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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Pan-Asian monsoon and its definition,principal modes of precipitation,and variability features

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Science China Earth Sciences 2012年第5期55卷 787-795页

作者： gao ya WANG HuiJun Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Graduate University of Chinese Academy of Sciences Beijing 100049China Climate Change Research Center Chinese Academy of SciencesBeijing 100029China

Here we propose a new concept,the Pan-Asian monsoon,and use empirical orthogonal function (EOF) analysis and linear regression approach to define it and to analyze the monsoon-related rainfall *** Pan-Asian monsoon is referred to as the monsoon occurred over the great region (60°E-140°E,10°S-35°N),consisting of the Indian monsoon,Southeast Asian monsoon,East Asian monsoon,and Western North Pacific *** Pan-Asian monsoon region is the principal region of the summer rainfall over the Asian-Pacific monsoon region and is also water vapor channel connecting several Asian-Pacific sub-monsoon *** first EOF mode of the Pan-Asian monsoon precipitation (PAMP_F) shows a meridional tripole pattern with more (less) rainfall zonal belt over the Bay of Bengal (BOB),the Indo-China Peninsula,South China,the South China Sea (SCS),Philippines and the Philippine Sea,and less (more) rainfall on both *** first rainfall mode is associated with the weakened Somali cross-equatorial flows,enhanced southerly over the eastern coast of Australia,and strengthened westerly over the tropical *** first EOF rainfall mode shows a close relationship with the simultaneous El Nio-Southern Oscillation (ENSO) and Pacific South America (PSA).The preceding spring and simultaneous summer Antarctic Oscillation (AAO) in the western Hemisphere (AAO in Pacific) has a connection with the first summer rainfall mode of the Pan-Asian *** the main influence factors are over the Pacific,the first rainfall mode is named as the Pacific *** second mode of the Pan-Asian monsoon precipitation (PAMP_S) shows a dipole pattern from northeast to southwest,which is associated with the weakened Somali cross-equatorial flows,enhanced easterlies over the Maritime Continent,and weak easterly over the tropical *** second rainfall model has a close relationship with the atmospheric convection activity and the sea surface temperature variability over the Maritime Conti

关键词： Pan-Asian monsoon precipitation ENSO teleconnections

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Shift of the principal mode of Pan-Asian monsoon summer precipitation in terms of spatial pattern

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Atmospheric and Oceanic Science Letters 2017年第3期10卷 221-227页

作者： gao ya Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Nanjing China

This paper documents that the principal mode of Pan-Asian monsoon summer precipitation experienced a prominent interdecadal shift around 1992/1993 in terms of spatial pattern and major driving factors. During 1979-1992 （Period 1, P1）, Pan-Asian monsoon summer precipitation anomalies mainly display a meridional dipole pattern from north to south, whereas in the period 1993-2016 （Period 2, P2）, it shows a meridional tripole pattern instead. The summer precipitation in P1 is primarily associated with a combination of the developing phase （central-eastern Pacific type） and decaying phase （eastern Pacific type） of El Nino-Southem Oscillation （ENSO）; while in P2, it is mainly associated with the decaying phase of central-eastern-Pacific-type ENSO.

关键词： Pan-Asian monsoon summer precipitation interdecadal shift ENSO phase Maritime Continent SST

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Interdecadal Variations of the South Asian Summer Monsoon Circulation Variability and the Associated Sea Surface Temperatures on Interannual Scales

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Advances in Atmospheric Sciences 2017年第7期34卷 816-832页

作者： ya gao Huijun WANG Dong CHEN Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Key Laboratory of Meteorological Disaster/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology

We investigate the interannual variability of the South Asian summer monsoon（SASM） circulation, which has experienced a significant interdecadal change since 2000. This change is primarily influenced by sea surface temperatures（SSTs）in the tropical Pacific and North Atlantic oceans. During the pre-2000 period examined in this study（1979-99）, the SASM is negatively correlated with eastern Pacific SSTs（the canonical ENSO mode） and positively correlated with the negative phase of the North Atlantic SST tripole（NAT）. During the post-2000 period（2000-14）, the SASM is negatively correlated with central Pacific SSTs and positively correlated with the positive phase of the NAT pattern. The associated Pacific SSTs change from the eastern to central region, leading to the rising（subsiding） branch of the Walker circulation moving westwards to the Maritime Continent in the latter period, which can impact the interannual variability of the SASM through modulating the wind field in the troposphere. In addition to Pacific SSTs, the NAT SSTs can propagate energy from the North Atlantic to the South Asian High（SAH） region through the wave activity flux, and then further impact the SASM via the *** the SASM is intimately related with precipitation over the Asian region, we briefly discuss the features of the precipitation patterns associated with the SASM during the two periods. The westward shifting Walker circulation leads to the shrinking and weakened anomalous westerlies of the SASM in the lower level, inducing the Maritime Continent rainfall location to move westwards and more moisture to arrive in southern China from the Pacific Ocean in the latter period.

关键词： interannual Atlantic ENSO anomalous equatorial tropical monsoon troposphere experienced eastern

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A New Inequality for Weakly (K_1,K_2)-Quasiregular Mappings

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2241-2246页

作者： Hong ya gao Shu Qing ZHOU ChinaCollege of Mathematics and Computer Hebei University Baoding 071002 P. R. Mathematical Study Center of Hebei Province Shijiazhuang 050016 P. R. China College of Mathematics and Computational Sciences Hu'nan Normal University Changsha 410081 P. R. China

We obtain a new inequality for weakly （K1,K2）-quasiregular mappings by using the McShane extension method. This inequality can be used to derive the self-improving regularity of （K1, K2）-Quasiregular Mappings.

关键词： (K1 K2)-Quasiregular mapping regularity McShane extension

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Weak WT_2-class of differential forms and weakly A-harmonic tensors

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Applied Mathematics(A Journal of Chinese Universities) 2010年第3期25卷 359-366页

作者： gao Hong-ya WANG yan-yan College of Mathematics and Computer Science Hebei University Baoding 071002 China Hebei Provincial Center of Mathematics Shijiazhuang 050016 China

In this paper, we give the definition of weak WT2-class of differential forms, and then obtain its weak reverse Holder inequality. As an application, we give an alternative proof of the higher integrability result of ... 详细信息

关键词： Weak WT2-class of differential forms weak reverse HSlder inequality weakly A-harmonic tensor,higher integrability.

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Some new integral inequalities for conjugate A-harmonic tensors

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 43-50页

作者： gao Hong-ya HOU Lan-ru College of Math. and Comput. Sci. Hebei University Baoding 071002 China. Mathematics Study Center of Hebei Province Shijiazhuang 050016 China. Beijing Science Technology and Management College Beijing 100086 China.

A new kind of weight-Ar^λ3 （λ1, λ2, Ω）-weight is used to prove the local and global integral inequalities for conjugate A-harmonic tensors, which can be regarded as generalizations of the classical results. Some... 详细信息

关键词： conjugate A-harmonic tensor Ar^λ3 (λ1 λ2 Ω)-weight weighted inequality quasiregular mapping.

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Joint channel selection and power control for video streaming over D2D communications based cognitive radio networks

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The Journal of China Universities of Posts and Telecommunications 2018年第1期25卷 1-14页

作者： gao ya Zhang Hailin Lu Xiaofeng State Key Laboratory of Integrated Services Networks Xidian University College of Physics and Electronic Information Luoyang Normal University

A joint channel selection and power control scheme is developed for video streaming in device-to-device （D2D） communications based cognitive radio networks. In particular, physical queue and virtual queue models by applying ＇M/G/1 queue＇ and ＇M/G/1 queue with vacations＇ theories are built up, respectively, to evaluate the delays experienced by various video traffics. Such delays play a vital role in calculating the packet loss rate for video streaming, which reflects the video distortion. Based on the distortion model, a video distortion minimization problem is formulated, subject to the rate constraint, maximum power constraint, primary users＇ tolerant interference constraint, and secondary users＇ minimum data rate requirement constraint. The optimization problem turns out to be a mixed integer nonlinear programming （MINLP） , which is generally nondeterministic in polynomial time. A Lagrangian dual method is thus employed to reformulate the video distortion minimization problem, based on which the sub-gradient algorithm is used to determine a relaxed solution. Thereafter, applying the iterative user removal yields the optimal joint channel selection and power control solution to the original MINLP problem. Extensive simulations validate our proposed scheme and demonstrate that it significantly increases the peak signal- to-noise ratio （PSNR） compared with the existing schemes.

关键词： channel selection power control cognitive radio networks D2D communications video streaming convex optimization

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Translating Solutions of the Nonparametric Mean Curvature Flow with Nonzero Neumann Boundary Data in Product Manifold M^(n)×R^(*)

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Chinese Annals of Mathematics,Series B 2022年第4期43卷 601-620页

作者： ya gao Yi-Juan GONG Jing MAO Faculty of Mathematics and Statistics Key Laboratory of Applied Mathematics of Hubei ProvinceHubei UniversityWuhan 430062China

In this paper,the authors can prove the existence of translating solutions to the nonparametric mean curvature flow with nonzero Neumann boundary data in a prescribed product manifold M^(n)×R,where M^(n) is an n-dime... 详细信息

关键词： Translating solutions Singularity Nonparametric mean curvature flow Convexity Ricci curvature

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Synthesis and Structure of a La(Ⅲ) Complex of 1,10-Phenanthroline-2,9-dicarboxylate:a Three-dimensional Network via Hydrogen Bonding Interactions

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Chinese Journal of Structural Chemistry 2008年第2期27卷 137-142页

作者： gao Qian XIE ya-Bo CHEN Yuan WANG Dao College of Environmental and Energy Engineering Beijing University of Technology Beijing 100022 China

A new La（Ⅲ） complex, {[La（L）（NO3）（H2O）3]·H2O}n （L = 1,10-phenanthroline- 2,9-dicarboxylate）, has been synthesized and structurally determined by X-ray diffraction analysis. The complex crystallizes in the monoclinic system, space group P21/c with a = 7.7358（17）, b = 8.1664（18）, c = 28.271（6） A, β= 95.184（4）°, V= 1778.6（7） A3, Z = 4, C14H14LaN3O11, Mr = 539.19, Dc = 2.014 g/cm^3, μ= 2.471 mm^-1, F（000） = 1056, the final R = 0.0350 and wR = 0.0659. In this complex, each metal center adopts a ten-coordination geometry formed by two N atoms from a ligand L and eight O atoms from three H2O molecules, a nitrate ion and carboxylates of two ligands. Each ligand adopts a N2,O3-pentdentate coordination mode using two N and two O atoms chelating a La（Ⅲ）, and using another O atom of carboxylate to bridge another La（Ⅲ） center resulting in a 1D helical chain molecule. Intermolecular strong O-H…O and weak C-H…O hydrogen bonds extend the 1D chain structure into a 3D supramolecular architecture.

关键词： hydrogen bonding 1,10-phenanthroline-2,9-dicarboxylate La(Ⅲ) complex,synthesis

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