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Haemoglobin,albumin,lymphocyte and platelet predicts postoperative survival in pancreatic cancer

World Journal of Gastroenterology 2020年第8期26卷 828-838页

作者： Shuai-Shuai Xu Shuo Li Hua-Xiang Xu Hao Li Chun-tao Wu Wen-Quan Wang He-Li gao Wang Jiang Wu-Hu zhang Tian-Jiao Li Quan-Xing Ni Liang liu Xian-jun Yu Department of Pancreatic Surgery Fudan UniversityShanghai Cancer CenterShanghai 20032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

BACKGROUND Systemic inflammation and nutrition status play an important role in cancer *** combined index of hemoglobin,albumin,lymphocyte,and platelet(HALP),consisting of haemoglobin,albumin,lymphocytes,and platelets,is considered as a novel marker to reflect both systemic inflammation and nutrition ***,no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical *** To evaluate the prognostic value of preoperative HALP in pancreatic cancer *** The preoperative serum levels of hemoglobin,albumin,lymphocyte counts,and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical *** relationship between postoperative survival and the preoperative level of HALP was *** Low levels of HALP were significantly associated with lymph node metastasis(P=0.002),poor tumor differentiation(P=0.032),high TNM stage(P=0.008),female patients(P=0.005)and tumor location in the head of the pancreas(P<0.001).Low levels of HALP were associated with early recurrence[7.3 mo vs 16.3 mo,P<0.001 for recurrence-free survival(RFS)]and short survival[11.5 mo vs 23.6 mo,P<0.001 for overall survival(OS)]in patients with resected pancreatic adenocarcinoma.A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor *** Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer.

关键词： Pancreatic adenocarcinoma HALP Systemic inflammation Nutrition status Postoperative survival

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Article Navigation Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis

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Journal of Molecular Cell Biology 2021年第11期13卷 834-837页

作者： McKay Mullen Fengrui Yang jun Cao Yang Cao Xu liu Gee Young Lee tao Li William Yao Zhihong Yang Jiahai zhang Kela Johnson Felix Aikhionbare Yong Chen Xinjiao gao Dongmei Wang Xia Ding Hadiyah-Nicole Green Xing liu Xuebiao Yao MOE Key Laboratory for Cellular Dynamics Anhui Key Laboratory for Chemical BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Science and Technology of ChinaHefei 230027China Keck Center for Oganoids Plasticity Morehouse School of MedicineAtlantaGA 30310USA Department of Hepatobiliary Surgery Xijing HospitalXi’an 710032China BUCM-USTC Collaborative Center for Parietal Cell Research Beijing University of Chinese MedicineBeijing 100029China Ora Lee Smith Cancer Research Foundation AtlantaGA 30310USA

Dear Editor,The hallmarks of cancer comprise several distinct biological characteristics acquired during the multistep development of human tumors with the unique feature of genomic instability(Shen,2011).These cancer characteristics include sustaining proliferative signaling,evading growth suppressors,resisting cell death,enabling replicative immortality,inducing angiogenesis,and activating invasion and metastasis(Chen et al.,2011;Song et al.,2018).Triple-negative breast cancer(TNBC),an aggressive disease with increased risks for visceral metastases,has a poor prognosis due to unavailable and viable therapeutic targets(Bianchini et al.,2016).A TNBC diagnosis indicates that cancer cells test negative for three key receptors:estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2(Bianchini et al.,2016).The absence of these three receptors renders existing hormone and targeted therapies ineffective.

关键词： metastasis breast

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Inhibition of human prostate cancer xenograft growth by 125I labeled triple-helin forming oligonucleotide directed against androgen receptor

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Chinese Medical Journal 2008年第22期121卷 2284-2289页

作者： zhang Yong MA Yi LU Han-ping gao Jin-hui LIANG Chang-sheng liu Chang-zheng ZOU jun-tao WANG Hua-qiao Department of Nuclear Medicine the Third Affiliated Hospital SUN Yat-sen University Guangzhou Guangdong 510630 China Department of Organ Transplantation Center the First Affiliated Hospital SUN Yat-sen University Guangzhou Guangdong 510630 China Department of Experimental Nuclear Medicine the School of Preclinical Medicine Sun Yat-sen University Guangzhon Guangdong 510080 China The Basic Medical Experimental Teaching Center the School of Preclinical Medicine Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Anatomy the School of Preclinical Medicine Sun Yat-sen University Guangzhou Guangdong 510080 China

Background The failure of hormone treatment for advanced prostate cancer might be related to aberrant activation of the androgen receptor. We have shown that 125I labeled triple-helix forming oligonucleotide （TFO） against the androgen receptor gene inhibits androgen receptor expression and cell proliferation of LNCaP prostate cancer cells in vitro. This study aimed at exploring the effects of the 125I-TFO on prostate tumor growth in vivo using a nude mouse xenograft model. Methods TFO was labeled with 125I by the iodogen method. Thirty-two nude mice bearing LNCaP xenograft tumors were randomized into 4 groups and were intratumorally injected with 125I-TFO, unlabeled TFO, Na125I and normal saline. Tumor size was measured weekly. The tumor growth inhibition rate （RI） was calculated by measurement of tumor weight. The expression of the androgen receptor gene was performed by RT-PCR and immunohistochemical study. The prostate specific antigen （PSA） serum levels were measured by enzyme linked immunosorbent assay. The tumor cell apoptosis index （AI） was detected by TUNEL assay. Results Tumor measurements showed that tumor development was significantly inhibited by either 125I-TFO or TFO, with tumor RIs of 50.79% and 32.80% respectively. 125I-TFO caused greater inhibition of androgen receptor expression and higher AIs in tumor tissue than TFO. Both the tumor weight and the PSA serum levels in 125I-TFO treated mice （（0.93±0.15） g and （17.43±1.85） ng/ml, respectively） were significantly lower than those （（1.27±0.21） g and （28.25±3.41） ng/ml, respectively） in TFO treated mice （all P〈0.05）. Na 125I did not significantly affect tumor growth and androgen receptor expression in tumor tissue. Conclusions The 125I-TFO can effectively inhibit androgen receptor expression and tumor growth of human prostate cancer xenografts in vivo. The inhibitory efficacy of 125I-TFO is more potent than that of TFO, providing a reference for future studies of antigen radiotherapy.

关键词： prostate cancer androgen receptor oligonucleotides iodine radioisotopes gene therapy

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一种新型的运动目标识别与跟踪算法研究

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交通运输系统工程与信息 2008年第4期8卷 83-88页

作者：高韬刘正光张军天津大学电气与自动化工程学院天津300072

提出了一种应用于智能交通监控系统的运动目标识别和跟踪方法.针对帧间差分提取运动目标的缺陷与不足,提出了一种基于冗余小波变换的运动目标识别算法,即直接在冗余小波变换域提取运动区域,从而检测出运动目标.对于检测出来的运动目标,... 详细信息

提出了一种应用于智能交通监控系统的运动目标识别和跟踪方法.针对帧间差分提取运动目标的缺陷与不足,提出了一种基于冗余小波变换的运动目标识别算法,即直接在冗余小波变换域提取运动区域,从而检测出运动目标.对于检测出来的运动目标,本文对mean-shift算法进行了改进,采用自适应mean-shift算法,对目标进行跟踪.实验结果表明,本文提出的算法可以有效地提取运动目标,即使目标与背景具有较高的相似度,也可以较准确地提取出前景运动信息,效果要好于传统的帧差法;跟踪目标准确度高,不受目标大小变化的影响.本算法具较高的实用价值和应用前景.

关键词：交通监控目标识别目标跟踪

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Design and tests of the prototype a beam monitor of the CSR external target experiment

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Nuclear Science and Techniques 2022年第3期33卷 137-151页

作者： Hu-Lin Wang Zhen Wang Chao-Song gao Jian-Wei Liao Xiang-Ming Sun Hai-Bo Yang Cheng-Xin Zhao jun liu Peng Ma Zi-Li Li Bi-Hui You Ping Yang Di Guo Le Xiao Dong-Liang zhang Yue-Zhao zhang Sheng Dong Wan-Han Feng Yu-Xin Qiao Zheng-Yu Hu Qing-Wen Ye Zeng-tao Guo Guang-Ming Huang Feng liu PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China Hubei Provincial Engineering Research Center of Silicon Pixel Chip&Detection Technology Wuhan 430079China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

A prototype beam monitor was designed to provide tracking information for heavy-ion projectiles for the cool storage ring(CSR)external target experiment(CEE)at the Heavy Ion Research Facility in Lanzhou(HIRFL).High granularity and direct charge sensing are the main features of this *** measures the beam position in a two-dimensional(2D)plane transverse to the beam direction on an event-by-event *** current design consists of two field cages inside a single vessel that operates independently and has electrical drift fields in orthogonal *** tests of the prototype were performed using a^(241)Am a *** results show that a spatial resolution of less than 40μm and a time resolution of less than 600 ns can be achieved.

关键词： CEE Beam monitor Heavy ion Topmetal sensor Tracking Field cage

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基于特征点的多运动目标跟踪

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电子与信息学报 2010年第5期32卷 1111-1115页

作者：高韬刘正光张军岳士弘天津大学电气与自动化工程学院天津300072

该文针对智能监控的需求,提出基于特征的多运动目标跟踪算法。通过自适应Marr小波核函数背景建模算法,在冗余离散小波域进行多运动目标识别。运动跟踪采用SIFT特征粒子滤波算法,并采用队列链表法记录多运动目标之间的数据关联,在提高识... 详细信息

该文针对智能监控的需求,提出基于特征的多运动目标跟踪算法。通过自适应Marr小波核函数背景建模算法,在冗余离散小波域进行多运动目标识别。运动跟踪采用SIFT特征粒子滤波算法,并采用队列链表法记录多运动目标之间的数据关联,在提高识别准确率的同时降低了运算的复杂度。实际测试表明,该算法对于多运动目标识别跟踪具有更优越的实时性和抗遮挡性,在智能监控领域具有较广泛的应用前景。

关键词：多运动目标跟踪运动识别智能监控

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NUMERICAL SIMULATIONS OF THE CAVITATION PROCESS IN A ROOM-TEMPERATURE IONIC LIQUID

NUMERICAL SIMULATIONS OF THE CAVITATION PROCESS IN A ROOM-TE...

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2013全国压电和声波理论及器件技术研讨会

作者： Hai-xiao zhang Bin gao Yue-tao YANG Shu-yi zhang Xiao-jun liu Key Laboratory of Modern Acoustics Ministry of EducationInstitute of AcousticsNanjing University

In this work,Flynn’s formulation is adopted to analyze the dynamics,temperature and pressure of the cavitation bubble in the room-temperature liquids（RTIL）because of their unique physical *** effects of the ultrasonic intensity,frequency and the initial radius of the bubble on the cavitation process are studied,and the temperature and pressure in the collapsing bubbles are also *** is found that the intensity of cavitation increases remarkably with the increase of the bulk solution temperature.

关键词： Ultrasonics Cavitation Room-temperature ionic liquid

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Effects and mechanisms of non-restrictive external stent for prevention of vein graft restenosis in a rabbit model

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Chinese Medical Journal 2010年第17期123卷 2400-2404页

作者： TIAN Xiao-dong ZHOU Nai-kang LI Bo-jun XIAO Cang-song liu Xi LIANG Chao-yang zhang tao gao Chang-qing Department of Thoracic Surgery General Hospital of Chinese People's Liberation Army Beijing 100853 China Department of Cardicovascular Surgery General Hospital of Chinese People's Liberation Army Beijing 100853 China

Background Among various treatments preventing vein graft restenosis, external stent is receiving more and more attention. This study aimed to investigate the effect of non-restrictive external stent on the prevention of vein graft restenosis and the potential mechanisms of platelet-derived growth factor （PDGF） in the process of *** Thirty-six ＂New Zealand white rabbits＂ were randomly divided into two groups, stented group （group S） and control group （non-stented group, group NS）. Each rabbit underwent a reversed autologous external jugular vein into common carotid artery bypass grafting. In group S, the vein grafts were surrounded by a non restrictive stent which was 6 mm in diameter （a kind of Dacron vascular prosthesis）; and in group NS, there was no stent to support the vein *** grafts were harvested at the first week （1W）, second week （2W） and fourth week （4W） after surgery respectively. The dimensions （including the thickness and area of the intima and media, luminal area） were measured by computer-aided image analysis system, and the intimal hyperplasia ratio was defined as the percentage of the area enclosed by the internal elastic lamina occupied by the *** At 1W, the difference of the thickness and area of the intima between groups S and NS was not significant （P 〉0.05）; at 2W and 4W, the thickness and area of the intima and the intimal hyperplasia ratio in group S were less significant than those in group NS （P 〈0.05）; from 1W to 4W, the thickness and area of the media in group S were smaller than those in group NS （P〈0.05）. Immunocytochemistry staining of PDGF-B showed that the percentage of positive cells of intima in both two groups was peaked at 2W, and a significantly smaller percentage was detected in group S compared with that in group NS at 2W and 4W （P 〈0.05）; the percentage of PDGF-B positive cells of media in both two groups was also peaked at 2W, and that in group S was smaller than that in group NS from 1W to

关键词： vein graft restenosis intimal hyperplasia non-restrictive external stent platelet-derived growth factor

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Genome-wide signatures of the geographic expansion and breeding of soybean

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Science China(Life Sciences) 2023年第2期66卷 350-365页

作者： Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing jun Wang Yongzhe Gu Xingpeng gao Delin Li Hongyu Li zhangxiong liu Xin Jing Beibei Feng tao Zhao Rongxia Guan Yong Guo jun liu Zhe Yan Lijuan zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin liu Shilin Tian Li-juan Qiu The National Key Facility for Crop Gene Resources and Genetic Improvement(NFCRI)/Key Laboratory of Crop Gene Resource and Germplasm Enhancement(MOA)/Key Laboratory of Soybean Biology(Beijing)(MOA) Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China Shenzhen Branch Guangdong Laboratory for Lingnan Modern Agriculture/Genome Analysis Laboratory of the Ministry of Agriculture/Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518000China Novogene Bioinformatics Institute Beijing 100098China State Key Laboratory of Crop Genetics and Germplasm Enhancement/Cytogenetics Institute Nanjing Agricultural UniversityNanjing 210095China Soybean Research Institute/MOA National Center for Soybean Improvement/MOA Key Laboratory for Biology and Genetic Improvement of Soybean(General)/State Key Laboratory for Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China College of Agriculture Yangtze UniversityJingzhou 451199China School of Agronomy Anhui Agricultural UniversityHefei 230036China Jilin Academy of Agricultural Sciences Changchun 130119China Hulun Buir Institution of Agricultural Sciences Hulun Buir 021008China Soybean Research Institute Heilongjiang Academy of Agricultural SciencesHarbin 150086China Key Laboratory of Soybean Biology in Chinese Ministry of Education(Key Laboratory of Soybean Biology and Breeding/Genetics of Chinese Agriculture Ministry) Northeast Agricultural UniversityHarbin 150030China Heihe Branch of Heilongjiang Academy of Agricultural Sciences Harbin 150086China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China Department of Breeding Research Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Gatersleben DE D-06466Germany Center for Applied Genetic Technologies University of GeorgiaAthens 30602USA Department of Ecology/Tibetan Centre for Ecology and Conservation at WHU-TU/Hubei Key

Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding.

关键词： soybean adaptation introgression flowering time breeding

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聚丙烯酰乙二胺盐酸盐水溶液黏度和pH值对温度的响应性

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高分子材料科学与工程 2010年第11期26卷 83-85,89页

作者：张涛高钧丁运生刘洋罗明灯合肥工业大学化学工程学院可控化学与材料化工安徽省重点实验室安徽合肥230009

合成了丙烯酰乙二胺盐酸盐及其聚合物聚丙烯酰乙二胺盐酸盐,并通过红外光谱(FT-IR)和核磁共振(1H-NMR)对单体及聚合物进行了结构表征,考察了温度对聚丙烯酰乙二胺盐酸盐水溶液的特性黏数和pH值的影响。实验结果表明,在20℃～60℃的范围... 详细信息

合成了丙烯酰乙二胺盐酸盐及其聚合物聚丙烯酰乙二胺盐酸盐,并通过红外光谱(FT-IR)和核磁共振(1H-NMR)对单体及聚合物进行了结构表征,考察了温度对聚丙烯酰乙二胺盐酸盐水溶液的特性黏数和pH值的影响。实验结果表明,在20℃～60℃的范围内聚丙烯酰乙二胺盐酸盐溶液的特性黏数符合Fouss经验式。当温度从20℃升至60℃时,特性黏数从28.49dL/g降低至15.77dL/g。温度从30℃升至55℃时,聚丙烯酰乙二胺盐酸盐溶液的pH降低了0.35。

关键词：聚丙烯酰乙二胺盐酸盐特性黏数 pH值温度

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