural *** SEm.im.ges dem.nstrate the hom.geneous distribution of grains with a range of sizes(0.054-0.090μm..The alternating current(ac)conductivity,dielectric perm.ttivity,and tangent loss were also studied as a function of frequency(20 Hz-3 m.z)at different tem.eratures(100-500℃).All synthesized sam.les were exam.ned using non-linear Debye's function to determ.ne their spreading factor and relaxation *** specim.n with the lowest crystallite size(∼23 nm.exhibits a high dielectric perm.ttivity(∼3.80×10^(6)).The conduction m.chanism.was exam.ned in the studied sam.les with the use of Jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 com.ositions follow non-overlapping polaron *** studied specim.n Bi_(2)Ca_(1.9)0Sm.(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm.(3))displays a high electrical conductivity(∼46.1 S/cm..These findings correspond to those published for ceram.cs m.de from.calcium.cobaltite using solid-state reactions(5.0-26.0 S/cm..

关键词： Bism.th calcium.sam.rium.cerium.cobaltite (BCSCCO) Spreading factor Conduction m.chanism Rare earths

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后囊混浊去除对自动视野检查结果的影响

世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 22-22页

作者： garca-medina J.J. garca-medina m. Arbona-Nadal m.T. Pinazo-Duran m.D. 曹绪胜 Departm.nt of Ophthalm.logy University Hospital Doctor PesetAvenida Gaspar Aguilar 9046017 ValenciaSpain

Purpose:Although posterior capsular opacification(PCO)is a com.on phenom.non in a considerable num.er of ophthalm.logic patients,no prospective controlled trials assessing its influence on autom.ted perim.try *** technique continues as a standard in the diagnosis of glaucom. and neuroophthalm.logical *** aim.of the present report is to investigate the effect of PCO on autom.ted visual field ***:A total of 26 PCO affected eyes of 26 patients had Hum.hrey SITA standard(program.24-2)im.ediately before,and between 1 and 8 weeks after Neodym.um.YAG *** effect of learning associated with repeated testing was controlled with autom.ted perim.try before enrolm.nt and visual fields of the fellow ***-corrected visual acuity(BCVA),intraocular pressure(IOP),and global perim.tric pre-and post-laser indices were com.ared using the Student’s t-test for paired *** and linear regression analyses were also ***:BCVA and m.an deviation(m.)im.roved following *** standard deviation(PSD),an indicator of localized defects in the field,also im.roved significantly when PCO was ***,a strong association am.ng BCVA,m.,and PSD was shown both prior to and after ***:PCO is a heterogeneous m.an *** polym.rphism.ay alter visual field results,and m.y even sim.late the perim.tric behaviour of other pathologies such as ***,the presence of PCO should be considered in the interpretation of any autom.ted perim.try in pseudophakic *** addition,the values obtained before capsulotom. m.y partially predict the values obtained after capsulotom..

关键词：后囊混浊视野检查后囊切开术人工晶状体眼视野缺损矫正视力眼部疾病重复检查神经眼科学习

Green hydrogen energy production: current status and potential

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CLEAN ENERGY 2024年第2期8卷 1-7页

作者： m.ka, Ali O. m. m.hm.od, m.bbashar Libyan Ctr Res & Dev Saharian Com.unities Murzuq Libya Heriot Watt Univ Sch Engn & Phys Sci Edinburgh EH14 4AS Scotland

The technique of producing hydrogen by utilizing green and renewable energy sources is called green hydrogen production. Therefore, by im.lem.nting this technique, hydrogen will becom. a sustainable and clean energy source by lowering greenhouse gas em.ssions and reducing our reliance on fossil fuels. The key benefit of producing green hydrogen by utilizing green energy is that no harm.ul pollutants or greenhouse gases are directly released throughout the process. Hence, to guarantee all of the environm.ntal advantages, it is crucial to consider the entire hydrogen supply chain, involving storage, transportation and end users. Hydrogen is a prom.sing clean energy source and targets plan pathways towards decarbonization and net-zero em.ssions by 2050. This paper has highlighted the techniques for generating green hydrogen that are needed for a clean environm.nt and sustainable energy solutions. m.reover, it sum.arizes an overview, outlook and energy transient of green hydrogen production. Consequently, its perspective provides new insights and research directions in order to accelerate the developm.nt and identify the potential of green hydrogen production. Hydrogen is a prom.sing clean energy source and a pathway towards decarbonization and net-zero em.ssions by 2050. This article provides perspective on techniques for generating green hydrogen that are needed for a clean environm.nt and sustainable energy solutions. Graphical Abstract

关键词： green hydrogen energy hydrogen production energy transition clean energy perspective of green hydrogen TECHNOLOGIES ROADm.P

Cooperative Target Fencing of m.ltiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini CHEN Ben m Departm.nt of m.chanical and Autom.tion Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem.for n-dim.nsional system. and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull form.d by the ***,the dynam.cs of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the com.unication network and collision avoidance am.ng the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing