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Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics

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Regenerative Biomaterials 2020年第2期7卷 171-180页

作者： Hong Xu Boxuan Ma Jizhou Jiang Sutong Xiao Rongrong Peng Weihua Zhuang gaocan li Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China College of Polymer Science and Engineering Sichuan UniversityChengdu 610064China

Nanodrug carriers with fluorescence radiation are widely used in cancer diagnosis and therapy due to their real-time imaging,less side effect,better drug utilization as well as the good bioimaging ***,traditional nanocarriers still suffer from unexpectable drug leakage,unsatisfactory tumor-targeted drug delivery and shallow imaging depth,which limit their further application in cancer *** this study,an integrated nanoplatform is constructed by polymeric prodrug micelles with two-photon and aggregation-induced emission bioimaging,charge reversal and drug delivery triggered by acidic *** prodrug micelles can be self-assembled by the TPPEI(DA/DOX)-PEG prodrug polymer,which consists of the two-photon fluorophore(TP),dimethylmaleic anhydride(DA)grafted polyethyleneimine(PEI)and polyethylene glycol(PEG).The PEG segment,DOX and DA are bridged to polymer by acid cleavable bonds,which provides the micelles a‘stealth’property and a satisfactory stability during blood circulation,while the outside PEG segment is abandoned along with the DA protection in the tumor acidic microenvironment,thus leading to charge reversal-mediated accelerated endocytosis and tumor-targeted drug *** great antitumor efficacy and reduced side effect of these pH-sensitive prodrug micelles are confirmed by antitumor assays in vitro and in ***,these micelles exhibited great deep-tissue two-photon bioimaging ability up to 150 lm in *** great antitumor efficacy,reduced side effect and deep two-photon tissue imaging make the TP-PEI(DA/DOX)-PEG prodrug micelles would be an efficient strategy for theranostic nanoplatform in cancer treatment.

关键词： aggregation-induced emission two-photon pH-sensitive charge reversal drug delivery system

Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation,anti-calcification,and endothelial proliferation bioprosthetic heart valves

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Journal of Leather Science and Engineering 2022年第1期4卷 320-332页

作者： Xiaotong Chen Tao Yu Qunshou Kong Dajun Kuang Hong Xu Zhiyu Zhao li Yang gaocan li Haojun Fan Yunbing Wang National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu 610065China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Venus Medtech(Hangzhou)Inc. HangzhouChina.

In the last decade,the number of transcatheter heart valve replacement for severe heart valve disease has increased *** the bioprosthetic artificial heart valve(BHV)has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve so that there is no need to take long-term anticoagulant drugs to prevent thromboembolism,transcatheter BHV replacement are still at risk for thrombosis during the first few months according to the clinical ***,the use of antithrombotic drugs can also increase the risk of ***,it is particularly important to improve the anticoagulant properties for the BHV *** this work,a kind of non-glutaraldehyde cross-linked BHV material with excellent antithrombotic ability has been prepared from carboxylated oxazolidine treated porcine pericardium(consisting of collagen,elastin and glycoprotein)with the further graft of the anticoagulant heparin sodium via hydrophilic modified *** with the similar mechanical properties and collagen stability comparable to the glutaraldehyde cross-linked porcine pericardium(PP),these functional non-glutaraldehyde cross-linked PPs exhibit better biocompatibility,promoted endothelial proliferation and superior anti-calcification *** importantly,excellent anticoagulant activity can be observed in the hematological experiments in vivo and in *** summary,these excellent performances make these functional non-glutaraldehyde cross-linked PPs great potentialities in the BHV applications.

关键词： Bioprosthetic heart valves Oxazolidine Cytocompatibility Anti-coagulation

海洋源壳聚糖与海藻酸盐在生物医药领域的应用

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生物医学工程学杂志 2019年第1期36卷 164-171页

作者：张婕妤胡雪丰李高参巨晓洁褚良银王云兵四川大学国家生物医学材料工程技术研究中心成都610064 四川大学化学工程学院成都610064

海洋源生物大分子具有资源丰富、功能独特、生物安全、成本低廉等特点,是生物医用材料研发的优良原料。海洋生物医用材料目前已成为生物医用材料产业的主要分支,符合全球倡导的"绿色产业、低碳经济"的发展大趋势,发展前景极为可观。壳... 详细信息

海洋源生物大分子具有资源丰富、功能独特、生物安全、成本低廉等特点,是生物医用材料研发的优良原料。海洋生物医用材料目前已成为生物医用材料产业的主要分支,符合全球倡导的"绿色产业、低碳经济"的发展大趋势,发展前景极为可观。壳聚糖与海藻酸盐是海洋源生物材料中商业化开发最多的两类材料,在伤口敷料、牙科材料、抗菌处理、药物控释、组织工程等领域均有广泛的应用。本文主要介绍壳聚糖与海藻酸盐的性质及其在生物医药领域的应用,以及作为医用材料发展面临的瓶颈与挑战。

关键词：壳聚糖海藻酸盐生物材料

Fluorescent compounds based on betaine′s imidazolium salts

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Fluorescent compounds based on betaine′s imidazolium salts

Electrolyte-gated SrCoO_(x) FET sensor for highly sensitive detecting pH in extreme alkalinity solution

中国化学会第十五届全国有机分析及生物分析学术研讨会

作者： Siping Wei,gaocan li,Jingbo Lan,Ge Gao,Xiaoyu Su,Jingsong You~* (Key Laboratory of Green Chemistry and Technology of Ministry of Education,College of Chemistry,and State Key Laboratory of Biotherapy,West China Medical School,Sichuan University,Chengdu 610064)

＜正＞The supramolecular hydrogel was prepared by heating the gelator 1a in water and subsequently cooling the resulting isotropic supersaturated solution to room temperature. Interestingly,the suspension of 1b in dioxane was submitted to sonication,a complete and homogeneous liquid gelation was observed,and the fluorescent phenomenon of organogelator 1b was exhibited under UV（365 nm） light.

关键词： Imidazolium salts Hydrogel Fluorescent sensor

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Nano Research 2024年第4期17卷 3079-3086页

作者： Han Zhou gaocan Qi Wenbin li Yuhang Wang Zhihao Yuan School of Materials Science and Engineering Tianjin Key Lab of Photoelectric Materials&Devicesand Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)Tianjin University of TechnologyTianjin 300384China

The pH monitoring is significantly important in chemical industry,biological process,and pollution ***,it remains a great challenge to measure pH in extreme alkalinity ***,we employ an electrolyte-gated field-effect-transistor(FET)strategy using non-stoichiometric SrCoO_(x) with rich oxygen-vacancy defects as channel materials for detecting extreme *** corresponding channel can provide effective oxygen-ion-migration sites for reversible transformation of OH-↔O_(2)-+H^(+)driven by electric *** resultant electrolyte-gated FET sensor exhibits a sensitive linear response to high concentrations of alkaline solution,1–20 ***,the sensor has the ability to directly indicate the pH values ranging from 14.0 to 17.0 in consideration of ion-activity coefficient *** work offers a great possibility for directly detecting base concentration as well as pH values in extreme alkaline solutions.

关键词： field-effect-transistor(FET) pH sensor extreme alkaline solution SrCoO_(x) oxygen-ion migration

一种新型冠状病毒类病毒结构疫苗的成药可能性

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国际生物制品学杂志 2024年第3期47卷 125-132页

作者：曾烽原张晶晶李艳梅马开利刘昌娥冯琳高冬秀母昌勇李红兵彭晓武王艺萱李慧娟谢冰孙丽红李誉琦何丽萍徐刚苏彦瑞王安司俊波王丽春张雄李高灿唐中曙张志晓岳蓉易红昆郑丽春何福芸李琦涵威瑞生物科技(昆明)有限责任公司研发部昆明650201 山东威高利彤生物制品有限公司研发部威海264200

目的探讨新型冠状病毒类病毒结构疫苗中的mRNA和蛋白使用剂量对小鼠免疫效果的影响, 以期确定最佳的mRNA和蛋白使用剂量及成药可能性。方法用ADT-脂质纳米颗粒递送系统装载和包封不同剂量的蛋白和mRNA, 转染不同细胞系检测相应抗原表达... 详细信息

目的探讨新型冠状病毒类病毒结构疫苗中的mRNA和蛋白使用剂量对小鼠免疫效果的影响, 以期确定最佳的mRNA和蛋白使用剂量及成药可能性。方法用ADT-脂质纳米颗粒递送系统装载和包封不同剂量的蛋白和mRNA, 转染不同细胞系检测相应抗原表达情况, 以及免疫动物检测血清的特异性抗体效价。结果类病毒结构疫苗在包裹较小剂量mRNA(10~20 μg/剂)并装载蛋白(5 μg/剂)的情况下, 能够特异性地激活小鼠树突状细胞, 同时激活天然免疫及获得性免疫保护。结论此研究的类病毒结构疫苗在小鼠实验中具有良好的免疫原性和抗体诱导功能, 具有成为新型疫苗的可能性。

关键词：新型冠状病毒类病毒结构疫苗保护性免疫

基于“阳化气,阴成形”与心外膜脂肪组织的相关性探讨心房颤动的中医药防治策略

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北京中医药大学学报 2024年第8期47卷 1131-1138页

作者：刘锦何庆勇任高灿李一翔河南中医药大学第一附属医院郑州450003 心脏中心/国家区域(中医)心血管诊疗中心中国中医科学院广安门医院中国中医科学院西苑医院

心外膜脂肪组织是紧贴心肌与脏层心包的脂肪库,具有特殊的解剖和生理特点,其体积大小及沉积部位与心房颤动的发生、发展关系紧密。本文基于中医学理论“阳化气,阴成形”的内涵,认为机体阳化气不足、阴成形太过是心外膜脂肪组织异常蓄积... 详细信息

心外膜脂肪组织是紧贴心肌与脏层心包的脂肪库,具有特殊的解剖和生理特点,其体积大小及沉积部位与心房颤动的发生、发展关系紧密。本文基于中医学理论“阳化气,阴成形”的内涵,认为机体阳化气不足、阴成形太过是心外膜脂肪组织异常蓄积的本质,阴邪渐积,局部阴阳失衡,出现分泌异常,邪郁日久,其内蕴之阳热相伴而生,且日渐亢盛,最终阴难制阳,造成心外膜脂肪组织浸润正常组织,诱发心房颤动。在该理论的指导下,当明辨机体与心外膜脂肪组织中阴阳的多寡,考虑整体和局部“阳化气”与“阴成形”的能力,合理选用扶阳与消阴之法。疾病之初以复“阳化气”为主,在避免阴邪蓄积的同时,消散已成之阴体;病进则以祛邪为要,针对病机辅以燥湿、行气、活血等不同治法。此外,整个疾病进程中当顾护患者虚损之体,注意时时扶阳补正,适时消阴祛邪,从而提高中医药治疗心房颤动的临床疗效。

关键词：阳化气阴成形心房颤动心外膜脂肪组织扶阳消阴

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地转涡内层结构解

力学学报 1986年第4期 289-296页

作者：凌国灿李显霖中国科学院力学研究所航天部五院计算中心

利用多重尺度渐近理论,考虑地转涡中心附近的粘性力,得到涡心附近有一个as量级的涡核结构。其中速度、大气自由面的高度均为有限值分布且随时间变化。克服了无粘地转涡理论在r→0时速度为无穷大、大气高度趋于负无穷大的奇性。

关键词：内层自由面方程组联立方程渐近理论涡核粘性系数输运系数(流体力学) 奇性控制方程无量纲

长时服役后的T23管与T91新管焊接接头组织与性能研究

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热加工工艺 2023年第9期52卷 66-71页

作者：李晋刚朱建强栾高灿景江峰夏咸喜张向前晋能控股山西电力股份有限公司河津发电分公司山西河津043300 苏州热工研究院有限公司江苏苏州215004

某电厂末级过热器管材质为T23钢,在服役13.5万小时后整体更换为T91钢。为掌握长期服役后的T23与T91新管焊接接头的焊接质量,为电厂的长期运行以及同类电厂的换管改造提供数据支撑,模拟了现场焊接工艺,对T23与T91管进行焊接,对焊后接头... 详细信息

某电厂末级过热器管材质为T23钢,在服役13.5万小时后整体更换为T91钢。为掌握长期服役后的T23与T91新管焊接接头的焊接质量,为电厂的长期运行以及同类电厂的换管改造提供数据支撑,模拟了现场焊接工艺,对T23与T91管进行焊接,对焊后接头的组织与性能进行研究。结果表明:焊缝与T23和T91两侧熔合良好,T23侧热影响区为室温、高温拉伸的性能薄弱区,接头强度与T23母材相比未发生明显下降。焊接过程中,T23侧粗晶区的第二相溶入母材,冷却后析出相少,而细晶区析出相长大粗化。盖面焊层焊缝硬度高于打底焊层,二者的热影响区硬度相近。利用等温线外推法外推计算焊接接头的剩余寿命,剩余蠕变寿命大于5万小时,满足电厂服役要求。

关键词：异种钢接头 T91钢 T23钢显微组织力学性能