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从中苏两国改革看社会主义国家改革必须注意的几个问题

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特区经济 2009年第1期240卷 141-142页

作者：高斌类延旭北京市海淀区清华园街道办事处

中国和苏联,作为社会主义的大国,都对自身社会体制的弊端进行改革,但由于采取了不同的路径,自然而然导致了不同的结局。本文试图从两个国家改革的比较中探索和总结社会主义国家改革的经验教训。

关键词：中国苏联社会主义改革

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan Cheng Hui gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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肩胛骨关节盂的位置数据测量及其临床意义

解剖学报 2016年第5期47卷 670-671页

作者：徐高磊许路阳张振华王浩人高文涛马钊郑州大学基础医学院人体解剖学系郑州大学临床医学7年制郑州450052

目的利用肩胛骨上较为明显的3个点获得关节盂的位置数据,从而分析出肱骨头和关节盂之间的力传递关系,为肩部运动障碍的治疗提供依据。方法选取干燥的标本68例,经过测量,计算出肩胛骨上3个可触及的点所决定的平面与关节盂中心和前两个点... 详细信息

目的利用肩胛骨上较为明显的3个点获得关节盂的位置数据,从而分析出肱骨头和关节盂之间的力传递关系,为肩部运动障碍的治疗提供依据。方法选取干燥的标本68例,经过测量,计算出肩胛骨上3个可触及的点所决定的平面与关节盂中心和前两个点所决定的平面所形成的角(临界角θ),这个临界角θ可以让我们从肩胛骨上3个明显的点获得关节盂的位置数据。结果经过测量,计算得到θ值的范围为(31.36±4.65)°。结论可利用已知的θ和肩胛骨上3个较为明显的点来计算跨肩关节的力,从而为肩部运动障碍的患者优化加强锻炼的选择。

关键词：肩胛骨关节盂肩部运动障碍解剖学测量人

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou gao Qin Dong Dan Zou Zhijun Yang Lili Guo Ruxiang xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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缸间齿轮联动液压发动机动态特性研究

现代制造工程 2016年第12期 16-20,75页

作者：舒培张洪信高雷徐威中车四方车辆有限公司青岛266111 青岛大学机电工程学院青岛266071

针对缸间齿轮联动液压发动机(GCHE)的结构原理,在多体动力学仿真软件ADAMS环境下搭建了两缸GCHE虚拟样机,并进行了仿真分析和动态特性研究,获取了标定工况下GCHE主运动系统的运动和受力情况,仿真结果为GCHE的进一步优化设计和整机性能... 详细信息

针对缸间齿轮联动液压发动机(GCHE)的结构原理,在多体动力学仿真软件ADAMS环境下搭建了两缸GCHE虚拟样机,并进行了仿真分析和动态特性研究,获取了标定工况下GCHE主运动系统的运动和受力情况,仿真结果为GCHE的进一步优化设计和整机性能改善提供了重要参考依据。

关键词：缸间齿轮联动液压发动机 ADAMS软件虚拟样机动态特性研究

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian Liang Li xu Changsheng Ding Yu Liu Yanfeng gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia Yue Ma Mingtong gao Shuai Hou Shanshan xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong xu Bin Jiang lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

2012～2017年我国部分地区规模化猪场PRV野毒流行病学调查

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中国动物传染病学报 2020年第1期28卷 87-90页

作者：高许雷郑辉邹敏刘爽刘蕾范根成吴发兴青岛市退役军人服务中心青岛266000 青岛易邦生物工程有限公司青岛266114 中国动物与卫生流行病学中心青岛266032

为了监测我国规模化猪场伪狂犬病病毒(Pseudorabies virus,PRV)野毒感染情况,本研究采用伪狂犬g E抗体ELISA检测试剂盒对2012年2月~2017年7月送检的我国11个省份925个规模化猪场的44809份猪血清样品进行PRV野毒抗体检测。结果显示,925... 详细信息

为了监测我国规模化猪场伪狂犬病病毒(Pseudorabies virus,PRV)野毒感染情况,本研究采用伪狂犬g E抗体ELISA检测试剂盒对2012年2月~2017年7月送检的我国11个省份925个规模化猪场的44809份猪血清样品进行PRV野毒抗体检测。结果显示,925个猪场中有508个野毒阳性猪场,占检测猪场总数的54.91%,检出9153份阳性猪血清,平均阳性率为20.42%。其中种猪的野毒感染情况最明显,检出率较高,阳性率为23.19%;育肥猪的阳性检出率最低为17.22%。调查表明,我国规模化猪场猪群中仍存在PRV野毒感染。同时,本调查分析了不同地区、不同日龄猪的PRV野毒感染情况及该病的流行趋势,为我国伪狂犬病的净化提供思路。

关键词：猪伪狂犬病病毒酶联免疫吸附试验阳性率