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杂交水稻 2024年第3期39卷 97-99页

作者：陈韦韦邓国富周维永李经成伍豪彭德马志广戴高兴广西壮族自治区农业科学院水稻研究所广西南宁530007 广西壮族自治区农业科学院广西南宁530007

万太优美占是广西农科院水稻所选育的超级杂交水稻新组合,具有生育期适中、株型紧凑、分蘖力强、制种产量高、肥料高效利用等特性。根据万太优美占在海南乐东连续3 a的制种实践,总结了其在海南高产制种的相关技术。

关键词：杂交水稻超级稻万太优美占海南制种

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基于案例-启发-探究多维教学模式的食品科学与工程专业课程改革研究--以南京财经大学为例

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农产品加工 2021年第19期 103-105页

作者：马高兴裴斐苏安祥杨帆夏季南京财经大学食品科学与工程学院江苏南京210023

传统讲授式教学模式使食品科学与工程专业相关课程中的理论知识无法与实践相结合,很难达到教学目的和人才培养的目标。通过构建相关课程的启发-案例-探究式多维教学模式,对推动课程的教学效果具有重要的推动意义。

关键词：案例式启发式探究式多维教学食品科学与工程

替吉奥联合奥沙利铂在晚期结肠癌化疗中的应用效果

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中国实用医刊 2024年第10期51卷 82-85页

作者：张静乔高星康健李玉芳王淑娟马柔柔杜书章郑州大学第一附属医院药学部郑州450000

目的研究替吉奥联合奥沙利铂在晚期结肠癌化疗中的应用效果。方法队列研究。抽取2021年7月至2022年7月郑州大学第一附属医院收治的晚期结肠癌患者74例, 通过红蓝摸球法随机分为常规组和观察组, 每组37例。常规组应用FOLFOX4方案(奥沙利... 详细信息

目的研究替吉奥联合奥沙利铂在晚期结肠癌化疗中的应用效果。方法队列研究。抽取2021年7月至2022年7月郑州大学第一附属医院收治的晚期结肠癌患者74例, 通过红蓝摸球法随机分为常规组和观察组, 每组37例。常规组应用FOLFOX4方案(奥沙利铂+亚叶酸钙+5-氟尿嘧啶)化疗, 观察组应用替吉奥联合奥沙利铂化疗。比较两组临床疗效、血清肿瘤标记物水平、不良反应发生情况及生存周期。结果观察组的客观缓解率(89.19%, 33/37)和疾病控制率(97.30%, 36/37)高于常规组(51.35%, 19/37;78.38%, 29/37), 差异均有统计学意义(P均<0.05)。治疗12周后, 两组糖类抗原199、结肠癌特异性抗原-2、癌胚抗原、细胞角蛋白19片段抗原21-1水平均下降, 且观察组低于常规组(P<0.05)。观察组恶心呕吐(8.11%, 3/37)、腹泻(5.41%, 2/37)发生率低于常规组(37.84%, 14/37;29.73%, 11/37), 差异均有统计学意义(P均<0.05)。观察组生存率(94.59%, 35/37)高于常规组(62.16%, 23/37), P<0.05。结论在晚期结肠癌化疗中应用替吉奥联合奥沙利铂进行化疗, 临床效果显著, 可降低患者的血清肿瘤标记物水平, 减少恶心呕吐、腹泻发生率, 延长患者生存周期。

关键词：奥沙利铂替吉奥晚期结肠癌不良反应

Comparative proteomic analysis of extracellular matrix proteins secreted by hypertrophic scar witb normal skin fibroblasts

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Burns & Trauma 2014年第2期2卷 76-83页

作者： Li ma Chengjun Gan Yong Huang Ying Wang gaoxing Luo Jun Wu Chongqing Key Laboratory for Disease Proteomics State Key Laboratory of Trauma Burns and Combined Injury Institute of Burn Research Southwest Hospital the Third Military Medical University Chongqing School of Environmental Air Security and Pollution Control Engineering Jinan University Guangzhou Chongqing Key Laboratory for Disease Proteomics State Key Laboratory of Trauma Burns and Combined Injury Institute of Burn Research Southwest Hospital the Third Military Medical University Chongqing The 421 Hospital People's Liberation Army Guangzhou China Chongqing Key Laboratory for Disease Proteomics State Key Laboratory of Trauma Burns and Combined Injury Institute of Burn Research Southwest Hospital the Third Military Medical University Chongqing

The formation of hypertrophic scars (HSs) is a fibroproliferative disorder of abnormal wound healing. HSs usually characterize excessive proliferation of fibroblasts, abnormal deposition of extracellular matrix (ECM) during wound healing, associated with cosmetic, functional, and psychological problems. Owing to the role of ECM proteins in scar formation, we comparatively analyzed matrix proteins secreted by normal skin fibroblasts (NSFs) and HS fibroblasts (HSFs). The acetone-extracted secreted proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and identified by mass spectrometry (MS). Based on Go annotation of MS data, the profiling of ECM proteins was established and scar-related proteins have been screened out. The functions of several ECM proteins identified by MS have been discussed, such as collagens I, VI, XII, fibronectin, decorin, lumican, and protein procollagen C endopeptidase enhancer 1 (PCPE-1). Among them, the MS result of PCPE-1 was supported by Western blotting that PCPE-1 from HSFs were significantly upregulated than that from NSFs. It is suggested that PCPE-1 could be a potential target for scar treatment. The exploration of scar related proteins may provide new perspectives on understanding the mechanism of scar formation and open a new way to scar treatment and prevention.

关键词： Extracellular matrix protein fibroblast proteomics hypertrophic scar

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基于卷积神经网络的中国北方冬小麦遥感估产

农业工程学报 2019年第15期35卷 119-128页

作者：周亮慕号伟马海姣陈高星兰州交通大学测绘与地理信息学院兰州730070 地理国情监测技术应用国家地方联合工程研究中心兰州730070 甘肃省地理国情监测工程实验室兰州730070 西北农林科技大学水利与建筑工程学院杨凌712100 北京地空数驰科技有限公司北京100871

针对传统的农作物估产方法过度依赖人工经验,以及实地采样成本高等问题。该研究使用MODIS数据构建了基于卷积神经网络(convolutional neural network,CNN)的冬小麦估产模型。对2006-2016年中国北方冬小麦核心区的60个地级市进行模型训练... 详细信息

针对传统的农作物估产方法过度依赖人工经验,以及实地采样成本高等问题。该研究使用MODIS数据构建了基于卷积神经网络(convolutional neural network,CNN)的冬小麦估产模型。对2006-2016年中国北方冬小麦核心区的60个地级市进行模型训练,鲁棒性检验以及估产误差空间特征分析。结果表明:1)估产模型在训练集和验证集的均方根误差(root mean square error,RMSE)分别为183.82 kg/hm^2、689.72 kg/hm^2,决定系数(R^2)分别为0.98、0.71。2)以同样的神经网络结构对2006-2016年估产样本分别作为验证集,训练11个独立模型的RMSE平均值是772.03 kg/hm^2,证明算法具有较高的鲁棒性。3)2007、2012和2016年不同省份的估产结果表明,模型对北方冬小麦区的平原区估产精度较高,尤其是河北和山东2省(RMSE为500 kg/hm^2)。该文构建的估产模型可以实现冬小麦单产的复杂拟合,可以应用于较大尺度(范围)冬小麦产量预报。

关键词：作物产量遥感作物估产卷积神经网络深度学习冬小麦

Mitsugumin 53 protects the kidney from severe burn injury in mice

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Burns & Trauma 2013年第3期1卷 128-133页

作者： Yanjun Wu Jian Huang Daisong Liu Jianglin Tan Yanmeng Peng Junjie Yang Yanyan Cui Weifeng He gaoxing Luo Jun Wu Institute of Burn Research Southwest Hospital Third Military Medical University Chongqing Department of Urinary Surgery Chengdu Seventh People's Hospital Chengdu tumor hospital Chengdu China

Mitsugumin 53 (MG53), a newly identified muscle-specific protein, is an essential component of the cell membrane repair machinery in skeletal and cardiac muscle. However, the role of MG53 after burns in other tissues remains unclear. This study aims to investigate the possible roles of MG53 in the protection of the kidney after severe burn injury, and an animal scalding model of 30% of total body surface area (TBSA) was used. Recombinant human MG53 (rhMG53) or bovine serum albumin (BSA) was injected intravenously via the tail vein. Data showed that the mortality in the MG53-treated group was lower than that in control group. Administration of rhMG53 may alleviate histological alterations in renal tubular epithelial cells after burn injury. Renal tubular injury scores and the average optical density score of kidney injury molecule-1 (KIM-1) immunohistochemical staining in the MG53-treated group were significantly lower than those in control group (P < 0.001). Exogenous rhMG53 was found to be located in renal tubular epithelial cells. Numerous polymerase I and transcript release factor (PTRF) were expressed in the mouse kidney after severe scalding. In conclusion, our data indicate that MG53 protein protects the kidney by involving local PTRF after severe burn injury.

关键词： Burn injury recombinant human Mitsugumin53 kidney polymeraseⅠand transcript release factor kidney injury molecule-1

Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization

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Burns & Trauma 2021年第1期9卷 299-310页

作者： Zengjun Yang Xiaohong Hu Lina Zhou Yaxiong He Xiaorong Zhang Jiacai Yang Zhenyu Ju Yih-Cherng Liou Han-Ming Shen gaoxing Luo Michael R.Hamblin Weifeng He Rui Yin Department of Dermatology Southwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Chongqing Key Laboratory for Disease Proteomics No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Department of Endocrinology Southwest HospitalThird Military Medical University(Army Medical University)No.30 Gaotanyan StreetShapingba DistrictChongqing400038China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityNo.601 Huangpu StreetTianhe DistrictGuangzhouGuangdong Province510632China Department of Biological Sciences National University of Singapore14 Science Drive 4117543Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of Singapore14 Science Drive 4117543Singapore Wellman Center for Photomedicine Massachusetts General HospitalHarvard Medical School40 Blossom StreetBostonMA02114USA Laser Research Centre Faculty of Health ScienceUniversity of JohannesburgDoornfontein 202817011 South Africa

Background:Epidermal stem cells(EpSCs)that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin *** is known about the effects of photochemical activation on EpSC differentiation,proliferation and migration during wound *** present study aimed to determine the effects of photodynamic therapy(PDT)on wound healing in vivo and in ***:We created mouse full-thickness skin resection models and applied 5-aminolevulinic acid(ALA)for PDT to the wound *** healing was analysed by gross evaluation and haematoxylin–eosin staining in *** cultured EpSCs,protein expression was measured using flow cytometry and *** migration was examined using a scratch model;apoptosis and differentiation were measured using flow ***:PDT accelerated wound closure by enhancing EpSC differentiation,proliferation and migration,thereby promoting re-epithelialization and *** inhibited inflammatory infiltration and expression of proinflammatory cytokines,whereas the secretion of growth factors was greater than in other *** proportion of transient amplifying cells was significantly greater in vivo and in vitro in the PDT *** migration was markedly enhanced after ALAinduced ***:Topical ALA-induced PDT stimulates wound healing by enhancing re-epithelialization,promoting angiogenesis as well as modulating skin *** work provides a preliminary theoretical foundation for the clinical administration of topical ALA-induced PDT in skin wound healing.

关键词： Photodynamic therapy Wound healing 5-aminolevulinic acid Re-epithelialization Epidermal stem cells Transient amplifying cells

石羊河下游不同衰退程度多枝柽柳灌丛水分利用格局研究

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生态学报 2022年第17期42卷 7187-7197页

作者：赵鹏徐先英姜生秀徐高兴柴成武张逸君马玉莲戚福俊高德才张国平甘肃省治沙研究所荒漠化与风沙灾害防治省部共建国家重点实验室培育基地兰州730070 中国科学院西北生态环境资源研究院沙漠与沙漠化重点实验室兰州730010 兰州大学西部生态安全省部共建协同创新中心兰州730010 古浪县海子滩林场古浪733100

多枝柽柳(Tamarix ramosissima)灌丛是石羊河下游防风固沙林的重要组成,对绿洲免受风沙灾害侵袭发挥着关键作用。由于区域水文环境的恶化,多枝柽柳灌丛大面积退化死亡,亟需人工恢复,但其季节水分来源尚不清楚。为此,基于氢氧稳定同位素... 详细信息

多枝柽柳(Tamarix ramosissima)灌丛是石羊河下游防风固沙林的重要组成,对绿洲免受风沙灾害侵袭发挥着关键作用。由于区域水文环境的恶化,多枝柽柳灌丛大面积退化死亡,亟需人工恢复,但其季节水分来源尚不清楚。为此,基于氢氧稳定同位素示踪技术,运用IsoSource模型,定量分析了不同衰退程度多枝柽柳灌丛的水分利用策略。结果表明:2016年石羊河下游降雨以小于5 mm小降雨事件为主,降雨氧稳定同位素值(δO)的季节效应明显。降水线方程为氢稳定同位素氘值δD=6.46δO-5.11,R^(2)=0.87。整体上,不同衰退程度多枝柽柳灌丛土壤水分在夏季较低,秋季略为恢复。由于衰退程度越严重蒸腾耗水越低,生长季多枝柽柳灌丛土壤水分大小排序为重度(3.48%)>极重度(2.69%)>中度(1.97%)>轻度(1.87%)。降雨与土壤水δD的变化关系分析表明,6—10月降雨对衰退多枝柽柳灌丛土壤水补给贡献较大。土壤水、降水、地下水是不同退化程度多枝柽柳灌丛的潜在水源。受春季蒸发损失小,冠层截留少,以及土壤生物结皮的综合影响,不同衰退阶段多枝柽柳春季对降水的平均利用比例达40.63%,大小排序为重度衰退(58.5%)>中度衰退(41.7%)>轻度衰退(39.3%)>极重度衰退(23%)。春季到秋季衰退多枝柽柳灌丛趋向于利用可靠的深层地下水。随生境水分可获得性的变化,不同衰退程度多枝柽柳选择性利用降雨、土壤水、地下水。虽然能勉强维持生存,但石羊河下游衰退多枝柽柳灌丛有被红砂(Reaumuria soongarica)等超耐旱小灌木替代的趋势。建议干旱区人工植被建设应以水定绿,灌草结合,少选择乔木、大灌木等高耗水植物种作为固沙造林树种。

关键词：多枝柽柳灌丛土壤水降水地下水水分来源稳定氢氧同位素

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甘肃沙葱产业化发展历程、现状及展望

甘肃林业科技 2023年第4期48卷 64-67,78页

作者：严子柱刘有军姚泽马全林姜生秀徐高兴甘肃省荒漠化与风沙灾害防治重点实验室甘肃兰州730070 甘肃民勤荒漠草地国家野外观测试验站甘肃民勤733300 甘肃省沙生植物工程技术研究中心甘肃兰州730070 甘肃省林业科学研究院甘肃兰州730020

本文通过资料收集、问卷调查和实地调研的方法,在数据资料分析的基础上,论述了甘肃野生沙葱驯化栽培、人工大田丰产栽培和温室反季节栽培的历程和现状,并总结了研究项目成果转化及推广的历程和现状,对沙葱产业化前景进行了展望。这将为... 详细信息

本文通过资料收集、问卷调查和实地调研的方法,在数据资料分析的基础上,论述了甘肃野生沙葱驯化栽培、人工大田丰产栽培和温室反季节栽培的历程和现状,并总结了研究项目成果转化及推广的历程和现状,对沙葱产业化前景进行了展望。这将为相关从业人员开展沙葱研究提供有益参考,并对沙葱产业未来的发展和研究方向提供理论指导。

关键词：沙葱产业化发展历程发展现状

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滑县某肉鸡饲养场AA肉鸡生产性能表现分析

畜牧与兽医 2020年第2期52卷 32-34页

作者：马发顺王高兴梁秀丽宋玉伟安阳工学院生物与食品工程学院河南安阳455000 河南省动物疫病防控与营养免疫院士工作站河南安阳455000 河南省滑县平上养鸡场河南滑县456400

为了掌握AA肉鸡在豫北地区特定环境条件下的生产性能表现,在河南省滑县某肉鸡饲养场收集了10栋鸡舍的原始生产记录,对1~5周龄环境条件与体重之间的关系进行了分析,计算了日增重、成活率、料重比和欧洲指数等生产性能指标,并以实际观测... 详细信息

为了掌握AA肉鸡在豫北地区特定环境条件下的生产性能表现,在河南省滑县某肉鸡饲养场收集了10栋鸡舍的原始生产记录,对1~5周龄环境条件与体重之间的关系进行了分析,计算了日增重、成活率、料重比和欧洲指数等生产性能指标,并以实际观测项目与饲养目标进行了逐项比较。结果显示:AA肉鸡对当地的环境条件适应性良好,温度控制高于目标温度1~2℃,湿度控制存在波动性,风速呈前期低后期高的态势,体感温度呈现平稳下降趋势;体重各周龄均极显著高于目标体重(P<0.01);日增重1~3周龄极显著高于饲养目标(P<0.01),4周龄显著高于饲养目标(P<0.05);成活率和料重比除1周龄外均极显著高于饲养目标(P<0.01);各周龄欧洲指数均超过320。说明AA肉鸡在豫北地区生长发育良好,生产性能表现优良,此研究结果可作为AA肉鸡饲养管理的参考,也可作为AA肉鸡相关研究的基础资料。

关键词： AA肉鸡饲养环境生产性能