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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu xu gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Real-time Feed-forward Force Compensation for Active Magnetic Bearings System Based on H∞ Controller

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Chinese Journal of Mechanical Engineering 2011年第1期24卷 58-66页

作者： gao Hui xu Longxiang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

There are two kinds of unbalance vibrations—force vibration and displacement vibration due to the existence of unbalance excitation in active magnetic bearings（AMB） system. And two unbalance compensation methods—closed-loop feedback and open loop feed-forward are presented to reduce the force vibration. The transfer function order of the control system directly influencing the system stability will be increased when the closed-loop method is adopted, which makes the real-time compensation not easily achieved. While the open loop method would not increase the primary transfer function order, it provides conditions for real-time compensation. But the real-time compensation signals are not easy to be obtained in the open loop method. To implement real-time force compensation, a new method is proposed to reduce the force vibration caused by the rotor unbalance on the basis of AMB active control. The method realizes real-time and on-line force auto-compensation based on H∞ controller and one novel feed-forward compensation controller, which makes the rotor rotate around its inertia axis. The time-variable feed-forward compensatory signal is provided by a modified adaptive variable step-size least mean square（VSLMS） algorithm. And the relevant least mean square（LMS） algorithm parameters are used to solve the H∞ controller weighting functions. The simulation of the new method to compensate some frequency-variable and sinusoidal signals is completed by MATLAB programming, and real-time compensation is implemented in the actual AMB experimental system. The simulation and experiment results show that the compensation scheme can improve the robust stability and the anti-interference ability of the whole AMB system by using H∞ controller to achieve close-loop control, and then real-time force unbalance compensation is implemented. The proposed research provides a new control strategy containing real-time algorithm and H∞ controller for the force compensation of AMB system. And

关键词： active magnetic bearings H∞ robust controller sensitivity and complementary sensitivity VSLMS algorithm feed-forward compensation

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Delay-dependent state feedback robust stabilization for uncertain singular time-delay systems

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Journal of Systems Engineering and Electronics 2008年第4期19卷 758-765页

作者： gao Huanli xu Bugong Coll. of Automation South China Univ. of Technology Guangzhou 510640 P. R. China

The problem of robust stabilization for uncertain singular time-delay systems is studied. First, a new delay-dependent asymptotic stability criteria for normal singular time-delay systems is given, which is less conservative. Using this result, the problem of state feedback robust stabilization for uncertain singular time-delay systems is discussed, Finally, two examples are given to illustrate the effectiveness of the results.

关键词： singular systems time-delay delay-dependent robust stabilization linear matrix inequalities(LMIs)

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Complex network theory-based condition recognition of electromechanical system in process industry

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Science China(Technological Sciences) 2016年第4期59卷 604-617页

作者： WANG RongXi gao JianMin gao ZhiYong gao xu JIANG HongQuan State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University

In order to recognize the different operating conditions of a distributed and complex electromechanical system in the process industry,this work proposed a novel method of condition recognition by combining complex network theory with phase space ***,a condition-space with complete information was reconstructed based on phase space reconstruction,and each condition in the space was transformed into a node of a complex ***,the limited penetrable visibility graph method was applied to establish an undirected and un-weighted complex network for the reconstructed ***,the statistical properties of this network were calculated to recognize the different operating conditions.A case study of a real chemical plant was conducted to illustrate the analysis and application processes of the proposed *** results showed that the method could effectively recognize the different conditions of electromechanical systems.A complex electromechanical system can be studied from the systematic and cyber perspectives,and the relationship between the network structure property and the system condition can also be analyzed by utilizing the proposed method.

关键词： complex network condition recognition phase space reconstruction complex electromechanical system

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Tensile ratcheting behaviors of bronze powder filled polytetrafluoroethylene

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 103-109页

作者： Wenjuan xu Hong gao LiLan gao xu CHEN Yong WANG School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

A series of tensile and ratcheting experiments for compacted polytetrafluoroethylene （PTFE） and bronze filled PTFE （PTFE/bronze） were conducted on dynamic mechanical analyzer （DMA-Q800）. The effects of mean stress, stress amplitude and temperature on the ratcheting behaviors of PTFE and PTFE/bronze were investigated. It is found that the stress-strain response of PTFE/bronze is nonlinear and its elastic modulus is higher than that of pure PTFE. For uniaxial ratcheting test, the dissipation strain energy density （DSED） decreases rapidly in the first l0 cycles and approaches a constant after 20 cycles. The ratcheting strain and the DSED corresponding to 100 cycles increase with increasing mean stress, stress amplitude and temperature. Additionally, the DSED and ratcheting strain of PTFE/bronze are much lower than those of pure PTFE under the same experimental conditions. It is also found that both pure PTFE and PTFE/bronze present cyclic hardening characteristics. Above all, the addition of bronze can improve both the uniaxial tensile property and the cyclic property of PTFE.

关键词： bronze filled polytetrafluoroethylene (PTFE/ bronze) uniaxial tensile behavior ratcheting behavior dissipation strain energy density (DSED)

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An artificial immune and incremental learning inspired novel framework for performance pattern identification of complex electromechanical systems

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Science China(Technological Sciences) 2020年第1期63卷 1-13页

作者： WANG RongXi gao xu gao JianMin gao ZhiYong CHEN Kun PENG CaiYuan State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong UniversityXi'an 710049China Xi'an Thermal Power Research Institute Co. Ltd.Xi'an 710054China

Performance pattern identification is the key basis for fault detection and condition prediction,which plays a major role in ensuring safety and reliability in complex electromechanical systems(CESs).However,there are a few problems related to the automatic and adaptive updating of an identification *** to solve the problem of identification model updating,a novel framework for performance pattern identification of the CESs based on the artificial immune systems and incremental learning is proposed in this paper to classify real-time monitoring data into different performance ***,an unsupervised clustering technique is used to construct an initial identification ***,the artificial immune and outlier detection algorithms are applied to identify abnormal data and determine the type of immune ***,incremental learning is employed to trace the dynamic changes of patterns,and operations such as pattern insertion,pattern removal,and pattern revision are designed to realize automatic and adaptive updates of an identification *** effectiveness of the proposed framework is demonstrated through experiments with the benchmark and actual pattern identification *** an unsupervised and self-adapting approach,the proposed framework inherits the preponderances of the conventional methods but overcomes some of their drawbacks because the retraining process is not required in perceiving the pattern ***,this method can be flexibly and efficiently used for performance pattern identification of the ***,the proposed method provides a foundation for fault detection and condition prediction,and can be used in other engineering applications.

关键词： performance pattern identification complex electromechanical systems artificial immune incremental learning data classification

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Atomic-scale simulations for lithium dendrite growth driven by strain gradient

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Applied Mathematics and Mechanics(English Edition) 2020年第4期41卷 533-542页

作者： gao xu Feng HAO Jiawang HONG Daining FANG State Key Laboratory for Turbulence and Complex Systems&Center for Applied Physics and Technology College of EngineeringPeking UniversityBeijing 100871China Department of Engineering Mechanics Shandong UniversityJinan 250100China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China

Dendrite formation is a major obstacle, e.g., capacity loss and short circuit,to the next-generation high-energy-density lithium(Li)-metal batteries. The development of successful Li dendrite mitigation strategies is impeded by an insu?cient understanding in Li dendrite growth mechanisms. The Li-plating-induced internal stress in Li-metal and its e?ects on dendrite growth have been widely studied, but the underlying microcosmic mechanism is elusive. In the present study, the role of the plating-induced stress in dendrite formation is analyzed through ?rst-principles calculations and ab initio molecular dynamic(AIMD) simulations. It is shown that the deposited Li forms a stable atomic nano?lm structure on the copper(Cu) substrate, and the adsorption energy of Li atoms increases from the Li-Cu interface to the deposited Li surface, leading to more aggregated Li atoms at the interface. Compared with the pristine Li-metal, the deposited Li in the early stage becomes compacted and su?ers the in-plane compressive stress. Interestingly,there is a giant strain gradient distribution from the Li-Cu interface to the deposited Li surface, making the deposited atoms adjacent to the Cu surface tend to press upwards with perturbation and causing the dendrite growth. This provides an insight into the atomicscale origin of Li dendrite growth, and may be useful for suppressing the Li dendrite in Li-metal-based rechargeable batteries.

关键词： lithium(Li)-metal-based battery Li dendrite strain gradient depositing

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Effect of inorganic salt on the thermal degradation of nitrocellulose and reaction mechanism of its mixture

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Defence Technology（防务技术） 2023年第9期27卷 111-118页

作者： Guo-zhong xu xu gao Mi Li Zhong-xuan Han Lin Jiang School of Mechanical Engineering Nanjing University of Science and TechnologyChina

In this study,to better understand the reaction mechanism between inorganic salts and nitrocellulose,CaCO_(3) and Li_(2)CO_(3) were evaluated with respect to their effects on the thermal degradation of NC in nitrogen atmosphere using TG/DSC at three different heating rates(2,5,10 K/min).The numerical relationship between activation energy(E)and conversion rate was obtained by FWO and KAS method,and it was discovered that CaCO_(3) could improve the thermal stability of *** energy values were calculated by Kissinger method,and it was found that NC that contain Li2CO3had the highest activation energy while NC containing CaCO3had the lowest E *** combining the thermal analysis data with Malek method,the most probable mechanism model of thermal degradation is obtained as Sesták-Berggren model,which expression is f(α)=α^(m)(1-α)^(n).As a result of this study,there are certain guiding principles that can be applied to the pyrolysis reaction model and to the actual production process of nitrocellulose.

关键词： Thermal analysis Thermal decomposition mechanism Malek method Nitrocellulose Inorganic salt

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Improvement and performance of parallel multilevel fast multipole algorithm

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Journal of Systems Engineering and Electronics 2011年第1期22卷 164-169页

作者： Zhanhe Liu Peilin Huang Zhe Wu xu gao School of Aeronautic Science and Engineering Beihang University Beijing 100191 P. R. China The First Aircraft Institute Aviation Industry Corporation of China Xi'an 710089 E R. China

The method of establishing data structures plays an important role in the efficiency of parallel multilevel fast multipole algorithm（PMLFMA）.Considering the main complements of multilevel fast multipole algorithm（MLFMA） memory,a new parallelization strategy and a modified data octree construction scheme are proposed to further reduce communication in order to improve parallel *** far interaction,a new scheme called dynamic memory allocation is *** analyze the workload balancing performance of a parallel implementation,the original concept of workload balancing factor is introduced and verified by numerical *** results show that the above measures improve the parallel efficiency and are suitable for the analysis of electrical large-scale scattering objects.

关键词： multilevel fast multipole algorithm(MLFMA) electromagnetic scattering parallelization radar cross section(RCS).

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An in Vitro Investigation of Acid Etching Treatment Prior to Post and Core Cementation and Teeth Fracture Resistance

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Journal of Wuhan University of Technology(Materials Science) 2019年第5期34卷 1233-1237页

作者： MA Xiaoni gao xu xu Xin School of Stomatology Shandong UniversityJinan 250012China Handong Provincial Key Laboratory of Oral Tissue Regeneration Jinan 250012China School of Material Science and Engineering Shandong UniversityJinan 250012China Yantai Stomatological Hospital Yantai 264000China

In order to investigate how to enhance the teeth fracture resistance after the post and core treatment, an in vitro study was conducted to measure the fracture resistance of endodontically treated teeth restored with cast post and core with two kinds of surface treatment technology and acid etching preparation on the dentinal surface. Sixty-four recently extracted human single-rooted first premolars were endodontically treated and sectioned approximately 1.5 mm above the cementoenamel junction to remove the coronal portion. Each specimen received a cast post, core build-up and a metal alloy crown restoration. All teeth were randomly divided into the smooth surface post, core repair group, the sand blasting surface post, and core repair group, each group was divided into 10 s, 30 s, 60 s acid corrosion treatment group and control group. In acid test groups, an acid etching solution was applied for 10, 30 and 60 seconds, respectively, to the root canal wall surface. Each specimen was embedded in acrylic resin block and tested in an electronic universal testing machine. Fracture loads results showed that canal acid etching could increase teeth fracture resistance strength both in smooth groups and sandblasting group, and achieved the best effect when acid etching for 30 s. Sand spray treatment on the surface of the cast metal post can improve the flexural strength of the teeth after postcrown restoration. Acid etching on the root canal wall surfaces and sand spray treatment on the surface of the cast metal post can improve the flexural strength of the root after post-crown restoration. Therefore, these two methods could be used to strengthen the tooth fracture resistance, and maintain the long-term therapeutic effect of cast post and core restoration.

关键词： acid etching cast post and core resistance strength surface treatment

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