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Primary malignant melanoma of the esophagus successfully treated with camrelizumab:A case report and literature review

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Oncology and Translational Medicine 2022年第4期8卷 201-208页

作者： gaoyang lin Xin Zheng Fuman Wang Daijun Xing Yufeng Cao Department of Cardiothoracic Surgery The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China Department 3 of the Cancer Center The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China

An 83-year-old Chinese woman presented with a 3-month history of *** also had a history of hypertension,type 2 diabetes,fundus hemorrhage,and cataract but no history of cutaneous,ocular,or other-site *** gastrointestinal tract angiography revealed gastritis and duodenal diverticulum;thus,an endoscopic review was *** computed tomography of the chest and upper abdomen revealed the following:(1)Esophageal space-occupying lesions and mediastinal lymph node enlargement(considering the high possibility of esophageal cancer,further endoscopy was recommended)and(2)A small amount of right pleural effusion,with no significant lymph node infiltration or distant *** identified a bulge mass blocking the esophagus from 23 to 30 cm from the *** upper mass had a spherical clustering,while the lower mass significantly *** biopsy samples were obtained from the esophagus 23 and 28 cm from the *** biopsy showed proliferation of large round tumor cells and *** showed positive findings for HMB45 and MelanA;partially positive findings for S100,CK7,CK5/6,CAM5.2,LCA,P63,and TTF-1;and negative findings for *** Ki-67 positivity index was approximately 60%.Based on these findings,the patient was diagnosed with malignant esophageal melanoma with enlarged mediastinal lymph *** was then treated with five cycles of camrelizumab therapy combined with chemotherapy from October 18,2019,to May 5,*** review following two courses of combination therapy revealed that the esophagus was 23-25 cm away from the incisors,and there were two continuous uplifted and beaded masses that had a smooth and black surface,with each of them having a length and diameter of approximately 1 *** of the mucosa around the lumen was observed at 40 cm from the incisors to the cardia;the dentate margin was clear;and the cardia had no *** patient then received fiv

关键词： primary malignant melanoma of the esophagus PD-1 mAb camrelizumab immunotherapy

Complete transthoracic resection of giant posterior mediastinal goiter: A case report and review of the surgical approaches

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Oncology and Translational Medicine 2018年第1期4卷 26-30页

作者： gaoyang lin Dadeng Gao Fang Yuan Yingyi Lv Zhenbo Liu Department of Thoracic Surgery The Affiliated Qingdao Hiser Medical Center of Qingdao University Medical College

Intrathoracic goiter(IG) is commonly located in the anterior mediastinum. Here, we report the case of a 54-year-old Chinese woman with successful removal of an intrathoracic goiter and improvement of dyspnea by a right posterolateral thoracotomy approach. Conclusion: Posterior mediastinal thyroid goiter with mediastinal compressive symptoms is an indication for surgery.

关键词： intrathoracic goiter(IG) posterior mediastinum goiter(PMG) thoracotomy Abbreviations

EZH2 is a biomarker associated with lung cancer diagnosis and immune infiltrates without prognostic specificity: a study based on the cancer genome atlas data

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Oncology and Translational Medicine 2023年第3期9卷 99-114页

作者： Xiaokun Wang Min Qi Xu Zhu Zhengtong Zhao Yufeng Cao Daijun Xing Fuman Wang gaoyang lin Cardiac Center(Department of Vascular Surgery) The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China Department of Clinical Laboratory The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China Department of Cardiothoracic Surgery The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China Department 3 of the Cancer Center The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China

Enhancer of zeste homolog 2(EZH2)is the catalytic subunit of polycomb repressive complex 2(PRC2).Dysregulation of EZH2 causes alteration of gene expression and functions,thereby promoting cancer *** studies suggest that EZH2 has a potential prognostic role in patients with nonsmall cell lung cancer(NSCLC).However,the prognostic value of EZH2 expression levels in NSCLC is *** this study,we evaluated the prognostic value in lung cancer(LC-LUAD/LUSC)based on data from The Cancer Genome Atlas(TCGA)***-Wallis test,Wilcoxon signed-rank test,and logistic regression were used to evaluate the relationship between EZH2 expression and clinicopathological *** regression and the Kaplan-Meier method were adopted to evaluate prognosis-related *** set enrichment analysis(GSEA)was performed to identify the key pathways related to *** correlations between EZH2 and cancer immune infiltrates were investigated by single-sample Gene Set Enrichment Analysis(ssGSEA).EZH2 was found to be up regulated with amplification in tumor tissues in multiple LC *** EZH2 expression was associated with poorer overall survival(OS).GSEA suggested that EZH2 regulates innate immune system,ECM affiliated,matrisome,surfactant ***,ssGSEA indicated that EZH2 expression was positively correlated with infiltrating levels of Th2 cells and significantly negatively correlated with mast cell infiltration *** results suggest that EZH2 is associated with LC immune infiltration and significantly over-expressed in lung cancer,and its diagnostic value is better than prognosis,which lays a foundation for further study of the immunomodulatory role of EZH2 in LC.

关键词： Enhancer of zeste homolog 2 lung cancer diagnosis prognosis immune infiltrating

Correlation between clinicopathological parameters of lung adenocarcinoma and lymph node metastasis

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Oncology and Translational Medicine 2020年第4期6卷 165-169页

作者： Shixun Wang gaoyang lin Nan Ge Ronghua Yang Mengjun Li Donghua Zhao Peng Li Yongjie Wang Qingdao University Qingdao 266000China Department of Thoracic Surgery The Affiliated Qingdao Hiser Medical Center of Qingdao UniversityQingdao 266000China Department of Thoracic Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000China

Objective The aim of the study was to study the correlation between the clinicopathological parameters of lung adenocarcinoma and lymph node metastasis and identify the risk factors of lymph node *** The data of 258 patients with postoperative lung adenocarcinoma(mainly based on their pathological data)were collected and analyzed,and their basic information was *** Maximum tumor diameter was found to be an independent risk factor for lymph node *** larger the maximum diameter of the tumor in patients with lung adenocarcinoma,the higher the likelihood of lymph node *** predominant adenocarcinoma with mucin production is as an independent risk factor for superior mediastinal and subcarinal lymph node *** adenocarcinomas in the lower lobe of the lung may have a higher rate of lymph node metastasis than those in the upper *** The known pathological subtypes of lung adenocarcinoma can be used for the prediction of lymph node metastasis in various regions and guide the dissection of lymph nodes that would improve patients’prognosis.

关键词： lung adenocarcinoma lymph node metastasis pathological subtype risk factors

Clinical significance of S100A7 protein in predicting recurrence of breast cancer in patients undergoing breast-conserving surgery with radiotherapy

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Oncology and Translational Medicine 2019年第5期5卷 211-217页

作者： Chao Zhang Changyou Li gaoyang lin Yao Qi Zhenfeng Li Jing Xu Tianhui Su Xin Liu Xiao Zou Department of Medicine Qingdao UniversityQingdao 266003China Biotherapy Center The Second Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Thoracic Surgery The Affiliated Qingdao Hiser Medical Center of Qingdao UniversityQingdao 266003China Department of Pathology The Second Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Breast Surgery The Second Affiliated Hospital of Qingdao UniversityQingdao 266003China

Objective To investigate the relationship between the expression of S100A7 protein and prediction of recurrence and prognosis of breast cancer in patients undergoing breast-conserving surgery combined with *** 349 samples of carcinoma tissue wax blocks were selected from January 2011 to January 2014 in Qingdao Central *** the patients had undergone breast-conserving *** analyzed S100A7 expression in tumor tissue by immunohistochemical *** univariate and multivariate analyses,we evaluated the relationship between S100A7 and clinical results,to explore independent risk factors for local regional recurrence(LRR).Results The positive expression of S100A7 in the recurrence group(66.7%)was significantly higher than in the non-recurrence group(38.4%),P=0.025.A log-rank test showed that high S100A7 expression was significantly correlated with 5-year regional recurrence free survival rate(RFS)(94.9%vs 89.5%,P=0.0408),distant metastasis free survival rate(DFS)(95.4%vs 83.5%,P<0.001),and overall survival rate(OS)(99.0%vs 92.5%,P=0.0011).Histological grade,vessel carcinoma embolus,lymph node metastasis,S100A7 expression,and tumor size were factors that influenced *** analysis of the Cox proportional hazard model showed that high S100A7 expression was an independent risk factor that affected breast cancer RFS(HR=6.864,95%CI:1.575-29.915,P=0.01).Thus,we concluded that high S100A7 expression is associated with increased risk of LRR and distant metastasis of breast cancer after breast-conserving surgery and postoperative radiotherapy.S100A7 can be used as a molecular marker to screen for patients with high recurrence risk after breast-conserving surgery.

关键词： S100A7 breast-conserving surgery radiotherapy locoregional recurrence prognosis

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MicroRNA调控肿瘤耐药的研究进展

中国肺癌杂志 2014年第10期17卷 741-749页

作者：林高阳徐克天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室天津300052

化学药物治疗(简称化疗)是目前治疗恶性肿瘤的主要手段之一,但肿瘤的多药耐药(multidurg resistance,MDR)是临床化疗失败的主要原因之一,然而肿瘤的耐药机制至今尚未被完全阐明。microRNA是近年来生命科学新的研究热点之一,microRNA通... 详细信息

化学药物治疗(简称化疗)是目前治疗恶性肿瘤的主要手段之一,但肿瘤的多药耐药(multidurg resistance,MDR)是临床化疗失败的主要原因之一,然而肿瘤的耐药机制至今尚未被完全阐明。microRNA是近年来生命科学新的研究热点之一,microRNA通过在转录后水平调控基因表达而参与调控一系列的生命活动,包括细胞增殖、凋亡、脂肪代谢、神经元发育、激素分泌、肿瘤血管生成、干细胞分化、肿瘤细胞浸润及转移等多种生理和病理过程。最近的研究表明,microRNA对多基因表达的调控具有高效性和特异性,对靶基因的异常调控可能构成肿瘤耐药机制,是肿瘤耐药复杂性调控的重要构成部分。因此,对microRNA与肿瘤耐药性的研究具有现实意义。本文对近年来肿瘤耐药性的研究,microRNA调控肿瘤耐药机制及microRNA作为肿瘤耐药治疗潜在靶点作一综述。

关键词： MicroRNA 肿瘤耐药 MDR 靶点

组学技术在氨基酸生产菌株选育中的研究现状与发展趋势

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发酵科技通讯 2017年第4期46卷 205-211页

作者：张权威林高扬马倩天津科技大学生物工程学院天津300457 代谢控制发酵技术国家地方联合工程实验室天津300457 天津市氨基酸高效绿色制造工程实验室天津300457

系统生物学研究手段包括基因组学、转录组学、代谢组学、蛋白组学和通量组学等,可以获得研究对象整体代谢途径、调控网络的信息.将组学技术应用于氨基酸的发酵菌株优化过程,可以为菌株的进一步代谢工程改造提供信息基础与理论指导.介绍... 详细信息

系统生物学研究手段包括基因组学、转录组学、代谢组学、蛋白组学和通量组学等,可以获得研究对象整体代谢途径、调控网络的信息.将组学技术应用于氨基酸的发酵菌株优化过程,可以为菌株的进一步代谢工程改造提供信息基础与理论指导.介绍各种组学技术在氨基酸微生物发酵研究中的应用与发展趋势,通过综合运用各种组学数据信息,可以更好地指导氨基酸发酵优良菌株的理性设计与构建.

关键词：氨基酸组学代谢工程理性设计高产菌株

初植和补植阔叶树对红壤丘陵区湿地松养分获取和转运的影响

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林业科学 2024年第1期60卷 47-57页

作者：夏成康林勇兰勇吴高洋王晟楠陈伏生江西农业大学林学院江西省森林培育重点实验室南昌330045 江西农业大学鄱阳湖流域森林生态系统保护与修复国家林业和草原局重点实验室南昌330045 江西官山国家级自然保护区管理局宜丰336300 江西省森林资源监测中心南昌330045

【目的】探究初植(同龄混植)和补植(异龄混植)阔叶树对湿地松养分获取和利用策略的影响,为湿地松林的科学管理提供参考。【方法】以种植于我国亚热带红壤丘陵区的湿地松林为对象,基于长期单种和混交试验平台,分别在林龄30年且立地条件... 详细信息

【目的】探究初植(同龄混植)和补植(异龄混植)阔叶树对湿地松养分获取和利用策略的影响,为湿地松林的科学管理提供参考。【方法】以种植于我国亚热带红壤丘陵区的湿地松林为对象,基于长期单种和混交试验平台,分别在林龄30年且立地条件相似的湿地松纯林、湿地松-木荷初植混交林、湿地松-木荷补植混交林(补植木荷14年)中构建5块20 m×20 m标准样地(共15块样地),采集湿地松标准木的根际土壤、细根、枝、新鲜叶和凋落叶样品,测定土壤和植物各器官的氮(N)、磷(P)含量,评估不同混交模式对根养分捕获能力、叶养分回收和树木养分转运的影响,揭示养分获取策略变化的驱动因素。【结果】混交阔叶树显著提高湿地松根际土壤的NH_4~+-N和矿质氮含量(P0.05);整体看,混交阔叶树提高湿地松各器官的N、P含量,其中初植混交效应比补植好。与纯林相比,初植混交林中湿地松根氮和磷捕获能力分别显著提高14.04%和46.16%,叶氮回收效率显著降低6.07%,磷回收效率显著提高15.49%。尽管补植阔叶树降低根养分捕获成本,但阔叶树根系抑制湿地松根系的养分捕获能力,导致补植混交林中湿地松根养分捕获能力和叶养分回收效率均无显著变化。此外,与纯林相比,初植混交林中湿地松运输根向枝、叶的N转运分别提高36.05%和15.61%,P转运分别降低35.13%和36.52%;补植混交林中N转运无显著变化,但运输根向枝、叶的P转运比在纯林分别降低53.21%和40.17%。【结论】混交阔叶树提高红壤丘陵区湿地松根际土壤和植株各器官的养分含量,改变湿地松养分获取策略,其中初植比补植更能促进湿地松的养分获取和利用。此外,养分在植物体内的转运过程可被检测,且反映根捕获和叶回收的权衡关系。

关键词：针阔混交林根捕获叶养分回收养分获取策略木荷

SMAD基因家族PCR引物设计及其在非小细胞肺癌中的表达

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山东医药 2018年第24期58卷 26-30页

作者：林高阳高大登袁方刘振波青岛大学附属青岛市海慈医疗集团山东青岛266033

目的自行设计并验证SMAD基因家族PCR引物,探讨应用上述引物进行RT-PCR检测SMAD基因在非小细胞肺癌中表达的可行性。方法自主设计并验证SMAD基因家族SMAD1~SMAD8特异引物,确定SMAD1-1、SMAD2-1、SMAD3-1、SMAD4-2、SMAD5-1、SMAD6-1、SMA... 详细信息

目的自行设计并验证SMAD基因家族PCR引物,探讨应用上述引物进行RT-PCR检测SMAD基因在非小细胞肺癌中表达的可行性。方法自主设计并验证SMAD基因家族SMAD1~SMAD8特异引物,确定SMAD1-1、SMAD2-1、SMAD3-1、SMAD4-2、SMAD5-1、SMAD6-1、SMAD7-1、SMAD8-2引物的扩增效率更高、特异性更强。采用RT-PCR技术检测SMAD1~SMAD8在人正常支气管上皮细胞系BEAS-2B,肺腺癌细胞系A549、H1299,肺鳞癌细胞系SK-MES-1中的表达变化,引物为SMAD1-1、SMAD2-1、SMAD3-1、SMAD4-2、SMAD5-1、SMAD6-1、SMAD7-1、SMAD8-2。结果以正常支气管上皮BEAS-2B细胞中SMAD1表达量为基准(校正RQ约为1),SMAD2相对表达量为6.590±0.459、SMAD3为10.977±0.312、SMAD4为4.651±0.115、SMAD5为16.762±0.389、SMAD6为3.248±0.108、SMAD7为2.007±0.012、SMAD8为1.144±0.103,均较SMAD1表达升高,其中SMAD5表达最高,SMAD3次之。SMAD2、SMAD4、SMAD5、SMAD6、SMAD7、SMAD8在肺腺癌A549、H1299细胞及肺鳞癌SK-MES-1细胞中的表达均低于人正常支气管上皮BEAS-2B细胞;在H1299、SK-MES-1细胞中SMAD1表达高于BEAS-2B和A549细胞,且在A549细胞中SMAD1表达低于BEAS-2B细胞;在SK-MES-1细胞中SMAD3表达升高,且在H1299、A549细胞中SMAD3表达较BEAS-2B细胞下降;在H1299细胞中SMAD2、SMAD6、SMAD7表较其他三种细胞均下降;各细胞间比较P<0.05或<0.01。结论成功自主设计SMAD基因家族特异引物,并用于检测非小细胞肺癌中SMAD基因表达;SMAD5可能参与了肺癌的发生、发展,SMAD3可能与上皮相关性疾病相关。

关键词：非小细胞肺癌聚合酶链式反应果蝇母源抗生物皮肤生长因子基因