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Big Theta Equals Small Theta Generically

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Acta Mathematica Sinica,English Series 2024年第3期40卷 717-730页

作者： Rui CHEN Jia liang zou Institute for Advanced Study in Mathmatics Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics University of Michigan530 Church StAnn ArborMI 48109USA

In this paper we consider the theta correspondence over a non-Archimedean local *** the homological method and the theory of derivatives,we show that under a mild condition the bigtheta lift is irreducible.

关键词： Theta correspondence derivatives

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Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1547-1563页

作者： Qiang zou Hao-Wen Wang Xi-liang Di Yuan Li Hui gao Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030Heilongjiang ProvinceChina Department of Hematology and Oncology Linyi People’s HospitalLinyi 251500Shandong ProvinceChina Department of Comprehensive Oncology Baotou Cancer HospitalBaotou 014030Inner Mongolia Autonomous RegionChina

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is *** targeted microbubble destruction mediated gene transfection is a new method to overexpress *** To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of *** In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,*** addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell ***,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and *** vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation *** We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of ***,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of *** miR-873-5p mimic counteracted the impact of ***,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to *** discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/*** vivo results showed that HAND2-AS1 silencing sig

关键词： Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA HAND2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2

Forming process chain for manufacturing complex conical-section profiled rings:On a co-design method

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Chinese Journal of Aeronautics 2024年第6期37卷 485-503页

作者： Lei liang Chaojiang zou lianggang GUO State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Guizhou Aviation Technology Development Co.Ltd Guiyang 550081China

The final quality of complex conical-section rings depends on co-design of multiple processes in forming process *** this study,for a complex aeroengine casing ring with a large slope and a flange on its end,a co-design method of the forming process chain is put forward towards the objective of precision forming,which not only proposes a standard process route composed of multiple processes of upsetting,punching,rectangular ring rolling,loose tooling forging and profiled ring rolling,but also presents co-design methods of dies and blanks for all the *** profiled ring rolling,a design method of preformed blank that makes the blank and the target conical-section ring have the same axial volume distribution is *** the method,the axial metal redistribution during the process can be alleviated greatly thus improving the forming stability and precision of the *** on the geometric features of designed preformed blank,design methods of blanks and dies for loose tolling forging,rectangular ring rolling,punching and upsetting are proposed *** view of the key roles of loose tooling forging(manufacturing the preformed blank)and profiled ring rolling on the final quality of the conical ring parts,inherited FE simulations for these two processes are performed to verify the proposed design methods and determine appropriate design *** is demonstrated that the proposed design method has significant advantages in improving forming ***,a suggestive value 1.5 of the rolling ratio for profiled ring rolling(a key design parameter)is given based on comprehensive consideration of multiple indicators such as ring roundness,deformation uniformity and forming *** corresponding industrial experiments performed illustrate that a high forming precision of the conical-section aeroengine casing ring is achieved.

关键词： Complex conical-section ring Co-design of forming process chain Profiled ringrolling Preformed blank Loose tooling forging

Arbuscular mycorrhizal fungi and endophytic fungi differentially modulate polyamines or proline of peach in response to soil flooding

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Pedosphere 2024年第2期34卷 460-472页

作者： Shengmin liang Yingning zou Bo SHU Qiangsheng WU Ministry of Education Engineering Research Center of Ecology and Agricultural Use of WetlandHubei Key Laboratory of Waterlogging Disaster and Agricultural Use of WetlandCollege of Horticulture and GardeningYangtze UniversityJingzhou 434025China

Symbiotic fungi are involved in plant flooding tolerance,while the underlying mechanism is not yet *** polyamines(PAs)and proline are also associated with stress tolerance,it is hypothesized that the enhancement of stress resistance by symbiotic fungi is associated with changes in PAs and/or *** aim of this study was to analyze the effect of inoculation with Funneliformis mosseae and Serendipita indica on plant growth,PAs,and proline and the metabolisms in peach(Prunus persica)under ***-week flooding did not affect root colonization frequence of ***,while it promoted root colonization frequence of *** flooding,plants inoculated with *** and *** maintained relatively higher growth rates than uninoculated *** mosseae promoted root ornithine(Orn)contentration and arginine(Arg)and Orn decarboxylase activities under flooding,which promoted putrescine(Put),cadaverine(Cad),and spermidine(Spd)***,*** decreased contentrations of Arg,Orn,and agmatine and Arg decarboxylase activities,thus decreasing PA contentrations under *** were negatively correlated with the expression of PA uptake transporter genes,PpPUT1 and PpPUT2,in *** transporter genes of ***(FmTPO)and ***(SiTPO)were regulated by flooding,of which FmTPO1 was positively correlated with Put,Cad,and Spd,along with positive correlations of Spd with SiTPO1,SiTPO2,and *** flooding,*** decreased proline concentration,while *** increased proline concentration and correlated with expression of a△^(1)-pyrroline-5-carboxylate synthetase gene,*** was thus concluded that *** modulated polyamine accumulation,while *** induced proline accumulation to tolerate flooding.

关键词： △^(1)-pyrroline-5-carboxylate synthetase flooding tolerance Funneliformis mosseae ornithine aminotransferase root colonization Serendipita indica spermidine transporter

Prognostic significance of grade of malignancy based on histopathological differentiation and Ki-67 in pancreatic ductal adenocarcinoma

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Cancer Biology & Medicine 2024年第5期21卷 416-432页

作者： Yuexiang liang Guannan Sheng Yu Guo Yiping zou Hanhan Guo Zhifei Li Shaofei Chang Quan Man Song gao Jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Gastrointestinal Oncology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Department of Gastrointestinal Pancreatic Surgery Shanxi Provincial People’s HospitalTaiyuan 030012China

Objective:Tumor cell malignancy is indicated by histopathological differentiation and cell ***-67,an indicator of cellular proliferation,has been used for tumor grading and classification in breast cancer and neuroendocrine ***,its prognostic significance in pancreatic ductal adenocarcinoma(PDAC)remains ***:Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled,and relevant prognostic factors were *** of malignancy(GOM),a novel index based on histopathological differentiation and Ki-67,is proposed,and its clinical significance was ***:The optimal threshold for Ki-67 was determined to be 30%.Patients with a Ki-67 expression level>30%rather than≤30%had significantly shorter 5-year overall survival(OS)and recurrence-free survival(RFS).In multivariate analysis,both histopathological differentiation and Ki-67 were identified as independent prognostic factors for OS and *** GOM was used to independently stratify OS and RFS into 3 tiers,regardless of TNM stage and other established prognostic *** tumor-nodemetastasis-GOM stage was used to stratify survival into 5 distinct tiers,and surpassed the predictive performance of TNM stage for OS and ***:Ki-67 is a valuable prognostic indicator for *** of the GOM in the TNM staging system may potentially enhance prognostic accuracy for PDAC.

关键词： Pancreatic ductal adenocarcinoma prognosis Ki-67 differentiation TNM stage

A THREE-DIMENSIONAL DESINGULARIZED HIGH ORDER PANEL METHOD BASED ON NURBS

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Journal of Hydrodynamics 2008年第2期20卷 137-146页

作者： gao Zhi-liang zou Zao-jian State Key Laboratory of Ocean Engineering Shanghai Jiaotong University Shanghai 200030 China School of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030 China

A desingularized high order panel method based on Non-Uniform Rational B-Spline （NURBS） was developed to deal with three-dimensional potential flow problems. A NURBS surface was used to precisely represent the body geometry. Velocity potential on the body surface was described by the B-spline after the source density distribution on the body surface had been solved. The collocation approach was employed to satisfy the Neurnann boundary condition and Gaussian quadrature points were chosen as both the collocation points and the source points. The singularity was removed by a combined method, so the process of the numerical computation was non-singular. In order to verify the method proposed, the unbounded flow problems of sphere and ellipsoid, the wave-making problem of a submerged ellipsoid were chosen as computational examples. It is shown that the numerical results are in good agreement with analytical solutions and other numerical results in all cases, and sufficient accuracy of numerical solution can be reached with a small number of panels.

关键词： potential flow high order panel method Non-Uniform Rational B-Spline (NURBS) desingularization

Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway

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World Journal of Gastroenterology 2022年第1期28卷 123-139页

作者： Tao Huang Yuan-Qing-Xiao Li Ming-Yu Zhou Rui-Han Hu gao-liang zou Jian-Chao Li Shu Feng Yong-Mei Liu Chang-Qin Xin Xue-Ke Zhao Department of Infectious Diseases Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Laboratory Center Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Infectious Diseases People’s Hospital of Weining YiHui and Miao Autonomous CountyWeining 553100Guizhou ProvinceChina

BACKGROUND Hepatic stellate cell(HSC)hyperactivation is a central link in liver fibrosis *** perform aerobic glycolysis to provide energy for their *** adhesion kinase(FAK)promotes aerobic glycolysis in cancer cells or fibroblasts,while FAK-related non-kinase(FRNK)inhibits FAK phosphorylation and biological *** To elucidate the effect of FRNK on liver fibrosis at the level of aerobic glycolytic metabolism in *** Mouse liver fibrosis models were established by administering CCl4,and the effect of FRNK on the degree of liver fibrosis in the model was *** growth factor-β1 was used to activate LX-2 *** phosphorylation at position 397(pY397-FAK)was detected to identify activated FAK,and the expression of the glycolysis-related proteins monocarboxylate transporter 1(MCT-1)and enolase1(ENO1)was *** analysis was performed to predict putative binding sites for c-myc in the ENO1 promoter region,which were validated with chromatin immunoprecipitation(ChIP)and dual luciferase reporter *** The pY397-FAK level was increased in human fibrotic liver *** knockout promoted liver fibrosis in mouse *** also increased the activation,migration,proliferation and aerobic glycolysis of primary hepatic stellate cells(pHSCs)but inhibited pHSC ***,opposite trends for these phenomena were observed after exogenous FRNK treatment in LX-2 ***,the FAK/Ras/c-myc/ENO1 pathway promoted aerobic glycolysis,which was inhibited by exogenous *** FRNK inhibits aerobic glycolysis in HSCs by inhibiting the FAK/Ras/c-myc/ENO1 pathway,thereby improving liver *** might be a potential target for liver fibrosis treatment.

关键词： Liver fibrosis Hepatic stellate cells Focal adhesion kinase Focal adhesion kinase-related non-kinase Aerobic glycolysis Enolase1

Mismatch loss analysis of solar array output power on stratospheric airship during flight

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Chinese Journal of Aeronautics 2024年第2期37卷 371-384页

作者： Siyu LIU Kangwen SUN Haoquan liang Xinzhe JI Tong zou Chuan SHAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Yunnan Innovation Institute Beihang UniversityKunming 650233China Institute of Unmanned System Beihang UniversityBeijing 100191China

Stratospheric airships are long-endurance aerostats and have broad *** of the energy required for their operation is obtained from solar radiation,which makes accurate calculation of the energy output from the solar array crucial to the design and flight planning of the ***,the status of each photovoltaic module in the solar array may differ due to the airship curvature,resulting in mismatch losses and lowered output power,which has not been widely *** this paper,an irradiation model and a thermal model are established based on the actual arrangement of the *** output power model is established considering the non-uniform radiation in the *** mismatch losses of the array are analyzed under different flight *** output power of the solar array is decreased by up to 31.6%compared to the ideal ***,the proportion of mismatch losses increases with latitude,but the maximum mismatch loss power occurs at ***,an array reconfiguration method is proposed based on the irradiance dispersion index and position dispersion *** reconfigured array increases output power by 11.5%and can maintain energy balance in continuous *** results can be used to correct the overestimation of the output power during the airship design or to guide the configuration of the solar array.

关键词： Stratospheric airship Solar panels Solar energy Non-uniform irradiation Mismatch loss assessment Reconfiguration

Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

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CHINESE JOURNAL OF POLYMER SCIENCE 2024年第8期42卷 1067-1076页

作者： Zhang, Chun-Peng gao, Si-Jia Luo, Ying zou, Lei Zhang, Yong-Jun Tiangong Univ Sch Mat Sci & Engn State Key Lab Separat Membranes & Membrane Proc Tianjin 300387 Peoples R China Tiangong Univ Sch Pharmaceut Sci State Key Lab Separat Membranes & Membrane Proc Tianjin 300387 Peoples R China Tiangong Univ Cangzhou Inst Cangzhou 061000 Peoples R China Nankai Univ Inst Hepatobiliary Dis Tianjin Key Lab Extracorporeal Life Support Crit D Affiliated Ctr Hosp 3 Tianjin 300170 Peoples R China

Glucose-sensitive membrane has potential application in self-regulating insulin release. Phenylboronic acid (PBA) is a well-known glucose reporter. Unfortunately, most PBA-based glucose-sensitive materials are expansion-type, which are not suitable as chemical valves in membrane pores for self-regulating insulin release. According to a new glucose-sensitive mechanism, we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels. Herein, a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. Through adjusting the chain length and chain density, the glucose-sensitivity of the membrane was optimized. The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum. The membrane also has good stability, anti-fouling and biocompatibility. It has potential application in self-regulating insulin release.

关键词： Phenylboronic acid Glucose-sensitive Membrane Surface grafting Insulin PHENYLBORONIC ACID BRUSHES DENSITY CHAINS LENGTH FILM