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Engineering nanotheranostic strategies for liver cancer

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1213-1228页

作者： Lei Cao Yu-Qin Zhu Zhi-Xian Wu gao-xiong wang Hong-Wei Cheng Department of Pathology Quanzhou Women's and Children's HospitalQuanzhou 362000Fujian ProvinceChina Department of Hepatobiliary Disease The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina School of Public Health Xiamen UniversityXiamen 361002Fujian ProvinceChina

The incidence and mortality of hepatocellular carcinoma have continued to increase over the last few years,and the medicine-based outlook of patients is poor.Given great ideas from the development of nanotechnology in medicine,especially the advantages in the treatments of liver cancer.Some engineering nanoparticles with active targeting,ligand modification,and passive targeting capacity achieve efficient drug delivery to tumor cells.In addition,the behavior of drug release is also applied to the drug loading nanosystem based on the tumor microenvironment.Considering clinical use of local treatment of liver cancer,in situ drug delivery of nanogels is also fully studied in orthotopic chemotherapy,radiotherapy,and ablation therapy.Furthermore,novel therapies including gene therapy,phototherapy,and immunotherapy are also applied as combined therapy for liver cancer.Engineering nonviral polymers to function as gene delivery vectors with increased efficiency and specificity,and strategies of co-delivery of therapeutic genes and drugs show great therapeutic effect against liver tumors,including drug-resistant tumors.Phototherapy is also applied in surgical procedures,chemotherapy,and immunotherapy.Combination strategies significantly enhance therapeutic effects and decrease side effects.Overall,the application of nanotechnology could bring a revolutionary change to the current treatment of liver cancer.

关键词： Liver cancer Poor prognosis Nanotheranostic Drug delivery Gene delivery Combination therapy

Synergistic effects and kinetics analysis for co-pyrolysis of vacuum residue and plastics

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 71-81页

作者： Chao wang Xiaogang Shi Aijun Duan Xingying Lan Jinsen gao Qingang xiong State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

This study utilizedathermogravimetric analyzer to assess the thermal decomposition behaviors and kinetics properties of vacuum residue(VR)and low-density polyethylene(LDPE)polymers.The kinetic parameters were calculated using the Friedman technique.To demonstrate the interactive effects between LDPE and VR during the co-pyrolysis process,the disparity in mass loss and mass loss rate between the experimental and calculated values was computed.The co-pyrolysis curves obtained through estimation and experimentation exhibited significantdeviations,whichwerei influencedby temperature and mixing ratio.A negative synergistic interaction was observed between LDPE and VR,although this inhibitory effect could be mitigated or eliminated by reducing the LDPE ratio in the mixture and increasing the co-pyrolysistemperature.Theco-pyrolysisprocess resulted in a reduction in carbon residue,which could be attributed to the interaction between LDPE and the heavy fractions,particularly resin and asphaltene,present in VR.These findings align with the pyrolysis behaviors exhibited by the four VR fractions.Furthermore,it was observed that the co-pyrolysis process exhibited lower activation energy as the VR ratio increased,indicating a continuous enhancement in the reactivity of the mixed samples during co-pyrolysis.

关键词： co-pyrolysis heavy residual oil polyethylene thermogravimetric analysis synergistic effects

Electrically tunable phase-change metasurface for dynamic infrared thermal camouflage

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Photonics Research 2024年第2期12卷 292-300页

作者： YUFENG xiong YUNZHENG wang CHAO FENG YAOLAN TIAN LIANG gao JUN-LEI wang ZHUANG ZHUO XIAN ZHAO Center for Optics Research and Engineering Key Laboratory of Laser&Infrared SystemMinistry of EducationShandong UniversityQingdao 266237China School of Information Science and Engineering Shandong UniversityQingdao 266237China

Dynamic infrared thermal camouflage technology has attracted extensive attention due to its ability to thermally conceal targets in various environmental backgrounds by tuning thermal emission.The use of phase change materials(PCMs)offers numerous advantages,including zero static power,rapid modulation rate,and large emissivity tuning range.However,existing PCM solutions still encounter several practical application challenges,such as temperature uniformity,amorphization achievement,and adaptability to different environments.In this paper,we present the design of an electrically controlled metal-insulator-metal thermal emitter based on a PCM metasurface,and numerically investigate its emissivity tunability,physical mechanisms,heat conduction,and thermal camouflage performance across different backgrounds.Furthermore,the influence of the quench rate on amorphization was studied to provide a guidance for evaluating and optimizing device structures.Simulation results reveal that the thermal emitter exhibits a wide spectral emissivity tuning range between 8 and 14μm,considerable quench rates for achieving amorphization,and the ability to provide thermal camouflage across a wide background temperature range.Therefore,it is anticipated that this contribution will promote the development of PCM-based thermal emitters for practical dynamic infrared thermal camouflage technology with broad applications in both civilian and military domains.

关键词： thermal dynamic phase

Dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates

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Opto-Electronic Advances 2024年第1期7卷 36-46页

作者： Yuncheng Liu Ke Xu Xuhao Fan Xinger wang Xuan Yu Wei xiong Hui gao Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

Interactive holography offers unmatched levels of immersion and user engagement in the field of future display.Despite of the substantial progress has been made in dynamic meta-holography,the realization of real-time,highly smooth interactive holography remains a significant challenge due to the computational and display frame rate limitations.In this study,we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates.To our knowledge,this is the first reported practical dynamic interactive metasurface holographic system.We spa-tially divided the metasurface device into multiple distinct channels,each projecting a reconstructed sub-pattern.The switching states of these channels were mapped to bitwise operations on a set of bit values,which avoids complex holo-gram computations,enabling an ultra-high computational frame rate.Our approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational platform.According to this methodology,we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay,color display,and on-the-fly hologram creation.Our technology presents an inspiration for advanced dynamic meta-holography,which is promising for a broad range of applications including advanced human-computer interaction,real-time 3D visualization,and next-generation virtual and augmented reality systems.

关键词： interactive display meta-holography bitwise operation ultra-high frame rate

In situ modification of heavy oil catalyzed by nanosized metal-organic framework at mild temperature and its mechanism

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Chinese Journal of Chemical Engineering 2024年第3期67卷 166-173页

作者： Li wang Ji-Xiang Guo Rui-Ying xiong Chen-Hao gao Xiao-Jun Zhang Dan Luo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing 102200China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China

Two catalysts, nano-sized cobalt-metal-organic framework(Co-MOF) and nickel(Ni)-MOF, were successfully prepared by the modification method. Tetralin(C10H12) was used as the hydrogen donor for the catalytic cracking and hydrogenation modification study of the dehydrated crude oil from the Shengli Oilfield. The optimal reaction conditions were determined through orthogonal experiments, and the components of the crude oil and modified oil samples were analyzed. The results revealed that the nanoMOF catalysts were successfully prepared and exhibited high catalytic activity. They could catalyze the cracking of large molecules in heavy oil at mild temperatures(<300°C), leading to the decomposition of the hydrogen donor. When the mass fraction of the catalyst was 0.2%, the mass fraction of the hydrogen donor was 1%, and the reaction temperature was 280°C, the Ni-MOF showed the best catalytic viscosity reduction effect. It could reduce the viscosity of heavy oil at 50°C from 15761.9 m Pa.s to 1266.2 m Pa.s,with a viscosity reduction rate of 91.97%. The modification effect of Co-MOF was the next best, which could reduce the viscosity of heavy oil to 2500.1 m Pa.s with a viscosity reduction rate of 84.14%. Molecular dynamics simulations revealed a strong interaction force between the MOF surface and asphaltene molecules. In the process of heavy-oil catalytic hydrogenation, the nano-MOF catalyst exhibited high catalytic activity. On the one hand, the empty d orbitals outside the metal atoms in the catalyst could polarize the carbon atoms in the organic matter, accelerating the breaking of long chains. On the other hand, the metal atoms in the catalyst could bond with the carbon σ bonds, breaking the carbon-carbon bonds. This disrupted the structure of the recombined components in the crude oil, irreversibly reducing the viscosity of the heavy oil and improving its fluidity.

关键词： Nano-sized MOF Petroleum Viscosity reduction Catalyst Nanomaterials

Effect of red clover isoflavones on hormone, immune, inflammatory,and plasma biochemistry in lactating dairy cows

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Animal Nutrition 2024年第1期16卷 306-312页

作者： Shiqi Zhang Xiaoyin Zhang Zhanbo xiong Kexin Li Yuan gao Ying Bu Nan Zheng Shengguo Zhao Jiaqi wang State Key Laboratory of Animal Nutrition Institute of Animal Sciences Chinese Academy of Agricultural Sciences

This study was to conducted to investigate the effect of red clover isoflavones on the health indicated by immune status and blood biochemistry in dairy cows. Sixty-eight healthy Holstein lactating cows were randomly divided into four treatments(n = 17 per treatment) from 5 blocks according to milk yield using a randomized complete block design. No initial differences in parity(2.13 ± 1.21), days in milk(165 ± 21 d), and milk yield(33.93 ± 3.81 kg/d) between groups. Cows were fed the basal diet supplemented with 0, 2, 4, or 8 g/kg red clover extract(RCE) in diet(dry matter based). Feeding, refusal feed weights, and milk yield were recorded three consecutive days in weeks 0, 4, 8, and 12. Blood was collected from the tail vein of the cows on the last day of weeks 4, 8 and 12, 1 h after the morning feeding,and analyzed for hormones, immunoglobulins, inflammatory markers, and markers of liver and kidney activities. The dry matter intake was significantly decreased by 3.7% in the 8 g/kg group(P 0.05). These results recommend the supplementation of RCE at a level from 2 to4 g/kg DM.

关键词： Dairy cow Red clover isoflavone Immunity Anti-inflammatory

Development review and the prospect of oil shale in-situ catalysis conversion technology

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Petroleum Science 2024年第2期21卷 1385-1395页

作者： Li wang Chen-Hao gao Rui-Ying xiong Xiao-Jun Zhang Ji-Xiang Guo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing102200China

As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology.

关键词： Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism

Tuning the local coordination environment of silver(Ⅰ) coordination networks with counterions for enhanced electrocatalytic CO_(2) reduction

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Science China Chemistry 2024年第5期67卷 1524-1530页

作者： Xiaofeng Cui Xueting wang Cong Fu Bing Liu Mei-Yan gao Tingting Kong Yujie xiong Anhui Engineering Research Center of Carbon Neutrality The Key Laboratory of Functional Molecular SolidsMinistry of EducationAnhui Laboratory of Molecular-Based MaterialsCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China Department of Chemical Sciences Bernal InstituteUniversity of LimerickLimerick V94 T9PXRepublic of Ireland School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China

Very recently, the local coordination environment of active sites has been found to strongly influence their performance in electrocatalytic CO_(2) reduction by tuning the intrinsic kinetics of CO_(2) activation and intermediate stabilization. It is imperative to elucidate the mechanism for such an influence towards the rational design of efficient catalysts;however, the complex interactions between the multiple factors involved in the system make it challenging to establish a clear structure–performance relationship. In this work, we chose ion-intercalated silver(I)-based coordination networks(AgCNs) with a well-defined structure as a model platform, which enables us to understand the regulation mechanism of counterions as the counterions are the only tuning factor involved in such a system. We prepared two isostructural Ag CNs with different intercalation ions or counterions of BF_(4)^(-) and ClO_(4)^(-)(named as AgCNs-BF_(4) and AgCNs-ClO_(4)) and found that the former has a more competitive CO_(2) electroreduction performance than the latter. AgCNs-BF_(4) achieves the highest Faradaic efficiency for CO_(2) to CO of 87.1% at-1.0 V(vs. RHE) with a higher partial current density, while AgCNs-ClO_(4) exhibits only 77.2% at the same applied potential.Spectroscopic characterizations and theoretical calculation reveal that the presence of BF_(4)^(-)is more favorable for stabilizing the COOH^(*) intermediate by weakening hydrogen bonds, which accounts for the superior activity of Ag CNs-BF_(4).

关键词： electrocatalytic CO_(2) reduction coordination networks local environment counterions intercalation ions

The late Early-Paleozoic granitic magmatism in Northwestern Fujian, China: constraints on intraplate orogeny in the South China block

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Acta Geochimica 2024年第1期43卷 134-149页

作者： WanLi gao ZongXiu wang Institute of Geomechanics Chinese Academy of Geological ScienceBeijing 100081People’s Republic of China Key Laboratory of Paleomagnetism and Tectonic Reconstruction of Ministry of Natural Resources Beijing 100081People’s Republic of China

The Early Paleozoic tectono-thermal event was a significant orogenic activity during the Phanerozoic era,which had a profound impact on the early crust of the South China Block(SCB) and established the foundation for later tectonic activity.The Wuyi-Yunkai orogenic belt in Southeastern China was extensively exposed to Early Paleozoic magmatism,the genetic mechanism of which remains controversial.To shed light on this issue,detailed petrological,geochemical,and zircon U-Pb-Hf isotopic studies were carried out on two granitoids,namely the Yuntongshan pluton and the gaoqiao pluton,identified in the central Wuyishan.Zircon U-Pb chronology of the Yuntongshan and gaoqiao bodies yielded ages of437±4 Ma(MSWD=2.2) and 404±2 Ma(MSWD=12),respectively,indicating that they were emplaced during the Early Silurian and Early Devonian periods.These granitoids are primarily composed of biotite-granite and biotite-monzonitic-granites,with high concentrations of S_(i)O_(2)(73.59-75.91 wt%),K_(2)O+Na_(2)O(8.31-8.73wt%),and low contents of MgO,CaO,Cr,Ni.They are classified as high-K calc-alkaline and weakly metaluminous-strongly peraluminous S-type granites.These granitoids are enriched in light rare earth elements(LREEs) and large ion lithophile elements(LILEs) and depleted in heavy rare earth elements(HREEs) and high field strength elements(HFSEs) with arc affinity.The εHf(t) values of-3.3 to-15.4 with two-stage Hf model ages ranging from 2829 to 1644 Ma,combined with the presence of Neoproterozoic inherited zircons,suggest that the primary magma of these granitoids was derived from the partial melting of Neoproterozoic crust with a Paleoproterozoic crustal model age.These findings,combined with the spatio-temporal distribution of regional magmatism,reveal that the late Early-Paleozoic granitoids formed in the intraplate orogenic background originating from the subduction of the proto-Tethys Ocean and proto-Pacific Ocean around the margin of the east Gondwana supercontinent.

关键词： Late Early-Paleozoic Granites Intraplate orogeny Cathysian block Zircon U-Pb-Hf Isotopic composition