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Asymmetric Dimethylarginine Predicts One-year Recurrent Cardiovascular Events: Potential Biomarker of "Toxin Syndrome" in Coronary Heart Disease

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Chinese Journal of Integrative Medicine 2019年第5期25卷 327-333页

作者： XU Hao CHEN zhuo SHANG Qing-hua gao zhu-ye YU Chang-an SHI Da-zhuo CHEN Ke-ji Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Cardiology China-Japan Friendship HospitalBeijing(100029)China

Objective: To examine the prognostic value of serum levels of asymmetric dimethylarginine(ADMA)in patients with stable coronary heart disease(CHD) thus explore a potential biomarker of "toxin syndrome" in ***: In this prospective nested case-control study, 36 of 1,503 Chinese patients with stable CHD experienced at least 1 recurrent cardiovascular event(RCE) during 1-year fol ow-up. Serum levels of ADMA at the start of fol ow-up were compared between these 36 cases and 36 controls which matched to cases in terms of gender, age, history of hypertension, and myocardial infarction. Results: Based on the crude model, subjects in the 2 highest ADMA quartiles showed signi?cantly higher risk of developing RCE than those in the lowest ADMA quartile [odds ratio(OR) 4.09, 95%confidence interval(CI) 1.01 to 16.58; OR 6.76, 95% CI 1.57 to 29.07]. This association was also observed in the case-mix model(OR 5.51, 95% CI 1.23 to 24.61; OR 7.83, 95% CI 1.68 to 36.41) and multivariable model(OR 6.64,95% CI 1.40 to 31.49; OR 13.14, 95% CI 2.28 to 75.71) after adjusting for confounders. The multivariable model which combined ADMA and high-sensitivity C-reactive protein(hs CRP) showed better predictive power with areas under the receiver operator characteristic curves(0.779) than the model of either ADMA(0.694) or hs CRP(0.636). Conclusion:Serum ADMA level may be a potential biomarker of "toxin syndrome" in CHD which shows favorable prognostic value in predicting 1-year RCE in patients with stable CHD. [The registration number is Chi CTR-PRNRC-07000012]

关键词： asymmetric dimethylarginine recurrent cardiovascular event nested case-control study coronary heart disease toxin syndrome

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Diagnostic Criterion of Blood Stasis Syndrome for Coronary Heart Disease

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Chinese Journal of Integrative Medicine 2016年第11期22卷 803-804页

作者： Chen Ke-ji Shi Da-zhuo Fu Chang-geng gao zhu-ye Xu Hao Lv Shu-zheng You Shi-jie Huang Li activating blood circulation committee of chinese association of integrative medicine

The diagnostic criterion of blood stasis syndrome（BSS） established in 1986 is a milestone in BSSdifferentiation of Chinese medicine （CM）. However,different disease has its own characteristics in BSS,thus establishing a BBS criterion of disease-syndromecombination has significance in clinical and basicstudies. BSS is the most common syndrome typeof CM in coronary heart disease （CHD）, but thereis not diagnostic criterion of BSS for CHD based ondisease-syndrome combination to date.

关键词： Diagnostic Criterion Syndrome

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Effectiveness of Integrative Medicine Therapy on Coronary Artery Disease Prognosis: A Real-World Study

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Chinese Journal of Integrative Medicine 2019年第1期25卷 9-15页

作者： ZHAO Kang TIAN Jin-fan ZHAO Cong YUAN Fei gao zhu-ye LI Li-zhi LIU Hong-xu WANG Xian GE Chang-jiang LU Shu-zheng Department of Cardiology Beijing Anzhen Hospital Affiliated to Capital Medical University-Beijing Institute of Heart Lung and Blood Vessel Diseases Center for Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Cardiology Beijing Chinese Medicine Hospital Affiliated to Capital Medical University Department of Cardiology Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine

Objective: To evaluate the effectiveness of integrative medicine(IM) on patients with coronary artery disease(CAD) and investigate the prognostic factors of CAD in a real-world setting. Methods: A total of 1,087 hospitalized patients with CAD from four hospitals in Beijing, China were consecutively selected between August 2011 and February 2012. The patients were assigned to two groups based on the treatment: Chinese medicine(CM) plus conventional treatment, i.e., IM therapy(IM group); or conventional treatment alone(CT group). The endpoint was major adverse cardiac events [MACE; including cardiac death, myocardial infarction(MI), and revascularization]. Results: A total of 1,040 patients finished the 2-year follow-up. Of them, 49.4%(514/1,040) received IM therapy. During the 2-year follow-up, the total incidence of MACE was 11.3%. Most of the events involved revascularization(9.3%). Cardiac death/MI occurred in 3.0% of cases. For revascularization, logistic stepwise regression analysis revealed that age 65 years [odds ratio(OR), 2.224], MI(OR, 2.561), diabetes mellitus(OR, 1.650), multi-vessel lesions(OR, 2.554), baseline high sensitivity C-reactive protein level 3 mg/L(OR, 1.678), and moderate or severe anxiety/depression(OR, 1.849) were negative predictors(Pyears(OR, 6.389) and heart failure(OR, 7.969) were negative predictors(P<0.05), while statin use(OR, 0.323) was a protective predictor(P<0.05) and IM therapy showed a beneficial tendency(OR, 0.587), although the difference was not statistically significant(P=0.218). Conclusion: In a real-world setting, for patients with CAD, IM therapy was associated with a decreased incidence of revascularization and showed a potential benefit in reducing the incidence of cardiac death or MI.

关键词： coronary artery disease Chinese medicine integrative medicine effectiveness real-world study

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302例冠心病合并糖尿病心力衰竭患者的中药应用分析

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中国中药杂志 2008年第19期33卷 2253-2256页

作者：荆鲁高铸烨中国中医科学院西苑医院北京100091 北京中医药大学北京100029

目的：回顾性分析302例冠心病合并糖尿病心力衰竭患者的临床资料，探讨冠心病合并糖尿病心衰患者的用药特点。方法：利用冠心病中医临床研究数据平台，采集2003年1月～2006年9月京津地区9家三甲医院冠心病合并糖尿病心力衰竭住院患者的... 详细信息

目的：回顾性分析302例冠心病合并糖尿病心力衰竭患者的临床资料，探讨冠心病合并糖尿病心衰患者的用药特点。方法：利用冠心病中医临床研究数据平台，采集2003年1月～2006年9月京津地区9家三甲医院冠心病合并糖尿病心力衰竭住院患者的信息，对其临床证候及中西药物治疗情况进行调查分析。结果：302例冠心病合并糖尿病心衰患者中药注射剂以葛根素、丹参、生脉、三七总皂苷、灯盏细辛注射液为主。中药治疗以益气、活血、化痰为主，中药口服煎剂中茯苓的使用频率最高，应用频度依次为：茯苓、甘草、黄芪、丹参、白术、半夏等。结论：京津地区9家三甲医院冠心病合并糖尿病心衰患者多采用中西医结合治疗，中药应用特点以益气、活血、化痰为主。

关键词：心力衰竭冠心病糖尿病药物分析

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病因病机研究与提高中西医结合临床水平

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中国中西医结合杂志 2011年第3期31卷 293-294页

作者：史大卓高铸烨中国中医科学院西苑医院心血管病中心北京100091

病因病机研究是提高中医药临床水平的重要方面。早在两千多年前的《黄帝内经》中即有＂夫百病之所生者,必起于燥湿、寒暑、风雨、阴阳、喜怒、饮食、居处＂的病因认识,强调辨证治疗过程中应＂审察病机,无失气宜＂;并将特定病因致病的病... 详细信息

病因病机研究是提高中医药临床水平的重要方面。早在两千多年前的《黄帝内经》中即有＂夫百病之所生者,必起于燥湿、寒暑、风雨、阴阳、喜怒、饮食、居处＂的病因认识,强调辨证治疗过程中应＂审察病机,无失气宜＂;并将特定病因致病的病理变化归纳为＂病机十九条＂,以执简驭繁,指导临床。

关键词：病因病机中西医结合临床《黄帝内经》水病机十九条辨证治疗病理变化

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Long-Term Follow-Up of Chinese Herbal Medicines Combined with Conventional Treatment in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: A Multicenter Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2017年第10期23卷 740-746页

作者： WANG Pei-li ZHANG Lei WANG Shao-li YANG Qiao-ning gao zhu-ye DU Jian-peng ZHANG Da-wu FU Chang-geng GU Feng XU Hao Li Li-zhi WANG Cheng-long SHI Da-zhuo Institute of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Gastroenterology Guang'anmen Hospital China Academy of Chinese Medical Sciences

Objective： To evaluate the prognosis effect of Chinese herbal medicines（CHMs） for benefiting qi and activating blood circulation adjunctive to conventional treatment in patients with acute coronary syndrome（ACS） after percutaneous coronary intervention（PCI）. Methods： A total of 702 patients with ACS who underwent PCI were enrolled and randomly assigned to receive conventional treatment plus CHMs for benefiting qi and activating blood circulation（treatment group, 351 cases） or conventional treatment alone（control group, 351 cases） for 6 months. Six months later, all patients received conventional treatment alone. Follow-ups were scheduled at 6th, 12 th, 18 th, 24 th month after enrollment in April 2008, and the final follow-up visit was during September 2011 and November 2011. The primary endpoint was the composite of cardiac death, nonfatal myocardial infarction or revascularization（PCI or coronary artery bypass grafting）; and the secondary endpoint was the composite of re-admission for ACS, congestive heart failure, nonfatal stroke or other thrombus events. Results： A total of 621（88.59%） patients completed 35.4±3.8 months follow-up, while 80（11.41%） patients withdrew from the trial（41 in the treatment group and 39 in the control group）. The incidence of primary endpoint was 5.7%（20 patients） in the treatment group versus 10.86%（38 patients） in the control group [relative risk（RR）： 0.53; 95% confidence interval（CI）： 0.30, 0.88; P=0.013; absolute risk reduction（ARR）： –0.052, 95% CI： –0.06, 0.01]. The incidence of secondary endpoint was 5.98%（21 patients） in the treatment group versus 10.28%（36 patients） in control group（RR： 0.58, 95% CI： 0.33, 0.97, P=0.037; ARR： –0.043, 95% CI： 0.06, 0.01）. Most of the primary and secondary endpoints were occurred in 18 months（84.50% in the treatment group versus 78.10% in the control group）. Conclusion： CHMs for benefiting qi and activating blood circulation adjunctive to conventional treatment improved clinical outcomes for patie

关键词： long-term follow-up Chinese medicine benefit qi and activate blood circulation acute coronary syndrome percutaneous coronary intervention

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Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong zhu Hualong Wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

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Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao gao Xingzhao Zhang Dacheng Ma Chuanlei zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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Simulation and analysis of the long-term impacts of 1.5°C global climate pledges on China's land systems

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Science China Earth Sciences 2025年

作者： Jiaying LV Changqing SONG Yifan gao Sijing ye Peichao gao State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Center for GeoData and Analysis Beijing Normal University

Global warming has become a shared issue for humanity. At the 26th Conference of the Parties to the United Nations Framework Convention on Climate Change in 2021, participating countries reached climate pledges aimed at making more proactive contributions to limit the global average temperature rise within 1.5°C by 2100. Land system changes are significant responses of land to climate change. As one of the contracting parties, China has proposed climate targets such as carbon peaking and carbon neutrality goals in recent years to support the global pledges of limiting global warming to1.5°C, which will profoundly impact China's future land system changes. This study focuses on China as the study area,produces data with a thematic resolution of 27 types of land systems, integrates the output of various land types by the Global Change Assessment Model(GCAM) into four categories of land service demand, and combines these with the improved CLUMondo model to simulate China's land system changes in 2100 under a 1.5°C global warming scenario and a reference scenario without updated emission reduction measures. The conclusions of this study are as follows:(1) The method of integrating the GCAM and improved CLUMondo model demonstrates high validation accuracy in simulating China's land system changes, effectively predicting the changes.(2) Under the 1.5°C global warming scenario, the quality of ecosystems related to mountains, water, forests, farmland, lakes, and grasslands in China improved. The areas of shrubland, wetland, and forest are projected to increase by 185%, 79%, and 33%, respectively, with low-density shrubland, high-density wetland, and high-density forest showing the most significant increases.(3) Compared with the reference scenario, the 1.5°C climate pledges drive greater changes in future land systems, with wetland and forest area growth levels exceeding those of the reference scenario by 20% and 10%, respectively. Notably, the changes in cropland, grasslan

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Recent advances of metal vacancies in energy and environmental catalysis:Synthesis,characterization,and roles

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Green Energy & Environment 2025年第1期10卷 84-108页

作者： Long Sun Shunzheng Zhao Sirui gao Ronghui zhu Yiran Tan Xiaolong Tang Honghong Yi School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing100083China

With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective ***,being one of the hallmarks of modern industry,offers a promising avenue for ***,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of *** engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent *** vacancies have received extensive attention due to their simple ***,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this ***,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic ***,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.

关键词： Metal vacancies Catalysis Construction strategies Characterization techniques Roles

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