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Transformation of Anaplastic Large Cell Lymphoma to High-grade Diffuse Large B-cell Ymphoma:Remission after Pegylated Liposomal Doxorubicin and Rituximab Immunotherapy

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中国实用内科杂志 2007年第S1期27卷 74-75页

作者： gao Lei CHEN xing-hua ZHANG Xi PENG Xian-gui gao Li LIU Yao SI Ying-jian ZHANG Cheng WANG Qing-yu

Summary:We demonstrate the usefulness of pegylated liposomal doxorubicin (PL-doxorubicin) combine with CD20 antibody Rituximab in a case of transformation of anaplastic large cell lymphoma (ALCL) to high-grade diffuse large B-cell lymphoma (B-DLCL).Case report:A 63-year-old woman suffering from anaplastic large cell lymphoma(stage Ⅳ a) since 2004 showed mediastinal relapse despite of 4 cyclesof chemotherapy following the

关键词： cell Cell Transformation of Anaplastic Large Cell Lymphoma to High-grade Diffuse Large B-cell Ymphoma high MTX

Photocatalytic applications and modification methods of two-dimensional nanomaterials:a review

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Tungsten 2024年第1期6卷 77-113页

作者： Fan Yang Ping Hu Fan Yang xing-Jiang hua Bo Chen Lili gao Kuai-She Wang School of Metallurgy Engineering Xi’an University of Architecture and TechnologyXi’an 710055China National and Local Joint Engineering Research Center for Functional Materials Processing Xi’an University of Architecture and TechnologyXi’an 710055China

Due to its unique electronic structure and special size effect,two-dimensional(2D)nanomaterials have shown great potential far beyond bulk materials in the field of *** to deeply explore the photocatalytic mechanism of 2D nanomaterials and design more efficient 2D semiconductor photocatalysts are research *** review provides a comprehensive introduction to typical 2D nanomaterials and discusses their current application status in the field of *** effects of material properties such as band structure,morphology,crystal face structure,crystal structure and surface defects on the photocatalytic process are *** main modification methods are highlighted,including doping,noble metal deposition,heterojunction,thickness adjustment,defect engineering,and dye sensitization in 2D material ***,the future development of 2D nanomaterials is *** is hoped that this paper can provide systematic and useful information for researchers engaged in the field of photocatalysis.

关键词： Photocatalysis Two-dimensional Nanomaterials Bandgap Modification strategy

Demixing microwave signals using system-on-chip photonic processor

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Light(Science & Applications) 2024年第3期13卷 399-401页

作者： Sheng gao Chu Wu xing Lin Department of Electronic Engineering Tsinghua University100084 BeijingChina Beijing National Research Center for Information Science and Technology Tsinghua University100084 BeijingChina

The integrated photonic processor,co-packaged with electronic peripherals,is proposed for blind source separation of microwave signals,which separates signal-of-interest from dynamic interference with real-time adapta... 详细信息

关键词： processor microwave mixing

Subungual squamous cell carcinoma treated by topical photodynamic therapy

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Chinese Medical Journal 2020年第7期133卷 881-882页

作者： Qian An Song Zheng Li Zhang xing-hua gao Jiu-Hong Li Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110000China

To the Edteor:Squamous cell carcinoma(SCC)in the ungual apparatus is a rare *** it is the most prevalent malignant tumor in this region,it often presents with non-specific features that lead to misdiagnosis and delayed treatment.[1]Various treatments have been proposed,including Mohs micrographic surgery,wide local excision with skin grafting,and amputation of the *** the rarity of the condition,there is no consensus on the optimal treatment.[2]Photodynamic therapy(PDT)has been extensively used to treat nonmelanoma skin cancers,such as actinic keratosis,basal cell carcinoma,and SCC in situ.[3]The difficult treatment of subungual SCC and the success rates of PDT for early SCC suggested that this treatment would be useful for treating the following patient,who was diagnosed with subungual SCC but refused surgery and was ultimately successfully treated with topical PDT.

关键词： surgery melanoma squamous

Room temperature self-healing liquid metals:capabilities,applications and challenges

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International Journal of Smart and Nano Materials 2024年第3期15卷 469-501页

作者： Chen hua Jianye gao Jing Liu Key Lab of Cryogenic Science and Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijingChina School of Future Technology University of Chinese Academy of SciencesBeijingChina School of Biomedical Engineering Tsinghua UniversityBeijingChina

Self-healing materials span diverse application fields,including flexible electronics,soft robotics,and energy ***,conventional self-healing materials pose a challenge in achiev-ing the delicate balance between flexibility and electrical ***,they also suffer from prolonged healing times,incomplete healing,and high manufacturing *** metals possess excellent self-healing capabilities owing to their unique combination of fluidic and metallic properties,high surface tension,and reversible solid-liquid phase change at room temperature,offering an intriguing material option for addressing the challenges associated with flexibility and elec-trical *** this review article,we comprehensively examine the domain of self-healing liquid metals from the standpoint of typical mechanisms underlying self-healing pro-cesses,as well as practical strategies employed for achieving such ***,we explore representative applications that showcase the potential of these materials while aiming to provide a valuable reference for advancing and enhancing the field of self-healing *** pro-spect along this direction is made.

关键词： Self-healing Liquid metal Smart materials

Metastatic melanoma misdiagnosed as lipoma manifesting as a subcutaneous soft-tissue mass

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Chinese Medical Journal 2019年第14期132卷 1760-1762页

作者： Qian An Jiu-Hong Li Li Zhang Hong-Duo Chen xing-hua gao Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China

To the Editor:Metastatic melanoma is a fatal disease with rapid systemic dissemination and a 5-year survival rate of about 1 7%.[1] More than half of primary metastases involve the skin as nodal,subcutaneous,or distant metastasis.[2] Cutaneous metastases of melanoma occur relatively frequently and can arise in early-or late-stage disease,with a variable clinical appearance and pattern distribution.[3] We describe herein a patient with a large subcutaneous nodule on the arm that we initially diagnosed as a *** obtaining further clinical history and reviewing the pathologic findings after excision,the nodule was determined to represent metastatic melanoma.

关键词： Metastatic melanoma lipoma subcutaneous soft-tissue

Multiscale causes of the 2022 Yangtze mega-flash drought under climate change

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Science China Earth Sciences 2024年第8期67卷 2649-2660页

作者： xing YUAN Yumiao WANG Shiyu ZHOU hua LI Chenyuan LI School of Hydrology and Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China

The 2022 Yangtze mega-flash drought is characterized by strong intensity and rapid development both in time and space,accompanied by a persistent anticyclonic circulation ***,the causes of the extreme event remain elusive given the multiscale nature of *** we presented a brief overview for the oceanic and terrestrial causes of the megaflash drought during the summer of 2022,and estimated the risk in a changing *** the soil moisture percentile as the drought index,it was found that the drought expanded to the entire Yangtze River basin within two months,with 80%of basin under severe drought conditions at the end of *** the intensity and onset speed of the 2022 mega-flash drought were ranked as the first during the past 62 years,with return periods of 86 and 259 years,*** results of composite analysis showed that the spring La Ni?a can facilitate the abrupt change from a wet/normal condition in May–June to drought in July–August over the Yangtze River basin,which was beneficial for the increase of flash drought intensity and onset speed *** analysis through the linear regression also indicated that the unprecedented intensity was associated with the negative phase of the Pacific Decadal *** by a coupling strength index for soil moisture and vapor pressure deficit,it was found that there was a strong land-atmosphere coupling over the Yangtze River basin during July–August *** attribution by using CMIP6 climate models suggested that land-atmosphere coupling increased the risks of flash drought intensity and onset speed like 2022 by 61%±6%and 64%±7%under natural climate forcings,and the synergy of coupling and anthropogenic climate change would increase the risks by 75%±22%and 85%±12%.Our findings emphasized the role of landatmosphere coupling combined with anthropogenic climate change in intensifying flash droughts.

关键词： Flash drought Yangtze River basin Land-atmosphere coupling Climate change Attribution

Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-hua He Jian-Fei gao Ling-Bin Kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis

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Chinese Medical Journal 2019年第6期132卷 690-698页

作者： Xue-Li Niu Yu huang Ya-Li gao Yu-Zhe Sun Yang Han Hong-Duo Chen xing-hua gao Rui-Qun Qi Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China NHC Key Laboratory of Immunodermatology China Medical University Shenyang Liaoning 110001 China Key Laboratory of Immunodermatology Ministry of Education Shenyang Liaoning 110001 China Central Hospital Affiliated to Shenyang Medical College Shenyang Liaoning 110001 China

Background: As a potent pro-inflammatory cytokine of the interleukin (IL)-1 family, IL-18 was elevated in early active progressive plaque-type psoriatic lesions and that serum or plasma levels of IL-18 correlated with the Psoriasis Area and Severity Index (PASI). Although results from previous studies have established that IL-18 may aggravate psoriatic inflammation, the mechanisms of this process remain unknown. In this study, IL-18 knock out (KO) mice and wild-type (WT) mice were used to investigate the effects of IL-18 within a mouse model of psoriasis. Methods: WT and IL-18 KO mice were divided into four groups, including imiquimod (IMQ)-treated IL-18 KO group (w = 11) and WT group (n = 13) as well as their respectively gene-matched control mice (receiving vaseline;w = 12). PASI scores were used to evaluate psoriatic lesions in IMQ-treated mice. Pathological features and dermal cellular infiltration were investigated by hematoxylin and eosin staining. The levels of psoriasis-related cytokines including IL-23, IL-17, IL-12, IL-10, IFNγ, IL-15, IL-27, and IL-4 were tested by real-time polymerase chain reaction (PCR). The protein level of IL-1β, IL-27, CXCL1, and Ly6g were investigated by immunohistochemistry (IHC). Results: Acanthosis (98.46±14.12 vs. 222.68土71.10μm, P<0.01) and dermal cell infiltration (572.25±47.45 vs. 762.47土 59.59cells/field, P< 0.01) were significantly milder in IMQ-induced IL-18 KO mice compared with that in WT mice. IMQ-induced IL-18 KO mice manifested larger areas of Munro microabscesses (11,467.83±5112.09 vs. 4093.19±2591.88 pirn2, P< 0.01) and scales (100,935.24 ±41,167.77 vs. 41,604.41 ± 14,184.10 μm, P<0.01) as compared with WT mice. In skin lesions ot IL-18 KO mice, the expressions of IL-1β, IL-4, and IL-27 were all significantly upregulated but IL-17 was decreased. Histologically, strong positive signals of Ly6g were observed within the epidermis of IL-18 KO mice but expressions of CXCL1 were decreased. Conclusions: IL-18 may exacerba

关键词： Interleukin-18 Psoriasis Cytokines Scales