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Vigorously Promoting Ecological Progress to Build a Beautiful China

Qiu Shi 2014年第2期6卷 5-26页

作者： zhang gaoli Member of the Standing Committee of the Political Bureau of the CPC Central Committee and Vice-Premier of the State Council

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Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight

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Genes & Diseases 2023年第2期10卷 608-617页

作者： Qian Zhu Yingzhi zhang Juan Kang Zhiwei Chen Mingli Peng Min Chen gaoli zhang Dejuan Xiang Shuang Xiao Hu Li Ying Mei Jie Yang Xiaoya Qi Dachuan Cai Hong Ren Department of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education)Institute for Viral HepatitisThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400061China Health Management Center The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400061China

Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese ***,limited literature exists to explore the effect of obesity on the humoral and cellular immune response to these *** this study,132 high BMI(Body mass index)(obesity and overweight,BMI≥24 kg/m^(2))and 82 normal BMI(BMI<24 kg/m^(2))participants were *** events(AEs),Spike receptor-binding domain IgG antibody(anti-RBD-IgG),neutralizing antibodies(NAbs),and specific B-cell and T-cell responses were evaluated 21–105 days after full-course inactivated COVID-19 *** overall incidence of AEs was similar in individuals with and without obesity/*** serious vaccine-related AEs *** with obesity/overweight had a reduced seropositivity rate of NAbs compared to those with normal ***-RBD-IgG and NAbs titers in the high BMI group were significantly lower than those in the normal BMI *** frequencies of RBD-specific memory B cells(MBCs)and the numbers of spike-specific TNF-α+spot-forming cells(SFCs)in individuals with obesity/overweight were reduced compared with those noted in individuals without obesity/overweight.A similar trend of weakened humoral responses was also observed in individuals with central *** study results suggested that inactivated COVID-19 vaccines were safe and well tolerated but induced poor humoral and cellular immune responses in Chinese individuals with obesity/overweight.

关键词： COVID-19 Immune response Inactivated vaccine Obesity Overweight

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Dynamic Humoral Immune Response to Primary and Booster Inactivated SARS-CoV-2 Vaccination in Patients with Cirrhosis

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1476-1484页

作者： Qian Zhu Lu Wang Xiaoxiao Hu Yingzhi zhang Tianquan Huang Taiyu He Zhiwei Chen gaoli zhang Mingli Peng Min Chen Dachuan Cai Xiaofeng Shi Hong Ren Department of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education)Institute for Viral HepatitisThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina

Background and Aims:Our aim was to determine the immune efficacy of a severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)booster vaccination in cirrhotic patients who had received the primary ***:We performed a longitudinal assessment in 48 patients with cirrhosis,57 patients with chronic hepatitis B(CHB)and 68 healthy controls(HCs)to continuously track the dynamics of SARS-CoV-2 specific antibodies and memory B cells after receiving the primary series and booster dose at different times.A pseudovirus neutralization assay was used to determine neutralization against Omicron subvariants BA.2.12.1,BA.4 and BA.5 from serum samples collected from three ***:Serum anti-receptor-binding domain(RBD)immunoglobulin(Ig)G and neutralizing antibody(NAb)levels in cirrhotic patients were elevated within 15–45 days after completing the primary series before rapidly declining and reaching a valley at around 165–195 *** receiving the booster dose,both antibody levels were significantly increased to levels comparable to patients with CHB and *** analysis showed that booster vaccination induced weaker antibody responses in patients with decompensated cirrhosis than in those with compensated *** SARS-CoV-2 memory B-cell response in cirrhotic patients was durable during follow-up regardless of the hepatic fibrocirrhosis ***,compared with the primary series,the booster dose did not result in an evident improvement of neutralization activity against the Omicron subvariants BA.2.12.1 and BA.4,and was followed by a significant decrease in the titer against ***:A booster dose elicited a robust and durable humoral response to the wild-type strain in cirrhotic patients but not the Omicron *** vaccination of inactivated SARS-CoV-2 vaccine may not benefit cirrhotic patients in neutralization against newly circulating strains.

关键词： SARS-CoV-2 Omicron subvariants Cirrhosis Booster dose Humoral response

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Safety and Immunogenicity After Primary and Booster Inactivated SARS-Cov-2 Vaccination in Patients with Autoimmune Liver Diseases

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 162-171页

作者： Zhiwei Chen Yuting Wang Taiyu He Hu Li Ling Ao Qingbo Pan Yingzhi Zhou Qian Zhu Dejuan Xiang gaoli zhang Ning Ling Min Chen Peng Hu Mingli Peng Dachuan Cai Dazhi zhang Hong Ren Department of Infectious Diseases the Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral Hepatitisthe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Background and Aims:SARS-CoV-2 vaccines-associated autoimmune liver diseases have been reported in several case ***,the safety and immunogenicity after primary and booster inactivated SARS-CoV-2 vaccination in patients with autoimmune liver diseases(AILD)is still ***:Eighty-four patients with AILD were prospectively followed up after the second dose(primary)of inactivated SARS-CoV-2 *** of them received the third dose(booster)of inactivated *** events(AEs),autoimmune activation,and liver inflammation exacerbation after primary and booster vaccination were ***,dynamics of antireceptor-binding-domain IgG(anti-RBD-IgG),neutralizing antibodies(NAbs)and RBD-specific B cells responses were ***:The overall AEs in AILD patients after primary and booster vaccination were 26.2%and 13.3%,*** decrease of C3 level and increase of immunoglobulin light chain K andλlevels were observed in AILD patients after primary vaccination,however,liver inflammation was not exacerbated,even after booster *** the seroprevalence and titers of anti-RBD-IgG and NAbs were decreased over time in AILD patients after primary ***,the antibody titers were significantly elevated after booster vaccination(10-fold in anti-RBD-IgG and 7.4-fold in NAbs,respectively),which was as high as in healthy ***,the inferior antibody response was not enhanced after booster vaccination in patients with *** of atypical memory B cells were inversely related to antibody levels,which indicate that the impaired immune memory was partially restored partly by the booster ***:The well tolerability and enhanced humoral immune response of inactivated vaccine supports an additional booster vaccination in AILD patients without immunosuppressants.

关键词： SARS-CoV-2 Autoimmune liver disease Inactivated SARS-CoV-2 vaccine Safety Antibody responses Memory B cells

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论禅茶与佛教中国化之关系

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农业考古 2022年第5期 150-155页

作者：施由明张高丽江西省社会科学院江西省博物馆

禅茶产生于佛教中国化的过程中。禅茶产生后助推佛教中国化,从而对佛教中国化有着重要贡献:一是禅茶,即以茶参禅、悟禅,使源自印度的不品茶、饮茶的佛教,适应了中国人,特别的文人士大夫的生活方式和生活情调的需要,让文人士大夫们与禅... 详细信息

禅茶产生于佛教中国化的过程中。禅茶产生后助推佛教中国化,从而对佛教中国化有着重要贡献:一是禅茶,即以茶参禅、悟禅,使源自印度的不品茶、饮茶的佛教,适应了中国人,特别的文人士大夫的生活方式和生活情调的需要,让文人士大夫们与禅僧们都沉湎于茶与禅,通过演绎茶艺和品茶,体悟禅境,助推了禅宗作为中国化的佛教在中国传承不衰。二是禅茶是佛教中国化的重要路径。佛门中人不仅以茶娱情、以茶悟禅,还以茶为媒介,制定修行的规矩,如制定茶规茶礼,按规定的程式和规矩饮茶,以茶表达佛门礼仪,从而使禅宗具有鲜明的中国特色。

关键词：禅茶佛教中国化

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Optimization of room temperature multi-wavelength erbium-doped fiber ring laser in the C-band

Optimization of room temperature multi-wavelength erbium-dop...

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Asia-pacific Optical Communications 2004

作者： gaoli zhang Yong Yao* Qi Wang Research Center of Laser Technology Harbin Institute of Technology ShenZhen China

Room temperature multi-wavelength erbium-doped fiber ring laser in the C-band is presented. Homogeneous gain broadening of erbium-doped fiber (EDF) is suppressed by adding a frequency shifter in the r

关键词： Erbium-doped fiber laser (EDFL) Multi-wavelength Optical fiber devices WDM frequency shifted feedback (FSFB)

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北宋初期佛教融摄道教初探——以赣州慈云寺塔所出《行瘟使者皈佛图》为例

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南方文物 2022年第4期 103-108页

作者：邓影张高丽中共四川省委党校哲学教研部江西省博物馆

佛教与道教的相互文化交流向来一直备受研究者关注,但由于文献缺乏的缘故,北宋初期佛教对道教文化的融摄问题却罕有研究。2004年江西赣州慈云寺塔所出的五代宋初绘本《行瘟使者皈佛图》为解决这一问题提供了重要图像资料。通过对此图中... 详细信息

佛教与道教的相互文化交流向来一直备受研究者关注,但由于文献缺乏的缘故,北宋初期佛教对道教文化的融摄问题却罕有研究。2004年江西赣州慈云寺塔所出的五代宋初绘本《行瘟使者皈佛图》为解决这一问题提供了重要图像资料。通过对此图中“五方行瘟使者”的源流及其与梵僧灵严大圣关系的分析发现,北宋初期的佛教依然在积极融摄道教知识,并且将道教神祇(行瘟使者)佛教化,但此一融摄过程却并非显而易见,而是通过满足民众需求与对民俗知识的继承来隐晦体现出来的。

关键词：融摄五方行瘟使者灵严大圣《行瘟使者皈佛图》

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计及用户贡献度的电动汽车主从博弈差异化充电套餐设计

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电力自动化设备 2022年第10期42卷 21-29页

作者：王华昕张高丽刘隽孙华本汤波上海电力大学电气工程学院上海200090 上海蔚来汽车有限公司上海201805

随着电力市场体制改革的不断深化,为改善国内大部分城市尚未达到激励大规模电动汽车(EV)参与需求响应的现状,并充分调动EV用户参与碳市场、绿电市场的积极性,提出了一种基于EV用户画像的多市场融合充电套餐策略。在保障用户充电满意度... 详细信息

随着电力市场体制改革的不断深化,为改善国内大部分城市尚未达到激励大规模电动汽车(EV)参与需求响应的现状,并充分调动EV用户参与碳市场、绿电市场的积极性,提出了一种基于EV用户画像的多市场融合充电套餐策略。在保障用户充电满意度的前提下,激励用户改变自身的充电行为,降低电网负荷峰谷差,实现EV聚合商的利润最大化。构建了主方以EV聚合商利润最大化为目标的套餐制定模型和从方以用户效用最大化为目标的套餐决策模型,采用Nash-Q算法求出纳什均衡解。通过实例表明差异化充电套餐策略有效提高了EV聚合商的营业利润、降低了用户充电成本。

关键词：电动汽车用户画像电动汽车聚合商需求响应充电

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进一步加快滨海新区开发开放为天津科学发展和谐发展率先发展而奋斗——在中国共产党天津市第九次代表大会上的报告

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港口经济 2007年第6期 5-15页

作者：张高丽

高举邓小平理论和“三个代表”重要思想伟大旗帜,全面贯彻落实科学发展观,抓住难得的历史性机遇,进一步加快滨海新区开发开放,为实现科学发展和谐发展率先发展,把天津建设成为国际港口城市、北方经济中心和生态城市而努力奋斗。

关键词：滨海新区天津市国际港口城市产业功能区国际物流中心经济和谐发展中华人民共和国代表

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农地流转模式对土地利用综合效益影响研究——以天津市静海区为例

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天津农业科学 2018年第10期24卷 35-38页

作者：张高丽天津城建大学经济与管理学院天津300384

以天津市静海区为调查对象,通过问卷调查和访谈相结合的方法,从经济、社会和生态3个视角,选择非农就业比、化肥使用量等6个指标构建指标体系,分析转包、出租和农村合作社3种模式的综合效益。结果表明:合作社模式的综合效益最高,为88.99... 详细信息

以天津市静海区为调查对象,通过问卷调查和访谈相结合的方法,从经济、社会和生态3个视角,选择非农就业比、化肥使用量等6个指标构建指标体系,分析转包、出租和农村合作社3种模式的综合效益。结果表明:合作社模式的综合效益最高,为88.99分;其次是转包,为67.11分;最低的是出租,为61.28分。因此,笔者建议在与天津相似的平原地区,政府应适当鼓励农户将土地流转给农村合作社实现规模经营。

关键词：农地流转综合效益流转模式

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