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Effects of two silicone resin coatings on performance of FeSiAl magnetic powder cores

Journal of Iron and Steel Research International 2024年第5期31卷 1279-1288页

作者： Jia-qi Liu Zheng-qu Zhu Pu Wang Yi-fan Li Jing Pang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Qingdao Yunlu Advanced Materials Technology Co. Ltd.Qingdao266232ShandongChina

Two silicon resins with excellent thermal stability,JH1123 and JH7102,are used as the insulated agents and binders for the gas-atomized FeSiAl powder,and corresponding magnetic powder cores(MPCs)are *** insulation capability and application prospects of the two silicon resins are evaluated by comparing the magnetic properties of the coated powder and *** scanning electron microscopy,energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy results show that uniform insulation layers are both formed on the powder ***1123 has stronger binding ability,and the JH1123-coated powder exhibits severe agglomeration,with d50(average particle size)approximately twice that of the JH7102-coated *** as-prepared MPCs exhibit outstanding soft magnetic ***,the permeability of FeSiAl@JH1123 is up to 74.0,which is 35.5%higher than that of FeSiAl@JH7102 because JH1123 can further improve the density of the *** for FeSiAl@JH7102,it has better direct current bias and lower core loss of 716.9 mW cm^(−3) at 20 mT and 1000 kHz due to its lower coercivity and greater anti-magnetic saturation ability.A comprehensive comparison shows that FeSiAl@JH1123 is suitable for medium and high frequency applications,while FeSiAl@JH7102 is more suitable for high frequency *** indicates that the use of JH1123 and JH7102 silicon resins for binding and insulated coating not only simplifies the preparation process of MPCs,but also enables the controlled production of MPCs for different applications.

关键词： FeSiAl Insulated coating Magnetic powder core Permeability Core loss

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Elucidation of potential relationship between endogenous proteases and key flavor substances in dry-cured pork coppa

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Food Science and Human Wellness 2024年第4期13卷 2152-2160页

作者： Mingming Li Qiujin Zhu Chao qu Xiaohui Gong Yunhan Zhang Xin Zhang Shouwei Wang China Meat Research Center Beijing 100068China Guizhou Provincial Key Laboratory of Agricultural and Animal Products Storage and Processing School of Liquor&Food EngineeringGuizhou UniversityGuiyang 550025China Beijing Academy of Food Sciences Beijing 100068China

Dry-cured meat products are considerably popular around the world due to unique *** is one of the enzymatic reactions from which flavor substances are derived,which is affected by endogenous *** purpose aimed to reveal the potential relationship between endogenous proteases and key flavor substances in dry-cured pork coppa in this *** dynamic changes of endogenous proteases activity,free amino acids,and volatiles during dry-cured pork coppa processing were *** results showed that 5 kinds of free amino acids,Glu,Lys,Val,Ala,and Leu,were identified as significant contributors to ***,key volatiles,such as hexanal,nonanal,octanal,benzaldehyde,3-methyl butanoic acid,2-methyl propanoic acid,and ethyl octanoate,greatly contributed to the flavor characteristics of dry-cured pork *** partial correlation analysis was performed to better elucidate the relationship among *** results revealed that close relationship between endogenous proteases and key *** not only significantly affected the accumulation of key active-amino acids,but also affected the accumulation of ethyl octanoate,2,3-pentanedione,and 2,3-octanedione by regulating the accumulation of octanoic acid and *** addition,cathepsin B and D,DPP II,DPP IV and RAP notably affected accumulation of hexanal.

关键词： Dry-cured pork coppa Endogenous proteases Proteolysis Key taste-active amino acids Volatile compounds

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Current observation and analysis based on mooring systems in the Andaman Sea

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Journal of Oceanology and Limnology 2024年第2期42卷 484-491页

作者： Yimeng WANG Jingsong GUO Dapeng qu Zhixin ZHANG Chalermrat SANGMANEE Varintha VASINAMEKHIN Binghuo GUO First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Shandong Key Laboratory of Marine Science and Numerical Modeling Qingdao 266061China Phuket Marine Biological Center Department of Marine and Coastal ResourcesPhuket 83000Thailand Marine and Coastal Resources Research&Development Institute Department of Marine and Coastal ResourcesBangkok 10210Thailand

The basic structure and intraseasonal evolution of currents in the southeastern Andaman Sea was analyzed based on data collected in 2017 from two subsurface moorings(C1 and C5).Periodic variation in the upper ocean currents of the Andaman Sea was investigated by combining observational and satellite *** observations show that rapid changes of current speed and direction occurred in May and June,with a significant increase in current velocity at the C1 *** the second half of the year,southward flow dominated at the C1 mooring,and alternating northward and southward flows were evident at the C5 mooring during the same period but the northward flow prevailed in boreal *** addition,analysis of the power spectra of the upper currents revealed that the tidal period at both moorings is primarily semidiurnal with weaker energy than that of the low-frequency *** upper ocean currents at the C1 and C5 moorings exhibited intraseasonal variation of 30-60 d and 120 d,while the zonal current at the C1 mooring exhibited a notable period of approximately 180 *** analysis indicated that the variability of currents in the Andaman Sea is influenced primarily by equatorial Kelvin waves and Rossby wave ***,our results suggest that equatorial Kelvin waves from the eastern Indian Ocean entered the Andaman Sea in the form of Wyrtki Jets and propagated primarily along two distinct pathways during the observation *** addition to coastal boundary Kelvin waves,it was found that a branch of the Wyrtki Jet that directly enters the Andaman Sea and flows northward along the slope of the continental shelf,and reflected Rossby wave packets by topography.

关键词： mooring observation Wyrtki Jet Rossby waves intraseasonal variation

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An MPI parallel DEM-IMB-LBM framework for simulating fluid-solid interaction problems

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2219-2231页

作者： Ming Xia Liuhong Deng Fengqiang Gong Tongming qu Y.T.Feng Jin Yu Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China School of Civil Engineering Southeast UniversityNanjing211189China Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyHong KongChina Zienkiewicz Centre for Computational Engineering Swansea UniversitySwanseaSA18ENUK Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

The high-resolution DEM-IMB-LBM model can accurately describe pore-scale fluid-solid interactions,but its potential for use in geotechnical engineering analysis has not been fully unleashed due to its prohibitive computational *** overcome this limitation,a message passing interface(MPI)parallel DEM-IMB-LBM framework is proposed aimed at enhancing computation *** framework utilises a static domain decomposition scheme,with the entire computation domain being decomposed into multiple subdomains according to predefined processors.A detailed parallel strategy is employed for both contact detection and hydrodynamic force *** particular,a particle ID re-numbering scheme is proposed to handle particle transitions across sub-domain *** benchmarks are conducted to validate the accuracy and overall performance of the proposed ***,the framework is applied to simulate scenarios involving multi-particle sedimentation and submarine *** numerical examples effectively demonstrate the robustness and applicability of the MPI parallel DEM-IMB-LBM framework.

关键词： Discrete element method(DEM) Lattice Boltzmann method(LBM) Immersed moving boundary(IMB) Multi-cores parallelization Message passing interface(MPI) CPU Submarine landslides

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Investigation of anisotropic strength criteria for layered rock mass

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1289-1304页

作者： Shuling Huang Jinxin Zhang Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu qu Key Laboratory of Geotechnical Mechanics and Engineering of the Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan430071China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430000China University of Chinese Academy of Sciences Beijing100049China

Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground *** investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination ***,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are *** results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding *** strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K *** for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K *** addition,the strength of the rock sample increases as confining pressure ***,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the *** shows that the predicted strength is in good agreement with the experimental *** test the applicability of the strength criterion,the strength data of several types of rock in the literature are ***,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks.

关键词： Layered rock Strength anisotropy Strength criterion Experimental verification

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A critical review on direct catalytic hydrogasification of coal into CH_(4):catalysis process configurations,evaluations,and prospects

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International Journal of Coal Science & Technology 2024年第3期11卷 51-85页

作者： Shuai Yan Jun Feng Shenfu Yuan Zihong Xia Fengshuang Han Xuan qu Jicheng Bi School of Materials and Chemical Engineering Ningbo University of TechnologyNingbo315211ZhejiangChina Zhejiang Institute of Tianjin University Ningbo315201ZhejiangChina State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan030001China School of Chemical Science and Engineering Key Laboratory of Medicinal Chemistry for Natural ResourceMinistry of EducationNational Center for Experimental Chemistry and Chemical Engineering Education DemonstrationYunnan Provincial Key Laboratory of Carbon Neutral and Green Low-Carbon TechnologyYunnan UniversityKunming650091China Department of Energy and Chemical Engineering East China University of Science and TechnologyShanghai200237China

Coal catalytic hydrogasification(CCHG)is a straightforward approach for producing CH_(4),which shows advantages over the mature coal-to-CH_(4) technologies from the perspectives of CH_(4) yield,thermal efficiency,and CO_(2) *** core of CCHG is to make carbon in coal convert into CH_(4) efficiently with a *** the past decades,intensive research has been devoted to catalytic hydrogasification of model carbon(pitch coke,activated carbon,coal char).However,the chemical process of CCHG is still not well understood because the coal structure is more complicated,and CCHG is a combination of coal catalytic hydropyrolysis and coal char catalytic *** review seeks to shed light on the catalytic process of raw coal during *** configuration of suitable catalysts,operating conditions,and feedstocks for tailoring CH_(4) formation were identified,and the underlying mechanisms were *** on these results,the CCHG process was evaluated,emphasizing pollutant emissions,energy efficiency,and reactor ***,the opportunities and strategic approaches for CCHG under the restraint of carbon neutrality were highlighted by considering the penetration of“green”H2,biomass,and CO_(2) into *** investigations from our laboratories demonstrated that the integrated CCHG and biomass/CO_(2) hydrogenation process could perform as an emerging pathway for boosting CH_(4) production by consuming fewer fossil fuels,fulfilling the context of green *** work not only provides systematic knowledge of CCHG but also helps to guide the efficient hydrogenation of other carbonaceous resources such as biomass,CO_(2),and coal-derived wastes.

关键词： Coal gasification Catalytic hydrogasification Methane Pressurized fluidized bed

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Sodium butyrate alleviates fructose-induced non-alcoholic fatty liver disease by remodeling gut microbiota to promoteγ-amino butyric acid production

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Food Science and Human Wellness 2024年第2期13卷 961-971页

作者： qu Chen Lei Wu Aijia Zhang Chen Wu Liuping Cai Yingping Xiao Yingdong Ni Key Laboratory of Animal Physiology and Biochemistry Ministry of Agriculture and Rural AffairsNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Managing Biotic and Chemical Threats to the quality and Safety of Agro-products Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou 310022China

Sodium butyrate(NaB)can regulate lipid metabolism and inhibit hepatic *** study aimed to investigate whether NaB can alleviate fructose-induced hepat ic steatosis via remodeling the gut microbiota and evaluate the anti-fatty liver *** results showed that NaB and NaB-remodeled gut microbiota significantly alleviated fructose-induced hepatic steatosis and increased plasma uric acid and fructose ***,both NaB and NaB-remodeled gut microbiota increased the abundance of Lactobacillus and altered the levels of plasma amino acids(upregulating gamma-amino butyric acid(GABA)and downregulating L-glutamic acid and L-arginine)in fructose-exposed *** correlation analysis showed that GABA levels positively correlated with Lactobacillus abundance,and increased GABA levels might promote the reduction of the hepatic triglyceride *** studies confirmed that GABA significantly reduced lipid deposition in mouse hepatocytes induced via fructose pretreatment in *** findings suggested that NaB could ameliorate fructose-induced hepatic steatosis by regulating gut microbiota.

关键词： Butyrate Fructose Gut microbiota Hepatic steatosis

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Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 667-681页

作者： Yue Zhang Jingwen gao Na Li Peng Xu Shimeng qu Jinqian Cheng Mingrui Wang Xueru Li Yaheng Song Fan Xiao Xinyu Yang Jihong Liu Hao Hong Ronghao Mu Xiaotian Li Youmei Wang Hui Xu Yuan Xie Tianming gao Guangji Wang Jiye Aa Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesResearch Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic CenterMinistry of Public SecurityBeijing 100193China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Foreign Languages China Pharmaceutical UniversityNanjing 211198China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pharmacology China Pharmaceutical UniversityNanjing 211198China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Studies have suggested that the nucleus accumbens(NAc)is implicated in the pathophysiology of major depression;however,the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been ***,we identified a specific reduction of cyclic adenosine monophosphate(cAMP)in the subset of dopamine D1 receptor medium spiny neurons(D1-MSNs)in the NAc that promoted stress susceptibility,while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like *** treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons(D2-MSNs)of depressed mice,however,the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc *** discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration,but not a lower *** fast onset property of crocin was verified through multicenter ***,crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on *** findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc,and provide a potential rapid antidepressant drug candidate,crocin.

关键词： CAMP Nucleus accumbens Depression D1-MSN D2-MSN

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Exploring the impact of non-small cell lung cancer tumor microbiome on the efficacy of chemotherapy and immune checkpoint inhibitors

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Cancer Advances 2024年第5期7卷 1-10页

作者： Yan Dong Tian-Hao qu Xi-Yue Zhang Hai-Yu Chen Yu-Jun Li Bin Zhang ping gao Ling Wang Chun-Xia Zhang Jia Li Xiao-Nan Cui Department of Oncology The First Hospital of Dalian Medical UniversityDalian 116000China.

Background:This study aimed to investigate the potential of intratumoral microbiota,gut microbiome,peripheral blood T-cell subsets,and inflammatory markers as predictive biomarkers for antitumor efficacy in patients with non-small cell lung ***:This study observed patients with metastatic non-driver mutation non-small cell lung cancer who were initially diagnosed at the First Affiliated Hospital of Dalian Medical University’s Department of Oncology from August 2021 to July 2022 and completed at least four cycles of chemotherapy combined with immune checkpoint inhibitor *** biopsy tissues,fecal,and peripheral blood samples were collected from these *** on the efficacy of the combined chemotherapy and immunotherapy,patients were divided into an effective group and an ineffective *** tumor microbiota,gut microbiome,peripheral blood T-cell subsets,and inflammatory markers were compared between the two *** lung and fecal microbiota were analyzed using 16S rRNA high-throughput *** cytometry was used to detect T-cell subsets,and enzyme-linked immunosorbent assay was employed to measure inflammatory ***:A total of 21 patients were *** were significant differences in the tumor microbiota between the responsive and non-responsive groups,particularly the proportion of the genera Sphingomonas and *** gut microbiome composition changed after treatment,but there were no differences between the two groups before *** were no significant differences in T-cell subsets and inflammatory markers between the responsive and non-responsive ***:The composition of intratumoral microbiota in non-small cell lung cancer patients may serve as an indicator of response to chemotherapy combined with *** predictive value of gut microbiota,T-cell subsets,and inflammatory markers appears *** research should further validate the predictive role of changes in gu

关键词： NSCLC tumor microenvironment gut microbiota tumor-associated microbiota

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医学数字孪生涉及的伦理问题论析

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中国医学伦理学 2024年第6期37卷 686-692页

作者：渠淑洁高翔广西中医药大学公共卫生与管理学院广西南宁530200

医学数字孪生作为新兴医学科学技术中的一把“双刃剑”,在为临床诊疗带来福音的同时也对医学伦理体系造成一定冲击。主要就数字孪生技术在医学领域应用中涉及的模拟实验结果的科学性和有效性问题、医患双方自主性、隐私与生命安全问题... 详细信息

医学数字孪生作为新兴医学科学技术中的一把“双刃剑”,在为临床诊疗带来福音的同时也对医学伦理体系造成一定冲击。主要就数字孪生技术在医学领域应用中涉及的模拟实验结果的科学性和有效性问题、医患双方自主性、隐私与生命安全问题和潜在的社会不公正等伦理风险和挑战展开探讨,从尊重、有利、不伤害及公正等生命伦理四原则出发分析其现状并探寻解决医学数字孪生伦理问题的防治对策或建议,以期及时、准确、有效地做到发现、预防和控制,从而更好地促进数字孪生技术在医学领域的合理开发、创新应用和健康发展。

关键词：医学数字孪生伦理问题伦理原则新兴医学

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