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复方土槿皮酊与外用液体药用高密度聚乙烯瓶相容性研究

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中国药业 2024年第11期33卷 48-52页

作者：苏锐辉江涛李高捷陈晓坚曾晨侯艳冬汤迎湛广州白云山敬修堂药业股份有限公司广东广州510130

目的探讨复方土槿皮酊与外用液体药用高密度聚乙烯瓶的相容性。方法采用高效液相色谱法测定苯甲酸和水杨酸的含量,按2020年版《中国药典(四部)》通则0711第一法(毛细管柱法)测定乙醇体积分数。依据《药品包装材料与药物相容性试验指... 详细信息

目的探讨复方土槿皮酊与外用液体药用高密度聚乙烯瓶的相容性。方法采用高效液相色谱法测定苯甲酸和水杨酸的含量,按2020年版《中国药典(四部)》通则0711第一法(毛细管柱法)测定乙醇体积分数。依据《药品包装材料与药物相容性试验指导原则》,通过加速试验[温度(40±2)℃、相对湿度(90±10)%条件下放置6个月],长期试验[温度(25±2)℃、相对湿度(60±10)%条件下放置12个月],加严条件的影响因素试验条件下[温度(25±2)℃、相对湿度(20±5)%(低湿)和温度(25±2)℃、相对湿度(90±10)%(高湿)条件下分别放置6个月],以及多次开启试验,考察高密度聚乙烯瓶包装的复方土槿皮酊实际使用过程中苯甲酸、水杨酸含量及乙醇体积分数的变化。结果苯甲酸和水杨酸的进样量分别在0.102~1.812μg和0.050~0.906μg范围内与峰面积线性关系良好(R~2=0.999 9,n=5);精密度、稳定性、重复性试验结果的RSD均小于0.5%(n=6);平均加样回收率分别为99.34%和99.24%,RSD分别为0.72%和0.92%(n=6)。加速试验、长期试验及加严条件的影响因素试验(低湿和高湿)条件下,3批样品均为黄棕色至红棕色的澄清溶液,无沉淀、浑浊、变色,无微粒、块状物析出。在加速试验中,3批样品中苯甲酸和水杨酸平均含量及乙醇平均体积分数分别为120.95~121.27 mg/mL、60.30~61.45 mg/mL、78.49%~79.49%,RSD均小于2.0%(n=18);在长期试验中,分别为121.06~121.89 mg/mL、60.49~61.81 mg/mL、79.40%~79.70%,RSD均小于2.0%(n=18);在低湿加严条件的影响因素试验中,分别为121.64~122.89 mg/mL、60.55~61.88 mg/mL、79.23%~80.05%,RSD均小于2.0%(n=18);在高湿加严条件的影响因素试验中,分别为121.11~122.99 mg/mL、60.51~61.88 mg/mL、79.45%~80.41%,RSD均小于2.0%(n=18)。多次开启试验结果显示,3批样品中苯甲酸和水杨酸平均含量及乙醇平均体积分数分别为121.86~123.90 mg/mL、60.60~62.08 mg/mL、79.74%~80.57%,RSD均小于2.0%(n=9)。结论所建立的高效液相色谱法结果准确、精密度和重复性均良好,可用于复方土槿皮酊中苯甲酸和水杨酸的含量测定。外用液体药用高密度聚乙烯瓶与复方土槿皮酊的相容性良好,可保证复方土槿皮酊的质量稳定。

关键词：复方土槿皮酊高密度聚乙烯瓶相容性苯甲酸水杨酸乙醇

Lp Solutions of BSDEs with Non-Uniformly linear Growth Generators and General Time Interval

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Journal of Mathematical Research with Applications 2016年第1期36卷 117-126页

作者： gaojie LU Long JIANG Depeng li Shengjun FAN Department of Mathematics Tongji Zhejiang College School of Sciences China University of Mining and Technology

In this paper, we establish the existence of the minimal L（p > 1） solution of backward stochastic differential equations（BSDEs） where the time horizon may be finite or infinite and the generators have a non-uniformly linear growth with respect to t. The main idea is to construct a sequence of solutions {（Y, Z）} which is a Cauchy sequence in S× Mspace, and finally we prove {（Y, Z）} converges to the L（p > 1） solution of BSDEs.

关键词： BSDEs finite or infinite time interval non-uniformly linear growth generators Cauchy sequence L~p(p > 1) solutions

Recent progress on electrolyte functional additives for protection of nickel-rich layered oxide cathode materials

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Journal of Energy Chemistry 2022年第2期31卷 280-292页

作者： Longshan li Dingming Wang gaojie Xu Qian Zhou Jun Ma Jianjun Zhang Aobing Du Zili Cui Xinhong Zhou Guanglei Cui College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyNo.53 Zhengzhou RoadQingdao 266042ShandongChina Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesNo.189 Songling RoadQingdao 266101ShandongChina

In advantages of their high capacity and high operating voltage,the nickel(Ni)-rich layered transition metal oxide cathode materials(liNi_(x)Co_(y)Mn_(z)O_(2)(NCMxyz,x+y+z=1,x≥0.5)and liNi_(0.8)Co_(0.15)Al_(0.05)O_(2)(NCA))have been arousing great interests to improve the energy density of ***,these Nirich cathodes always suffer from rapid capacity degradation induced by unstable cathode-electrolyte interphase(CEI)layer and destruction of bulk crystal ***,varied electrode/electrolyte interface engineering strategies(such as electrolyte formulation,material coating or doping)have been developed for Ni-rich cathodes *** them,developing electrolyte functional additives has been proven to be a simple,effective,and economic method to improve the cycling stability of Nirich *** is achieved by removing unfavorable species(such as HF,H_(2)O)or constructing a stable and protective CEI layer against unfavorable reactive species(such as HF,H_(2)O).Herein,this review mainly introduces the varied classes of electrolyte functional additives and their working mechanism for interfacial engineering of Ni-rich ***,key favorable species for stabilizing CEI layer are *** importantly,we put forward perspectives for screening and customizing ideal functional additives for high performance Ni-rich cathodes based liBs.

关键词： Nickel-rich layered oxide cathode Electrolyte additive Functional group Working mechanism Cathode-electrolyte interphase(CEI)

Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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Journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： Ziyi lin Xiaolong Fan gaojie Chen Youwei Hong Mengren li lingling Xu Baoye Hu Chen Yang Yanting Chen Zhiqian Shao Jinsheng Chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,*** concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and *** on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping *** to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace *** the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain *** risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source

Revealing the importance of suppressing formation of lithium hydride and hydrogen in li anode protection

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Interdisciplinary Materials 2023年第2期2卷 337-347页

作者： gaojie Xu Xiaofan Du Shenghang Zhang Jiedong li Shanmu Dong Zhiwei Hu Guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdaoChina Shandong Energy Institute QingdaoChina Qingdao New Energy Shandong Laboratory QingdaoChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina School of Future Technology University of Chinese Academy of Sciences BeijingChina Max Planck Institute for Chemical Physics of Solids DresdenGermany

The reviving of the“Holy Grail”lithium metal batteries(LMBs)is greatly hindered by severe parasitic reactions between li anode and ***,first,we comprehensively summarize the failure mechanisms and protection principles of the li ***,despite being in dispute,the formation of lithium hydride(liH)is demonstrated to be one of the most critical factors for li anode ***,we trace the research history of liH at electrodes of lithium *** LMBs,liH formation is suggested to be greatly associated with the generation of H_(2)from li/electrolyte intrinsic parasitic reactions,and these intrinsic reactions are still not fully ***,density functional theory calculations reveal that H_(2)adsorption ability of representative li anode protective species(such as liF,li_(3)N,BN,li_(2)O,and graphene)is much higher than that of li and ***,as an important supplement of well-known lithiophilicity theory/high interfacial energy theory and three key principles(mechanical stability,uniform ion transport,and chemical passivation),we propose that constructing an artificial solid electrolyte interphase layer enriched of components with much higher H_(2)adsorption ability than li will serve as an effective principle for li anode *** summary,suppressing formation of liH and H_(2)will be very important for cycle life enhancement of practical LMBs.

关键词： density functional theory H_(2)adsorption ability li anode protection lithium hydride solid electrolyte interphase

Geochemistry of Heavy Oil in the T Block,Oriente Basin and its Origin Mechanism

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Acta Geologica Sinica(English Edition) 2010年第2期84卷 406-414页

作者： HU Ying YIN Jiquan SU Yongdi XIE Yinfu WANG Xiaoxia XIAO gaojie YU Zhaohua WANG li Research Institute of Petroleum Exploration and Development Beijing 100083 China

Exploration and development experience show that there is obvious oil gravity difference between the southern part and northern part of the ＂M1＂reservoir in the Fanny oil field in the slope of the Oriente Basin, Ecuador. The American Petroleum Institute Gravity （API） values of oils in the northern part are higher than the one in the southern part of the Fanny oil field, with the values of 20° and 10.0°-13.0°, respectively. So the primary purpose of this study was to analyze the heavy oil characteristics of biodegradation and the oil-oil correlation according to the biomarker data and the δ^13C signature of oil samples from T block. The results of the hydrocarbon gas chromatography fingermark and the inversion attribute characteristics indicated that there are fluid compartments between the ＂M1＂ reservoir of Fanny south. Finally, the models of oil-gas accumulation under the control of multiple-activities of complicated fault systems, as well as the origin of heavy oil, are contended. The early stage oils from the western part of the basin were biodegraded heavily in varying degrees in the whole basin, and the later stage oils were derived from the southern part in a large scale and were mature and lighter. Generally, oil mixing is the primary control of net oil properties, such as API gravity in Oriente Basin. We therefore predicted that the API gravity variation of oil pools radically depends on the injection amount of the later stage oil. Because of the shale barrier in the ＂M1＂reservoir of Fanny south, the later stage hydrocarbon could not pass through and contribute to increase the oil API value.

关键词： heavy oil geochemistry biomarker origin mechanism Oriente Basin

The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in rice

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Molecular Plant 2024年第2期17卷 258-276页

作者： Yuqing He Yao Zhao Jitao Hu Lanlan Wang linying li Xueying Zhang Zhongjing Zhou lili Chen Hua Wangl Jiaoyu Wang gaojie Hong State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Virology and BiotechnologyZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China Key Laboratory of Traceability for Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural AffairsHangzhou 310021P.R.China College of life Sciences Zhejiang Sci-Tech UniversityHangzhou 310018P.R.China State Key Laboratory for Managing Biotic and Chemical Threats to the Qualty and Safety of Agro-products Zhejang Academy of Agricultural SciencesHangzhou 310021P.R.China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Key Labory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China

The growth-promoting hormones brassinosteroids(BRs)and their key signaling component BZR1 play a vital role in balancing normal growth and defense ***,we discovered that BRs and OsBZR1 up-regulated sakuranetin accumulation and conferred basal defense against Magnaporthe oryzae infection under normal *** shortages,including phosphate(Pi)deficiency,potentially disrupt this growth-defense ***1 and OsSPX2 have been reported to sense Pi concentration and interact with the Pi signal mediator OsPHR2,thus regulating Pi starvation *** this study,we discovered that OsSPX1/2 interacts with OsBZR1 in both Pi-sufficient and Pi-deficient conditions,inhibit-ing BR-responsive *** Pi is sufficient,OsSPX1/2 is captured by OsPHR2,enabling most of OsBzR1 to promote plant growth and maintain basal *** response to Pi starvation,more OsSPX1/2 is released from OsPHR2 to inhibit OsBZR1 activity,resulting in slower ***,our study reveals that the OsBZR1-SPX1/2 module balances the plant growth-immunity trade-off in *** Y.,Zhao Y.,Hu J.,Wang L.,li L.,Zhang X.,Zhou Z.,Chen L.,Wang H.,Wang J.,and Hong G.(2024).The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in esponse to Pi availability.

关键词： immunity maintain adaptation

WRKY33 negatively regulates anthocyanin biosynthesis and cooperates with PHR1 to mediate acclimation to phosphate starvation

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Plant Communications 2024年第5期5卷 134-147页

作者： Han Tao Fei Gao linying li Yuqing He Xueying Zhang Mengyu Wang Jia Wei Yao Zhao Chi Zhang Qiaomei Wang gaojie Hong State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Biotechnology in Plant Protection of the MOA of China and Zhejiang ProvinceInstitute of Virology and BiotechnologyZhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory of Subtropical Silviculture Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese MedicineZhejiang A&F UniversityHangzhou 311300China Department of Horticulture College of Agriculture and BiotechnologyZhejiang UniversityKey Laboratory of Horticultural Plant GrowthDevelopment and Quality ImprovementMinistry of AgricultureHangzhouZhejiangChina Institute of Sericulture and Tea Zhejiang Academy of Agricultural SciencesHangzhou 310000China

Anthocyanin accumulation is acknowledged as a phenotypic indicator of phosphate(Pi)***,negative regulators of this process and their molecular mechanisms remain largely *** this study,we demonstrate that WRKY33 acts as a negative regulator of phosphorus-status-dependent anthocyanin ***33 regulates the expression of the gene encoding dihydroﬂavonol 4-reductase(DFR),a rate-limiting enzyme in anthocyanin production,both directly and ***33 binds directly to the DFR promoter to repress its expression and also interferes with the MBW complex through interacting with PAP1 to indirectly inﬂuence DFR transcriptional ***�Pi conditions,PHR1 interacts with WRKY33,and the protein level of WRKY33 decreases;the repression of DFR expression by WRKY33 is thus attenuated,leading to anthocyanin accumulation in *** genetic and biochemical assays suggest that PHR1 is also involved in regulating factors that affect WRKY33 protein *** together,ourfindings reveal that Pi starvation represses WRKY33,a repressor of anthocyanin biosynthesis,tofinely tune anthocyanin ***‘‘double-negative logic’’regulation of phosphorus-status-dependent anthocyanin biosynthesis is required for the mainte-nance of plant metabolic homeostasis during acclimation to Pi starvation.

关键词： WRKY33 phosphate signaling PHR1 Arabidopsis thaliana anthocyanins

Atmospheric oxidation capacity and O_(3) formation in a coastal city of southeast China:Results from simulation based on four-season observation

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Journal of Environmental Sciences 2024年第2期136卷 68-80页

作者： gaojie Chen Taotao liu Jinsheng Chen lingling Xu Baoye Hu Chen Yang Xiaolong Fan Mengren li Youwei Hong Xiaoting Ji Jinfang Chen Fuwang Zhang Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China College of Harbour and Coastal Engineering Jimei UniversityXiamen 361021China Environmental Monitoring Center of Fujian Fuzhou 350013China

The pollution of atmospheric ozone in China shows an obvious upward trend in the past ***,the studies on the atmospheric oxidation capacity and O_(3)formation in four seasons in the southeastern coastal region of China with the rapid urbanization remain ***,a four-season field observation was carried out in a coastal city of southeast China,using an observation-based model combining with the Master Chemical Mechanism,to explore the atmospheric oxidation capacity(AOC),radical chemistry,O_(3)formation pathways and *** results showed that the average net O_(3)production rate(14.55 ppbv/hr)in summer was the strongest,but the average O_(3)concentrations in autumn was *** AOC and ROx levels presented an obvious seasonal pattern with the maximum value in summer,while the OH reactivity in winter was the highest with an average value of 22.75 sec^(-1).The OH reactivity was dominated by oxygenated VOCs(OVOCs)(30.6%-42.8%),CO(23.2%-26.8%),NO_(2)(13.6%-22.0%),and alkenes(8.4%-12.5%)in different *** photolysis dominated OH primary source on daytime in winter,while in other seasons,HONO photolysis in the morning and ozone photolysis in the afternoon contributed *** analysis indicated that O_(3)production was controlled by VOCs in spring,autumn and winter,but a VOC-limited and NOx-limited regime in summer,and alkene and aromatic species were the major controlling factors to O_(3)***,the study characterized the atmospheric oxidation capacity and elucidated the controlling factors for O_(3)production in the coastal area with the rapid urbanization in China.

关键词： Atmospheric oxidation capacity Radical chemistry Ozone production Sensitivity analysis