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Delivering Microrobots in the Musculoskeletal System

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Nano-Micro Letters 2024年第11期16卷 585-617页

作者： Mumin Cao Renwang Sheng Yimin Sun Ying Cao Hao Wang Ming Zhang Yunmeng Pu Yucheng Gao Yuanwei Zhang Panpan Lu gaojun Teng Qianqian Wang Yunfeng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuPeople’s Republic of China School of Medicine Southeast UniversityNanjing 210009People’s Republic of China Orthopaedic Trauma Institute(OTI) Southeast UniversityNanjing 210009People’s Republic of China Jiangsu Key Laboratory for Design and Manufacture of Micro‑Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 210009People’s Republic of China Center of Interventional Radiology and Vascular Surgery Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009People’s Republic of China

Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited *** often suffer chronic pain and might eventually have to undergo end-stage ***,future treatments should focus on early detection and intervention of regional *** have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted *** the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for *** the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the *** to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/*** review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal *** summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.

关键词： Microrobot Musculoskeletal system Targeted delivery Microrobotic systems Magnetic actuation

Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1693-1710页

作者： Xiong Chen Jinfu Qian Shiqi Liang Jianchang Qian Wu Luo Yujuan Shi Hong Zhu Xiang Hu gaojun Wu Xiaokun Li Guang Liang Department of Endocrinology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China Department of Wound Repair the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Department of Cardiology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China School of Pharmaceutical Sciences Hangzhou Medical CollegeHangzhou 311399China

Protein tyrosine kinases (RTKs) modulate a wide range of pathophysiological events in several non-malignant disorders, including diabetic complications. To find new targets driving the development of diabetic cardiomyopathy (DCM), we profiled an RTKs phosphorylation array in diabetic mouse hearts and identified increased phosphorylated fibroblast growth factor receptor 1 (p-FGFR1) levels in cardiomyocytes, indicating that FGFR1 may contribute to the pathogenesis of DCM. Using primary cardiomyocytes and H9C2 cell lines, we discovered that high-concentration glucose (HG) transactivates FGFR1 kinase domain through toll-like receptor 4 (TLR4) and c-Src, independent of FGF ligands. Knocking down the levels of either TLR4 or c-Src prevents HG-activated FGFR1 in cardiomyocytes. RNA-sequencing analysis indicates that the elevated FGFR1 activity induces pro-inflammatory responses via MAPKs–NFκB signaling pathway in HG-challenged cardiomyocytes, which further results in fibrosis and hypertrophy. We then generated cardiomyocyte-specific FGFR1 knockout mice and showed that a lack of FGFR1 in cardiomyocytes prevents diabetes-induced cardiac inflammation and preserves cardiac function in mice. Pharmacological inhibition of FGFR1 by a selective inhibitor, AZD4547, also prevents cardiac inflammation, fibrosis, and dysfunction in both type 1 and type 2 diabetic mice. These studies have identified FGFR1 as a new player in driving DCM and support further testing of FGFR1 inhibitors for possible cardioprotective benefits.

关键词： Diabetic cardiomyopathy Protein tyrosine kinases FGFR1 Cardiomyocytes Inflammatory responses Toll-like receptor4 c-Src NFkB

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减肥栓塞术现状及展望

介入放射学杂志 2024年第8期33卷 817-820页

作者：曹清越王志滕皋军东南大学医学院东南大学附属中大医院介入与血管外科江苏南京210009

过去50年间,全球肥胖发病率大幅增加,严重威胁人类健康。常规减重手段,如饮食、运动疗法等难以获得稳定、快速的减肥效果,而目前多数具有减重作用药物的主要适应证为糖尿病,不宜用于单纯肥胖人群。传统外科减肥手术普及率低、手术费用... 详细信息

过去50年间,全球肥胖发病率大幅增加,严重威胁人类健康。常规减重手段,如饮食、运动疗法等难以获得稳定、快速的减肥效果,而目前多数具有减重作用药物的主要适应证为糖尿病,不宜用于单纯肥胖人群。传统外科减肥手术普及率低、手术费用及并发症风险高。因此,减肥栓塞术(bariatricarteryembolization,BAE)作为新兴的减肥疗法应运而生,快速发展。BAE不仅能实现长期有效的体重控制,还可能给糖尿病前驱期患者带来额外的血糖获益,且相比于传统减重手术,BAE创伤小、恢复快、术后并发症风险低。但目前对于术中栓塞材料及栓塞位点的选择尚无统一标准,术后胃功能的变化情况以及机体代谢改善的具体机制也有待进一步探讨。本文对BAE的研究背景、技术原理、国内外最新研究进展及存在的问题进行介绍。

关键词：栓塞减肥肥胖饥饿素糖代谢

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国际视野下数字教育的战略重点与发展趋势

中国电化教育 2024年第5期 61-70页

作者：杨俊锋孙耀施高俊朱浩田杭州师范大学经亨颐教育学院浙江杭州311121 教育部教育信息化战略研究基地(北京) 北京100857

数字教育是教育高质量发展的重要突破口。然而,学术和实践领域对数字教育的内涵意蕴和方向定位尚未充分讨论和达成共识。该文从国际视野出发,分析了全球40余份数字教育政策文本,对数字教育内涵和价值进行深入解读。研究发现,当前世界数... 详细信息

数字教育是教育高质量发展的重要突破口。然而,学术和实践领域对数字教育的内涵意蕴和方向定位尚未充分讨论和达成共识。该文从国际视野出发,分析了全球40余份数字教育政策文本,对数字教育内涵和价值进行深入解读。研究发现,当前世界数字教育政策聚焦于六大战略重点:教育包容公平与质量、数字教育新基建规划、数字素养及高阶思维、数字化教学方法创新、以人为本的个性化评价、校企社高效联动互通。此外,探讨了国际上数字教育的发展趋势,包括元宇宙、GAI、大数据、区块链等新兴技术的充分应用,并凸显人文价值、智能素养、伦理规范等基础保障,促进数字教育生态体系的健康发展。

关键词：数字教育教育数字化教育政策国际比较

基于社会图式理论的目的地形象错位与调控研究——以丁真现象为例

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旅游学刊 2024年第6期39卷 101-114页

作者：王雨莎高凌云张高军暨南大学深圳旅游学院广东深圳518053 中南大学商学院湖南长沙410012 武汉大学经济与管理学院湖北武汉430072

形象对旅游目的地可持续发展的重要作用已成共识,但囿于刻板印象和认知复杂性,旅游形象与真实的目的地并不总是匹配,甚至存在偏差,对这种形象错位需要给予更多关注。文章从“四川丁真带火西藏”现象切入,应用内容分析法、图式分析法和... 详细信息

形象对旅游目的地可持续发展的重要作用已成共识,但囿于刻板印象和认知复杂性,旅游形象与真实的目的地并不总是匹配,甚至存在偏差,对这种形象错位需要给予更多关注。文章从“四川丁真带火西藏”现象切入,应用内容分析法、图式分析法和物种多样性评价方法,系统分析调控前后用户评论数据,总结概括其中的形象错位现象、形成原因及调控结果。结果表明:1)形象错位受刻板形象的直接影响,由人的认知规律支配,地理相似性和文化交互性是形象错位产生的动力因素,当实际形象与刻板形象不匹配时,就会产生形象错位,而形象错位的影响通常是负面的;2)外部信息是调控形象错位的关键,新信息注入能够有效突破既有图式,产生新的图式,从而调控形象错位;3)社交媒体能够使形象错位的调控效果最大化;4)与形象符号关联较远的要素及图式容易得到修正,而联系紧密的部分调控效果有限,此外,与目的地紧密相关的自然地理图式,尤其是社会经济图式调控效果显著,对目的地营销实践也更具价值。

关键词：旅游形象形象错位刻板形象社会图式理论

高浓度氨氮对厌氧膜生物反应器处理养猪废水的抑制影响及生物炭缓解效能

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环境工程学报 2024年第5期18卷 1283-1291页

作者：张波王高骏付鹏陈奕志张祥陈荣西安建筑科技大学环境与市政工程学院西安710055 西安建筑科技大学西北水资源与环境生态教育部重点实验室西安710055

针对养猪废水中高浓度氨氮对甲烷发酵过程的抑制问题,研究了不同氨氮负荷对厌氧膜生物反应器(anaerobic membrane bioreactor,AnMBR)处理养猪废水效能的影响及生物炭投加的缓解调控效能。结果表明,在(外源)氨氮负荷为0、3000、4500 mg·... 详细信息

针对养猪废水中高浓度氨氮对甲烷发酵过程的抑制问题,研究了不同氨氮负荷对厌氧膜生物反应器(anaerobic membrane bioreactor,AnMBR)处理养猪废水效能的影响及生物炭投加的缓解调控效能。结果表明,在(外源)氨氮负荷为0、3000、4500 mg·L^(−1)时,常规AnMBR的甲烷产率分别为85.2%、73.2%、51.7%,生物炭的投加可使甲烷产率提高至93.2%、83.7%、63.7%。随着氨氮负荷的提高,AnMBR对污染物的去除能力下降:氨氮负荷由0提升至4500 mg·L^(−1)时,常规AnMBR对养猪废水中化学需氧量(chemical oxygen demand,COD)、多糖、蛋白的去除率分别由94.0%、95.7%、86.8%降低至92.4%、90.2%、80.2%,生物炭的投加使其去除率维持在92.7%、91.6%、84.3%。进一步研究发现,高浓度游离氨(free ammonia,FAN)的存在是导致AnMBR发酵效能下降的主要原因。且在氨氮负荷由3000 mg·L^(−1)提高到4500 mg·L^(−1)时,常规AnMBR污泥中的可溶性微生物产物(soluble microbial products,SMP)与微生物胞外聚合物(extracellular polymeric substances,EPS)含量分别提高了84.1%、62.6%,其中,芳香族蛋白类是微生物代谢产物的主要物质;生物炭的投加减少了17.9%~27.1%的SMP含量与2.6%~9.3%的EPS含量。挥发性脂肪酸(volatile fatty acids,VFA)甲烷发酵活性实验结果表明,高浓度氨氮主要抑制了乙酸降解微生物的比产甲烷活性,而生物炭的投加利于维持污泥在高氨氮浓度下的乙酸盐降解产甲烷能力。本研究结果可为缓解高浓度氨氮抑制AnMBR处理养猪废水效能的应用提供参考。

关键词：养猪废水厌氧膜生物反应器氨氮抑制生物炭微生物代谢产物

旅游者照片更能提升人们的旅游意愿吗?——基于ISM-DEMATEL方法和实验的双重检验

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浙江大学学报（理学版） 2024年第5期51卷 636-650页

作者：张若愚张高军蒋婧怡程泷暨南大学深圳旅游学院广东深圳518053 中铁十一局集团第五工程有限公司重庆400037

在大量的目的地营销机构和旅游者比较研究中,一个重要的理论假设是旅游者上传的公开信息,如文案、照片,更能激发人们的旅游意愿,但此假设未经实证研究证实。为验证此假设,首先构建旅游照片影响旅游意愿的指标体系,包括明示、暗示、信息... 详细信息

在大量的目的地营销机构和旅游者比较研究中,一个重要的理论假设是旅游者上传的公开信息,如文案、照片,更能激发人们的旅游意愿,但此假设未经实证研究证实。为验证此假设,首先构建旅游照片影响旅游意愿的指标体系,包括明示、暗示、信息质量三类共18个因素,引入基于专家打分的集成解释结构模型-决策实验室分析(ISM-DEMATEL)方法构建解释结构模型,将照片对旅游意愿的影响分为4个层级,其中最重要的是真实性,而具有旅游者生成内容(tourist generated content,TGC)典型特征的因素层级普遍高于具有官方生成内容(official generated content,OGC)典型特征的,TGC对旅游意愿的刺激作用更大。然后,设计了对照实验,以潜在旅游者为被试,检测三类照片对旅游意愿的影响情况,交叉检验有利于进一步提高研究结果的稳健性,得到了相似的结果,即生成内容能够显著提高人们的旅游意愿,其中具有TGC典型特征的照片提升效果最好,其次是具有OGC和TGC共同特征的照片,最后是具有OGC典型特征的照片。在理论层面,从专家和旅游者的角度通过量化关系回答了为什么TGC对旅游意愿的吸引力较OGC强;在实践层面,提出目的地营销机构应重点关注TGC的信息质量,并适当借鉴TGC的形式与风格,在保持官方特色的基础上贴近旅游者。

关键词： ISM-DEMATEL 旅游照片旅游目的地形象旅游意愿

Big difference in ^87Sr/ ^86Sr ratios of basalt and basin water： higher ^87Sr/ ^86Sr ratios in plagioclase

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Acta Geochimica 2017年第3期36卷 486-488页

作者： Laifeng Li gaojun Li MOE Key Laboratory of Surflcial Geochemistry Department of Earth Sciences Nanjing University 163 Xianlindadao Nanjing 210046 China

We analyzed the ^(87)Sr/^(86)Sr ratios of basaltic rocks and basin water in Xuyi,China,and found a big difference,which may challenge conventional wisdom on the contribution of basalt weathering in end-member *** of an in-house weathering experiment suggest that rainwater and dust are not responsible for the *** isolating the major minerals in basalt,we found that plagioclase has much higher ^(87)Sr/^(86)Sr ratios than bulk basalt and basin water,which might explain the difference in ^(87)Sr/^(86)Sr ratios of basalt and basin *** inferthatlow-temperaturehydrothermalalteration increased the ^(87)Sr/^(86)Sr ratios of *** analyses of end-member contribution in a mixed-rock basin should take into account that basin water and plagioclase have higher ^(87)Sr/^(86)Sr ratios than basaltic rocks.

关键词： Basalt Weathering ^87Sr/ ^86Sr Plagioclase

Geochemical studies on the source region of Asian dust

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Science China Earth Sciences 2011年第9期54卷 1279-1301页

作者： CHEN Jun LI gaojun Department of Earth Sciences Nanjing University Nanjing 210093 China

The North China and the neighbouring Mongolia in Asian Interior is characterized by extremely dry climate, resulted in one of the world＇s major dust emission centres. Deciphering the source region of Asian dust is critical for revealing the mechanism of the dust production, interpreting the paleo-environrnental records of eolian deposits, predicting the overall environmental effects of dust, and setting the strategies for the control of contemporary dust storms. This paper summarizes the geochemical methods applied to the source tracing of Asian dust. Nd-Sr isotopes were the most extensively studied source tracer of Asian dust and have been successfully applied in many cases. Geochemistry of detrital monomineral shows great theoretical advantages in source tracing and deserves further studies. The short-range transportation of Chinese loess with direction similar to that of the prevailing near surface wind is revealed. Source tracing also shows that the Asian dust has two ultimate material sources from the northern margin of the Tibetan Plateau and the Central Asian Orogen, which confirms the importance of mountain processes in the production of silt eolian particles. Based on the recent progresses on the source tracing of Asian dust, discussions are expanded on the natural background of Asian dust storms and potential anthropogenic influence, the materials evolution of the source regions of Asian dust and its relationships with climate changes and Tibetan uplift, and the role of Tibetan uplift in the Asian dust system.

关键词： desert loess Asian dust dust storm Tibetan Plateau