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Pterostilbene supresses inflammation-induced melanoma metastasis by impeding neutrophil elastase-mediated thrombospondin-1 degradation

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Chinese Herbal Medicines 2023年第1期15卷 94-101页

作者： Dan Su Shan Xu Kailin Ji Hailing Xu Yan Li Zhisheng Zhang Yuqing Shen gaoyang chen Department of Pharmacy Changzhou No.2 People’s HospitalAffiliated Hospital of Nanjing Medical UniversityChangzhou 213004China School of Pharmacy Changzhou UniversityChangzhou 213164China Department of Oncology The Second People’s Hospital of TaizhouTaizhou 225300China

Objective: Chronic inflammation plays a fatal role in tumor metastasis. Pterostilbene(PTE) is a natural dimethylated analogue of resveratrol with anticancer and anti-inflammatory activities. This study aimed to investigate the inhibitory effect of PTE on inflammation-associated metastasis and explore the underlying ***: Lipopolysaccharide(LPS)-induced lung inflammation and melanoma metastasis models were established in mice. After PTE treatment for four weeks, the organ index, histological changes, proinflammatory cytokines, and the expression and activity of neutrophil elastase(NE), a biomarker of neutrophil influx in the lungs, were analysed. Additionally, direct effects of PTE on NE-induced B16 cell migration were explored in wound healing and Transwell assays, and the expression of thrombospondin-1(TSP-1) and epithelial-mesenchymal transition(EMT) markers were also ***: PTE obviously attenuated the LPS-induced metastasis of circulatory B16 cells to lungs by reducing the number of metastatic nodules on the lung surfaces and the lung weight/body weight ratio. PTE treatment also significantly reduced LPS-activated increase levels of tumor necrosis factor(TNF)-a and interleukin(IL)-6 in the lungs of tumor-bearing mice. In addition, increased expression and enzyme activity of NE and decreased expression of TSP-1 were observed, and these were blocked by PTE. In vitro, PTE at concentrations without cytotoxicity also markedly suppressed NE-triggered B16 cell migration, prevented NE-induced TSP-1 proteolysis and reversed the expression of vimentin, N-cadherin and ***: PTE could block inflammation-enhanced tumor metastasis, and the underlying mechanism might be associated with the inhibition of NE-mediated TSP-1 degradation.

关键词： inflammation melanoma metastasis neutrophil elastase pterostilbene thrombospondin-1

Circular RNA circStag1 promotes bone regeneration by interacting with HuR

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Bone Research 2022年第3期10卷 565-577页

作者： gaoyang chen Canling Long Shang Wang Zhenmin Wang Xin chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng Department of Spine Surgery and Institute for Orthopaedic Research the Second Clinical Medical College of Jinan University(Shenzhen People’s Hospital)Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function RestorationShenzhen 518020China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518055China The First Affiliated Hospital Jinan UniversityGuangzhou 510630China School of Medicine Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China

Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of ***,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone ***,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain ***,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with *** of circ Stag1 significantly promoted the osteogenic capability of ***,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of ***,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized ***,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis.

关键词： metabolism thereby promoted

The Clinical Study of Multigene Combination Test to Guide Chemotherapy Combined with Targeted Therapy in Patients with Advanced Gastrointestinal Tumors

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Proceedings of Anticancer Research 2020年第5期4卷 17-20页

作者： Zhisheng Zhang gaoyang chen Qin Dai Taizhou Second People’s Hospital Taizhou City 225500Jiangsu ProvinceChina

Objective:To study the clinical effects of multigene combination test to guide chemotherapy combined with targeted therapy in patients with advanced gastrointestinal ***:The samples were selected from 60 patients with advanced gastrointestinal tumors admitted to our hospital from March 2019 to July 2020,and were divided into a study group and a control group using a random number table model;patients in the control group did not undergo genetic testing and FOLLOX4+PD-1 chemotherapy,while patients in the study group underwent TYMS,ERCC1,EGFR,and KRAS and VEGF gene expression levels test,and the sensitive treatment plan was determined based on the test results,and the clinical indexes were compared between the two ***:By comparing the total effective rate,survival time,and time to disease progression of chemotherapy in the two groups,the study group has a significant advantage(P<0.05).Conclusion:The combination of chemotherapy and targeted therapy for advanced gastrointestinal tumor patients can improve the efficiency of chemotherapy and prolong the time of disease progression and survival,which is worthy of comprehensive promotion.

关键词： Multigene combination test Advanced gastrointestinal tumors Chemotherapy Targeted therapy

Significance of extracellular signal-regulated kinase (ERK) in the development of rectal carcinoma

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The Chinese-German Journal of Clinical Oncology 2008年第1期7卷 27-30页

作者： Weirong chen Ziqun Liao Maogen chen gaoyang Cai Tinghan Li Department of General Surgery Second Affiliated Hospital of Shantou University Medical College Shantou 515041 China

Objective: To study the ERK expression and its significance in the development of human rectal carcinoma. Methods: Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent normal rectal tissue. Western blot was used to measure the expression of ERK-1 and ERK-2. S-P immunohistochemical method was used to count the microvessel density (MVD). Results: ERK-1 and ERK-2 protein levels were increased in rectal carcinoma tissue compared with those in adjacent normal tissues (t = 2.980 and 2.194, P < 0.01 and 0.05 respectively). The MVD was higher in patients with higher ERK-1 and/or ERK-2 protein levels than that in cases with lower ERK-1 and/or ERK-2 levels. Conclu- sion: Overexpression of ERK-1 and/or ERK-2 may play an important role in the development of human rectal carcinoma, the overexpression can enhance the growth of tumor microvessel and promote the development of human rectal carcinoma.

关键词： rectal carcinoma ERK microvessel density

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船舶航向模糊滑模控制及仿真

江苏科技大学学报（自然科学版） 2010年第4期24卷 372-376页

作者：高键陈高阳江苏科技大学电子信息学院江苏镇江212003

为了削弱抖振,结合模糊控制和滑模变结构控制的特点,并按照航向保持和航向改变的控制要求,设计了一种组合式航向控制器.当航向偏差较大时采用基于指数趋近律的滑模控制以缩短操舵时间,反之则采用模糊滑模控制柔化控制信号.仿真结果表明... 详细信息

为了削弱抖振,结合模糊控制和滑模变结构控制的特点,并按照航向保持和航向改变的控制要求,设计了一种组合式航向控制器.当航向偏差较大时采用基于指数趋近律的滑模控制以缩短操舵时间,反之则采用模糊滑模控制柔化控制信号.仿真结果表明,所设计的模糊滑模控制器无论在响应时间还是在超调量上都优于常规滑模控制器,并对系统的参数摄动和外扰具有强鲁棒性,能满足船舶航向实时控制要求.

关键词：船舶航向控制模糊控制滑模控制仿真

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我国古代的死刑慎用思想及慎用死刑的特点

重庆科技学院学报（社会科学版） 2010年第7期 70-71,77页

作者：陈高杨西南政法大学研究生部

从经济、政治、文化方面分析了我国古代重视人命、慎用死刑思想产生和发展的原因,阐述了死刑慎用思想在古代刑事审判和执行程序方面的表现和特点。认为古代慎用死刑的基本思想和防止错杀无辜的一些制度,对于今天我国的法制建设仍具有借... 详细信息

从经济、政治、文化方面分析了我国古代重视人命、慎用死刑思想产生和发展的原因,阐述了死刑慎用思想在古代刑事审判和执行程序方面的表现和特点。认为古代慎用死刑的基本思想和防止错杀无辜的一些制度,对于今天我国的法制建设仍具有借鉴意义。

关键词：死刑慎用死刑适用死刑复核权古代中国

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不辞风雨追梦路

人民司法 2023年第36期 18-19页

作者：陈高扬(文/图) 宁波海事法院

“书藏古今、港通天下”,是浙江省宁波市的城市形象宣传语。在这8个字的背后,有着知行合一的文化沉淀与勇立潮头的奋斗精神,持续地浸润着我这个土生土长的宁波人,也为我和海商法的结缘埋下了伏笔。我第一次接触海商法是在钱塘江畔、月... 详细信息

“书藏古今、港通天下”,是浙江省宁波市的城市形象宣传语。在这8个字的背后,有着知行合一的文化沉淀与勇立潮头的奋斗精神,持续地浸润着我这个土生土长的宁波人,也为我和海商法的结缘埋下了伏笔。我第一次接触海商法是在钱塘江畔、月轮山上,浙大之江校区髯古树映衬下的教室里。彼时经济全球化正飞速推进,作为世界经济晴雨表的海运贸易处于蓬勃发展之中,因此,直接调整海上运输关系的海商法愈发受到关注。

关键词：海运贸易宁波人知行合一文化沉淀海商法海上运输钱塘江畔奋斗精神

基于单螺旋扭转结构的取样布拉格光纤光栅及其传感特性

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激光与光电子学进展 2018年第9期55卷 84-89页

作者：陈高杨马鹏李杰孙立朋武创关柏鸥暨南大学光子技术研究院广东广州510632 广东省光纤传感与通信技术重点实验室广东广州510632

提出一种新型取样布拉格光纤光栅传感器,用于温度和轴向应变的传感。为了制作该传感器,利用特种光纤熔接机在单模光纤上制造出单螺旋扭转结构,然后在单螺旋结构上利用紫外激光侧写和相位掩模板技术刻写布拉格光纤光栅。该取样光栅反射... 详细信息

提出一种新型取样布拉格光纤光栅传感器,用于温度和轴向应变的传感。为了制作该传感器,利用特种光纤熔接机在单模光纤上制造出单螺旋扭转结构,然后在单螺旋结构上利用紫外激光侧写和相位掩模板技术刻写布拉格光纤光栅。该取样光栅反射谱具有等间距、窄带宽的特点,并且可通过调整单螺旋扭转率来自由改变取样周期。通过实验研究了传感器对温度和光纤轴向应变的响应,结果表明:当单螺旋扭转周期P=504.0μm(扭转率α=12.47rad/mm),布拉格光栅周期Λ=544.6nm,器件长度L=5.0 mm时,温度和轴向应变灵敏度分别为10.12pm/℃和1.12pm/με。较同类型取样光栅传感器,该传感器具有制作简单、灵活性高、稳定性高和成本低的优点,且在多波长光纤激光器和多通道光谱滤波器等领域展现出应用潜力。

关键词：光纤光学光纤传感器布拉格光纤光栅单螺旋扭转

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公安网ARP问题及其解决方案浅析

吉林公安高等专科学校学报 2008年第6期23卷 57-59页

作者：陈高阳吉林公安高等专科学校吉林长春130117

ARP病毒是目前对局域网影响最大的病毒之一。在公安网内导致ARP问题的原因不仅仅是病毒,某些内网安全管理软件也可能导致ARP问题出现。实践证明,通过一整套解决方案可以彻底解决公安网内的ARP问题。

关键词： ARP病毒局域网预防