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Studies on aggregation-propensities and secondary structural transformations of proteins

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Nuclear Science and Techniques 2005年第1期16卷 6-11页

作者： JlLi-Na gaoyong-Guang ZHANGFeng LIHong-Tao HUHong-Yu HUJun ShanghaiInstituteofAppliedPhysics theChineseAcademyofSciencesShanghai201800 KeyLaboratoryofProteomicsInstituteofBiochemistryandCellBiology ShanghaiInstituteforBiologicalSciencestheChineseAcademyofSciencesShanghai200031 Bio-XResearchCenter ShanghaiJiaotongUniversity Shanghai200030 ShanghaiInstituteofAppliedPhysics theChineseAcademyofSciencesShanghai201800／／Bio-XResearchCenterShanghaiJiaotongUniversity Shanghai200030

The insoluble and fibrillar aggregates of some proteins are thought to be the pathological cause of neu- rodegenerative diseases. The aggregation-propensities of different types of proteins were investigated by Thioflavine T fluorescence assay and atomic force microscopy imaging. Then, the structural transformations of the proteins from aqueous state to solid state were studied by circular dichroism spectroscopy. The results indicate that proteins of dif- ferent secondary structure show variations in their aggregation-propensities, together with their various structural transformations from aqueous state to solid state. Our studies imply that the structural transformation of proteins from solution to solid state is closely associated with their aggregation-propensities, which will provide insight into the molecular mechanism of protein aggregation in neurodegenerative diseases.

关键词：聚集性质次要结构变换原子力学显微镜成像法周期分色光谱蛋白质 ThT荧光

A SUFFICIENT CONDITION FOR ONE CONVEX BODY CONTAINING ANOTHER

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Chinese Annals of Mathematics 1988年第4期9卷 447-451页

作者：张高勇 Wuhan Institute of Iron and Steel Technology

A sufficient condition for one convex body to be able to contain another in 3-dimensionalEuclidean space has been derived by estimating the kinematic measure of one ccnvexbody moving in another. The equality of estima... 详细信息

关键词：二护 A SUFFICIENT CONDITION FOR ONE CONVEX BODY CONTAINING ANOTHER BODY

Perineal Hernia after Laparoscopic Abdominoperineal Resection for Rectal Cancer: A Case Report and Review of the Literature

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Journal of Cancer Therapy 2015年第2期6卷 222-226页

作者： Zhenhua He gaoyong Zhu Sen Zhang Department of Gastrointestinal Surgery He Zhou People’s Hospital Guangxi China Department of Colorectal Surgery The First Affiliated Hospital Guangxi Medical University Guangxi China

Perineal hernias are uncommon complications following laparoscopic abdominoperineal operations. There is still very little known about perineal hernia. There are only few case reports to describe the repair of postoperative hernias after laparoscopic abdominoperineal resection (APR) in the literature. Here we present one patient with a perineal hernia after laparoscopic abdominoperineal resection for rectal cancer. The surgical management with manual purse-string suture is described and discussed in this case report.

关键词： Perineal Hernia Laparoscopic Abdominoperineal Resection

超声引导针刀松解椎枕肌群治疗颈源性眩晕的临床观察

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中国中医急症 2024年第6期33卷 1005-1008页

作者：李明波付高勇陈晓英卿帅刘婷罗渊张健豪余泽芸四川省宜宾市第一人民医院四川宜宾644000 四川省宜宾市中医院四川宜宾644600

目的观察超声引导针刀松解椎枕肌群治疗颈源性眩晕的安全性及临床疗效。方法将患者根据随机数字表法分为3组,A组采用超声引导针刀松解椎枕肌治疗;B组采用毫针针刺治疗;C组采用手法推拿椎枕肌治疗。治疗2周后将各组治疗前后的颈源性眩晕... 详细信息

目的观察超声引导针刀松解椎枕肌群治疗颈源性眩晕的安全性及临床疗效。方法将患者根据随机数字表法分为3组,A组采用超声引导针刀松解椎枕肌治疗;B组采用毫针针刺治疗;C组采用手法推拿椎枕肌治疗。治疗2周后将各组治疗前后的颈源性眩晕症状与功能评估量表(ESCV)评分、生活质量评分(SF-36)及左椎动脉(LVA)、右椎动脉(RVA)及基底动脉(BA)平均血流速度进行组间与组内的对比观察。结果治疗2周后各组ESCV、SF-36评分,LVA、RVA及BA平均血流速度均较治疗前改善(P<0.05),治疗2周后A组ESCV、SF-36评分,LVA、RVA及BA平均血流速度均优于B组和C组(P<0.05)。结论超声引导针刀松解椎枕肌群治疗颈源性眩晕具有较好的疗效,能够快速缓解颈源性眩晕,且治疗方法精准、安全、规范。

关键词：颈源性眩晕超声引导针刀椎枕肌群精准治疗

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硝酸银及其产物银对六角相液晶流变性影响

化学学报 2003年第1期61卷 40-46页

作者：王红霞张高勇武汉大学化学与分子科学学院

用偏光显微镜测定了硝酸银及其产物银对NP 10/水六角相区的影响,用动态(应力和频率扫描)和稳态(蠕变 -恢复)方法研究了硝酸银的加入和银的生成对该体系粘弹性的影响.无机前驱物硝酸银和银的生成能使六角相区略缩,动态流变实验表明,无机... 详细信息

用偏光显微镜测定了硝酸银及其产物银对NP 10/水六角相区的影响,用动态(应力和频率扫描)和稳态(蠕变 -恢复)方法研究了硝酸银的加入和银的生成对该体系粘弹性的影响.无机前驱物硝酸银和银的生成能使六角相区略缩,动态流变实验表明,无机物引入纯六角相液晶体系中会使其抗剪切的能力降低,对相区两侧影响与振荡所采用的频率有关.生成的银原子会在胶束表面聚集,增加了胶束内部不同EO链之间的交联,造成松弛时间变长,粘弹性指数降低.稳态实验所得到的结果与动态实验一致,并将粘性和弹性定量化.用弹簧

关键词：硝酸银六角相液晶相结构流变性纳米银

Effect of Complexation with Hydroxylpropyl-β-Cyclodextrin on Solubility, Dissolution Rate and Chemical Stability of Prostaglandin E1

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Journal of Chinese Pharmaceutical Sciences 2004年第3期13卷 158-165页

作者： GUFu-gen CUIFu-de gaoyong-liang DepartmentofPharmaceutics ShenyangPharmaceuticalUniversityShenyang110016China DepartmentofPharmaceutics InstituteofPharmacologyandToxicologyAcademyofMilitaryMedicalSciencesBeifing100850China

Aim To study the effect of complexation with hydroxylpropyl-β-cyclodextrin(HP-β-CD) on the solubility, dissolution rate and chemical stability of prostaglandin E_1 (PGE_1) ,thereby providing a basis for preparing a stable solid or aqueous preparation of PGE_1 formulatedwith HP-β-CD. Methods The effect of HP-β-CD on the solubility of PGE_1 was studied by phasesolubility method. The formation of inclusion complexes of PGE_1 with HP-β-CD in the aqueoussolution was confirmed by UV spectra, circular dichroism spectroscopy, and that in the solid stateby IR spectra and X-ray diffractome-try. An solid inclusion complex of PGE_1 with HP-β-CD wasprepared by lyophilization. The dissolution rate and stability of the inclusion complex weredetermined and compared with those of PGE_1 alone. Meanwhile, the stability of PGE_1 aqueoussolutions in the presence of HP-β-CD was studied under different pH conditions. Results Thesolubility of PGE_1 increased linearly with increasing HP-β-CD concentration in various pH bufferedsolutions, showing typical A_L-type phase solubility diagrams. The stability and dissolution rateof the solid inclusion complex of PGE_1 were significantly increased, compared with those of purePGE_1 . The stability of PGE_1 in HP-β-CD solutions was also obviously improved under acidic andbasic conditions, but the stabilizing effect was absent under neutral conditions. Conclusions Thesolubility,dissolution rate and chemical stability of PGE_1 are markedly improved by complexationwith HP-β-CD: It is quite possible to prepare a stable PGE_1 inclusion complex-containing soliddosage forms, but almost impossible to obtain a stable aqueous preparation of PGE_1 formulated withHP-β-CD.

关键词： PGE_1 HP-β-CD inclusion complex solubility dissolution rate stability

Synthesis of Nanocrystalline Ce1-x NdxO2-x／2（0≤x≤0.6） Powders by Low Temperature Combustion Process

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Journal of Rare Earths 2005年第2期23卷 i002-i002页

作者： gaoyong WangLingling LiuHuangqing DepartmentofAppliedPhysics HunanUniversityChangsha410082China DepartmentofAppliedPhysics HunanUniversityChangsha410082China／／CollegeofMaterialsScienceandEngineeringHunanUniver-sityChangsha410082China

设施内不同遮阴处理对草莓生长和光合特性及产量品质的影响

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中国果树 2024年第5期 68-74页

作者：黄宁旺蒋琪玮王晶如李浩鹿高勇张培培薛俊龙宫明永赵林肖伟李玲山东农业大学园艺科学与工程学院山东果蔬优质高效生产协同创新中心泰安271018 沂源县农业技术服务中心山东省创新发展研究院

以雪沁香草莓为试验材料,分别设置遮阴度30%、50%和70%处理,探究设施内不同遮阴处理对草莓生长、光合特性及产量、品质的影响。结果表明,遮阴后植株间温度和叶面光合有效辐射(PAR)均显著降低,遮阴处理使净光合速率(Pn)、气孔导度(Gs)、... 详细信息

以雪沁香草莓为试验材料,分别设置遮阴度30%、50%和70%处理,探究设施内不同遮阴处理对草莓生长、光合特性及产量、品质的影响。结果表明,遮阴后植株间温度和叶面光合有效辐射(PAR)均显著降低,遮阴处理使净光合速率(Pn)、气孔导度(Gs)、蒸腾速率(Tr)、胞间CO_(2)浓度(Ci)的日变化曲线均由原来的“双峰”型变成了“单峰”型,且显著提高了叶绿素含量。30%遮阴处理下草莓植株的生长状态和果实产量均达到最佳,且对果实品质影响较小,而70%遮阴处理下各项指标均降至最差。综上,在设施内进行30%遮阴处理有助于设施草莓提质增产。

关键词：草莓设施内遮阴生长特性光合特性产量品质温度光照

清末阅读媒介的变与不变:基于邸报在近代中国演变的考察

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出版发行研究 2019年第7期 98-103页

作者：李龙许高勇暨南大学湘潭大学

清末阅读媒介的变更并非一蹴而就,而是历经邸报—官报—新报的重叠与更替。每种媒介形态的变化也不是凭空而出,而是新旧媒介之间的相互勾连、传承与创新,背后折射出的是复杂的社会因素。通过对邸报演变的考察,发现晚清邸报继承中国古代... 详细信息

清末阅读媒介的变更并非一蹴而就,而是历经邸报—官报—新报的重叠与更替。每种媒介形态的变化也不是凭空而出,而是新旧媒介之间的相互勾连、传承与创新,背后折射出的是复杂的社会因素。通过对邸报演变的考察,发现晚清邸报继承中国古代邸报制度基因。但在大变局之下,又出现新的变异,突显邸报的"不变"与"变"。一些近代报刊刻意模仿邸报的模式及接受邸报的相关信息,丰富了近代报刊的内容,阅读习惯得到进一步的改良。其中体现的是近代读书人读报活动从邸报到新报的"阅读"转移过程,阅读媒介由精英阅读向大众化的转向。

关键词：邸报新报报刊阅读中国近代报刊史