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Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

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Asian Journal of Andrology 2024年第2期26卷 165-174页

作者： Hai-Wei Feng Yu Zhao Yan-Ling gao Dong-teng Liu Li-jun Huo Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionEducation Ministry of ChinaCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Maternal-Fetal Medicine Institute Department of Obstetrics and GynaecologyShenzhen Baoan Women's and Children's HospitalJinan UniversityShenzhen 518100China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various *** mitochondrial protease complex(ClpXP),which consists of caseinolytic mitochondrial matrix peptidase X(ClpX)and caseinolytic protease P(ClpP)and mediates the degradation of misfolded,damaged,and oxidized proteins,is essential for maintaining mitochondrial *** has been implicated in meiosis regulation,but its precise role is currently *** this study,we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X(Clpx^(cKO))mouse model to investigate the function of ClpX in *** found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the ***,it caused asynapsis of homologous chromosomes and impaired meiotic recombination,resulting in meiotic arrest in the zygotene-to-pachytene transition *** loss of ClpX compromised the double-strand break(DSB)repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolog 1(RAD51)to DSB *** dysfunction may be due to an insufficient supply of energy from the aberrant mitochondria in Clpx^(cKO) spermatocytes,as discerned by electron ***,ubiquitination signals on chromosomes and the expression of oxidative phosphorylation subunits were both significantly attenuated in Clpx^(cKO) *** together,we propose that ClpX is essential for maintaining mitochondrial protein homeostasis and ensuring homologous chromosome pairing,synapsis,and recombination in spermatocytes during meiotic prophase I.

关键词： ClpX homologous chromosome meiosis mitochondrial recombination synapsis

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Elastic Behavior of Polymer Chains

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Chinese Journal of Chemical Physics 2008年第5期21卷 463-468页

作者： teng Lu Tao Chen Hao-jun Liang Hefei National Laboratory for Physical Sciences at Microscale Department of Polymer Science andEngineering University of Science and Technology of China Hefei 230025 China

The elastic behavior of the polymer chain was investigated in a three-dimensional off-lattice model. We sample more than 109 conformations of each kind of polymer chain by using a Monte Carlo algorithm, then analyze them with the non-Gaussian theory of rubberlike elasticity, and end with a statistical study. Through observing the effect of the chain flexibility and the stretching ratio on the mean-square end-to-end distance, the average energy, the average Helmholtz free energy, the elastic force, the contribution of energy to the elastic force, and the entropy contribution to elastic force of the polymer chain, we find that a rigid polymer chain is much easier to stretch than a flexible polymer chain. Also, a rigid polymer chain will become difficult to stretch only at a quite high stretching ratio because of the effect of the entropy contribution. These results of our simulation calculation may explain some of the macroscopic phenomena of polymer and biomacromolecular elasticity.

关键词： Monte Carlo algorithm Three-dimensional off-lattice model Elastic behavior Polymer

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A brief discussion on offshore wind turbine hydrodynamics problem

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Journal of Hydrodynamics 2022年第1期34卷 15-30页

作者： Zhi-teng gao Xing-ya Feng Zi-tan Zhang Zheng-liang Liu Xiao-xia gao Li-jun Zhang Shan Li Ye Li Multi-function Towing Tank School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen518055China Hebei key Laboratory of Low Carbon and High Efficiency Power Generation Technology Department of Power EngineeringNorth China Electric Power UniversityBaoding071003China

Recently, offshore renewable energy has received significant attentions from most oceanic countries. Its multiple disciplinary nature appears as a hot research spot. Among those resources, offshore wind has been experiencing a rapid growth with strong industrial and governmental support. Among the research topics related to offshore wind turbine, those related to efficiency and safety issue receive most attentions, and they cover hydrodynamics, aerodynamics, structural dynamics, elasticity and so on. Hydrodynamics is considered as the key of these research for offshore wind turbine. This is not only because it is the fundamental of ocean engineering, but also it is similar to low speed aerodynamics which is the key of wind turbine rotor. In order to provide a comprehensive understanding of the important problems of offshore wind turbine hydrodynamics, we briefly review the evolution of offshore wind turbine and discuss the hydrodynamics problem associated with the research and development activities.

关键词： Offshore renewable energy offshore wind turbine hydrodynamics low speed aerodynamics aero-hydro dynamics coupling

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Improvement of decentralized random decrement technique for data processing in wireless sensor network

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Earthquake Engineering and Engineering Vibration 2016年第3期15卷 627-635页

作者： Liu Chengyin Xu Chunchuan teng jun School of Civil and Environmental Engineering Harbin Institute of Technology Shenzhen Graduate School Underground Systems Inc. 84 Business Park DriveArmonk

The Random Decrement Technique （RDT）, based on decentralized computing approaches implemented in wireless sensor networks （WSNs）, has shown advantages for modal parameter and data aggregation identification. However, previous studies of RDT-based approaches from ambient vibration data are based on the assumption of a broad-band stochastic process input excitation. The process normally is modeled by filtered white or white noise. In addition, the choice of the triggering condition in RDT is closely related to data communication. In this project, research has been conducted to study the nonstationary white noise excitations as the input to verify the random decrement technique. A local extremum triggering condition is chosen and implemented for the purpose of minimum data communication in a RDT-based distributed computing strategy. Numerical simulation results show that the proposed technique is capable of minimizing the amount of data transmitted over the network with accuracy in modal parameters identification.

关键词： RDT decentralized computing wireless sensor networks nonstationary

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Distributed Source-Load-Storage Cooperative Low-Carbon Scheduling Strategy Considering Vehicle-to-Grid Aggregators

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 440-453页

作者： Xiao Xu Ziwen Qiu teng Zhang Hui gao School of Automation Nanjing University of Posts and TelecommunicationsNanjing210023China

The vehicle-to-grid(V2G)technology enables the bidirectional power flow between electric vehicle(EV)batteries and the power grid,making EV-based mobile energy storage an appealing supplement to stationary energy storage ***,the stochastic and volatile charging behaviors pose a challenge for EV fleets to engage directly in multi-agent *** unlock the scheduling potential of EVs,this paper proposes a source-load-storage cooperative low-carbon scheduling strategy considering V2G *** uncertainty of EV charging patterns is managed through a rolling-horizon control framework,where the scheduling and control horizons are adaptively adjusted according to the availability periods of ***,a Minkowski-sum based aggregation method is employed to evaluate the scheduling potential of aggregated EV fleets within a given scheduling *** method effectively reduces the variable dimension while preserving the charging and discharging constraints of individual ***,a Nash bargaining based cooperative scheduling model involving a distribution system operator(DSO),an EV aggregator(EVA),and a load aggregator(LA)is established to maximize the social welfare and improve the low-carbon performance of the *** model is solved by the alternating direction method of multipliers(ADMM)algorithm in a distributed manner,with privacy of participants fully *** proposed strategy is proven to achieve the objective of low-carbon economic operation.

关键词： Electric vehicle(EV) low-carbon scheduling mobile storage system Nash bargaining power flexibility alternating direction method of multipliers(ADMM).

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The mitigation effects of exogenous dopamine on low nitrogen stress in Malus hupehensis

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Journal of Integrative Agriculture 2020年第11期19卷 2709-2724页

作者： LIU Xiao-min gao teng-teng ZHANG Zhi-jun TAN Ke-xin JIN Yi-bo ZHAO Yong-juan MA Fengwang LI Chao State Key Laboratory of Crop Stress Biology for Arid Areas Ministry of Science and Technology/Shaanxi Key Laboratory of AppleNorthwest A&F UniversityYangling 712100P.R.China

Dopamine plays numerous physiological roles in *** explored its role in the regulation of growth,nutrient absorption,and response to nitrogen(N)deficiency in Malus hupehensis *** low N condition,plant growth slowed,and the net photosynthetic rates,chlorophyll contents,and maximal quantum yield of PSII(Fv/Fm)decreased ***,the application of 100μmol L−1 exogenous dopamine significantly reduced the inhibition of low N stress on plant *** addition to modifying root system architecture under low N supply,exogenous dopamine also changed the uptake,transport,and distribution of N,P,and ***,exogenous dopamine enhances the tolerance to low nitrogen stress by increasing the activity of enzymes(nitrate reductase,nitrite reductase,glutamic acid synthase and glutamine synthetase)involved in N *** also found that exogenous dopamine promoted the expression of ethylene signaling genes(ERF1,ERF2,EIL1,ERS2,ETR1,and EIN4)under low N ***,we hypothesized that ethylene might be involved in dopamine response to low N stress in *** results suggest that exogenous dopamine can mitigate low N stress by regulating the absorption of mineral nutrients,possibly through the regulation of the ethylene signaling pathway.

关键词： nitrogen deficiency dopamine root system architecture ethylene Malus hupehensis

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Tissue distribution and changes in dopamine during development and stress responses in Malus germplasm

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Journal of Integrative Agriculture 2022年第3期21卷 710-724页

作者： ZHANG Zhi-jun ZHANG Jing TANG Zhong-wen WANG Yan-peng gao teng-teng LIU Xiao-min MA Feng-wang LI Chao State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYangling 712100P.R.China

Dopamine is a catecholamine and an anti-oxidant which functions in responses to stress and it interacts with plant hormones to mediate plant *** present,there are few studies on the functions of dopamine in *** study developed a method for dopamine determination which was used to analyze dopamine in Malus germplasm,in order to clarify the tissue distribution,developmental changes,diurnal variations,and stress responses in apple ***,the proposed method was *** linear range of quantification was robust from 0.1 to 20 ng mL^(–1).The instrumental,inter-day precision,and sample repeatability relative standard deviations were 1.024,5.607,and 7.237%,*** spiked recovery was greater than 100%,indicating the feasibility of the method and its suitability for the rapid analysis of dopamine in ***,the dopamine content was measured in 322 Malus *** results showed that the dopamine level in Malus was low and the average dopamine content in leaf was higher than in peel and *** dopamine had a skewed distribution that deviated to the right in cultivars and wild ***,the tissue specificity,developmental changes,diurnal changes,and responses to stress were *** cultivar ‘Pinova’(Malus domestica),the dopamine concentration was the highest in leaf buds and lowest in *** dopamine contents in leaf and flesh decreased with the growth and development of cultivar ‘Liangxiang’(Malus domestica).The dopamine content of apple leaves was higher after either drought or salinity stress as compared to the *** this study,a dopamine detection method for apple was established based on HPLC-MS and shown to be a robust *** study provides a framework for future research on elucidating the tissue distribution,developmental changes,diurnal variation,and stress responses of dopamine in apple trees.

关键词： dopamine Malus HPLC-MS cultivar wild accession

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Micro water dissolution machining principle and its application in ultra-precision processing of KDP optical crystal

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Science China(Technological Sciences) 2015年第11期58卷 1877-1883页

作者： gao Hang WANG Xu teng XiaoJi GUO DongMing Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education Dalian University of Technology

In this paper, a micro water dissolution machining （MWDM） principle is proposed for machining potassium dihydrogen phosphate （KDP） crystal using water-in-oil micro-emulsion as an abrasive-free polishing fluid. In addition, two instances of the application of this principle to ultra-precision machining of KDP crystals are presented. Computer-controlled optical surfacing （CCOS） and diamond wire cutting （DWC） process were carried out according to the MWDM principle. In the case of the CCOS technology, it is found that the micro-waviness was removed completely by following the MWDM principle. The surface undulation decreased from 40 nm to less than 10 nm, and the surface root-mean-square （rms） roughness obviously reduced from 8.147 to 2.660 nm. In the case of the DWC process, the surface rms roughness reduced from 8.012 to 2.391 gm, and the cutting efficiency was improved. These results indicate that the MWDM principle can efficiently improve the machining quality of KDP optical crystal and has a great potential to machine water-soluble materials.

关键词： potassium dihydrogen phosphate (KDP) crystal micro water dissolution machining (MWDM) principle ultra-precision machining surface root-mean-square (rms) roughness

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Mechanism,Actuation,Perception,and Control of Highly Dynamic Multilegged Robots:A Review

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Chinese Journal of Mechanical Engineering 2020年第5期33卷 120-149页

作者： jun He Feng gao State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Multilegged robots have the potential to serve as assistants for humans,replacing them in performing dangerous,dull,or unclean ***,they are still far from being sufficiently versatile and robust for many *** paper addresses key points that might yield breakthroughs for highly dynamic multilegged robots with the abilities of running(or jumping and hopping)and ***,21 typical multilegged robots from the last five years are surveyed,and the most impressive performances of these robots are ***,current developments regarding key technologies of highly dynamic multilegged robots are reviewed in *** latest leg mechanisms with serial-parallel hybrid topologies and rigid–flexible coupling configurations are ***,the development trends of three typical actuators,namely hydraulic,quasi-direct drive,and serial elastic actuators,are *** that,the sensors and modeling methods used for perception are ***,this paper pays special attention to the review of control approaches since control is a great challenge for highly dynamic multilegged *** dynamics-based control methods and two model-free control methods are described in ***,key open topics of future research concerning the mechanism,actuation,perception,and control of highly dynamic multilegged robots are *** paper reviews the state of the art development for multilegged robots,and discusses the future trend of multilegged robots.

关键词： Multilegged robot Mechanism Actuation Perception Control

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Springback Prediction and Optimization of Variable Stretch Force Trajectory in Three-dimensional Stretch Bending Process

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Chinese Journal of Mechanical Engineering 2015年第6期28卷 1132-1140页

作者： teng Fei ZHANG Wanxi LIANG Jicai gao Song State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology School of Automotive Engineering Dalian University of Technology

Most of the existing studies use constant force to reduce springback while researching stretch force. However, variable stretch force can reduce springback more efficiently. The current research on springback prediction in stretch bending forming mainly focuses on artificial neural networks combined with the finite element simulation. There is a lack of springback prediction by support vector regression（SVR）. In this paper, SVR is applied to predict springback in the three-dimensional stretch bending forming process, and variable stretch force trajectory is optimized. Six parameters of variable stretch force trajectory are chosen as the input parameters of the SVR model. Sixty experiments generated by design of experiments（DOE） are carried out to train and test the SVR model. The experimental results confirm that the accuracy of the SVR model is higher than that of artificial neural networks. Based on this model, an optimization algorithm of variable stretch force trajectory using particle swarm optimization（PSO） is proposed. The springback amount is used as the objective function. Changes of local thickness are applied as the criterion of forming constraints. The objection and constraints are formulated by response surface models. The precision of response surface models is examined. Six different stretch force trajectories are employed to certify springback reduction in the optimum stretch force trajectory, which can efficiently reduce springback. This research proposes a new method of springback prediction using SVR and optimizes variable stretch force trajectory to reduce springback.

关键词： springback prediction support vector regression(SVR) response surface particle swarm optimization(PSO)

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